Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0508 | 0.0508 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0066 | 0.0404 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0066 | 0.0789 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0508 | 0.0508 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0066 | 0.0789 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0066 | 0.1303 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0508 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0005 | 0.0007 | 0.0043 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0066 | 0.0066 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0066 | 0.0404 |
Leishmania major | basic transcription factor 3a, putative | 0.0036 | 0.0375 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0508 | 0.6055 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0066 | 0.0404 |
Loa Loa (eye worm) | ICD-1 protein | 0.0036 | 0.0375 | 0.2283 |
Mycobacterium leprae | Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0592 | 0.7166 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0005 | 0.0005 | 0.003 |
Brugia malayi | Death domain containing protein | 0.0014 | 0.0116 | 0.0709 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0066 | 0.0789 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0014 | 0.0116 | 0.0709 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 0.1641 | 1 |
Brugia malayi | Uncoordinated protein 44 | 0.0014 | 0.0116 | 0.0709 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0007 | 0.0043 |
Schistosoma mansoni | netrin receptor unc5 | 0.0014 | 0.0116 | 0.2288 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0066 | 0.0404 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0007 | 0.0043 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0508 | 0.3098 |
Echinococcus multilocularis | smad | 0.0009 | 0.0057 | 0.0057 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0066 | 0.0066 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0066 | 0.0404 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0005 | 0.0007 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0007 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0118 | 0.0718 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0007 | 0.0043 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0014 | 0.0116 | 0.1385 |
Onchocerca volvulus | Netrin receptor homolog | 0.0014 | 0.0116 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0066 | 0.0404 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0066 | 0.0404 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0066 | 0.0066 |
Echinococcus multilocularis | transcription factor btf3 | 0.0036 | 0.0375 | 0.0375 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0066 | 0.0404 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0066 | 0.0404 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0066 | 0.1303 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0036 | 0.0375 | 0.5 |
Echinococcus multilocularis | Ankyrin | 0.0014 | 0.0118 | 0.0118 |
Brugia malayi | beta-NAC-like protein | 0.0036 | 0.0375 | 0.2283 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0005 | 0.003 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0066 | 0.0404 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0066 | 0.0066 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0007 | 0.0043 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0508 | 0.3098 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0005 | 0.0007 | 0.0084 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0066 | 0.5695 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0066 | 0.1303 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0066 | 0.0404 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0066 | 0.0066 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0066 | 0.1303 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0375 | 0.5 |
Schistosoma mansoni | Smad4 | 0.0009 | 0.0057 | 0.1115 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0057 | 0.1115 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0066 | 0.0404 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0066 | 0.1303 |
Brugia malayi | MH2 domain containing protein | 0.0139 | 0.1641 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 0.1641 | 1 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.0592 | 0.7166 | 0.5 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0074 | 0.0839 | 0.0839 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0036 | 0.0375 | 0.5 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0009 | 0.0057 | 0.0675 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0036 | 0.0375 | 0.5 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0007 | 0.0043 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0066 | 0.0404 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0066 | 0.0404 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0005 | 0.0007 | 0.014 |
Onchocerca volvulus | 0.001 | 0.0066 | 0.5695 | |
Brugia malayi | MH1 domain containing protein | 0.0005 | 0.0005 | 0.003 |
Echinococcus granulosus | smad | 0.0009 | 0.0057 | 0.0675 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0066 | 0.0404 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0066 | 0.0404 |
Schistosoma mansoni | transcription factor btf3 | 0.0036 | 0.0375 | 0.7369 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0014 | 0.0116 | 0.2288 |
Echinococcus granulosus | transcription factor btf3 | 0.0036 | 0.0375 | 0.4462 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0066 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0066 | 0.0404 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0066 | 0.0066 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0057 | 0.1115 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0375 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0066 | 0.0066 |
Echinococcus granulosus | Ankyrin | 0.0014 | 0.0118 | 0.1403 |
Echinococcus granulosus | death domain containing protein | 0.0014 | 0.0116 | 0.1385 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0066 | 0.1303 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0066 | 0.1303 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0066 | 0.1303 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0066 | 0.5695 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0066 | 0.0404 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.0592 | 0.7166 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0066 | 0.0789 |
Schistosoma mansoni | smad | 0.0009 | 0.0057 | 0.1115 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0066 | 0.1303 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0066 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0116 | 0.0709 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.0057 | 0.1115 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0036 | 0.0375 | 0.5 |
Loa Loa (eye worm) | Smad1 | 0.0009 | 0.0057 | 0.0345 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0036 | 0.0375 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0014 | 0.0116 | 0.0709 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0057 | 0.0345 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0375 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0057 | 0.1115 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0005 | 0.0007 | 0.014 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0066 | 0.0404 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0066 | 0.1303 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0375 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0066 | 0.0404 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0014 | 0.0116 | 0.0116 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0116 | 0.0709 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0066 | 0.0404 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0009 | 0.0057 | 0.0057 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0007 | 0.0043 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0066 | 0.0789 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0057 | 0.0345 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0009 | 0.0057 | 0.0345 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0066 | 0.0404 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0508 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0066 | 0.0404 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0057 | 0.0345 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0066 | 0.0404 |
Echinococcus granulosus | Smad4 | 0.0009 | 0.0057 | 0.0675 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0066 | 0.0404 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0036 | 0.0375 | 0.5 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0014 | 0.0116 | 0.0116 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0009 | 0.0057 | 0.0675 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0066 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0066 | 0.0404 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0066 | 0.0789 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0014 | 0.0118 | 0.2317 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0007 | 0.0043 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0066 | 0.0404 |
Loa Loa (eye worm) | nuclear factor I | 0.0005 | 0.0005 | 0.003 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0074 | 0.0839 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0066 | 0.1303 |
Echinococcus multilocularis | Smad4 | 0.0009 | 0.0057 | 0.0057 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0057 | 0.0345 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0005 | 0.0007 | 0.0007 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0066 | 0.0404 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0066 | 0.0404 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0066 | 0.0404 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0066 | 0.0404 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0066 | 0.1303 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0066 | 0.5695 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0066 | 0.0789 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0066 | 0.1303 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0066 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0007 | 0.0043 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0508 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0066 | 0.0789 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0508 | 0.6055 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0014 | 0.0116 | 0.1385 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0009 | 0.0057 | 0.0057 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0009 | 0.0057 | 0.0345 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0116 | 0.2288 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0066 | 0.0404 |
Brugia malayi | Smad1 | 0.0009 | 0.0057 | 0.0345 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0066 | 0.0404 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0592 | 0.7166 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 31 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.