Detailed information for compound 1047437

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 369.884 | Formula: C22H24ClNO2
  • H donors: 0 H acceptors: 1 LogP: 4.3 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CC2(CCCN(C2)Cc2ccccc2)OC=C1c1ccccc1.Cl
  • InChi: 1S/C22H23NO2.ClH/c24-21-14-22(25-16-20(21)19-10-5-2-6-11-19)12-7-13-23(17-22)15-18-8-3-1-4-9-18;/h1-6,8-11,16H,7,12-15,17H2;1H
  • InChiKey: RFUBFERIAMRHPN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sigma non-opioid intracellular receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0148 0.1885 0.2641
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.014 0.1771 0.2482
Loa Loa (eye worm) RPT-2 protein 0.0017 0.0000019717 0.0000024826
Schistosoma mansoni carbonic anhydrase 0.0054 0.0537 0.0537
Entamoeba histolytica proteasome regulatory subunit, putative 0.0025 0.0108 0.0151
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.014 0.1771 0.1771
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0031 0.0203 0.0284
Giardia lamblia Proteasome subunit beta type 2 0.0141 0.1792 0.2511
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0108 0.0151
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0189 0.248 0.3475
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.0197 0.0197
Brugia malayi Protein kinase domain containing protein 0.0031 0.0197 0.0197
Echinococcus granulosus death domain containing protein 0.0031 0.0197 0.0197
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0219 0.0219
Toxoplasma gondii proteasome beta subunit 0.0141 0.1792 0.2511
Echinococcus multilocularis beta tubulin 0.0022 0.0066 0.0066
Schistosoma mansoni tubulin subunit beta 0.0022 0.0066 0.0066
Trypanosoma brucei proteasome subunit beta type-5, putative 0.051 0.7137 1
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0141 0.1792 0.1792
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0054 0.0537 0.0537
Schistosoma mansoni hypothetical protein 0.0337 0.462 0.462
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0118 0.146 0.2046
Plasmodium falciparum proteasome subunit beta type-5 0.051 0.7137 1
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0018 0.0015 0.0019
Echinococcus multilocularis geminin 0.0166 0.2152 0.2152
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0146 0.1864 0.2612
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0143 0.018
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.051 0.7137 1
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.0237 0.0237
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0037 0.0289 0.0405
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0141 0.1792 0.2511
Toxoplasma gondii PCI domain-containing protein 0.0026 0.0125 0.0175
Schistosoma mansoni tubulin subunit beta 0.0022 0.0066 0.0066
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0219 0.0219
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0064 0.0681 0.0955
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0157 0.2018 0.2828
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0066 0.0066
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0143 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0143 0.0143
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0031 0.0203 0.0284
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0156 0.2006 0.2006
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0066 0.0066
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0033 0.0219 0.0219
Brugia malayi Endoplasmic Reticulum Oxidoreductin 1 0.0054 0.0533 0.0533
Onchocerca volvulus 0.004 0.0324 0.1719
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0143 0.0143
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0143 0.0143
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0157 0.2018 0.2828
Echinococcus granulosus Endoplasmic reticulum oxidoreductin 1 0.0054 0.0533 0.0533
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0149 0.0149
Giardia lamblia 20S proteasome alpha subunit 6 0.0146 0.1858 0.2603
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0026 0.0127 0.0178
Brugia malayi Proteasome A-type and B-type family protein 0.051 0.7137 0.7137
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0118 0.146 0.2046
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0025 0.0108 0.0151
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0026 0.0127 0.016
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0192 0.253 0.3186
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0185 0.243 0.243
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.0237 0.0332
Toxoplasma gondii proteasome regulatory subunit 0.0026 0.0127 0.0178
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0143 0.0143
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0143 0.0143
Echinococcus granulosus subfamily T1A non peptidase ue 0.0156 0.2006 0.2006
Loa Loa (eye worm) tubulin beta chain 0.0022 0.0066 0.0084
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0026 0.0127 0.0178
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.018
Echinococcus granulosus tubulin beta 4A class IVa 0.0022 0.0066 0.0066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0143 0.0143
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0189 0.248 0.3475
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0018 0.0015 0.0015
Mycobacterium leprae proteasome (beta subunit) PrcB 0.051 0.7137 1
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0165 0.2136 0.2993
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Schistosoma mansoni ero1-related 0.0054 0.0533 0.0533
Schistosoma mansoni hypothetical protein 0.0031 0.0197 0.0197
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0026 0.0125 0.0125
Toxoplasma gondii proteasome subunit alpha type, putative 0.0146 0.1864 0.2612
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0189 0.248 0.3475
Toxoplasma gondii endoplasmic reticulum oxidoreductin, putative 0.0054 0.0533 0.0747
Loa Loa (eye worm) proteasome subunit beta type 3 0.0141 0.1792 0.2256
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0031 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0101
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0141 0.1792 0.1792
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.0537 0.0537
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0028 0.0159 0.0223
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0141 0.1792 0.2511
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0259 0.0259
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0018 0.0015 0.0021
Loa Loa (eye worm) proteasome regulatory particle 0.0031 0.0203 0.0255
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0146 0.1864 0.2612
Schistosoma mansoni tubulin subunit beta 0.0022 0.0066 0.0066
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0165 0.2136 0.2993
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0066 0.0093
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0082 0.0928 0.1169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0143 0.018
Giardia lamblia 20S proteasome alpha subunit 5 0.0156 0.2006 0.2811
Giardia lamblia 26S proteasome regulatory subunit, putative 0.0019 0.003 0.0042
Leishmania major proteasome alpha 1 subunit, putative 0.0146 0.1858 0.2603
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0142 0.1803 0.1803
Loa Loa (eye worm) carbonic anhydrase 3 0.0147 0.1872 0.2357
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0026 0.0125 0.0175
Brugia malayi ecdysteroid receptor 0.0027 0.0143 0.0143
Plasmodium vivax proteasome subunit beta type-5, putative 0.051 0.7137 1
Brugia malayi PCI domain containing protein 0.0026 0.0125 0.0125
Schistosoma mansoni hypothetical protein 0.0033 0.0219 0.0219
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0018 0.0014 0.0014
Loa Loa (eye worm) PAS-3 protein 0.0132 0.1661 0.2091
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0146 0.1858 0.2339
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0146 0.1858 0.1858
Trypanosoma brucei RNA helicase, putative 0.0337 0.462 0.6474
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0026 0.0127 0.016
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0192 0.253 0.3545
Brugia malayi PCI domain containing protein 0.0028 0.0161 0.0161
Entamoeba histolytica hypothetical protein 0.0035 0.0259 0.0363
Entamoeba histolytica hypothetical protein 0.0035 0.0259 0.0363
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0165 0.2136 0.2136
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.014 0.1771 0.2482
Schistosoma mansoni hypothetical protein 0.0026 0.0125 0.0125
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0028 0.0159 0.0223
Toxoplasma gondii beta tubulin 0.0022 0.0066 0.0093
Entamoeba histolytica proteasome regulatory subunit, putative 0.0031 0.0203 0.0284
Giardia lamblia Beta tubulin 0.0022 0.0066 0.0093
Mycobacterium ulcerans aldehyde dehydrogenase 0.005 0.0473 0.0367
Echinococcus multilocularis carbonic anhydrase 0.0054 0.0537 0.0537
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0189 0.248 0.248
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.0197 0.0197
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0189 0.248 0.3475
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0025 0.0108 0.0151
Schistosoma mansoni aldehyde dehydrogenase 0.005 0.0473 0.0473
Toxoplasma gondii hypothetical protein 0.0022 0.007 0.0098
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0037 0.0289 0.0405
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0147 0.187 0.2354
Plasmodium vivax proteasome subunit beta type-1, putative 0.0165 0.2136 0.2993
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.6184 0.8665
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0066 0.0093
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0118 0.146 0.2046
Trichomonas vaginalis tubulin, putative 0.0022 0.0066 0.0093
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0028 0.0149 0.0188
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0026 0.0127 0.0178
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.051 0.7137 0.8986
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0015 0.0021
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0199 0.0199
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0018 0.0015 0.0021
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0143 0.0758
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0028 0.0161 0.0225
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.051 0.7137 1
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0034 0.0237 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0143 0.018
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0143 0.0143
Entamoeba histolytica tubulin family protein 0.0022 0.0066 0.0093
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0197 0.0248
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0156 0.2006 0.2006
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0022 0.0066 0.0066
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0147 0.187 0.187
Echinococcus granulosus Ankyrin 0.0031 0.0199 0.0199
Echinococcus granulosus peptidase Clp S14 family 0.0042 0.036 0.036
Echinococcus granulosus beta tubulin 0.0022 0.0066 0.0066
Echinococcus multilocularis carbonic anhydrase 0.0054 0.0537 0.0537
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0031 0.0203 0.0284
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0028 0.0159 0.0159
Trypanosoma cruzi beta tubulin, putative 0.0022 0.0066 0.0093
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0028 0.0159 0.0223
Toxoplasma gondii hypothetical protein 0.0054 0.0537 0.0753
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0192 0.253 0.3545
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0219 0.0219
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0018 0.0015 0.0015
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0197 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0143 0.0143
Echinococcus granulosus adhesion regulating molecule 1 0.0082 0.0928 0.0928
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0026 0.0127 0.0178
Loa Loa (eye worm) hypothetical protein 0.0566 0.7942 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0197 0.0248
Mycobacterium ulcerans aldehyde dehydrogenase 0.005 0.0473 0.0367
Echinococcus granulosus nuclear factor of activated T cells 5 0.0303 0.4136 0.4136
Plasmodium vivax proteasome subunit beta type-6, putative 0.0147 0.187 0.262
Trypanosoma brucei proteasome beta 6 subunit 0.0165 0.2136 0.2993
Giardia lamblia Proteasome subunit beta type 5 precursor 0.051 0.7137 1
Echinococcus granulosus proteasome prosome macropain 0.051 0.7137 0.7137
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0143 0.0143
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0066 0.0066
Leishmania major hypothetical protein, conserved 0.0042 0.0363 0.0509
Schistosoma mansoni aldehyde dehydrogenase 0.005 0.0473 0.0473
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0034 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.018
Brugia malayi proteasome subunit beta type 1 0.0165 0.2136 0.2136
Loa Loa (eye worm) PCI domain-containing protein 0.0028 0.0161 0.0203
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0143 0.0143
Loa Loa (eye worm) proteasome Regulatory Particle 0.0028 0.0159 0.0201
Echinococcus granulosus tubulin subunit beta 0.0022 0.0066 0.0066
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.0537 0.0537
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0143 0.0143
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0075 0.0841 0.0841
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0143 0.0143
Trypanosoma brucei carbonic anhydrase-like protein 0.0147 0.1872 0.2623
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0026 0.0127 0.0127
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0031 0.0203 0.0284
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0018 0.0015 0.0021
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0146 0.1864 0.2612
Onchocerca volvulus 0.0033 0.0219 0.1163
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0143 0.0143
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.015 0.1926 0.2699
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.051 0.7137 1
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0156 0.2006 0.2006
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0147 0.187 0.262
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0127 0.0178
Plasmodium falciparum proteasome subunit beta type-4 0.014 0.1771 0.2482
Toxoplasma gondii PCI domain-containing protein 0.0031 0.0203 0.0284
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0219 0.0219
Mycobacterium ulcerans proteasome PrcB 0.051 0.7137 1
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0143 0.0143
Loa Loa (eye worm) tubulin beta-4 chain 0.0022 0.0066 0.0084
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0037 0.0289 0.0405
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.018
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0033 0.023 0.0322
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0148 0.1885 0.2641
Echinococcus multilocularis carbonic anhydrase 0.0054 0.0537 0.0537
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0066 0.0066
Plasmodium vivax proteasome subunit alpha type-2, putative 0.015 0.1926 0.2699
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0028 0.0159 0.0223
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0118 0.146 0.146
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0018 0.0014 0.002
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0028 0.0159 0.0223
Mycobacterium ulcerans aldehyde dehydrogenase 0.005 0.0473 0.0367
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0064 0.0681 0.0955
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0189 0.248 0.3475
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0189 0.248 0.3475
Onchocerca volvulus 0.0033 0.0219 0.1163
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0141 0.1792 0.2511
Loa Loa (eye worm) proteasome subunit beta type 1 0.0165 0.2136 0.2689
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0192 0.253 0.3545
Leishmania major proteasome beta 5 subunit, putative 0.051 0.7137 1
Trypanosoma brucei beta tubulin 0.0022 0.0066 0.0093
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.0537 0.0537
Brugia malayi hypothetical protein 0.0195 0.2569 0.2569
Giardia lamblia Proteasome subunit beta type 4 precursor 0.014 0.1771 0.2482
Loa Loa (eye worm) hypothetical protein 0.0054 0.0537 0.0676
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0018 0.0014 0.002
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0026 0.0127 0.0178
Loa Loa (eye worm) hypothetical protein 0.0064 0.0681 0.0858
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0026 0.0127 0.0178
Loa Loa (eye worm) BEN-1 protein 0.0022 0.0066 0.0084
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0148 0.1885 0.2641
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0108 0.0108
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0537 0.0537
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0033 0.023 0.023
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0026 0.0127 0.0178
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0143 0.0143
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0219 0.0219
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.014 0.1771 0.2482
Echinococcus granulosus glycoprotein Antigen 5 0.0033 0.0219 0.0219
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0146 0.1858 0.2603
Echinococcus multilocularis beta tubulin 0.0022 0.0066 0.0066
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0219 0.0219
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0157 0.2018 0.2018
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0146 0.1864 0.2612
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0143 0.018
Toxoplasma gondii beta-tubulin, putative 0.0022 0.0066 0.0093
Brugia malayi Proteasome subunit alpha type 7-1 0.0189 0.248 0.248
Loa Loa (eye worm) hypothetical protein 0.0227 0.3038 0.3825
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0028 0.0161 0.0225
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0147 0.187 0.262
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0165 0.2136 0.2136
Brugia malayi proteasome subunit beta type 2 0.0141 0.1792 0.1792
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0189 0.248 0.248
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0108 0.0108
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.014 0.1771 0.2482
Giardia lamblia Beta tubulin 0.0022 0.0066 0.0093
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0143 0.0758
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0146 0.1864 0.1864
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0165 0.2136 0.2993
Echinococcus granulosus Mastin 0.0033 0.0219 0.0219
Brugia malayi Proteasome A-type and B-type family protein 0.0147 0.187 0.187
Echinococcus multilocularis tubulin beta 1 chain 0.0022 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0035 0.0259 0.0363
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0537 0.0537
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0148 0.1885 0.1884
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0259 0.0259
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0026 0.0125 0.0175
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0146 0.1864 0.1864
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0141 0.1792 0.2511
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0026 0.0127 0.0178
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0028 0.0159 0.0159
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0146 0.1864 0.2612
Brugia malayi 20S proteasome alpha5 subunit 0.0156 0.2006 0.2006
Leishmania major proteasome alpha 7 subunit, putative 0.0189 0.248 0.3475
Schistosoma mansoni hypothetical protein 0.0035 0.0259 0.0259
Toxoplasma gondii SAC3/GANP family protein 0.0025 0.0108 0.0151
Entamoeba histolytica hypothetical protein 0.0035 0.0259 0.0363
Leishmania major proteasome beta 7 subunit, putative 0.014 0.1771 0.2482
Leishmania major proteasome beta-1 subunit, putative 0.0147 0.187 0.262
Onchocerca volvulus 0.0033 0.0219 0.1163
Schistosoma mansoni hypothetical protein 0.0075 0.0841 0.0841
Onchocerca volvulus 0.0027 0.0143 0.0758
Loa Loa (eye worm) hypothetical protein 0.0445 0.6184 0.7786
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0018 0.0007 0.001
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0042 0.0363 0.0509
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0143 0.0143
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0037 0.0289 0.0405
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.015 0.1926 0.2699
Leishmania major proteasome alpha 2 subunit, putative 0.015 0.1926 0.2699
Plasmodium falciparum endoplasmic reticulum oxidoreductin, putative 0.0054 0.0533 0.0747
Echinococcus multilocularis proteasome subunit alpha type 2 0.015 0.1926 0.1926
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0026 0.0125 0.0175
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0147 0.187 0.262
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0147 0.1872 0.1872
Echinococcus granulosus beta tubulin 0.0022 0.0066 0.0066
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0028 0.0161 0.0225
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0034 0.0237 0.0332
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.005 0.0473 0.0473
Plasmodium vivax proteasome subunit beta type-2, putative 0.0141 0.1792 0.2511
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0066 0.0066
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0143 0.0758
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0037 0.0289 0.0289
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.0197 0.0197
Onchocerca volvulus 0.0033 0.0219 0.1163
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0118 0.146 0.2046
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0143 0.0143
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0708 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0219 0.0219
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0146 0.1858 0.2603
Brugia malayi Trypsin family protein 0.0033 0.0219 0.0219
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0082 0.0928 0.1301
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.0276
Echinococcus granulosus Proteasome subunit alpha type 7 0.0189 0.248 0.248
Leishmania major proteasome beta 3 subunit, putative 0.0141 0.1792 0.2511
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0143 0.018
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.014 0.1771 0.2482
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0026 0.0127 0.0127
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0147 0.1872 0.1872
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0054 0.0537 0.0537
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0143 0.0143
Echinococcus multilocularis enteropeptidase 0.0033 0.0219 0.0219
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0033 0.023 0.0322
Brugia malayi proteasome subunit alpha type 4 0.0132 0.1661 0.1661
Echinococcus multilocularis tubulin subunit beta 0.0022 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0143 0.0143
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0118 0.146 0.2046
Plasmodium vivax tubulin beta chain, putative 0.0022 0.0066 0.0093
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.018
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0156 0.2006 0.2811
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0054 0.0537 0.0676
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.005 0.0473 0.0166
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0028 0.0161 0.0225
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0026 0.0125 0.0125
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0108 0.0151
Onchocerca volvulus Notchless protein homolog 0.0148 0.1885 1
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0141 0.1792 0.2511
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0064 0.0681 1
Plasmodium vivax proteasome subunit beta type-4, putative 0.014 0.1771 0.2482
Brugia malayi Death domain containing protein 0.0031 0.0197 0.0197
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0028 0.0161 0.0161
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0143 0.0143
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0022 0.007 0.0098
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0026 0.0127 0.0127
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0026 0.0127 0.0127
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Toxoplasma gondii aldehyde dehydrogenase 0.005 0.0473 0.0662
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0028 0.0159 0.0159
Toxoplasma gondii beta-1 tubulin, putative 0.0022 0.0066 0.0093
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0028 0.0159 0.0159
Echinococcus multilocularis survival motor neuron protein 1 0.0195 0.2569 0.2569
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0018 0.0015 0.0015
Toxoplasma gondii proteasome subunit alpha type, putative 0.007 0.0768 0.1076
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0033 0.023 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0143 0.0143
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0015 0.0021
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0141 0.1792 0.2511
Brugia malayi Trypsin family protein 0.0033 0.0219 0.0219
Giardia lamblia Hypothetical protein 0.0031 0.0203 0.0284
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0147 0.1872 0.1872
Brugia malayi Tubulin beta-1 chain 0.0022 0.0066 0.0066
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.004 0.0324 0.0324
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0141 0.1792 0.2511
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0018 0.0015 0.0015
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0146 0.1858 0.1858
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0018 0.0015 0.0021
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0219 0.0219
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0192 0.253 0.3545
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0147 0.1872 0.2623
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0064 0.0681 0.5
Brugia malayi proteasome subunit alpha type 1 0.0146 0.1858 0.1858
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0031 0.0203 0.0284
Loa Loa (eye worm) hypothetical protein 0.0025 0.0108 0.0136
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0146 0.1864 0.1864
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0108 0.0151
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0156 0.2006 0.2811
Schistosoma mansoni hypothetical protein 0.0166 0.2152 0.2152
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0143 0.0143
Brugia malayi Trypsin-like protease protein 5 0.0033 0.0219 0.0219
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0026 0.0127 0.0178
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0143 0.0143
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.005 0.0473 0.0473
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0136 0.1723 0.2415
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0031 0.0203 0.0284
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0037 0.0289 0.0289
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0037 0.0289 0.0289
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0026 0.0125 0.0175
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0143 0.0143
Brugia malayi steroid hormone receptor 0.0027 0.0143 0.0143
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0026 0.0125 0.0175
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0141 0.1792 0.2511
Toxoplasma gondii proteasome subunit beta type, putative 0.051 0.7137 1
Echinococcus granulosus carbonic anhydrase 0.0054 0.0537 0.0537
Echinococcus granulosus Proteasome subunit alpha beta 0.0148 0.1885 0.1884
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0143 0.0143
Loa Loa (eye worm) RPN-3 protein 0.0034 0.0237 0.0299
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0026 0.0127 0.0127
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0052 0.0498 0.264
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0037 0.0289 0.0405
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0219 0.0219
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0219 0.0219
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0156 0.2006 0.2811
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0064 0.0681 0.5
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0064 0.0681 0.0668
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.0276
Giardia lamblia 20S proteasome alpha subunit 1 0.0157 0.2018 0.2828
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0033 0.023 0.023
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0028 0.0159 0.0223
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0156 0.2006 0.2526
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0026 0.0127 0.0178
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.0237 0.0237
Trichomonas vaginalis 26S proteasome subunit, putative 0.0026 0.0125 0.0175
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0146 0.1858 0.1858
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0147 0.1872 0.2623
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0156 0.2006 0.2811
Echinococcus multilocularis Mastin 0.0033 0.0219 0.0219
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0148 0.1885 0.2641
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0156 0.2006 0.2811
Brugia malayi Trypsin family protein 0.0033 0.0219 0.0219
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.015 0.1926 0.1926
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Plasmodium vivax proteasome subunit beta type-3, putative 0.0141 0.1792 0.2511
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.018
Brugia malayi beta-tubulin, identical 0.0022 0.0066 0.0066
Schistosoma mansoni tubulin subunit beta 0.0022 0.0066 0.0066
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0034 0.0237 0.0332
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0141 0.1792 0.1792
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0064 0.0681 0.0681
Giardia lamblia 20S proteasome alpha subunit 3 0.0146 0.1864 0.2612
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0018 0.0015 0.0021
Brugia malayi proteasome subunit alpha type 2 0.015 0.1926 0.1926
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.0276
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.015 0.1926 0.2699
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0018 0.0007 0.001
Schistosoma mansoni hypothetical protein 0.0051 0.0482 0.0482
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.051 0.7137 1
Trypanosoma cruzi 20S proteasome subunit 0.0141 0.1792 0.2511
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0259 0.0259
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0082 0.0928 0.0928
Echinococcus multilocularis proteasome (prosome, macropain) 0.051 0.7137 0.7137
Onchocerca volvulus Netrin receptor homolog 0.0031 0.0197 0.1047
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0028 0.0161 0.0225
Brugia malayi nuclear hormone receptor 0.0027 0.0143 0.0143
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0025 0.0108 0.0151
Echinococcus multilocularis adhesion regulating molecule 1 0.0082 0.0928 0.0928
Toxoplasma gondii proteasome subunit alpha1, putative 0.0157 0.2018 0.2828
Trypanosoma brucei proteasome alpha 7 subunit 0.0148 0.1885 0.2641
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0143 0.0143
Leishmania major proteasome beta 2 subunit, putative 0.0141 0.1792 0.2511
Schistosoma mansoni hypothetical protein 0.0185 0.243 0.243
Schistosoma mansoni hypothetical protein 0.004 0.0324 0.0324
Giardia lamblia Proteasome subunit beta type 3 0.0141 0.1792 0.2511
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0141 0.1792 0.1792
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0146 0.1864 0.2612
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0042 0.036 0.041
Trypanosoma brucei beta tubulin 0.0022 0.0066 0.0093
Toxoplasma gondii proteasome subunit 0.0147 0.187 0.262
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0147 0.187 0.262
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0143 0.0143
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0146 0.1858 0.2603
Loa Loa (eye worm) hypothetical protein 0.0195 0.2569 0.3234
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0026 0.0125 0.0175
Echinococcus multilocularis peptidase Clp (S14 family) 0.0042 0.036 0.036
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0141 0.1792 0.1792
Entamoeba histolytica hypothetical protein 0.0033 0.023 0.0322
Schistosoma mansoni tubulin subunit beta 0.0022 0.0066 0.0066
Schistosoma mansoni survival motor neuron protein 0.004 0.0324 0.0324
Loa Loa (eye worm) tubulin beta-2A chain 0.0022 0.0066 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0143 0.0143
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.6184 0.8665
Loa Loa (eye worm) tubulin beta-1 chain 0.0022 0.0066 0.0084
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0189 0.248 0.3122
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0037 0.0289 0.0405
Giardia lamblia Proteasome subunit beta type 1 0.0165 0.2136 0.2993
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0189 0.248 0.3475
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0537 0.0537
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0192 0.253 0.3545
Giardia lamblia 26S protease regulatory subunit 6A 0.0018 0.0015 0.0021
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0141 0.1792 0.1792
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0149 0.0149
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0148 0.1885 0.1884
Entamoeba histolytica proteasome regulatory subunit, putative 0.0028 0.0159 0.0223
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0146 0.1858 0.2603
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0064 0.0681 0.0681
Echinococcus granulosus netrin receptor unc 5 0.0031 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0025 0.0108 0.0136
Plasmodium falciparum carbonic anhydrase 0.0054 0.0537 0.0753
Schistosoma mansoni tubulin subunit beta 0.0022 0.0066 0.0066
Trichomonas vaginalis tubulin alpha chain, putative 0.0022 0.0066 0.0093
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.014 0.1771 0.2482
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0118 0.146 0.2046
Brugia malayi hypothetical protein 0.0033 0.0219 0.0219
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.6184 0.8665
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0219 0.0219
Schistosoma mansoni 26S proteasome subunit S9 0.0031 0.0203 0.0203
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0156 0.2006 0.2811
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0143 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0143 0.0143
Schistosoma mansoni proteasome regulatory subunit-related 0.0028 0.0161 0.0161
Onchocerca volvulus 0.0033 0.0219 0.1163
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0146 0.1858 0.2603
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0141 0.1792 0.2511
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0075 0.0841 0.0841
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0143 0.018
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0108 0.0108
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0157 0.2018 0.2828
Brugia malayi proteasome subunit beta type 3 0.0141 0.1792 0.1792
Loa Loa (eye worm) hypothetical protein 0.0054 0.0537 0.0676
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0033 0.0219 0.0219
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.6184 0.6184
Plasmodium falciparum tubulin beta chain 0.0022 0.0066 0.0093
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0018 0.0015 0.0021
Trichomonas vaginalis tubulin gamma chain, putative 0.0022 0.0066 0.0093
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0146 0.1858 0.2603
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0219 0.0219
Echinococcus multilocularis Endoplasmic reticulum oxidoreductin 1 0.0054 0.0533 0.0533
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0033 0.023 0.023
Brugia malayi nuclear receptor NHR-88 0.0027 0.0143 0.0143
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.005 0.0473 0.0662
Schistosoma mansoni netrin receptor unc5 0.0031 0.0197 0.0197
Trypanosoma brucei proteasome beta 7 subunit 0.014 0.1771 0.2482
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0026 0.0127 0.0127
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0143 0.0143
Plasmodium vivax endoplasmic reticulum oxidoreductin, putative 0.0054 0.0533 0.0747
Brugia malayi Probable ClpP-like protease 0.0064 0.0681 0.0681
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0219 0.0219
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.014 0.1771 0.1771
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0141 0.1792 0.2511
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0037 0.0289 0.0289
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0143 0.0143
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0141 0.1792 0.2511
Echinococcus multilocularis carbonic anhydrase II 0.0147 0.1872 0.1872
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0219 0.0219
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0165 0.2136 0.2993
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0189 0.248 0.248
Trypanosoma brucei pol-associated gene 1 0.0054 0.0533 0.0747
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0303 0.4136 0.4136
Echinococcus granulosus proteasome subunit beta t family 0.0141 0.1792 0.1792
Echinococcus multilocularis Ankyrin 0.0031 0.0199 0.0199
Echinococcus granulosus proteasome subunit beta type 7 0.0708 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0219 0.0219
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0143 0.0143
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0157 0.2018 0.2828
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0157 0.2018 0.2828
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0165 0.2136 0.2136
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0037 0.0289 0.0289
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0118 0.146 1
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0066 0.0093
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0156 0.2006 0.2811
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0148 0.1885 0.2373
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0157 0.2018 0.2541
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0156 0.2006 0.2811
Echinococcus granulosus carbonic anhydrase 0.0054 0.0537 0.0537
Giardia lamblia Beta tubulin 0.0022 0.0066 0.0093
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0143 0.0143
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.014 0.1771 0.2482
Loa Loa (eye worm) hypothetical protein 0.0185 0.243 0.3059
Loa Loa (eye worm) trypsin family protein 0.0033 0.0219 0.0276
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0143 0.0143
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0082 0.0928 0.0928
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.0197 0.0197
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0028 0.0149 0.0209
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0143 0.0143
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0066 0.0066
Trypanosoma cruzi endoplasmic reticulum oxidoreductin, putative 0.0054 0.0533 0.0747
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0143 0.0143
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0141 0.1792 0.1792
Echinococcus granulosus enteropeptidase 0.0033 0.0219 0.0219
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Brugia malayi Proteasome subunit alpha type 1 0.0132 0.1655 0.1655
Schistosoma mansoni coup transcription factor 0.0027 0.0143 0.0143
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0165 0.2136 0.2993
Trypanosoma brucei beta tubulin 0.0022 0.0066 0.0093
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0147 0.1872 0.2357
Leishmania major proteasome alpha 3 subunit, putative 0.0146 0.1864 0.2612
Leishmania major proteasome alpha 1 subunit, putative 0.0157 0.2018 0.2828
Brugia malayi proteasome subunit alpha type 6 0.0157 0.2018 0.2018
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0033 0.0219 0.0219
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.015 0.1926 0.2699
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0018 0.0014 0.0014
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0157 0.2018 0.2828
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0064 0.0681 0.0955
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.014 0.1771 0.2482
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.014 0.1771 0.2482
Echinococcus granulosus proteasome subunit alpha type 6 0.0157 0.2018 0.2018
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0025 0.0108 0.0108
Leishmania major proteasome alpha 7 subunit, putative 0.0148 0.1885 0.2641
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0034 0.0237 0.0332
Toxoplasma gondii proteasome 26S regulatory subunit 0.0018 0.0007 0.001
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0031 0.0203 0.0203
Brugia malayi proteasome subunit alpha type 3 0.0148 0.1885 0.1884
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0219 0.0219
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0028 0.0159 0.0223
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0018 0.0014 0.002
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0025 0.0115 0.016
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0064 0.0681 0.0865
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0026 0.0127 0.0178
Entamoeba histolytica proteasome regulatory subunit, putative 0.0018 0.0014 0.002
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0118 0.146 0.1967
Toxoplasma gondii peptidase, T1 family protein 0.0148 0.1885 0.2641
Echinococcus granulosus proteasome subunit alpha type 2 0.015 0.1926 0.1926
Echinococcus multilocularis transmembrane protease serine 3 0.0033 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0054 0.0537 0.0676
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0026 0.0127 0.0127
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0064 0.0681 0.0668
Trypanosoma brucei beta tubulin 0.0022 0.0066 0.0093
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0192 0.253 0.3545
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0118 0.146 0.2046
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0219 0.0219
Echinococcus granulosus proteasome subunit beta type 6 0.0147 0.187 0.187
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.018
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0031 0.0203 0.0203
Mycobacterium ulcerans proteasome PrcA 0.0118 0.146 0.1794
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0118 0.146 0.1624
Brugia malayi Proteasome A-type and B-type family protein 0.014 0.1771 0.1771
Entamoeba histolytica proteasome regulatory subunit, putative 0.0026 0.0125 0.0175
Toxoplasma gondii hypothetical protein 0.0023 0.008 0.0113
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0148 0.1885 0.2641
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0018 0.0015 0.0021
Echinococcus granulosus transmembrane protease serine 3 0.0033 0.0219 0.0219
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Entamoeba histolytica tubulin family protein 0.0022 0.0066 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0000019717 0.0000024826
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0156 0.2006 0.2811
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0028 0.0161 0.0225
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0108 0.0108
Echinococcus multilocularis glycoprotein Antigen 5 0.0033 0.0219 0.0219
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0141 0.1792 0.2511
Giardia lamblia 20S proteasome alpha subunit 4 0.0189 0.248 0.3475
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0019 0.003 0.0042
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0146 0.1864 0.2612
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.0276
Loa Loa (eye worm) beta-tubulin 0.0022 0.0066 0.0084
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0189 0.248 0.248
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.051 0.7137 1
Plasmodium vivax proteasome subunit beta type-7, putative 0.0192 0.253 0.3545
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0219 0.0219
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0064 0.0681 0.0955
Giardia lamblia 20S proteasome alpha subunit 2 0.015 0.1926 0.2699
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0143 0.0143
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0037 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.0276
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0028 0.0161 0.0161
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0143 0.0143
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.018
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0028 0.0161 0.0225
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0165 0.2136 0.2993
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0018 0.0014 0.0014
Leishmania major endoplasmic reticulum oxidoreductin, putative 0.0054 0.0533 0.0747
Schistosoma mansoni hypothetical protein 0.0166 0.2152 0.2152
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.014 0.1771 0.2482
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0066 0.0066
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0108 0.0151
Echinococcus granulosus survival motor neuron protein 1 0.0195 0.2569 0.2569
Schistosoma mansoni peptidase Clp (S14 family) 0.0064 0.0681 0.0681
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0033 0.0219 0.0219
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Echinococcus multilocularis proteasome subunit alpha type 6 0.0157 0.2018 0.2018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0143 0.018
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0219 0.0219
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0165 0.2136 0.2993
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0034 0.0237 0.0332
Brugia malayi Trypsin family protein 0.0033 0.0219 0.0219
Echinococcus granulosus carbonic anhydrase 0.0054 0.0537 0.0537
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0143 0.018
Toxoplasma gondii PCI domain-containing protein 0.0034 0.0237 0.0332
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0066 0.0066
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0018 0.0015 0.0015
Entamoeba histolytica proteasome regulatory subunit, putative 0.0028 0.0161 0.0225
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0146 0.1858 0.2603
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.051 0.7137 0.7137
Toxoplasma gondii heat shock protein hslv, putative 0.0118 0.146 0.2046
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0018 0.0015 0.0021
Leishmania major carbonic anhydrase-like protein 0.0147 0.1872 0.2623
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.015 0.1926 0.2699
Echinococcus granulosus carbonic anhydrase II 0.0147 0.1872 0.1872
Loa Loa (eye worm) proteasome subunit alpha type 2 0.015 0.1926 0.2426
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0147 0.1872 0.1872
Loa Loa (eye worm) hypothetical protein 0.0054 0.0533 0.0671
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.014 0.1771 0.1771
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0033 0.0219 0.0219
Onchocerca volvulus 0.0033 0.0219 0.1163
Brugia malayi Uncoordinated protein 44 0.0031 0.0197 0.0197
Echinococcus granulosus tubulin beta 1 chain 0.0022 0.0066 0.0066
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0147 0.187 0.262
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0033 0.023 0.0322
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0143 0.0143
Brugia malayi 26S protease regulatory subunit 6A 0.0018 0.0015 0.0015
Leishmania major beta tubulin 0.0022 0.0066 0.0093
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.014 0.1771 0.223
Leishmania major proteasome beta 2 subunit, putative 0.0192 0.253 0.3545
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0157 0.2018 0.2828
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0132 0.1663 0.2331
Loa Loa (eye worm) hypothetical protein 0.0031 0.0199 0.0251
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0136 0.1723 0.2415
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0143 0.0143
Schistosoma mansoni multiubiquitin binding protein S5a 0.0018 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0054 0.0537 0.0537
Giardia lamblia 20S proteasome alpha subunit 7 0.0148 0.1885 0.2641
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0147 0.187 0.262
Brugia malayi Ubiquitin interaction motif family protein 0.0018 0.0014 0.0014
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0026 0.0127 0.0127
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0146 0.1864 0.2612
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0034 0.0237 0.0237
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0143 0.0143
Echinococcus granulosus geminin 0.0166 0.2152 0.2152
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0026 0.0127 0.0178
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0108 0.0151
Loa Loa (eye worm) PCI domain-containing protein 0.0026 0.0125 0.0158
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0028 0.0159 0.0223
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0148 0.1885 0.2641
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0143 0.0143
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0192 0.253 0.3545
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0147 0.187 0.262
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.0276
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0037 0.0289 0.0405
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0143 0.0143
Brugia malayi hypothetical protein 0.0035 0.0259 0.0259
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0148 0.1885 0.2641
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0033 0.0219 0.0219
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0141 0.1792 0.2511
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0022 0.007 0.0098
Loa Loa (eye worm) BEN-1 protein 0.0022 0.0066 0.0084
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0037 0.0289 0.0364
Brugia malayi small heat shock protein 0.0566 0.7942 0.7942
Echinococcus multilocularis proteasome subunit beta type 7 0.0708 1 1
Echinococcus multilocularis proteasome subunit beta type 6 0.0147 0.187 0.187
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0189 0.248 0.3475
Loa Loa (eye worm) proteasome subunit beta type 2 0.0141 0.1792 0.2256
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0156 0.2006 0.2811

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 13 nM Binding affinity for sigma receptor using [3H]-(+)-SKF- 10,047 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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