Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.6488 | 0.6488 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.6488 | 0.6488 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.6488 | 0.6488 |
Onchocerca volvulus | 0.0028 | 0.6488 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.6488 | 0.6488 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 1 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.6488 | 0.6488 |
Echinococcus multilocularis | musashi | 0.0028 | 0.6488 | 0.6488 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0036 | 1 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.6488 | 0.6238 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.6259 | 0.6259 |
Echinococcus granulosus | lamin | 0.0028 | 0.6488 | 0.6488 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 1 | 0.5 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0036 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.6488 | 0.6488 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 1 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0036 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0.6488 | 0.5 | |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0036 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0666 | 0.0666 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.6488 | 0.6238 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 1 | 0.5 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0036 | 1 | 0.5 |
Echinococcus multilocularis | lamin | 0.0028 | 0.6488 | 0.6488 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 1 | 0.5 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0036 | 1 | 0.5 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 1 | 1 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0036 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 1 | 1 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 7 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.