Detailed information for compound 1048503

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 307.428 | Formula: C18H29NO3
  • H donors: 0 H acceptors: 1 LogP: 3.85 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCOc1ccc(c(c1)OC)C(=O)CCN(C)C
  • InChi: 1S/C18H29NO3/c1-5-6-7-8-13-22-15-9-10-16(18(14-15)21-4)17(20)11-12-19(2)3/h9-10,14H,5-8,11-13H2,1-4H3
  • InChiKey: DFSUFPSHAGYTDU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0403 0.2469
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0206 0.0202
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0206 0.1095
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0266 0.1619
Brugia malayi exodeoxyribonuclease III family protein 0.0074 0.0506 0.1013
Echinococcus multilocularis muscleblind protein 0.0145 0.1104 0.1272
Loa Loa (eye worm) inositol-1 0.0043 0.0244 0.0302
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.0347 0.0863
Loa Loa (eye worm) hypothetical protein 0.0187 0.1461 0.181
Mycobacterium tuberculosis Conserved protein 0.0187 0.1461 0.1458
Trichomonas vaginalis glutaminase, putative 0.0272 0.2186 0.5492
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1844 0.2124
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0191 0.1496 0.1723
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.0074 0.0506 0.1264
Echinococcus multilocularis Niemann Pick C1 protein 0.02 0.1572 0.181
Plasmodium falciparum ataxin-2 like protein, putative 0.0107 0.0782 0.4807
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0403 0.0464
Loa Loa (eye worm) hypothetical protein 0.0232 0.1844 0.2284
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0003 0.0004
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0003 0.0004
Schistosoma mansoni ran 0.0046 0.0266 0.0306
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0007
Echinococcus granulosus dna polymerase eta 0.0113 0.0833 0.0959
Schistosoma mansoni ap endonuclease 0.0074 0.0506 0.0582
Echinococcus granulosus dnaJ subfamily B 0.0871 0.727 0.8372
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0383 0.1633
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0383 0.2347
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0088 0.0213
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0074 0.0506 0.3202
Echinococcus granulosus tar DNA binding protein 0.0071 0.0478 0.055
Echinococcus granulosus geminin 0.1037 0.8683 1
Echinococcus multilocularis GPCR, family 2 0.0191 0.1496 0.1723
Leishmania major hypothetical protein, conserved 0.0107 0.0782 0.4807
Echinococcus granulosus tumor protein p63 0.0336 0.2731 0.3146
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1844 0.2124
Brugia malayi glutaminase DH11.1 0.0272 0.2186 0.4378
Schistosoma mansoni apoferritin-2 0.0018 0.0031 0.0036
Brugia malayi beta-lactamase 0.0187 0.1461 0.2926
Trypanosoma brucei importin beta-1 subunit, putative 0.009 0.0644 0.3959
Mycobacterium tuberculosis Conserved protein 0.0187 0.1461 0.1458
Trypanosoma cruzi PAB1-binding protein , putative 0.0107 0.0782 0.4807
Echinococcus multilocularis cpg binding protein 0.0065 0.0425 0.049
Schistosoma mansoni inositol monophosphatase 0.0043 0.0244 0.0281
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0004
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0223 0.0552
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0024 0.0028
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1104 0.1272
Schistosoma mansoni hypothetical protein 0.0191 0.1496 0.1723
Brugia malayi Pre-SET motif family protein 0.0425 0.3481 0.697
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0031 0.0028
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0187 0.1461 0.2926
Schistosoma mansoni neutral sphingomyelinase 0.0015 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.0073 0.0492 0.0567
Trichomonas vaginalis importin beta-1, putative 0.0073 0.0499 0.1247
Brugia malayi RNA binding protein 0.0071 0.0478 0.0957
Mycobacterium ulcerans glutaminase 0.0272 0.2186 1
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.0347 0.0429
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0187 0.1461 0.1458
Plasmodium falciparum transportin 0.0017 0.0022 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.1461 0.9005
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0007
Leishmania major hypothetical protein, conserved 0.0017 0.0022 0.0112
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0074 0.0506 0.0626
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0134 0.0269
Echinococcus multilocularis neutral sphingomyelinase 0.0015 0.0003 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0318 0.2578 0.2968
Trichomonas vaginalis esterase, putative 0.0187 0.1461 0.3668
Leishmania major GTP-binding protein, putative 0.0046 0.0266 0.1619
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0478 0.055
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0007
Brugia malayi ImpB/MucB/SamB family protein 0.0113 0.0833 0.1667
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0233 0.1856 0.2137
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0034 0.0187
Trypanosoma brucei unspecified product 0.006 0.0383 0.2347
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0478 0.055
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0191 0.1496 0.1723
Loa Loa (eye worm) hypothetical protein 0.009 0.0644 0.0798
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0074 0.0506 0.3103
Schistosoma mansoni hypothetical protein 0.0965 0.8073 0.9297
Echinococcus multilocularis transportin 1 0.0017 0.0022 0.0025
Trypanosoma brucei importin beta-1 subunit, putative 0.009 0.0644 0.3959
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0041 0.0224 0.1365
Trichomonas vaginalis set domain proteins, putative 0.0483 0.3977 1
Schistosoma mansoni hypothetical protein 0.0871 0.727 0.8372
Entamoeba histolytica hypothetical protein 0.0073 0.0492 0.3117
Brugia malayi hypothetical protein 0.0073 0.0492 0.0986
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0187 0.1461 0.1458
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.1461 0.9005
Schistosoma mansoni ferritin 0.0018 0.0031 0.0036
Trypanosoma brucei unspecified product 0.0041 0.0226 0.1375
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0041 0.0224 0.1365
Trichomonas vaginalis D-aminoacylase, putative 0.0187 0.1461 0.3668
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.0996 0.1148
Onchocerca volvulus 0.0187 0.1461 0.3668
Plasmodium vivax SET domain protein, putative 0.0062 0.0403 0.2469
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.0034 0.0187
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0088 0.0213
Trichomonas vaginalis penicillin-binding protein, putative 0.0187 0.1461 0.3668
Trichomonas vaginalis D-aminoacylase, putative 0.0187 0.1461 0.3668
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0074 0.0506 0.2982
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.6623 0.7628
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0244 0.1487
Loa Loa (eye worm) hypothetical protein 0.003 0.0129 0.0159
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0074 0.0506 0.3103
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0244 0.1487
Loa Loa (eye worm) hypothetical protein 0.0113 0.0833 0.1031
Mycobacterium tuberculosis Probable hydrolase 0.0187 0.1461 0.1458
Loa Loa (eye worm) hypothetical protein 0.0049 0.0294 0.0365
Mycobacterium ulcerans leucyl aminopeptidase 0.0206 0.1622 0.7382
Schistosoma mansoni carbon catabolite repressor protein 0.0015 0.0003 0.0004
Echinococcus multilocularis leucine aminopeptidase protein 0.0206 0.1622 0.1868
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0048 0.0282 0.0325
Onchocerca volvulus 0.0187 0.1461 0.3668
Loa Loa (eye worm) hypothetical protein 0.0603 0.4994 0.6186
Echinococcus multilocularis dnaJ subfamily B 0.0871 0.727 0.8372
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0104 0.0254
Toxoplasma gondii ABC1 family protein 0.0187 0.1461 0.9005
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0015 0.0018
Brugia malayi cytosol aminopeptidase 0.0041 0.0224 0.0449
Brugia malayi polk-prov protein 0.0019 0.0034 0.0068
Mycobacterium leprae Probable lipase LipE 0.0187 0.1461 0.8987
Echinococcus multilocularis expressed protein 0.0018 0.0031 0.0036
Entamoeba histolytica hypothetical protein 0.0073 0.0492 0.3117
Loa Loa (eye worm) hypothetical protein 0.0063 0.0412 0.051
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0867 0.1074
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0604 0.0748
Plasmodium vivax transportin, putative 0.0017 0.0022 0.0112
Mycobacterium leprae conserved hypothetical protein 0.0187 0.1461 0.8987
Trypanosoma brucei unspecified product 0.0041 0.0226 0.1375
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.0412 0.0474
Loa Loa (eye worm) hypothetical protein 0.0187 0.1461 0.181
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0604 0.0696
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0383 0.2347
Trichomonas vaginalis penicillin-binding protein, putative 0.0187 0.1461 0.3668
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0318 0.2578 0.2968
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0203 0.1598 0.184
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.0412 0.0824
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0191 0.1496 0.1723
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0499 0.1247
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0244 0.1487
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0244 0.0606
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0244 0.0606
Echinococcus granulosus leucyl aminopeptidase 0.0041 0.0224 0.0258
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0396 0.049
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0024 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0198 0.049
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0206 0.1622 0.1619
Entamoeba histolytica hypothetical protein 0.0073 0.0492 0.3117
Loa Loa (eye worm) hypothetical protein 0.0105 0.0768 0.0951
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0383 0.2347
Brugia malayi CCR4 0.0015 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0191 0.1496 0.1853
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0318 0.2578 0.2968
Brugia malayi latrophilin 2 splice variant baaae 0.0412 0.3375 0.6758
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.006 0.0383 0.0442
Echinococcus granulosus GPCR family 2 0.0191 0.1496 0.1723
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0347 0.0399
Leishmania major DNA polymerase eta, putative 0.0113 0.0833 0.5122
Brugia malayi SET domain containing protein 0.0015 0.0001 0.0001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0056 0.0065
Echinococcus multilocularis translational activator gcn1 0.0017 0.0022 0.0025
Leishmania major DNA damage repair protein, putative 0.0019 0.0034 0.0187
Plasmodium vivax hypothetical protein, conserved 0.0187 0.1461 0.9005
Echinococcus granulosus snurportin 1 0.0965 0.8073 0.9297
Brugia malayi mbt repeat family protein 0.0055 0.0347 0.0694
Trypanosoma cruzi importin beta-1 subunit, putative 0.0073 0.0499 0.3062
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0041 0.0224 0.1365
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0034 0.0187
Onchocerca volvulus 0.0061 0.0396 0.0987
Echinococcus granulosus importin subunit beta 1 0.009 0.0644 0.0742
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0191 0.1496 0.1723
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0206 0.1622 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0266 0.1619
Loa Loa (eye worm) glutaminase 2 0.0272 0.2186 0.2708
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0383 0.2347
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0187 0.1461 0.181
Loa Loa (eye worm) hypothetical protein 0.0145 0.1104 0.1368
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0383 0.2347
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0266 0.1619
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0024 0.0028
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.0412 0.0474
Schistosoma mansoni chromobox protein 0.0068 0.045 0.0519
Schistosoma mansoni cpg binding protein 0.0065 0.0425 0.049
Giardia lamblia DINP protein human, muc B family 0.006 0.0383 0.7564
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0041 0.0224 0.0278
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0007
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0244 0.1487
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0041 0.0224 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0383 0.2347
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0318 0.2578 0.5161
Chlamydia trachomatis cytosol aminopeptidase 0.0206 0.1622 0.5
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0244 0.0606
Echinococcus granulosus muscleblind protein 0.0145 0.1104 0.1272
Schistosoma mansoni hypothetical protein 0.0191 0.1496 0.1723
Plasmodium vivax importin-beta 2, putative 0.009 0.0644 0.3959
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0492 0.0567
Mycobacterium ulcerans lipase LipD 0.0187 0.1461 0.6635
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0266 0.1619
Trichomonas vaginalis ran, putative 0.0046 0.0266 0.0659
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0003 0.0004
Schistosoma mansoni apoferritin-2 0.0018 0.0031 0.0036
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0206 0.1622 1
Brugia malayi Inositol-1 0.0043 0.0244 0.0489
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0007
Echinococcus granulosus cpg binding protein 0.0065 0.0425 0.049
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0478 0.055
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.0383 0.0768
Trichomonas vaginalis chromobox protein, putative 0.0068 0.045 0.1125
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0088 0.0213
Entamoeba histolytica Ran family GTPase 0.0046 0.0266 0.1671
Loa Loa (eye worm) hypothetical protein 0.02 0.1572 0.1947
Loa Loa (eye worm) hypothetical protein 0.0038 0.0198 0.0246
Loa Loa (eye worm) latrophilin receptor protein 2 0.0191 0.1496 0.1853
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0266 0.0306
Toxoplasma gondii exonuclease III APE 0.0074 0.0506 0.3103
Brugia malayi Latrophilin receptor protein 2 0.0191 0.1496 0.2995
Onchocerca volvulus 0.0483 0.3977 1
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0034 0.0187
Entamoeba histolytica HEAT repeat domain containing protein 0.0017 0.0022 0.0116
Brugia malayi TAR-binding protein 0.0071 0.0478 0.0957
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0604 0.0696
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0015 0.0029
Schistosoma mansoni importin-beta 2 0.0017 0.0022 0.0025
Giardia lamblia DNA damage repair protein 0.0019 0.0034 0.0603
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0373 0.0429
Loa Loa (eye worm) hypothetical protein 0.0187 0.1461 0.181
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0104 0.0254
Echinococcus granulosus translational activator gcn1 0.0017 0.0022 0.0025
Onchocerca volvulus 0.003 0.0129 0.0315
Echinococcus multilocularis chromobox protein 1 0.0068 0.045 0.0519
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0198 0.049
Echinococcus granulosus leucine aminopeptidase protein 0.0206 0.1622 0.1868
Schistosoma mansoni lamin 0.003 0.0134 0.0155
Echinococcus granulosus leucyl aminopeptidase 0.0041 0.0224 0.0258
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0318 0.2578 0.2968
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0034 0.0187
Loa Loa (eye worm) glutaminase 0.0272 0.2186 0.2708
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0383 0.2347
Echinococcus multilocularis musashi 0.003 0.0134 0.0155
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0206 0.1622 1
Leishmania major DNA polymerase eta, putative 0.0071 0.0483 0.2962
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0266 0.1619
Onchocerca volvulus 0.003 0.0134 0.0329
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.0347 0.0399
Echinococcus granulosus lamin 0.003 0.0134 0.0155
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0034 0.0187
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0088 0.0213
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0071 0.0483 0.2962
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0074 0.0506 0.2201
Entamoeba histolytica hypothetical protein 0.0073 0.0499 0.316
Echinococcus granulosus transportin 1 0.0017 0.0022 0.0025
Brugia malayi CXXC zinc finger family protein 0.0061 0.0396 0.0792
Echinococcus multilocularis Niemann Pick C1 protein 0.0285 0.2299 0.2648
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.0383 0.0956
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0206 0.1622 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.1104 0.1368
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0383 0.2347
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0403 0.0464
Echinococcus granulosus neutral sphingomyelinase 0.0015 0.0003 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0478 0.055
Leishmania major DNA polymerase kappa, putative 0.006 0.0383 0.2347
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0056 0.0069
Schistosoma mansoni cpg binding protein 0.0065 0.0425 0.049
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0278 0.0556
Echinococcus multilocularis ferritin 0.0018 0.0031 0.0036
Echinococcus granulosus chromobox protein 1 0.0068 0.045 0.0519
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.0412 0.0474
Echinococcus multilocularis leucyl aminopeptidase 0.0041 0.0224 0.0258
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0034 0.0187
Schistosoma mansoni cpg binding protein 0.0061 0.0396 0.0456
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0223 0.0552
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.0383 0.0956
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0206 0.1622 1
Echinococcus granulosus ferritin 0.0018 0.0031 0.0036
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0007
Echinococcus granulosus FTZ F1 alpha 0.0381 0.3114 0.3586
Schistosoma mansoni ferritin light chain 0.0018 0.0031 0.0036
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0134 0.0166
Leishmania major hypothetical protein, conserved 0.0187 0.1461 0.9005
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.0347 0.0399
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0041 0.0224 0.0278
Schistosoma mansoni DNA polymerase eta 0.0113 0.0833 0.0959
Onchocerca volvulus 0.0055 0.0347 0.0863
Echinococcus multilocularis leucyl aminopeptidase 0.0041 0.0224 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0383 0.2347
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0206 0.1622 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0187 0.1461 0.1683
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0318 0.2578 0.2968
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0017 0.0022 0.0112
Echinococcus multilocularis lamin 0.003 0.0134 0.0155
Mycobacterium tuberculosis Conserved protein 0.0187 0.1461 0.1458
Echinococcus granulosus Niemann Pick C1 protein 0.0285 0.2299 0.2648
Echinococcus multilocularis leucyl aminopeptidase 0.0041 0.0224 0.0258
Schistosoma mansoni patched 1 0.0086 0.0604 0.0696
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0056 0.0065
Plasmodium vivax ataxin-2 like protein, putative 0.0107 0.0782 0.4807
Schistosoma mansoni synaptojanin 0.0015 0.0003 0.0004
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0041 0.0224 0.1365
Echinococcus granulosus chromobox protein 1 0.0068 0.045 0.0519
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.045 0.0558
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0022 0.0112
Echinococcus granulosus beta LACTamase domain containing family member 0.0187 0.1461 0.1683
Brugia malayi Niemann-Pick C1 protein precursor 0.02 0.1572 0.3147
Echinococcus multilocularis tumor protein p63 0.0336 0.2731 0.3146
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0867 0.1074
Treponema pallidum exodeoxyribonuclease (exoA) 0.0074 0.0506 1
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0031 0.0556
Loa Loa (eye worm) hypothetical protein 0.0187 0.1461 0.181
Echinococcus granulosus importin 5 0.0017 0.0022 0.0025
Echinococcus granulosus intermediate filament protein 0.003 0.0134 0.0155
Brugia malayi kap beta 3 protein 0.0017 0.0022 0.0043
Echinococcus multilocularis protein patched 0.0086 0.0604 0.0696
Echinococcus multilocularis protein dispatched 1 0.0098 0.0707 0.0814
Onchocerca volvulus 0.0187 0.1461 0.3668
Schistosoma mansoni inositol monophosphatase 0.0043 0.0244 0.0281
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0034 0.0039
Schistosoma mansoni cript-related 0.0015 0.0003 0.0004
Echinococcus granulosus expressed conserved protein 0.0188 0.1469 0.1692
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0031 0.0028
Leishmania major importin beta-1 subunit, putative 0.0073 0.0499 0.3062
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0022 0.0112
Entamoeba histolytica hypothetical protein 0.0073 0.0492 0.3117
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0048 0.0282 0.0325
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0041 0.0224 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0383 0.2347
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0041 0.0224 0.0449
Trichomonas vaginalis chromobox protein, putative 0.0068 0.045 0.1125
Loa Loa (eye worm) hypothetical protein 0.0107 0.0782 0.0968
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0226 0.1375
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0017 0.0022 0.0112
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0223 0.0552
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0383 0.038
Loa Loa (eye worm) MBCTL1 0.0063 0.0412 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0198 0.049
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0604 0.1511
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0403 0.0464
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0088 0.0213
Loa Loa (eye worm) hypothetical protein 0.0055 0.0347 0.0429
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.0347 0.0399
Trypanosoma cruzi DNA polymerase eta, putative 0.0071 0.0483 0.2962
Schistosoma mansoni ferritin 0.0018 0.0031 0.0036
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0187 0.1461 0.6635
Schistosoma mansoni ferritin light chain 0.0018 0.0031 0.0036
Trichomonas vaginalis ap endonuclease, putative 0.0074 0.0506 0.1264
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.02 0.1572 1
Schistosoma mansoni hypothetical protein 0.0083 0.0578 0.0665
Schistosoma mansoni survival motor neuron protein 0.0047 0.0278 0.032
Echinococcus granulosus dna polymerase kappa 0.006 0.0383 0.0442
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0244 0.0281
Schistosoma mansoni chromobox protein 0.0068 0.045 0.0519
Schistosoma mansoni intermediate filament proteins 0.003 0.0134 0.0155
Echinococcus multilocularis lamin dm0 0.003 0.0134 0.0155
Echinococcus multilocularis beta LACTamase domain containing family member 0.0187 0.1461 0.1683
Schistosoma mansoni hypothetical protein 0.0083 0.0578 0.0665
Trypanosoma brucei PAB1-binding protein , putative 0.0107 0.0782 0.4807
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0025 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0187
Trypanosoma brucei aminopeptidase, putative 0.0041 0.0224 0.1365
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0266 0.0532
Loa Loa (eye worm) hypothetical protein 0.003 0.0129 0.016
Mycobacterium ulcerans hypothetical protein 0.0187 0.1461 0.6635
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0015 0.0003 0.0004
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0347 0.0399
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0041 0.0224 0.1365
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0015 0.0003 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0478 0.0592
Plasmodium falciparum M17 leucyl aminopeptidase 0.0206 0.1622 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0107 0.0782 0.4807
Trypanosoma cruzi DNA polymerase eta, putative 0.0113 0.0833 0.5122
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0383 0.2347
Mycobacterium tuberculosis Conserved hypothetical protein 0.006 0.0383 0.038
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0499 0.1247
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0497 0.0573
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0015 0.0003 0.0004
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0074 0.0506 1
Loa Loa (eye worm) hypothetical protein 0.0412 0.3375 0.418
Toxoplasma gondii HEAT repeat-containing protein 0.009 0.0644 0.3959
Echinococcus granulosus synaptojanin 1 0.0015 0.0003 0.0004
Schistosoma mansoni ferritin 0.0018 0.0031 0.0036
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0024 0.0028
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0266 0.5218
Schistosoma mansoni hypothetical protein 0.1037 0.8683 1
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0034 0.0187
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0034 0.0187
Schistosoma mansoni hypothetical protein 0.0352 0.2861 0.3295
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0001 0.0001
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0492 0.0567
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0074 0.0506 0.3103
Loa Loa (eye worm) importin-beta domain-containing protein 0.0017 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0004
Echinococcus granulosus lamin dm0 0.003 0.0134 0.0155
Echinococcus multilocularis dna polymerase kappa 0.006 0.0383 0.0442
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0034 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0226 0.1375
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.0412 0.0474
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0294 0.0339
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0187 0.1461 0.1683
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0074 0.0506 0.0502
Echinococcus multilocularis geminin 0.1037 0.8683 1
Mycobacterium tuberculosis Probable lipase LipD 0.0187 0.1461 0.1458
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0041 0.0224 0.1365
Mycobacterium ulcerans esterase/lipase LipP 0.0187 0.1461 0.6635
Echinococcus multilocularis importin subunit beta 1 0.009 0.0644 0.0742
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0003 0.0004
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0244 0.1337
Brugia malayi Calcitonin receptor-like protein seb-1 0.0603 0.4994 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0088 0.0213
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0383 0.2347
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0015 0.0003 0.0004
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.0412 0.0474
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0041 0.0224 0.0449
Echinococcus granulosus traf and tnf receptor associated protein 0.0015 0.0003 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0088 0.0213
Mycobacterium ulcerans beta-lactamase 0.0187 0.1461 0.6635
Brugia malayi hypothetical protein 0.0232 0.1844 0.3692
Trichomonas vaginalis hypothetical protein 0.0017 0.0022 0.0046
Toxoplasma gondii leucyl aminopeptidase LAP 0.0206 0.1622 1
Brugia malayi chromobox protein homolog 3 0.0038 0.0198 0.0397
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0403 0.0464
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0187
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0007
Echinococcus multilocularis dna polymerase eta 0.0113 0.0833 0.0959
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0187 0.1461 0.181
Echinococcus multilocularis traf and tnf receptor associated protein 0.0015 0.0003 0.0004
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.006 0.0383 0.0475
Brugia malayi RNA, U transporter 1 0.0257 0.206 0.4125
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0478 0.0957
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0034 0.0187
Echinococcus multilocularis synaptojanin 1 0.0015 0.0003 0.0004
Brugia malayi beta-lactamase family protein 0.0187 0.1461 0.2926
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0226 0.1375
Plasmodium falciparum importin beta, putative 0.009 0.0644 0.3959
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0266 0.0306
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0166
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0034 0.0187
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0266 0.0329
Brugia malayi CHE-14 protein 0.0086 0.0604 0.1209
Schistosoma mansoni hypothetical protein 0.0083 0.0578 0.0665
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0965 0.8073 1
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0244 0.0281
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0034 0.0187
Schistosoma mansoni hypothetical protein 0.0191 0.1496 0.1723
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0206 0.1622 1
Trichomonas vaginalis D-aminoacylase, putative 0.0187 0.1461 0.3668
Brugia malayi intermediate filament protein 0.003 0.0134 0.0269
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0004
Loa Loa (eye worm) RNA binding protein 0.0071 0.0478 0.0592
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0318 0.2578 0.2968
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0603 0.4994 0.6186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0318 0.2578 0.2968
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.0347 0.0399
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0244 0.1487
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0403 0.0464
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0003 0.0004
Schistosoma mansoni importin beta-1 0.009 0.0644 0.0742
Echinococcus multilocularis chromobox protein 1 0.0068 0.045 0.0519
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0383 0.2347
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0478 0.055
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0074 0.0506 0.3103
Trypanosoma brucei hypothetical protein, conserved 0.0187 0.1461 0.9005
Schistosoma mansoni glutaminase 0.0272 0.2186 0.2518
Schistosoma mansoni leucine aminopeptidase 0.0041 0.0224 0.0258
Brugia malayi hypothetical protein 0.0107 0.0782 0.1565
Brugia malayi Heterochromatin protein 1 0.0068 0.045 0.0902
Loa Loa (eye worm) intermediate filament protein 0.003 0.0134 0.0166
Schistosoma mansoni terminal deoxycytidyl transferase 0.006 0.0383 0.0442
Brugia malayi hypothetical protein 0.0069 0.0461 0.0923
Schistosoma mansoni ap endonuclease 0.0074 0.0506 0.0582
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0266 0.1619
Brugia malayi Muscleblind-like protein 0.0145 0.1104 0.2212
Echinococcus granulosus expressed protein 0.0018 0.0031 0.0036
Echinococcus multilocularis snurportin 1 0.0965 0.8073 0.9297
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0478 0.055
Onchocerca volvulus 0.003 0.0134 0.0329
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0604 0.0696
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0383 0.2347
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.006 0.0383 0.0442
Mycobacterium tuberculosis Probable esterase LipL 0.0187 0.1461 0.1458
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0244 0.0987
Echinococcus multilocularis importin 5 0.0017 0.0022 0.0025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0603 0.4994 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0478 0.0592
Onchocerca volvulus 0.0047 0.0278 0.069
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0003 0.0004
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0054 0.0108
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0383 0.2347
Brugia malayi mbt repeat family protein 0.0055 0.0347 0.0694
Brugia malayi Pre-SET motif family protein 0.0062 0.0403 0.0807
Trichomonas vaginalis ferritin, putative 0.0018 0.0031 0.007
Echinococcus granulosus Niemann Pick C1 protein 0.02 0.1572 0.181
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0233 0.1856 0.2137
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0318 0.2578 0.3193
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.025 0.05
Schistosoma mansoni nocturnin 0.0015 0.0003 0.0004
Loa Loa (eye worm) beta-lactamase 0.0187 0.1461 0.181
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0191 0.1496 0.2995
Leishmania major DNA polymerase kappa, putative 0.0019 0.0034 0.0187
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0403 0.0464
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0383 0.2347
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.0086 0.0604 0.0748
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0001 0.0001
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0041 0.0224 0.1365
Schistosoma mansoni hypothetical protein 0.0048 0.0282 0.0325
Brugia malayi beta-lactamase family protein 0.0187 0.1461 0.2926
Plasmodium falciparum ataxin-2 like protein, putative 0.0107 0.0782 0.4807
Schistosoma mansoni hypothetical protein 0.0412 0.3375 0.3887
Echinococcus multilocularis deoxyribonuclease 1 2 0.0015 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.0191 0.1496 0.1723
Brugia malayi MH2 domain containing protein 0.0117 0.0867 0.1737
Loa Loa (eye worm) hypothetical protein 0.0062 0.0403 0.0499
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0074 0.0506 0.0582
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0383 0.2347
Onchocerca volvulus 0.0049 0.0294 0.0732
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0074 0.0506 0.3103
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0383 0.2347
Loa Loa (eye worm) hypothetical protein 0.0187 0.1461 0.181
Trypanosoma brucei DNA polymerase eta, putative 0.0113 0.0833 0.5122
Schistosoma mansoni hypothetical protein 0.0083 0.0578 0.0665
Brugia malayi Importin beta-1 subunit 0.009 0.0644 0.129
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0492 0.0567
Loa Loa (eye worm) kap beta 3 protein 0.0017 0.0022 0.0027
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.3481 0.4312
Schistosoma mansoni ran 0.0046 0.0266 0.0306
Schistosoma mansoni synaptojanin 0.0015 0.0003 0.0004
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.0879 0.5408
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0383 0.1633
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0074 0.0506 0.3103
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.006 0.0383 0.0442
Mycobacterium tuberculosis Probable lipase LipE 0.0187 0.1461 0.1458
Toxoplasma gondii LsmAD domain-containing protein 0.0107 0.0782 0.4807
Echinococcus multilocularis expressed conserved protein 0.0188 0.1469 0.1692
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0244 0.1534
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0003 0.0007
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0074 0.0506 0.0582
Entamoeba histolytica deoxycytidyl transferase, putative 0.006 0.0383 0.2422
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0034 0.0076
Schistosoma mansoni ferritin 0.0018 0.0031 0.0036
Schistosoma mansoni hypothetical protein 0.0047 0.0278 0.032
Schistosoma mansoni lamin 0.003 0.0134 0.0155
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.0347 0.0399
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0034 0.0076
Onchocerca volvulus 0.0073 0.0497 0.1242
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0088 0.0213
Schistosoma mansoni hypothetical protein 0.1037 0.8683 1
Mycobacterium ulcerans hypothetical protein 0.0019 0.0034 0.0011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0187 0.1461 0.1458

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 62 uM Cytotoxicity against human HepG2 cells after 48 hrs by luminescence cell viability assay ChEMBL. 19469546
IC50 (binding) = 22.2 uM Inhibition of SRC2 binding to TRalpha receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay ChEMBL. 19469546
IC50 (binding) = 25.3 uM Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay ChEMBL. 19469546

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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