Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.064 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0123 | 0.1527 | 0.1501 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0089 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0031 | 0.012 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0031 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0031 | 0.012 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0031 | 0.012 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0089 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0089 | 0.5 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0193 | 0.2549 | 0.2526 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0089 | 0.1394 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0089 | 0.1394 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0123 | 0.1527 | 0.1501 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0193 | 0.2549 | 0.2526 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0056 | 0.0549 | 0.2053 |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 0.1822 | 0.1796 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0467 | 0.173 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0056 | 0.0549 | 0.052 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0089 | 0.1394 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0089 | 0.1394 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0703 | 1 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0031 | 0.012 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.064 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0031 | 0.012 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0193 | 0.2555 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0049 | 0.045 | 0.0421 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0236 | 0.0206 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.045 | 0.0421 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0089 | 0.0232 |
Onchocerca volvulus | 0.0024 | 0.0089 | 0.1395 | |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0031 | 0.012 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0031 | 0.012 |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 0.1822 | 0.1796 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0549 | 0.2149 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0031 | 0.012 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0089 | 0.0232 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0049 | 0.045 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0193 | 0.2555 | 0.2532 |
Schistosoma mansoni | tar DNA-binding protein | 0.0193 | 0.2555 | 0.2532 |
Echinococcus multilocularis | tar DNA binding protein | 0.0193 | 0.2555 | 0.2532 |
Loa Loa (eye worm) | TAR-binding protein | 0.0193 | 0.2555 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0193 | 0.2555 | 0.2532 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.064 | 0.0611 |
Schistosoma mansoni | tar DNA-binding protein | 0.0193 | 0.2555 | 0.2532 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.064 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0089 | 0.1394 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0049 | 0.045 | 0.0421 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0031 | 0.012 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0056 | 0.0549 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.045 | 0.1762 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.1527 | 0.1501 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.045 | 0.0421 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0089 | 0.0232 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0089 | 0.1394 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.064 | 0.0611 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0031 | 0.012 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0089 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.064 | 1 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0049 | 0.045 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0089 | 0.0349 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0056 | 0.0549 | 0.052 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0143 | 0.1822 | 0.1796 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.045 | 0.1662 |
Onchocerca volvulus | 0.0049 | 0.045 | 1 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0031 | 0.012 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0049 | 0.045 | 0.0421 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.064 | 1 |
Loa Loa (eye worm) | MBCTL1 | 0.0056 | 0.0549 | 0.2149 |
Echinococcus granulosus | tar DNA binding protein | 0.0193 | 0.2555 | 0.2532 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0089 | 0.1394 |
Schistosoma mansoni | tar DNA-binding protein | 0.0193 | 0.2555 | 0.2532 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0089 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.064 | 0.0611 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0193 | 0.2555 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0089 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0089 | 0.0349 |
Brugia malayi | RNA binding protein | 0.0193 | 0.2555 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0031 | 0.012 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0467 | 0.1829 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0467 | 0.173 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0236 | 0.0924 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.064 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0193 | 0.2555 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0031 | 0.012 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.064 | 0.0611 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0031 | 0.012 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.4075 | 0.4057 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.045 | 0.1662 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0056 | 0.0549 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0089 | 0.0349 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0089 | 0.1394 |
Brugia malayi | TAR-binding protein | 0.0193 | 0.2555 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0703 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0031 | 0.012 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0049 | 0.045 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0467 | 0.1829 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0236 | 0.0814 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0056 | 0.0549 | 0.052 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0049 | 0.045 | 0.1762 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.