Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Nitric-oxide synthase, brain | Starlite/ChEMBL | References |
Bos taurus | Nitric-oxide synthase, endothelial | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0059 | 0.9321 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0037 | 0.2136 | 0.2136 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.8649 | 0.8283 |
Trypanosoma cruzi | p450 reductase, putative | 0.0059 | 0.9321 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.8649 | 0.8283 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0052 | 0.7186 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0059 | 0.9321 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0059 | 0.9321 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0059 | 0.9321 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0059 | 0.9321 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.9321 | 0.9137 |
Brugia malayi | FAD binding domain containing protein | 0.0059 | 0.9321 | 0.9137 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0059 | 0.9321 | 0.9137 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0059 | 0.9321 | 0.9137 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0059 | 0.9321 | 0.9321 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0059 | 0.9321 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0059 | 0.9321 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0059 | 0.9321 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0059 | 0.9321 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0059 | 0.9321 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2918 | 0.2918 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0037 | 0.2136 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.8649 | 0.8283 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.8649 | 0.8283 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0059 | 0.9321 | 0.9137 |
Giardia lamblia | Hypothetical protein | 0.0052 | 0.7186 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2918 | 0.0995 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0059 | 0.9321 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.2918 | 0.0995 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0059 | 0.9321 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0059 | 0.9321 | 0.9137 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0059 | 0.9321 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0059 | 0.9321 | 0.9137 |
Brugia malayi | flavodoxin family protein | 0.0059 | 0.9321 | 0.9137 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.47 uM | Inhibitory concentration of the compound tested against neuronal nitric oxide synthase (nNOS ) from rat cerebellum | ChEMBL. | 12482425 |
IC50 (binding) | = 4.9 uM | Inhibitory concentration of the compound tested against bovine endothelial nitric oxide synthase (eNOS) | ChEMBL. | 12482425 |
Selectivity ratio (binding) | = 10.4 | Selectivity ratio for inhibition of Endothelial Nitric oxide synthase to that of Neuronal Nitric oxide synthase in rat | ChEMBL. | 12482425 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.