TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 384.431 | Formula: C23H20N4O2
H donors: 2 H acceptors: 4 LogP: 2.91 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: N#CCNC(=O)[C@@H](NC(=O)c1ccccc1)Cc1cccc(c1)c1ccccn1
InChi: 1S/C23H20N4O2/c24-12-14-26-23(29)21(27-22(28)18-8-2-1-3-9-18)16-17-7-6-10-19(15-17)20-11-4-5-13-25-20/h1-11,13,15,21H,14,16H2,(H,26,29)(H,27,28)/t21-/m0/s1
InChiKey: XWMHXUUSBYGQDC-NRFANRHFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin S	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin V	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin V	334 aa	357 aa	29.7 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Encystation-specific protease	0.0025	0.0422	0.0593
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0113	0.2253	0.2253
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0347	0.7118	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0113	0.2253	1
Entamoeba histolytica	cysteine proteinase, putative	0.0113	0.2253	0.3165
Loa Loa (eye worm)	ctsf protein	0.0113	0.2253	0.4008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2253	1
Schistosoma mansoni	cpg binding protein	0.0034	0.0613	0.0613
Entamoeba histolytica	cysteine proteinase, putative	0.0077	0.1511	0.2122
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.2253	0.5974
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.0816	0.3622
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2253	0.3165
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0036	0.0647	0.115
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0647	0.115
Leishmania major	cathepsin L-like protease	0.0113	0.2253	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0113	0.2253	0.4008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2253	0.3165
Treponema pallidum	fructose-bisphosphate aldolase	0.0347	0.7118	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2253	0.3165
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.0422	0.0751
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0081	0.0081
Giardia lamblia	Cysteine protease	0.0025	0.0422	0.0593
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0054	0.1033	0.1839
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0077	0.1511	0.4006
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0065	0.1247	0.5537
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	0.1511	0.2122
Plasmodium vivax	vivapain-1	0.0061	0.1164	0.4054
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0044	0.0817	0.1148
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0025	0.0422	0.0593
Echinococcus granulosus	inositol monophosphatase 1	0.0044	0.0816	0.0816
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2253	0.3165
Loa Loa (eye worm)	hypothetical protein	0.0113	0.2253	0.4008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2253	0.3165
Echinococcus multilocularis	cathepsin L	0.0061	0.1164	0.1164
Brugia malayi	Papain family cysteine protease containing protein	0.0113	0.2253	0.4008
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0025	0.0422	0.0751
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0422	0.0593
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.1164	0.1164
Entamoeba histolytica	cysteine proteinase, putative	0.0113	0.2253	0.3165
Onchocerca volvulus		0.0113	0.2253	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2253	0.3165
Trypanosoma cruzi	cysteine peptidase, putative	0.0036	0.0647	0.1715
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0091
Echinococcus multilocularis	cysteine protease	0.0113	0.2253	0.2253
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1164	0.1636
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0422	0.0593
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0061	0.1164	0.3088
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0422	0.0593
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2253	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2253	1
Giardia lamblia	Cathepsin B precursor	0.0025	0.0422	0.0593
Giardia lamblia	Cathepsin B precursor	0.0025	0.0422	0.0593
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0124	0.0124
Echinococcus multilocularis	cpg binding protein	0.0036	0.0654	0.0654
Onchocerca volvulus	Cathepsin L homolog	0.0113	0.2253	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1164	0.1636
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0081	0.0081
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0025	0.0422	0.0593
Leishmania major	cathepsin L-like protease	0.0113	0.2253	1
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0044	0.0817	0.0817
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.0422	0.0422
Echinococcus multilocularis	cathepsin L cysteine protease	0.0113	0.2253	0.2253
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0025	0.0422	0.0593
Echinococcus multilocularis	cathepsin b	0.0186	0.3771	0.3771
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0025	0.0422	0.0593
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.0422	0.0422
Giardia lamblia	Cathepsin L precursor	0.0025	0.0422	0.0593
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0169	0.3428	1
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0044	0.0816	0.238
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1164	0.1636
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.3771	0.3771
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0647	0.115
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0025	0.0422	0.0422
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0169	0.3428	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2253	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0186	0.3771	0.6709
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.0422	0.0422
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.1164	0.1164
Echinococcus multilocularis	cysteine protease	0.0113	0.2253	0.2253
Brugia malayi	Cathepsin L-like precursor	0.0077	0.1511	0.2688
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0347	0.7118	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0044	0.0816	0.1146
Onchocerca volvulus		0.0025	0.0422	0.1874
Leishmania major	cathepsin L-like protease	0.0113	0.2253	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0065	0.0091
Giardia lamblia	Cathepsin B precursor	0.0075	0.1458	0.2048
Schistosoma mansoni	cathepsin F (C01 family)	0.0113	0.2253	0.2253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0422	0.0593
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0422	0.0593
Echinococcus granulosus	cpg binding protein	0.0036	0.0654	0.0654
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0121	0.0215
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0347	0.7118	1
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2253	0.4008
Giardia lamblia	Cathepsin B precursor	0.0075	0.1458	0.2048
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0113	0.2253	0.3165
Giardia lamblia	Cathepsin B precursor	0.0025	0.0422	0.0593
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0025	0.0422	0.0751
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0044	0.0816	0.1146
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0422	0.0751
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0091
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2253	0.3165
Trypanosoma cruzi	cysteine peptidase, putative	0.0061	0.1164	0.3088
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0422	0.0593
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2253	0.3165
Toxoplasma gondii	cathepsin B	0.0075	0.1458	0.6472
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.1033	0.1033
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.1033	0.1033
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0124	0.0124
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1164	0.1636
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0061	0.1164	0.4054
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0044	0.0816	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.1033	0.1033
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0034	0.0613	0.1091
Brugia malayi	CXXC zinc finger family protein	0.0034	0.0613	0.1091
Brugia malayi	hypothetical protein	0.0043	0.0792	0.141
Giardia lamblia	Cathepsin L precursor	0.0025	0.0422	0.0593
Echinococcus multilocularis	cathepsin b	0.0186	0.3771	0.3771
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0422	0.0751
Echinococcus granulosus	cathepsin L	0.0025	0.0422	0.0422
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0091
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0025	0.0422	0.0751
Echinococcus multilocularis	cathepsin L cysteine protease	0.0113	0.2253	0.2253
Brugia malayi	cathepsin L-like cysteine proteinase	0.0025	0.0422	0.0751
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0044	0.0816	0.1146
Trypanosoma cruzi	cysteine protease, putative	0.0061	0.1164	0.3088
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0025	0.0422	0.0422
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0044	0.0817	0.0817
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0065	0.0091
Brugia malayi	Cathepsin L-like precursor	0.0077	0.1511	0.2688
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0005	0.0006	0.0006
Schistosoma mansoni	cathepsin B (C01 family)	0.0025	0.0422	0.0422
Schistosoma mansoni	hypothetical protein	0.0043	0.0792	0.0792
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2253	0.3165
Brugia malayi	Papain family cysteine protease containing protein	0.0061	0.1164	0.2072
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0044	0.0817	0.2167
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0347	0.7118	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0422	0.0751
Entamoeba histolytica	hypothetical protein	0.0043	0.0792	0.1113
Echinococcus granulosus	cathepsin l1	0.0077	0.1511	0.1511
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1164	0.1636
Onchocerca volvulus		0.0034	0.0613	0.2722
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.1164	0.1164
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0025	0.0422	0.0593
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0347	0.7118	1
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1164	0.1636
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0422	0.0751
Echinococcus multilocularis	dnaJ subfamily B	0.0485	1	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0422	0.0751
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0169	0.3428	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2253	0.3165
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0075	0.1458	0.6472
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.1164	0.1636
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0817	0.1148
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1164	0.1636
Schistosoma mansoni	cathepsin F (C01 family)	0.0077	0.1511	0.1511
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0077	0.1511	0.2688
Trypanosoma cruzi	major cysteine proteinase, putative	0.0025	0.0422	0.112
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0347	0.7118	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.1164	0.5169
Entamoeba histolytica	hypothetical protein	0.0025	0.0422	0.0593
Trichomonas vaginalis	helicase, putative	0.0008	0.0065	0.0091
Chlamydia trachomatis	3'(2'),5'-bisphosphate nucleotidase CysQ	0.0005	0	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.1033	0.1033
Onchocerca volvulus		0.0113	0.2253	1
Echinococcus granulosus	cathepsin l1	0.0113	0.2253	0.2253
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0186	0.3771	1
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2253	0.4008
Giardia lamblia	Hypothetical protein	0.0025	0.0422	0.0593
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2253	0.3165
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0091
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.2253	0.5974
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1164	0.1636
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0075	0.1458	0.3866
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0054	0.1033	0.1839
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1164	0.1636
Toxoplasma gondii	cathepsin CPL	0.0113	0.2253	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	0.1511	0.2122
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2253	0.3165
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0422	0.0593
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.1033	0.1033
Schistosoma mansoni	cathepsin s	0.0036	0.0647	0.0647
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0422	0.0751
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0025	0.0422	0.0593
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0075	0.1458	0.1458
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0422	0.0593
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0025	0.0422	0.0593
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0044	0.0817	0.3627
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2253	0.3165
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0113	0.2253	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1511	0.2688
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0044	0.0817	0.3627
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2253	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.0816	0.3622
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0347	0.7118	1
Brugia malayi	Papain family cysteine protease containing protein	0.0061	0.1164	0.2072
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0647	0.115
Brugia malayi	cathepsin L-like precursor	0.0077	0.1511	0.2688
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2253	0.3165
Echinococcus granulosus	cysteine protease	0.0061	0.1164	0.1164
Schistosoma mansoni	inositol monophosphatase	0.0044	0.0816	0.0816
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0422	0.0593
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0422	0.0593
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2253	0.3165
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2253	0.3165
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1511	0.2688
Giardia lamblia	Cathepsin B precursor	0.0025	0.0422	0.0593
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.1164	0.5169
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2253	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2253	0.3165
Trypanosoma cruzi	cruzipain precursor, putative	0.0036	0.0647	0.1715
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0113	0.2253	0.2253
Entamoeba histolytica	cysteine proteinase 1, putative	0.0061	0.1164	0.1636
Echinococcus multilocularis	ubiquitin specific protease 41	0.0044	0.0817	0.0817
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0075	0.1458	0.6472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2253	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.3771	0.3771
Plasmodium vivax	unspecified product	0.0036	0.0647	0.1225
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0422	0.0751
Toxoplasma gondii	cathepsin CPC1	0.0025	0.0422	0.1874
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.1033	0.1033
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.1164	0.1636
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0422	0.0593
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0422	0.0593
Trypanosoma cruzi	cruzipain precursor, putative	0.0113	0.2253	0.5974
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0044	0.0817	0.0817
Entamoeba histolytica	hypothetical protein	0.0043	0.0792	0.1113
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0422	0.0593
Brugia malayi	cathepsin F-like cysteine proteinase	0.0036	0.0647	0.115
Plasmodium vivax	vivapain-2	0.0113	0.2253	1
Schistosoma mansoni	inositol monophosphatase	0.0044	0.0816	0.0816
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2253	0.3165
Onchocerca volvulus		0.0113	0.2253	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0113	0.2253	1
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1164	0.1636
Giardia lamblia	Cathepsin L-like protease	0.0025	0.0422	0.0593
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0025	0.0422	0.0422
Plasmodium vivax	vivapain-2	0.0113	0.2253	1
Loa Loa (eye worm)	cathepsin B	0.0075	0.1458	0.2594
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0065	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0817	0.1454
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0072	0.1408	0.1408
Trypanosoma cruzi	cysteine proteinase, putative	0.0061	0.1164	0.3088
Toxoplasma gondii	cathepsin CPC2	0.0025	0.0422	0.1874
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2253	0.3165
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0065	0.0091
Schistosoma mansoni	hypothetical protein	0.0485	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0422	0.0751
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0044	0.0817	0.1148
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2253	0.4008
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0792	0.0792
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0065	0.0091
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0044	0.0816	0.1146
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0065	0.0091
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0044	0.0817	0.0817
Onchocerca volvulus		0.0113	0.2253	1
Leishmania major	cysteine peptidase A (CPA)	0.0113	0.2253	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2253	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0025	0.0422	0.0593
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0113	0.2253	0.4008
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0422	0.0593
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.0816	0.2164
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0025	0.0422	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1511	0.2688
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0275	0.5621	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.0816	0.2164
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.1033	0.1033
Plasmodium vivax	unspecified product	0.0061	0.1164	0.4054
Trypanosoma cruzi	major cysteine proteinase, putative	0.0025	0.0422	0.112
Brugia malayi	cathepsin F-like cysteine proteinase	0.0025	0.0422	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0422	0.0751
Echinococcus multilocularis	inositol monophosphatase 1	0.0044	0.0816	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0186	0.3771	0.6709
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0044	0.0817	0.1454
Giardia lamblia	Cathepsin L precursor	0.0025	0.0422	0.0593
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0347	0.7118	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0025	0.0422	0.0593
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0422	0.0593
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1164	0.1636
Echinococcus granulosus	cathepsin L cysteine protease	0.0061	0.1164	0.1164
Brugia malayi	cathepsin L precursor	0.0025	0.0422	0.0751
Onchocerca volvulus		0.0113	0.2253	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1164	0.1636
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.0422	0.0422
Leishmania major	cathepsin L-like protease	0.0113	0.2253	1
Brugia malayi	Inositol-1	0.0044	0.0816	0.1452
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2253	0.4008
Giardia lamblia	Cathepsin L precursor	0.0025	0.0422	0.0593
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2253	0.4008
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0044	0.0817	0.0817
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2253	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0025	0.0422	0.0422
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1164	0.1636
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.0422	0.0751
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1164	0.1636
Trypanosoma cruzi	cysteine proteinase, putative	0.0061	0.1164	0.3088
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0647	0.115
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0025	0.0422	0.0593
Leishmania major	cathepsin L-like protease	0.0113	0.2253	1
Giardia lamblia	Cathepsin B precursor	0.0075	0.1458	0.2048
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0025	0.0422	0.0593
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0025	0.0422	0.0593
Plasmodium vivax	vivapain-3	0.0061	0.1164	0.4054
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0044	0.0816	0.3622
Giardia lamblia	Cathepsin L precursor	0.0025	0.0422	0.0593
Schistosoma mansoni	cathepsin F (C01 family)	0.0113	0.2253	0.2253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2253	0.3165
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0039	0.0721	0.2102
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1164	0.1636
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0025	0.0422	0.0751
Schistosoma mansoni	cpg binding protein	0.0036	0.0654	0.0654
Onchocerca volvulus		0.0113	0.2253	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0081	0.0081
Echinococcus granulosus	cathepsin b	0.0186	0.3771	0.3771
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0113	0.2253	0.2253
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0044	0.0817	0.0817
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2253	1
Echinococcus granulosus	cathepsin b	0.0186	0.3771	0.3771
Echinococcus granulosus	ubiquitin specific protease 41	0.0044	0.0817	0.0817
Brugia malayi	fibroinase precursor	0.0025	0.0422	0.0751
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2253	1
Loa Loa (eye worm)	cysteine protease	0.0113	0.2253	0.4008
Brugia malayi	follicle stimulating hormone receptor	0.0275	0.5621	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0044	0.0817	0.2167
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0025	0.0422	0.0593
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0065	0.0091
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0347	0.7118	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1164	0.1636
Onchocerca volvulus		0.0113	0.2253	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2253	0.3165
Onchocerca volvulus		0.0077	0.1511	0.6706
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0113	0.2253	0.2253
Giardia lamblia	Cathepsin L precursor	0.0025	0.0422	0.0593
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0075	0.1458	0.2048
Entamoeba histolytica	hypothetical protein	0.0043	0.0792	0.1113
Entamoeba histolytica	cysteine proteinase 2	0.0061	0.1164	0.1636
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0039	0.0721	0.2102
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0044	0.0817	0.1148
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0186	0.3771	0.3771
Giardia lamblia	Hypothetical protein	0.0025	0.0422	0.0593
Giardia lamblia	Fructose-bisphosphate aldolase	0.0347	0.7118	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0113	0.2253	0.3165
Onchocerca volvulus	Cathepsin L homolog	0.0025	0.0422	0.1874
Schistosoma mansoni	cathepsin S (C01 family)	0.0025	0.0422	0.0422
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0025	0.0422	0.1874
Leishmania major	cathepsin L-like protease	0.0113	0.2253	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0044	0.0817	0.1148
Entamoeba histolytica	hypothetical protein	0.0043	0.0792	0.1113
Giardia lamblia	Cysteine protease	0.0025	0.0422	0.0593
Giardia lamblia	Cysteine protease	0.0025	0.0422	0.0593
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0081	0.0081
Entamoeba histolytica	cysteine protease, putative	0.0113	0.2253	0.3165
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0647	0.115
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.0422	0.0422
Leishmania major	cathepsin L-like protease	0.0113	0.2253	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0081	0.0081
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0792	0.0792
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0065	0.0091
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.3771	0.3771
Leishmania major	cathepsin L-like protease	0.0113	0.2253	1
Giardia lamblia	Cathepsin L-like protease	0.0025	0.0422	0.0593
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0065	0.0091
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0124	0.022
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0347	0.7118	1
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1164	0.1636
Schistosoma mansoni	cathepsin C	0.0025	0.0422	0.0422
Schistosoma mansoni	cpg binding protein	0.0036	0.0654	0.0654
Giardia lamblia	Cysteine protease	0.0025	0.0422	0.0593
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2253	0.3165
Loa Loa (eye worm)	inositol-1	0.0044	0.0816	0.1452
Loa Loa (eye worm)	fibroinase	0.0113	0.2253	0.4008
Echinococcus granulosus	cathepsin L	0.0061	0.1164	0.1164
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0792	0.0792
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.2253	0.5974
Echinococcus multilocularis	cathepsin L	0.0025	0.0422	0.0422
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2253	0.3165
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.2253	0.5974
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0422	0.0593
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2253	0.4008
Onchocerca volvulus	Cathepsin L homolog	0.0113	0.2253	1
Giardia lamblia	Cathepsin B precursor	0.0025	0.0422	0.0593
Onchocerca volvulus	Cathepsin F homolog	0.0113	0.2253	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0422	0.0593

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 5	Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage	ChEMBL.	19616430
IC50 (binding)	> 5	Inhibition of cathepsin K assessed as inhibition of fluorogenic substrate cleavage	ChEMBL.	19616430
IC50 (binding)	= 5.2	Inhibition of human liver cathepsin B assessed as inhibition of fluorogenic substrate cleavage	ChEMBL.	19616430
IC50 (binding)	= 5.5	Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavage	ChEMBL.	19616430
IC50 (binding)	= 6.2	Inhibition of cathepsin S assessed as inhibition of fluorogenic substrate cleavage	ChEMBL.	19616430

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL556434

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1048833