Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.01 | 0.845 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.845 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.845 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0046 | 0.0054 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0112 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.5371 | 0.5371 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.01 | 0.845 | 0.845 |
Brugia malayi | RNA binding protein | 0.0063 | 0.3602 | 0.3602 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.01 | 0.845 | 0.845 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3602 | 0.4262 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3602 | 0.4262 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3602 | 0.4262 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3602 | 0.4262 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0046 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.3602 | 0.3602 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.5371 | 0.6357 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.01 | 0.845 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0046 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0046 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3602 | 0.4262 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.3602 | 0.4262 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.3602 | 0.3602 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0046 | 0.0054 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.845 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.3602 | 0.3602 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.01 | 0.845 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0046 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.3602 | 0.4262 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0112 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.01 | 0.845 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0046 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0076 | 0.5371 | 0.5371 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0046 | 0.0054 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.3602 | 0.3602 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.3602 | 0.3602 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 16 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.