Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.0862 | 0.3419 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.077 | 0.2714 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.0862 | 0.6315 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0132 | 0.3452 | 0.3452 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0048 | 0.028 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.077 | 0.2714 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.077 | 0.4488 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.1716 | 0.1716 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.1716 | 0.3785 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.3764 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0132 | 0.3452 | 0.3452 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0073 | 0.1716 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0142 | 0.3764 | 0.3764 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0468 | 0.2517 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.1716 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0509 | 0.2969 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.1716 | 0.3785 |
Brugia malayi | Heterochromatin protein 1 | 0.0073 | 0.1716 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0468 | 0.2517 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.1091 | 0.1891 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.3452 | 0.9053 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0468 | 0.0468 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0451 | 0.263 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.1716 | 0.1716 |
Echinococcus granulosus | lamin | 0.0031 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0468 | 0.2727 |
Brugia malayi | chromobox protein homolog 3 | 0.0041 | 0.077 | 0.4329 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.077 | 0.4846 |
Onchocerca volvulus | 0.0052 | 0.1091 | 1 | |
Onchocerca volvulus | 0.0032 | 0.0509 | 0.0666 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0468 | 0.2727 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.0862 | 0.3419 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0468 | 0.2727 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.1716 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.1716 | 0.1716 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0468 | 0.0468 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0468 | 0.0468 |
Echinococcus multilocularis | tumor protein p63 | 0.0353 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1091 | 0.6361 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0468 | 0.0468 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.3764 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.1716 | 0.1716 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 9 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.