Detailed information for compound 1046537

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 791.853 | Formula: C35H37N9O9S2
  • H donors: 8 H acceptors: 11 LogP: 0.62 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]1OC([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2Nc1ccc(cc1)CC(=O)Nc1ccc(cc1)CC(=O)NCC/N=C(/Nc1ccc(cc1)S(=O)(=O)O)\S
  • InChi: 1S/C35H37N9O9S2/c45-17-26-30(48)31(49)34(53-26)44-19-40-29-32(38-18-39-33(29)44)42-23-7-3-21(4-8-23)16-28(47)41-22-5-1-20(2-6-22)15-27(46)36-13-14-37-35(54)43-24-9-11-25(12-10-24)55(50,51)52/h1-12,18-19,26,30-31,34,45,48-49H,13-17H2,(H,36,46)(H,41,47)(H2,37,43,54)(H,38,39,42)(H,50,51,52)/t26-,30-,31-,34?/m1/s1
  • InChiKey: RITDPUPNZCETTH-TWADQQKPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0307 0.0307
Schistosoma mansoni jumonji/arid domain-containing protein 0.005 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0026
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0247 0.0623
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0016 0.0025
Schistosoma mansoni lipoxygenase 0.0106 0.1234 0.1234
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0026
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0247 0.0607
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0016 0.0016
Loa Loa (eye worm) MBCTL1 0.0057 0.0537 0.0892
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0636 0.3503
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4068 1
Schistosoma mansoni hypothetical protein 0.0095 0.1075 0.1075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0411 0.0411
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0307 0.1692
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0046 0.0046
Toxoplasma gondii ABC1 family protein 0.0037 0.0247 0.1262
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0436 0.0436
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0537 0.0835
Echinococcus multilocularis geminin 0.0172 0.2186 0.2186
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.1839 0.4638
Brugia malayi beta-lactamase family protein 0.0037 0.0247 0.0385
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0016 0.0016
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0371 0.5061 0.5061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4068 1
Onchocerca volvulus 0.0041 0.0298 0.0877
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0016 0.0026
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1817 0.4466
Schistosoma mansoni hypothetical protein 0.0312 0.4208 0.4208
Trypanosoma cruzi transcription factor btf3, putative 0.0146 0.1817 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0411 0.064
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0247 0.0411
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0046 0.0046
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0137 0.1684 0.1684
Leishmania major hypothetical protein, conserved 0.0052 0.046 0.2533
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0016 0.0025
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0016 0.0016
Brugia malayi PHD-finger family protein 0.0156 0.1958 0.3046
Schistosoma mansoni loxhd1 0.0041 0.0298 0.0298
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0307 0.0307
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0661 0.1029
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0179 0.2292 0.2292
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0247 0.0607
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.002 0.0112
Echinococcus granulosus lysine specific demethylase 5A 0.005 0.043 0.043
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.002 0.0112
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.0032
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0295 0.3965 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0247 0.0385
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0247 0.0623
Loa Loa (eye worm) hypothetical protein 0.0266 0.354 0.5881
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0636 0.3503
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0016 0.0026
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0194
Echinococcus granulosus geminin 0.0172 0.2186 0.2186
Schistosoma mansoni importin beta-1 0.0029 0.0132 0.0132
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0016 0.0025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0247 0.0247
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0026
Plasmodium falciparum phd finger protein, putative 0.003 0.0143 0.0311
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0016 0.0016
Loa Loa (eye worm) bromodomain containing protein 0.0109 0.1286 0.2137
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0307 0.0756
Loa Loa (eye worm) hypothetical protein 0.0438 0.602 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0298 0.0298
Loa Loa (eye worm) PHD-finger family protein 0.0128 0.1551 0.2577
Mycobacterium ulcerans lipase LipD 0.0037 0.0247 0.0623
Schistosoma mansoni transcription factor btf3 0.0146 0.1817 0.1817
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.2571 0.2571
Schistosoma mansoni coup transcription factor 0.0021 0.0016 0.0016
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0247 0.0623
Brugia malayi jmjC domain containing protein 0.0098 0.1128 0.1755
Schistosoma mansoni hypothetical protein 0.0128 0.1551 0.1551
Trypanosoma cruzi ISWI complex protein 0.0095 0.1075 0.5918
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0052 0.0128
Brugia malayi hypothetical protein 0.0052 0.046 0.0716
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0026
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0247 0.0623
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0307 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0016 0.0025
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0223 0.2916 0.2916
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0247 0.0623
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0537 0.0537
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0041 0.0298 0.0495
Brugia malayi follicle stimulating hormone receptor 0.024 0.3164 0.4923
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.1128 0.1128
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0163 0.0795
Mycobacterium ulcerans beta-lactamase 0.0037 0.0247 0.0623
Schistosoma mansoni jumonji/arid domain-containing protein 0.005 0.043 0.043
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0247 0.0623
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0016 0.0016
Brugia malayi mbt repeat family protein 0.005 0.0436 0.0679
Entamoeba histolytica hypothetical protein 0.0146 0.1817 0.4466
Echinococcus granulosus importin subunit beta 1 0.0029 0.0132 0.0132
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0436 0.0436
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0141 0.1747 0.1747
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0537 0.0537
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0247 0.0411
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.046 0.1115
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0436 0.0436
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.0219
Schistosoma mansoni methyl-cpg binding protein mbd 0.0106 0.1232 0.1232
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0661 0.1099
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.1128 0.1128
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0026
Brugia malayi PHD-finger family protein 0.003 0.0143 0.0223
Brugia malayi Bromodomain containing protein 0.0045 0.0354 0.0551
Plasmodium vivax importin-beta 2, putative 0.0029 0.0132 0.0282
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4068 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0307 0.0756
Schistosoma mansoni hypothetical protein 0.0172 0.2186 0.2186
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0556 0.306
Echinococcus multilocularis cpg binding protein 0.0044 0.0346 0.0346
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0371 0.5061 0.5061
Trypanosoma cruzi transcription factor btf3, putative 0.0146 0.1817 1
Loa Loa (eye worm) doublecortin family protein 0.0041 0.0298 0.0495
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0026
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.046 0.1115
Treponema pallidum fructose-bisphosphate aldolase 0.0303 0.4068 1
Echinococcus multilocularis RUN 0.0041 0.0298 0.0298
Echinococcus multilocularis snurportin 1 0.0312 0.4208 0.4208
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0295 0.3965 1
Echinococcus granulosus cpg binding protein 0.0044 0.0346 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1817 0.4466
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0438 0.2412
Echinococcus granulosus methyl CpG binding domain protein 2 0.0106 0.1232 0.1232
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0016 0.0025
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0436 0.0436
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0636 0.3503
Brugia malayi Bromodomain containing protein 0.0466 0.6426 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0052 0.0128
Brugia malayi mbt repeat family protein 0.005 0.0436 0.0679
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0016 0.0025
Loa Loa (eye worm) hypothetical protein 0.005 0.0436 0.0725
Brugia malayi beta-NAC-like protein 0.0146 0.1817 0.2827
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0411 0.0411
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0436 0.0725
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0016 0.0026
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0436 0.1305
Brugia malayi hypothetical protein 0.0034 0.0194 0.0303
Onchocerca volvulus 0.005 0.0436 0.1305
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0137 0.1684 0.1684
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0247 0.0247
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0137 0.1684 0.1684
Echinococcus multilocularis transcription factor btf3 0.0146 0.1817 0.1817
Mycobacterium tuberculosis Conserved protein 0.0037 0.0247 0.0623
Leishmania major cathepsin L-like protease 0.0064 0.0636 0.3503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0636 0.3503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0636 0.3503
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0295 0.3965 1
Schistosoma mansoni hypothetical protein 0.003 0.0143 0.0143
Trichomonas vaginalis ran, putative 0.0022 0.002 0.005
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0298 0.0298
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0016 0.0016
Loa Loa (eye worm) RNA binding protein 0.0066 0.0661 0.1099
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0307 0.1692
Onchocerca volvulus 0.0245 0.3237 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0636 0.3503
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.314 0.7919
Leishmania major GTP-binding protein, putative 0.0022 0.002 0.0112
Onchocerca volvulus 0.0037 0.0247 0.0718
Loa Loa (eye worm) hypothetical protein 0.0137 0.1684 0.2798
Brugia malayi PHD-finger family protein 0.0023 0.0047 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0636 0.3503
Leishmania major basic transcription factor 3a, putative 0.0146 0.1817 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0016 0.0016
Brugia malayi hypothetical protein 0.0146 0.182 0.2832
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0016 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0163 0.0163
Trichomonas vaginalis esterase, putative 0.0037 0.0247 0.0607
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0661 0.0661
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0143 0.0238
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0436 0.0436
Echinococcus granulosus tar DNA binding protein 0.0066 0.0661 0.0661
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0436 0.0436
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.3164 0.5256
Mycobacterium tuberculosis Conserved protein 0.0037 0.0247 0.0623
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.0298 0.0704
Giardia lamblia PHD finger protein 15 0.003 0.0143 0.0352
Loa Loa (eye worm) hypothetical protein 0.0037 0.0247 0.0411
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0295 0.3965 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0411 0.0683
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0016 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0411 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0016 0.0025
Brugia malayi nuclear receptor NHR-88 0.0021 0.0016 0.0025
Schistosoma mansoni hypothetical protein 0.0041 0.0298 0.0298
Schistosoma mansoni microtubule-associated protein tau 0.0714 1 1
Brugia malayi RNA binding protein 0.0066 0.0661 0.1029
Loa Loa (eye worm) beta-lactamase 0.0037 0.0247 0.0411
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0247 0.0607
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0052 0.0128
Onchocerca volvulus 0.0037 0.0247 0.0718
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0132 0.0132
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.4068 1
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0173 0.0269
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0636 0.3503
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.003 0.0143 0.0238
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0661 0.0661
Loa Loa (eye worm) hypothetical protein 0.0037 0.0247 0.0411
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0163 0.0163
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0604 0.1003
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0298 0.0298
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.0023 0.0047 0.0047
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0247 0.0575
Leishmania major cathepsin L-like protease 0.0064 0.0636 0.3503
Loa Loa (eye worm) hypothetical protein 0.0252 0.3345 0.5556
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0661 0.0661
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0661 0.0661
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4068 1
Schistosoma mansoni cpg binding protein 0.0044 0.0346 0.0346
Schistosoma mansoni cpg binding protein 0.0031 0.015 0.015
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0016 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0016 0.0026
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0016 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4068 1
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.0298 0.0298
Echinococcus granulosus histone lysine methyltransferase setb 0.0137 0.1684 0.1684
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.0034
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0057 0.0537 0.0892
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0307 0.0307
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0411 0.0411
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0016 0.0016
Loa Loa (eye worm) ICD-1 protein 0.0146 0.1817 0.3018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0016 0.0025
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0179 0.2292 0.2292
Entamoeba histolytica transcription factor BTF3, putative 0.0146 0.1817 0.4466
Echinococcus multilocularis microtubule associated protein 2 0.0714 1 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0307 0.0307
Onchocerca volvulus 0.0041 0.0298 0.0877
Schistosoma mansoni methyl-cpg binding protein mbd 0.0106 0.1232 0.1232
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0016 0.0025
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0016 0.0016
Brugia malayi Importin beta-1 subunit 0.0029 0.0132 0.0205
Plasmodium falciparum basic transcription factor 3b, putative 0.0146 0.1817 0.4554
Brugia malayi Bromodomain containing protein 0.0237 0.3127 0.4866
Onchocerca volvulus 0.0031 0.015 0.0418
Brugia malayi Pre-SET motif family protein 0.0031 0.0163 0.0254
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0016 0.0016
Toxoplasma gondii histone lysine methyltransferase SET1 0.0074 0.0772 0.4183
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0661 0.0661
Brugia malayi CXXC zinc finger family protein 0.0031 0.015 0.0234
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.4068 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0016 0.0016
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0636 0.3503
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.4068 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.0298 0.0298
Brugia malayi steroid hormone receptor 0.0021 0.0016 0.0025
Schistosoma mansoni rab6-interacting 0.0041 0.0298 0.0298
Entamoeba histolytica hypothetical protein 0.0024 0.0052 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0247 0.136
Loa Loa (eye worm) hypothetical protein 0.0037 0.0247 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0016 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.046 0.2533
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0143 0.0143
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0307 0.0756
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0016 0.0026
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4068 1
Brugia malayi hypothetical protein 0.0041 0.0298 0.0464
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.002 0.002
Plasmodium vivax SET domain protein, putative 0.0031 0.0163 0.0362
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0026
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0143 0.0143
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0411 0.0411
Brugia malayi beta-lactamase 0.0037 0.0247 0.0385
Echinococcus granulosus peregrin 0.0045 0.0354 0.0354
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0537 0.0537
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0052 0.0286
Loa Loa (eye worm) hypothetical protein 0.0052 0.046 0.0765
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.046 0.2533
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.002 0.002
Echinococcus granulosus snurportin 1 0.0312 0.4208 0.4208
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0106 0.1232 0.1232
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0137 0.0137
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0307 0.0478
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0247 0.0623
Brugia malayi beta-lactamase family protein 0.0037 0.0247 0.0385
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0016 0.0025
Schistosoma mansoni lipoxygenase 0.0179 0.2292 0.2292
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.4208 0.6991
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0016 0.0016
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0016 0.0016
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0307 0.1692
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.2571 0.2571
Toxoplasma gondii NAC domain-containing protein 0.0146 0.1817 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0141 0.1747 0.1747
Trypanosoma cruzi ISWI complex protein 0.0095 0.1075 0.5918
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0016 0.0016
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0307 0.0307
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0247 0.0247
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0436 0.0436
Loa Loa (eye worm) hypothetical protein 0.0146 0.182 0.3023
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.1839 0.4638
Echinococcus granulosus fetal alzheimer antigen falz 0.0141 0.1747 0.1747
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0234 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0636 0.3503
Onchocerca volvulus 0.0037 0.0247 0.0718
Brugia malayi TAR-binding protein 0.0066 0.0661 0.1029
Brugia malayi nuclear hormone receptor 0.0021 0.0016 0.0025
Echinococcus multilocularis zinc finger protein 0.0123 0.1482 0.1482
Leishmania major hypothetical protein, conserved 0.0037 0.0247 0.136
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0016 0.0026
Trypanosoma brucei ISWI complex protein 0.0095 0.1075 0.5918
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0307 0.0756
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0636 0.3503
Schistosoma mansoni polycystin 1-related 0.0041 0.0298 0.0298
Leishmania major hypothetical protein, conserved 0.0095 0.1075 0.5918
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0132 0.0619
Leishmania major cathepsin L-like protease 0.0064 0.0636 0.3503
Echinococcus multilocularis peregrin 0.0045 0.0354 0.0354
Schistosoma mansoni cpg binding protein 0.0044 0.0346 0.0346
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0016 0.0016
Trichomonas vaginalis set domain proteins, putative 0.0245 0.3237 0.7956
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.002 0.0112
Mycobacterium ulcerans hypothetical protein 0.0037 0.0247 0.0623
Mycobacterium tuberculosis Conserved protein 0.0037 0.0247 0.0623
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0247 0.0623
Brugia malayi jmjC domain containing protein 0.005 0.043 0.0669
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0143 0.0683
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.046 0.2449
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.005
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.1839 0.4282
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0307 0.0756
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0016 0.0016
Echinococcus granulosus zinc finger protein 0.0123 0.1482 0.1482
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0016 0.0026
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0247 0.0607
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0295 0.3965 1
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0313 0.0313
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0016 0.0025
Schistosoma mansoni bromodomain containing protein 0.0028 0.0117 0.0117
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0837 0.0837
Echinococcus granulosus RUN 0.0041 0.0298 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1817 0.4466
Brugia malayi ecdysteroid receptor 0.0021 0.0016 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0016 0.0025
Brugia malayi RNA, U transporter 1 0.0083 0.0908 0.1414
Trypanosoma brucei transcription factor BTF3, putative 0.0146 0.1817 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.015 0.025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0247 0.0411
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.046 0.1115
Brugia malayi Pre-SET motif family protein 0.0215 0.281 0.4373
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0016 0.0025
Loa Loa (eye worm) jmjC domain-containing protein 0.005 0.043 0.0714
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0247 0.136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4068 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0247 0.136
Echinococcus granulosus transcription factor btf3 0.0146 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.0037 0.0247 0.0411
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0537 0.0537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0636 0.3503
Brugia malayi Doublecortin family protein 0.0041 0.0298 0.0464
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.046 0.2533
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.0298 0.0704
Schistosoma mansoni hypothetical protein 0.0306 0.4124 0.4124
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.281 0.4668
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4068 1
Schistosoma mansoni bromodomain containing protein 0.0394 0.5381 0.5381
Loa Loa (eye worm) hypothetical protein 0.0041 0.0307 0.0511
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0016 0.0016
Schistosoma mansoni ran 0.0022 0.002 0.002
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0143 0.0683
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0247 0.0607
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0636 0.3503
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0016 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0636 0.3503
Plasmodium vivax basic transcription factor 3b, putative 0.0146 0.1817 0.4554
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0307 0.0307
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0016 0.0026
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0298 0.0298
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0016 0.0016
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0132 0.0725
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0537 0.0537
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0661 0.0661
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0313 0.0313
Entamoeba histolytica Ran family GTPase 0.0022 0.002 0.005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0047 0.0079
Onchocerca volvulus 0.0031 0.0163 0.0457
Schistosoma mansoni zinc finger protein 0.0123 0.1482 0.1482
Onchocerca volvulus 0.0146 0.182 0.5601
Onchocerca volvulus Alhambra homolog 0.003 0.0143 0.0395
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0047 0.0047
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0163 0.0163
Brugia malayi hypothetical protein 0.0041 0.0298 0.0464
Schistosoma mansoni zinc finger protein 0.0095 0.1075 0.1075
Plasmodium vivax hypothetical protein, conserved 0.003 0.0143 0.0311
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0636 0.3503
Loa Loa (eye worm) hypothetical protein 0.0238 0.3133 0.5205
Schistosoma mansoni ran 0.0022 0.002 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0016 0.0016
Schistosoma mansoni rab6-interacting 0.0041 0.0298 0.0298
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0661 0.1099
Loa Loa (eye worm) hypothetical protein 0.0041 0.0298 0.0495
Schistosoma mansoni hypothetical protein 0.0172 0.2186 0.2186
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.066 0.066
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0016 0.0016
Leishmania major importin beta-1 subunit, putative 0.0024 0.0052 0.0286
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0016 0.0016
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0247 0.0623
Plasmodium falciparum importin beta, putative 0.0029 0.0132 0.0282
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0223 0.2916 0.2916
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0052 0.0452 0.0752
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0132 0.0725
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0307 0.1692

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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