Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0077 | 0.0527 | 0.0527 |
Onchocerca volvulus | 0.0162 | 1 | 1 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0162 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0077 | 0.0527 | 0.0527 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0162 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0162 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0162 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0162 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0162 | 1 | 1 |
Giardia lamblia | CDC8 | 0.0072 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0162 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0162 | 1 | 1 |
Chlamydia trachomatis | thymidylate kinase | 0.0072 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0072 | 0 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0162 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0162 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.0527 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0162 | 1 | 1 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0072 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0162 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0077 | 0.0527 | 0.0527 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0162 | 1 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0072 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 19 nM | Displacement of the radioligand [3H]-YM-09151-2 from cloned human Dopamine receptor D3 expressed in CHO cells | ChEMBL. | 11992769 |
Ki (binding) | = 1522 nM | Displacement of the radioligand [3H]-spiperone from the cloned human Dopamine receptor D2 long expressed in CHO cells | ChEMBL. | 11992769 |
Ki (binding) | = 2314 nM | Displacement of the radioligand [3H]-spiperone from the cloned human dopamine receptor D4 expressed in CHO cells | ChEMBL. | 11992769 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.