Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0013 | 0.0357 | 0.0334 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0816 | 0.0794 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0025 | 0.0816 | 0.2755 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0013 | 0.0357 | 0.3432 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0043 | 0.1484 | 0.5162 |
Schistosoma mansoni | DNA helicase recq1 | 0.0007 | 0.0122 | 0.0098 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0013 | 0.0357 | 0.579 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0013 | 0.0357 | 0.579 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0016 | 0.0475 | 0.1595 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0025 | 0.0816 | 0.2801 |
Echinococcus granulosus | expressed protein | 0.0009 | 0.0218 | 0.0098 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0009 | 0.0218 | 0.5837 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0357 | 0.3432 |
Echinococcus multilocularis | geminin | 0.0273 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0009 | 0.0207 | 0.1887 |
Echinococcus granulosus | dna polymerase kappa | 0.0013 | 0.0357 | 0.0238 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0357 | 0.3432 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.191 | 0.1891 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0009 | 0.0207 | 0.1887 |
Echinococcus granulosus | dna polymerase eta | 0.003 | 0.0995 | 0.0884 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0043 | 0.1484 | 0.1464 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0007 | 0.0122 | 0.2596 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0816 | 0.2755 |
Loa Loa (eye worm) | RecQ helicase | 0.0016 | 0.0475 | 0.1569 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0007 | 0.0122 | 0.184 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0007 | 0.0122 | 0.2945 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0009 | 0.0218 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0013 | 0.0357 | 0.0334 |
Trichomonas vaginalis | ferritin, putative | 0.0009 | 0.0218 | 0.0835 |
Brugia malayi | RNA binding protein | 0.0069 | 0.2449 | 0.8572 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0009 | 0.0195 | 0.1762 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0043 | 0.1484 | 0.1379 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0357 | 0.3432 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0025 | 0.0816 | 0.0703 |
Schistosoma mansoni | DNA polymerase eta | 0.003 | 0.0995 | 0.0974 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0021 | 0.0662 | 0.6568 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0816 | 0.0794 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0004 | 0.0024 | 0.0355 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0025 | 0.0816 | 0.0703 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0013 | 0.0357 | 0.1179 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0357 | 0.3432 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0043 | 0.1484 | 0.1464 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0007 | 0.0122 | 0.0341 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0218 | 0.0195 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0357 | 0.3432 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0122 | 0.0341 |
Echinococcus multilocularis | ferritin | 0.0009 | 0.0218 | 0.0098 |
Leishmania major | DNA polymerase eta, putative | 0.0021 | 0.0662 | 0.6568 |
Echinococcus granulosus | ferritin | 0.0009 | 0.0218 | 0.0098 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0218 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.2853 | 0.9833 |
Echinococcus multilocularis | dna polymerase eta | 0.003 | 0.0995 | 0.0884 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0013 | 0.0357 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0013 | 0.0357 | 0.3432 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0013 | 0.0357 | 0.3432 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0218 | 0.0195 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0218 | 0.0195 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0011 | 0.028 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0357 | 0.3432 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0275 | 0.416 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0004 | 0.0024 | 0.0355 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0995 | 0.3377 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0007 | 0.0122 | 0.0347 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0816 | 0.0794 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0357 | 0.3432 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0009 | 0.0218 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0357 | 0.3432 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.2449 | 0.8429 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0357 | 0.3432 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.2449 | 0.8572 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0014 | 0.0402 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0043 | 0.1484 | 0.1464 |
Echinococcus granulosus | bloom syndrome protein | 0.0016 | 0.0475 | 0.0357 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0013 | 0.0357 | 0.3432 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0043 | 0.1484 | 0.1379 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0013 | 0.0357 | 0.0238 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.2449 | 0.2431 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.2449 | 0.8429 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0009 | 0.0218 | 0.5 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0218 | 0.0195 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.2449 | 0.2431 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.2449 | 0.8572 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0009 | 0.0207 | 0.1887 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0013 | 0.0357 | 0.3432 |
Echinococcus multilocularis | GPCR, family 2 | 0.0025 | 0.0816 | 0.0703 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0025 | 0.0816 | 0.0703 |
Leishmania major | DNA polymerase eta, putative | 0.003 | 0.0995 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.003 | 0.0995 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0009 | 0.0195 | 0.1762 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0025 | 0.0816 | 0.2801 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.008 | 0.2853 | 0.9833 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0816 | 0.0794 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.2449 | 0.2431 |
Echinococcus granulosus | GPCR family 2 | 0.0025 | 0.0816 | 0.0703 |
Echinococcus multilocularis | dna polymerase kappa | 0.0013 | 0.0357 | 0.0238 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0013 | 0.0357 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0009 | 0.0195 | 0.5456 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0043 | 0.1484 | 0.1379 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.003 | 0.0995 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0016 | 0.0475 | 0.0357 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0013 | 0.0357 | 0.3432 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0013 | 0.0357 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0013 | 0.0357 | 0.3432 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0025 | 0.0816 | 0.0703 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0021 | 0.0662 | 1 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0218 | 0.0195 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0013 | 0.0357 | 0.1159 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.2449 | 0.2356 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0043 | 0.1484 | 0.1379 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0016 | 0.0475 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.2449 | 0.2356 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.0357 | 0.3432 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0013 | 0.0357 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0013 | 0.0357 | 0.3432 |
Giardia lamblia | DINP protein human, muc B family | 0.0013 | 0.0357 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0013 | 0.0348 | 0.0326 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.2449 | 0.2431 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2901 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.008 | 0.2853 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.008 | 0.2853 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0007 | 0.0122 | 0.0347 |
Trypanosoma brucei | unspecified product | 0.0009 | 0.0207 | 0.1887 |
Echinococcus multilocularis | expressed protein | 0.0009 | 0.0218 | 0.0098 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.2449 | 0.2431 |
Trypanosoma brucei | unspecified product | 0.0009 | 0.0207 | 0.1887 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0013 | 0.0357 | 0.0238 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0013 | 0.0357 | 1 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0009 | 0.0218 | 0.5837 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0357 | 0.3432 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.191 | 0.6557 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0007 | 0.0122 | 0.184 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0043 | 0.1484 | 0.5076 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0013 | 0.0357 | 0.3432 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0009 | 0.0195 | 0.1762 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0218 | 0.0195 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.2449 | 0.8429 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.003 | 0.0995 | 0.3434 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0016 | 0.0475 | 1 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0218 | 0.0195 |
Schistosoma mansoni | DNA helicase recq5 | 0.0007 | 0.0122 | 0.0098 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0055 | 0.191 | 0.6668 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 3.1 % | Antiinflammatory activity in Swiss albino mouse assessed as inhibition of carrageenan-induced paw edema at 100 mg/kg, po administered before 60 mins of carrageenan-challenge measured after 90 mins | ChEMBL. | 19535179 |
Inhibition (functional) | = 3.9 % | Antiinflammatory activity in Swiss albino mouse assessed as inhibition of carrageenan-induced paw edema at 100 mg/kg, po administered before 60 mins of carrageenan-challenge measured after 180 mins | ChEMBL. | 19535179 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.