Detailed information for compound 1049096

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 359.911 | Formula: C17H26ClNO3S
  • H donors: 0 H acceptors: 3 LogP: 3.78 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCS(=O)(=O)c1ccc(c(c1)Cl)C(=O)CCN(C)C
  • InChi: 1S/C17H26ClNO3S/c1-4-5-6-7-12-23(21,22)14-8-9-15(16(18)13-14)17(20)10-11-19(2)3/h8-9,13H,4-7,10-12H2,1-3H3
  • InChiKey: BUOFMFBFLRBMKL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0143 0.0175
Onchocerca volvulus 0.0266 0.4531 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0059 0.0045
Trypanosoma brucei heat shock protein, putative 0.0081 0.115 0.3904
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.029 0.0776
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.1361 0.4633
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0404 0.7048 0.8952
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0858 0.1049
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0026 0.0146 0.0741
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Echinococcus granulosus thioredoxin glutathione reductase 0.0178 0.2929 0.3579
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0096 0.0408
Brugia malayi 6-phosphofructokinase 0.0106 0.1614 0.1972
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0279 0.0341
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0026 0.0146 0.0425
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0279 0.0887
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0286 0.0349
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0279 0.0341
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0279 0.074
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0286 0.0286
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0061 0.0799 0.2484
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.3405 0.416
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0202 0.1126
Trichomonas vaginalis endoplasmin, putative 0.0054 0.0673 0.4087
Trichomonas vaginalis heat shock protein, putative 0.0081 0.115 0.7085
Leishmania major heat shock protein, putative 0.0044 0.049 0.1617
Leishmania major 60S ribosomal protein L19, putative 0.0026 0.0146 0.0425
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0799 0.2688
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.0349
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0202 0.1126
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0858 0.1049
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0286 0.0349
Plasmodium vivax glutathione reductase, putative 0.0177 0.291 0.9569
Echinococcus multilocularis ribosomal protein L19 0.0026 0.0146 0.0178
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0286 0.0349
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1614 1
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0882 0.1078
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Echinococcus multilocularis dna polymerase eta 0.0019 0.0023 0.0028
Echinococcus multilocularis GPCR, family 2 0.0065 0.0858 0.1049
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0061 0.0799 0.2688
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0279 0.0341
Mycobacterium tuberculosis Probable dehydrogenase 0.0404 0.7048 0.8952
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0279 0.0887
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0286 0.0349
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1614 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0279 0.0341
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0096 0.0238
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0059 0.0124
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0202 0.1339
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0279 0.074
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0026 0.0146 0.0425
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0026 0.0146 0.0425
Plasmodium falciparum glutathione reductase 0.0061 0.0799 0.2484
Schistosoma mansoni hypothetical protein 0.014 0.2226 0.2226
Echinococcus granulosus muscleblind protein 0.0466 0.8185 1
Schistosoma mansoni hypothetical protein 0.0065 0.0858 0.0858
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1361 0.8407
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0059 0.0072
Giardia lamblia Ribosomal protein L19 0.0026 0.0146 0.0917
Trypanosoma brucei heat shock protein, putative 0.0081 0.115 0.3904
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1614 1
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.029 0.0776
Echinococcus granulosus smad 0.0025 0.0143 0.0175
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0059 0.0267
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.2453 0.2997
Loa Loa (eye worm) hypothetical protein 0.014 0.2226 0.272
Brugia malayi 60S ribosomal protein L19 0.0026 0.0146 0.0178
Trichomonas vaginalis heat shock protein, putative 0.0071 0.0967 0.5931
Trypanosoma brucei heat shock protein 90, putative 0.0081 0.115 0.3904
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0858 0.1049
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0286 0.0349
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.1361 0.2532
Loa Loa (eye worm) heat shock protein 90 0.0081 0.115 0.1405
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0286 0.0286
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.1361 0.1662
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0061 0.0799 0.4877
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.1159 0.1416
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0799 0.2688
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0178
Toxoplasma gondii ribosomal protein RPL19 0.0026 0.0146 0.0292
Loa Loa (eye worm) heat shock protein 75 0.0044 0.049 0.0599
Brugia malayi 6-phosphofructokinase 0.0106 0.1614 0.1972
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0286 0.0349
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1361 0.8407
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0449 0.787 1
Brugia malayi steroid hormone receptor 0.0033 0.0286 0.0349
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Plasmodium falciparum heat shock protein 90 0.0081 0.115 0.3663
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0286 0.0349
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0858 0.1049
Loa Loa (eye worm) hepatopoietin HPO2 0.0033 0.029 0.0355
Schistosoma mansoni smad1 5 8 and 0.0025 0.0143 0.0143
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0059 0.0224
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0279 0.0887
Echinococcus granulosus heat shock protein 90 0.0067 0.0899 0.1098
Echinococcus granulosus ribosomal protein L19 0.0026 0.0146 0.0178
Schistosoma mansoni smad1 5 8 and 0.0025 0.0143 0.0143
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0286 0.0286
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0882 0.0882
Plasmodium vivax heat shock protein 90, putative 0.0044 0.049 0.1447
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1361 0.8407
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.1614 0.2027
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0061 0.0799 0.0799
Loa Loa (eye worm) thioredoxin reductase 0.0177 0.291 0.3555
Loa Loa (eye worm) phosphofructokinase 0.0106 0.1614 0.1972
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.029 0.0776
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0279 0.0341
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0061 0.0799 0.2688
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0061 0.0799 0.8153
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0286 0.0349
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0026 0.0146 0.0771
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0512 0.3072
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0044 0.049 0.282
Mycobacterium tuberculosis Probable oxidoreductase 0.0449 0.787 1
Brugia malayi glutathione reductase 0.0177 0.291 0.3555
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0202 0.1126
Toxoplasma gondii thioredoxin reductase 0.0177 0.291 0.9569
Toxoplasma gondii heat shock protein 75, putative 0.0044 0.049 0.1447
Mycobacterium tuberculosis Probable reductase 0.0404 0.7048 0.8952
Brugia malayi Hsp90 protein 0.0044 0.049 0.0599
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0071 0.0967 0.3269
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.1361 0.1662
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0279 0.074
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.2226 0.272
Echinococcus granulosus ribosomal protein L19 0.0026 0.0146 0.0178
Echinococcus multilocularis heat shock protein 90 0.0081 0.115 0.1405
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0061 0.0799 0.2688
Leishmania major hypothetical protein, conserved 0.0033 0.029 0.0925
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.1614 0.1953
Brugia malayi Muscleblind-like protein 0.0466 0.8185 1
Loa Loa (eye worm) transcription factor SMAD2 0.0373 0.6477 0.7914
Plasmodium falciparum thioredoxin reductase 0.0177 0.291 0.9569
Trypanosoma brucei Heat shock protein 83, putative 0.0081 0.115 0.3904
Loa Loa (eye worm) RNA binding protein 0.0066 0.0882 0.1078
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0404 0.7048 0.8952
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0858 0.1049
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0286 0.0349
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0286 0.0349
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0202 0.0482
Trichomonas vaginalis mercuric reductase, putative 0.0061 0.0799 0.4877
Brugia malayi MH1 domain containing protein 0.0025 0.0143 0.0175
Onchocerca volvulus Heat shock factor protein 2 homolog 0.011 0.1678 0.328
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0548 0.067
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0023 0.0028
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0143 0.0175
Trypanosoma brucei heat shock protein, putative 0.0081 0.115 0.3904
Trypanosoma cruzi heat shock protein 85, putative 0.0081 0.115 0.3904
Plasmodium falciparum endoplasmin, putative 0.0054 0.0673 0.2063
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.029 0.0925
Trypanosoma brucei heat shock protein 90, putative 0.0081 0.115 0.3904
Entamoeba histolytica hypothetical protein 0.0023 0.0096 0.0439
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0548 0.0548
Schistosoma mansoni kinase 0.0047 0.0534 0.0534
Brugia malayi RNA binding protein 0.0066 0.0882 0.1078
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0286 0.0349
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0882 0.0882
Schistosoma mansoni thyroid hormone receptor 0.0185 0.306 0.306
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0882 0.1078
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.3405 0.416
Brugia malayi MH2 domain containing protein 0.0025 0.0143 0.0175
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.1361 0.1662
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0061 0.0799 0.0976
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0286 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0286 0.0349
Onchocerca volvulus 0.0081 0.1159 0.2057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0286 0.0349
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0286 0.0286
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.1614 0.1972
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0799 0.2688
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0202 0.0482
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0286 0.0349
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0061 0.0799 0.4877
Schistosoma mansoni hypothetical protein 0.0152 0.2453 0.2453
Loa Loa (eye worm) glutathione reductase 0.0177 0.291 0.3555
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0061 0.0799 0.2688
Giardia lamblia Heat shock protein HSP 90-alpha 0.0081 0.115 0.8427
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0026 0.0146 0.0425
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.0349
Schistosoma mansoni heat shock protein 0.0081 0.115 0.115
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0286 0.0349
Toxoplasma gondii heat shock protein HSP90 0.0081 0.115 0.3663
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0286 0.0349
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0061 0.0799 0.8153
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0286 0.0349
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0286 0.0349
Toxoplasma gondii Hsp90 domain-containing protein 0.0184 0.3038 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0799 0.2688
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.0349
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.1159 0.1416
Echinococcus multilocularis thioredoxin glutathione reductase 0.0178 0.2929 0.3579
Trichomonas vaginalis heat shock protein, putative 0.0067 0.0899 0.5506
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0512 0.3072
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0286 0.0286
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0059 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0286 0.0349
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0286 0.0349
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0061 0.0799 0.2688
Brugia malayi Augmenter of liver regeneration 0.0033 0.029 0.0355
Echinococcus granulosus tar DNA binding protein 0.0066 0.0882 0.1078
Schistosoma mansoni endoplasmin 0.0081 0.115 0.115
Trypanosoma cruzi heat shock protein 85, putative 0.0081 0.115 0.3904
Trypanosoma cruzi heat shock protein 85, putative 0.0081 0.115 0.3904
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0799 0.2688
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0143 0.0175
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0286 0.0349
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0096 0.0252
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0858 0.1049
Brugia malayi HSF-type DNA-binding domain containing protein 0.011 0.1678 0.205
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.029 0.0925
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1614 0.1972
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0286 0.0286
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1614 0.9611
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1361 0.8407
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0061 0.0799 0.2484
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.0349
Brugia malayi nuclear hormone receptor 0.0033 0.0286 0.0349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0286 0.0349
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0279 0.0341
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0059 0.0072
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.1614 1
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0286 0.0349
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0061 0.0799 0.2484
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0202 0.0923
Echinococcus multilocularis heat shock protein 0.0081 0.115 0.1405
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0028
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0202 0.0482
Entamoeba histolytica heat shock transcription factor, putative 0.011 0.1678 1
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0026 0.0146 0.0741
Loa Loa (eye worm) hypothetical protein 0.0065 0.0858 0.1049
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0067 0.0899 0.1098
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.1614 0.5511
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0449 0.787 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0286 0.0349
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Trypanosoma cruzi heat shock protein, putative 0.0044 0.049 0.1617
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.3405 0.416
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0286 0.0349
Plasmodium vivax thioredoxin reductase, putative 0.0177 0.291 0.9569
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0061 0.0799 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0279 0.0341
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0033 0.029 0.0355
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0548 0.067
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.1159 0.1159
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0177 0.291 0.3679
Echinococcus granulosus GPCR family 2 0.0065 0.0858 0.1049
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0096 0.0457
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0279 0.0341
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0028
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0061 0.0799 0.0989
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0286 0.0349
Trypanosoma cruzi heat shock protein 90, putative 0.0067 0.0899 0.3034
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0096 0.0457
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1361 0.4633
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0404 0.7048 0.8942
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0202 0.1126
Schistosoma mansoni hypothetical protein 0.0065 0.0858 0.0858
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0026 0.0146 0.0425
Giardia lamblia Kinase, PLK 0.0092 0.1361 1
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0044 0.049 0.0599
Brugia malayi Smad1 0.0025 0.0143 0.0175
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0045 0.0502 0.0613
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.2453 0.2997
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0028
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0059 0.0124
Brugia malayi Pax transcription factor protein 2 0.0266 0.4531 0.5536
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0059 0.0124
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0449 0.787 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0143 0.0175
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0202 0.1514
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.0349
Schistosoma mansoni hypothetical protein 0.0065 0.0858 0.0858
Trypanosoma brucei trypanothione reductase 0.0177 0.291 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0081 0.115 0.3904
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0408 0.1333
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0061 0.0799 0.2688
Leishmania major trypanothione reductase 0.0177 0.291 1
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0286 0.0349
Brugia malayi nuclear receptor NHR-88 0.0033 0.0286 0.0349
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.1361 0.8081
Plasmodium vivax heat shock protein, putative 0.0184 0.3038 1
Echinococcus multilocularis ribosomal protein L19 0.0026 0.0146 0.0178
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0061 0.0799 0.4877
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0026 0.0146 0.0771
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.029 0.0925
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1614 0.5511
Trypanosoma brucei polo-like protein kinase 0.0092 0.1361 0.4633
Schistosoma mansoni 60S ribosomal protein L19 0.0026 0.0146 0.0146
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0882 0.1078
Trypanosoma cruzi trypanothione reductase, putative 0.0061 0.0799 0.2688
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0023 0.0023
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0071 0.0967 1
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0286 0.0349
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.1614 0.1972
Loa Loa (eye worm) hypothetical protein 0.0081 0.1159 0.1416
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0059 0.0072
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0286 0.0349
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0044 0.049 0.048
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0673 0.4087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0286 0.0349
Entamoeba histolytica heat shock transcription factor, putative 0.011 0.1678 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0096 0.0124
Schistosoma mansoni ap endonuclease 0.0021 0.0059 0.0059
Echinococcus granulosus endoplasmin 0.0071 0.0967 0.1181
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.029 0.0925
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0286 0.0349
Toxoplasma gondii heat shock protein 90, putative 0.0081 0.115 0.3663
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0202 0.0482
Schistosoma mansoni hypothetical protein 0.0187 0.3095 0.3095
Leishmania major 60S ribosomal protein L19, putative 0.0026 0.0146 0.0425
Plasmodium falciparum heat shock protein 90, putative 0.0041 0.0422 0.1219
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0096 0.0252
Plasmodium falciparum glutathione reductase 0.0177 0.291 0.9569
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0286 0.0286
Echinococcus granulosus Smad4 0.0025 0.0143 0.0175
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0548 0.0548
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0548 0.067
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1614 0.9611
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.1361 0.1662
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0548 0.067
Trypanosoma cruzi trypanothione reductase, putative 0.0177 0.291 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0286 0.0349
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1614 0.5511
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0026 0.0146 0.0771
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0026 0.0146 0.0771
Plasmodium falciparum thioredoxin reductase 0.0061 0.0799 0.2484
Loa Loa (eye worm) hypothetical protein 0.0466 0.8185 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0061 0.0799 0.2688
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.029 0.0776
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0033 0.029 0.0355
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.1361 0.1361
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0882 0.0882
Brugia malayi heat shock protein 90 0.0081 0.115 0.1405
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0286 0.0349
Giardia lamblia Grp94/Hsp90 0.0071 0.0967 0.7055
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0202 0.0482
Treponema pallidum heat shock protein 90 0.0071 0.0967 0.5838
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0096 0.0093
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0202 0.1126
Brugia malayi MH1 domain containing protein 0.0025 0.0143 0.0175
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1361 0.8407
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0023 0.0023
Brugia malayi phosphofructokinase 0.0106 0.1614 0.1972
Trichomonas vaginalis heat shock protein, putative 0.0071 0.0967 0.5931
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0286 0.0349
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0023 0.0028
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0071 0.0967 0.1202
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0023 0.0028
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.0349
Loa Loa (eye worm) hypothetical protein 0.0466 0.8185 1
Trypanosoma brucei heat shock protein, putative 0.0081 0.115 0.3904
Echinococcus multilocularis endoplasmin 0.0071 0.0967 0.1181
Plasmodium falciparum heat shock protein 90, putative 0.0184 0.3038 1
Trypanosoma brucei heat shock protein, putative 0.0081 0.115 0.3904
Echinococcus multilocularis thyroid hormone receptor alpha 0.0185 0.306 0.3738
Giardia lamblia NADH oxidase lateral transfer candidate 0.0061 0.0799 0.5801
Entamoeba histolytica heat shock protein 90, putative 0.0081 0.115 0.681
Toxoplasma gondii NADPH-glutathione reductase 0.0061 0.0799 0.2484
Plasmodium vivax 60S ribosomal protein L19, putative 0.0026 0.0146 0.0292
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1614 0.1614
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0286 0.0349
Trypanosoma brucei heat shock protein 84, putative 0.0044 0.049 0.1617
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0279 0.0326
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0044 0.049 0.0599
Trypanosoma brucei heat shock protein, putative 0.0081 0.115 0.3904
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0045 0.0502 0.0613
Entamoeba histolytica heat shock transcription factor, putative 0.011 0.1678 1
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1614 0.1614
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1614 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0286 0.0349
Echinococcus multilocularis geminin 0.0187 0.3095 0.3782
Brugia malayi isocitrate dehydrogenase 0.0033 0.0279 0.0341
Trypanosoma brucei heat shock protein, putative 0.0081 0.115 0.3904
Entamoeba histolytica heat shock protein 90, putative 0.0081 0.115 0.681
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1361 0.8407
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1361 0.8407
Schistosoma mansoni endoplasmin 0.0081 0.115 0.115
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0286 0.0286
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0096 0.0124
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0143 0.0175
Echinococcus multilocularis Smad4 0.0025 0.0143 0.0175
Trichomonas vaginalis heat shock protein, putative 0.0041 0.0422 0.2508
Brugia malayi Endoplasmin precursor 0.0081 0.115 0.1405
Trypanosoma cruzi heat shock protein 90, putative 0.0081 0.115 0.3904
Schistosoma mansoni smad1 5 8 and 0.0025 0.0143 0.0143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0548 0.067
Schistosoma mansoni DNA polymerase eta 0.0019 0.0023 0.0023
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.1159 0.1416
Loa Loa (eye worm) pax transcription factor protein 2 0.0266 0.4531 0.5536
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0061 0.0799 0.2484
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0026 0.0146 0.0425
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0059 0.0224
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0202 0.1126
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0882 0.0882
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1614 0.9611
Schistosoma mansoni hypothetical protein 0.0187 0.3095 0.3095
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0143 0.0143
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0404 0.7048 0.8952
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0404 0.7048 0.8952
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0279 0.0887
Brugia malayi TAR-binding protein 0.0066 0.0882 0.1078
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0202 0.1082
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0279 0.0887
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1614 0.1972
Echinococcus multilocularis muscleblind protein 0.0466 0.8185 1
Trichomonas vaginalis glutathione reductase, putative 0.0061 0.0799 0.4877
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0882 0.1078
Loa Loa (eye worm) endoplasmin 0.0081 0.115 0.1405
Brugia malayi Thioredoxin reductase 0.0177 0.291 0.3555
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0858 0.1049
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1361 0.4633
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0286 0.0349
Echinococcus multilocularis heat shock protein 90 0.0067 0.0899 0.1098
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0279 0.0279
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0096 0.0124
Echinococcus granulosus dna polymerase kappa 0.0019 0.0023 0.0028
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0286 0.0286
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0143 0.0175
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0799 0.2688
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0286 0.0349
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0061 0.0799 0.2484
Echinococcus multilocularis muscleblind protein 1 0.0466 0.8185 1
Schistosoma mansoni heat shock protein 0.0081 0.115 0.115
Schistosoma mansoni hypothetical protein 0.0065 0.0858 0.0858
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0061 0.0799 0.0976
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0202 0.1514
Brugia malayi ecdysteroid receptor 0.0033 0.0286 0.0349
Brugia malayi MH2 domain containing protein 0.0373 0.6477 0.7914
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.0349
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0061 0.0799 0.2688
Plasmodium vivax endoplasmin, putative 0.0081 0.115 0.3663
Echinococcus granulosus dna polymerase eta 0.0019 0.0023 0.0028
Echinococcus granulosus heat shock protein 90 0.0081 0.115 0.1405
Trypanosoma brucei heat shock protein, putative 0.0081 0.115 0.3904
Echinococcus granulosus geminin 0.0187 0.3095 0.3782
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0059 0.0124
Echinococcus multilocularis smad 0.0025 0.0143 0.0175
Schistosoma mansoni smad 0.0025 0.0143 0.0143
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0202 0.0482
Plasmodium falciparum 60S ribosomal protein L19 0.0026 0.0146 0.0292
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0059 0.0224
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.0349
Loa Loa (eye worm) MH2 domain-containing protein 0.0373 0.6477 0.7914
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0882 0.0882
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0061 0.0799 0.2688
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0061 0.0799 0.0976
Schistosoma mansoni heat shock protein 0.0044 0.049 0.049
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0286 0.0349
Plasmodium vivax heat shock protein 86, putative 0.0081 0.115 0.3663
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0061 0.0799 0.2688
Schistosoma mansoni Smad4 0.0025 0.0143 0.0143
Brugia malayi MH2 domain containing protein 0.0025 0.0143 0.0175
Loa Loa (eye worm) Smad1 0.0025 0.0143 0.0175
Mycobacterium ulcerans heat shock protein 90 0.0071 0.0967 0.5931
Schistosoma mansoni coup transcription factor 0.0033 0.0286 0.0286
Leishmania major heat shock protein 83-1 0.0081 0.115 0.3904
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0286 0.0349
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0286 0.0349
Loa Loa (eye worm) hypothetical protein 0.011 0.1678 0.205
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0202 0.1126
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.1614 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0279 0.074
Treponema pallidum NADH oxidase 0.0061 0.0799 0.476
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0548 0.0548
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0096 0.0124
Giardia lamblia Heat shock protein HSP 90-alpha 0.0067 0.0899 0.6549
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0023 0.0028
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0059 0.0215
Trypanosoma cruzi heat shock protein 85, putative 0.0067 0.0899 0.3034
Loa Loa (eye worm) hypothetical protein 0.0204 0.3405 0.416
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0548 0.067
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0202 0.0482
Echinococcus granulosus heat shock protein 0.0081 0.115 0.1405
Schistosoma mansoni ap endonuclease 0.0021 0.0059 0.0059
Schistosoma mansoni thyroid hormone receptor 0.0185 0.306 0.306
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0071 0.0967 0.112

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 66 uM Cytotoxicity against human HepG2 cells after 48 hrs by luminescence cell viability assay ChEMBL. 19469546
IC50 (binding) = 3.6 uM Inhibition of SRC2 binding to human TRbeta receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay ChEMBL. 19469546
Inhibition (binding) = 10 % Inhibition of human ERG expressed in HEK293 cells assessed as blockade of KCl-stimulated depolarization relative to terfenadine ChEMBL. 19469546

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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