Detailed information for compound 1049529

Basic information

Technical information
  • TDR Targets ID: 1049529
  • Name: 3,4-dichloro-N,N'-dimethylbenzenecarboximidam ide hydrochloride
  • MW: 253.556 | Formula: C9H11Cl3N2
  • H donors: 1 H acceptors: 0 LogP: 3.44 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN/C(=N\C)/c1ccc(c(c1)Cl)Cl.Cl
  • InChi: 1S/C9H10Cl2N2.ClH/c1-12-9(13-2)6-3-4-7(10)8(11)5-6;/h3-5H,1-2H3,(H,12,13);1H
  • InChiKey: SESUZOLXSAPAIT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,4-dichloro-N,N'-dimethyl-benzamidine hydrochloride
  • 3,4-Dichloro-N,N'-dimethylbenzamidine hydrochloride
  • 3,4-dichloro-N,N'-dimethyl-benzenecarboximidamide hydrochloride
  • CV6142000
  • Benzamidine, 3,4-dichloro-N,N'-dimethyl-, monohydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0011 0.0011
Mycobacterium tuberculosis Conserved protein 0.0189 0.0311 0.112
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0049 0.0281
Brugia malayi Bromodomain containing protein 0.003 0.0011 0.0029
Brugia malayi RNA, U transporter 1 0.0257 0.044 0.118
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0097 0.0139 0.4254
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.0544 0.3733
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0187 0.0307 0.0861
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.025 0.0669
Brugia malayi beta-lactamase 0.0189 0.0311 0.0833
Trichomonas vaginalis D-aminoacylase, putative 0.0189 0.0311 0.2031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0182 0.0298 0.1059
Brugia malayi Pre-SET motif family protein 0.0097 0.0139 0.0371
Toxoplasma gondii hypothetical protein 0.0056 0.0059 0.1608
Loa Loa (eye worm) hypothetical protein 0.0189 0.0311 0.0872
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0189 0.0311 0.0872
Brugia malayi nuclear hormone receptor 0.0187 0.0307 0.0823
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0049 0.0281
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0139 0.059
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0187 0.0307 0.0823
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0054 0.0145
Plasmodium vivax importin-beta 2, putative 0.009 0.0125 0.3801
Schistosoma mansoni cpg binding protein 0.0065 0.0078 0.0331
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0066 0.008 0.1292
Brugia malayi hypothetical protein 0.0298 0.0519 0.139
Schistosoma mansoni hypothetical protein 0.1079 0.1998 0.8497
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0068 0.0613
Loa Loa (eye worm) hypothetical protein 0.0187 0.0307 0.0861
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.0311 0.0311
Trichomonas vaginalis set domain proteins, putative 0.0764 0.1401 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0001 0.0006
Echinococcus multilocularis importin subunit beta 1 0.009 0.0125 0.0125
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0068 0.5029
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0283 0.049 0.1373
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0088 0.0121 0.0604
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.001 0.0027
Schistosoma mansoni cpg binding protein 0.0062 0.0071 0.0302
Echinococcus granulosus Nuclear hormone receptor HR96 0.0088 0.0121 0.0604
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0191 0.0811
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0068 0.0613
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0068 0.0183
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0066 0.008 0.0814
Onchocerca volvulus 0.0298 0.0519 0.3653
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.0544 0.3733
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0325 0.2129
Echinococcus granulosus nuclear receptor nhr 48 0.0088 0.0121 0.0604
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0066 0.008 0.0814
Echinococcus granulosus neuropeptide receptor A26 0.093 0.1715 0.8584
Brugia malayi hypothetical protein 0.0056 0.0059 0.0159
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0059 0.4225
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0049 0.0118
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0066 0.008 0.604
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0072 0.0201
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0046 0.0218
Loa Loa (eye worm) hypothetical protein 0.0189 0.0311 0.0872
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0306 0.1991
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.1908 0.3567 1
Brugia malayi nuclear receptor RXR 0.0088 0.0121 0.0323
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0073 0.0181
Mycobacterium ulcerans beta-lactamase 0.0189 0.0311 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0088 0.0121 0.0121
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0033 0.074
Leishmania major importin beta-1 subunit, putative 0.0073 0.0093 0.1037
Schistosoma mansoni hypothetical protein 0.0358 0.0631 0.2686
Loa Loa (eye worm) nuclear receptor NHR-67 0.0088 0.0121 0.0338
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.0191 0.0535
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0187 0.0307 0.0823
Loa Loa (eye worm) transcription factor SMAD2 0.0357 0.0629 0.1764
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0033 0.0093
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0048 0.0048
Onchocerca volvulus 0.0088 0.0121 0.0788
Brugia malayi nuclear receptor NHR-88 0.0187 0.0307 0.0823
Schistosoma mansoni steroid hormone receptor ad4bp 0.0187 0.0307 0.1307
Trypanosoma brucei hypothetical protein, conserved 0.0189 0.0311 0.4845
Brugia malayi PHD-finger family protein 0.003 0.0011 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0306 0.1991
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0302 0.0527 0.224
Onchocerca volvulus Huntingtin homolog 0.0121 0.0183 0.1239
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0066 0.008 0.0814
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0049 0.0719
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0015 0.004
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0088 0.0121 0.0513
Brugia malayi Glycosyl hydrolases family 31 protein 0.0189 0.0311 0.0833
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.049 0.3337
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0011 0.0031
Brugia malayi Importin beta-1 subunit 0.009 0.0125 0.0335
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0048 0.0133
Echinococcus granulosus Nuclear hormone receptor HR96 0.0088 0.0121 0.0604
Loa Loa (eye worm) hypothetical protein 0.0187 0.0307 0.0861
Echinococcus granulosus snurportin 1 0.0964 0.178 0.891
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0068 0.0257
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0345 0.0607 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0183 0.5717
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0187 0.0307 0.1538
Schistosoma mansoni hypothetical protein 0.0295 0.0512 0.2178
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.003 0.0083
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.0059 0.1606
Loa Loa (eye worm) hypothetical protein 0.0189 0.0311 0.0872
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0088 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0053 0.0054 0.0152
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.1079 0.1998 1
Echinococcus multilocularis neuropeptide receptor A26 0.093 0.1715 0.1715
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0306 0.1991
Brugia malayi MAP kinase sur-1 0.005 0.0049 0.0132
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0187 0.0307 0.0307
Brugia malayi hypothetical protein 0.0099 0.0141 0.0377
Onchocerca volvulus 0.0109 0.0161 0.1075
Echinococcus granulosus thyroid hormone receptor alpha 0.0088 0.0121 0.0604
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0001 0.0001
Schistosoma mansoni zinc finger protein 0.0088 0.0121 0.0513
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0191 0.0811
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0068 0.0068
Entamoeba histolytica hypothetical protein 0.0116 0.0173 0.2735
Echinococcus granulosus lysosomal alpha glucosidase 0.0189 0.0311 0.1557
Schistosoma mansoni nuclear hormone receptor 0.0088 0.0121 0.0513
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0088 0.0121 0.0121
Echinococcus granulosus importin subunit beta 1 0.009 0.0125 0.0626
Trichomonas vaginalis esterase, putative 0.0189 0.0311 0.2031
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0033 0.0033
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.025 0.07
Schistosoma mansoni ap endonuclease 0.006 0.0068 0.0291
Brugia malayi jmjC domain containing protein 0.004 0.003 0.008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0187 0.0307 0.0823
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0187 0.0307 0.1307
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.0311 0.0311
Echinococcus granulosus cpg binding protein 0.0065 0.0078 0.0389
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.049 0.3337
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0302 0.0527 0.0527
Echinococcus multilocularis nuclear receptor nhr 48 0.0088 0.0121 0.0121
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.003 0.0126
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0097 0.0139 0.0139
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0068 0.0613
Loa Loa (eye worm) hypothetical protein 0.0088 0.0121 0.0338
Loa Loa (eye worm) nuclear hormone receptor 0.0088 0.0121 0.0338
Trypanosoma cruzi importin beta-1 subunit, putative 0.0073 0.0093 0.1037
Brugia malayi beta-lactamase family protein 0.0189 0.0311 0.0833
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0011 0.0055
Schistosoma mansoni hypothetical protein 0.0104 0.0151 0.0642
Loa Loa (eye worm) hypothetical protein 0.0052 0.0052 0.0145
Loa Loa (eye worm) hypothetical protein 0.0099 0.0141 0.0394
Toxoplasma gondii ABC1 family protein 0.0189 0.0311 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0302 0.0527 0.2636
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0345 0.0607 1
Trichomonas vaginalis ran, putative 0.0066 0.008 0.0341
Trichomonas vaginalis D-aminoacylase, putative 0.0189 0.0311 0.2031
Schistosoma mansoni survival motor neuron protein 0.0104 0.0151 0.0642
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.0263 0.4005
Plasmodium vivax hypothetical protein, conserved 0.0189 0.0311 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0121 0.0338
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.0191 0.0511
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0059 0.4225
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0068 0.0257
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0187 0.0307 0.1307
Trichomonas vaginalis penicillin-binding protein, putative 0.0189 0.0311 0.2031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0187 0.0307 0.0861
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.049 0.3337
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0073 0.0181
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0306 0.1991
Echinococcus multilocularis survival motor neuron protein 1 0.051 0.092 0.092
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.0121 0.0604
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.0544 0.3733
Trypanosoma cruzi hypothetical protein, conserved 0.0189 0.0311 0.4845
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.0151 0.0404
Schistosoma mansoni hypothetical protein 0.0049 0.0048 0.0202
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0306 0.1991
Schistosoma mansoni alpha-glucosidase 0.0162 0.0261 0.1112
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0049 0.0118
Echinococcus multilocularis snurportin 1 0.0964 0.178 0.178
Mycobacterium leprae conserved hypothetical protein 0.0189 0.0311 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0187 0.0307 0.1538
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0042 0.0042
Entamoeba histolytica Ran family GTPase 0.0066 0.008 0.0913
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0049 0.0281
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0099 0.0141 0.0598
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0068 0.0613
Trichomonas vaginalis D-aminoacylase, putative 0.0189 0.0311 0.2031
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0306 0.1991
Schistosoma mansoni thyroid hormone receptor 0.1266 0.2351 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0054 0.0271
Loa Loa (eye worm) hypothetical protein 0.0099 0.0141 0.0394
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0187 0.0307 0.0823
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.0544 0.3733
Echinococcus granulosus histone lysine methyltransferase setb 0.0097 0.0139 0.0694
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0187 0.0307 0.1307
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0306 0.1991
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0187 0.0307 0.0307
Schistosoma mansoni transcription factor LCR-F1 0.0116 0.0173 0.0736
Schistosoma mansoni importin beta-1 0.009 0.0125 0.0532
Loa Loa (eye worm) hypothetical protein 0.0187 0.0307 0.0861
Loa Loa (eye worm) hypothetical protein 0.0088 0.0121 0.0338
Plasmodium vivax SET domain protein, putative 0.0097 0.0139 0.4254
Brugia malayi hypothetical protein 0.0121 0.0183 0.0491
Loa Loa (eye worm) hypothetical protein 0.0088 0.0121 0.0338
Brugia malayi Nuclear hormone receptor-like 1 0.1996 0.3733 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0187 0.0307 0.0823
Echinococcus multilocularis beta LACTamase domain containing family member 0.0189 0.0311 0.0311
Brugia malayi nuclear hormone receptor 0.0088 0.0121 0.0323
Loa Loa (eye worm) hypothetical protein 0.0121 0.0183 0.0514
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0068 0.1912
Trypanosoma brucei importin beta-1 subunit, putative 0.009 0.0125 0.1602
Mycobacterium tuberculosis Probable hydrolase 0.0189 0.0311 0.112
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0189 0.0311 1
Loa Loa (eye worm) MBCTL1 0.0053 0.0054 0.0152
Echinococcus granulosus GPCR family 2 0.0049 0.0048 0.0238
Echinococcus multilocularis dnaJ subfamily B 0.048 0.0863 0.0863
Schistosoma mansoni nuclear receptor 0.0088 0.0121 0.0513
Onchocerca volvulus Huntingtin homolog 0.0121 0.0183 0.1239
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0049 0.0247
Mycobacterium tuberculosis Probable esterase LipL 0.0189 0.0311 0.112
Leishmania major GTP-binding protein, putative 0.0066 0.008 0.0814
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.049 0.3337
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0073 0.2058
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0189 0.0311 0.112
Brugia malayi Steroid receptor seven-up type 2 0.0187 0.0307 0.0823
Loa Loa (eye worm) hypothetical protein 0.0107 0.0156 0.0438
Echinococcus granulosus survival motor neuron protein 1 0.051 0.092 0.4604
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0073 0.0364
Brugia malayi mbt repeat family protein 0.0046 0.0042 0.0112
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0046 0.0218
Loa Loa (eye worm) hypothetical protein 0.0099 0.0141 0.0394
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.0242 0.7164
Loa Loa (eye worm) hypothetical protein 0.0187 0.0307 0.0861
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0358 0.0631 0.2686
Mycobacterium tuberculosis Probable lipase LipD 0.0189 0.0311 0.112
Loa Loa (eye worm) hypothetical protein 0.0187 0.0307 0.0861
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0097 0.0139 0.059
Brugia malayi CXXC zinc finger family protein 0.0062 0.0071 0.019
Loa Loa (eye worm) hypothetical protein 0.0187 0.0307 0.0861
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0042 0.0179
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0042 0.0118
Brugia malayi Nuclear hormone receptor-like 1 0.1908 0.3567 0.9554
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0187 0.0307 0.0823
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0042 0.021
Loa Loa (eye worm) hypothetical protein 0.0088 0.0121 0.0338
Onchocerca volvulus 0.0062 0.0071 0.0432
Loa Loa (eye worm) beta-lactamase 0.0189 0.0311 0.0872
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.006 0.0068 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.025 0.0669
Loa Loa (eye worm) hypothetical protein 0.0189 0.0311 0.0872
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.0324 0.1621
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.0324 0.0324
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0099 0.0141 0.0141
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0302 0.0527 0.2636
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0054 0.0054
Trichomonas vaginalis penicillin-binding protein, putative 0.0189 0.0311 0.2031
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0049 0.0138
Onchocerca volvulus Protein ultraspiracle homolog 0.0187 0.0307 0.2131
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.049 0.3337
Schistosoma mansoni RAR-like nuclear receptor 0.0187 0.0307 0.1307
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0049 0.0049
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.1079 0.1998 0.1998
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0033 0.0166
Brugia malayi Pre-SET motif family protein 0.0672 0.1226 0.3284
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0187 0.0307 0.1538
Brugia malayi mbt repeat family protein 0.0046 0.0042 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0187 0.0307 0.0823
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.049 0.3337
Schistosoma mansoni thyroid hormone receptor 0.1266 0.2351 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.0544 1
Schistosoma mansoni hypothetical protein 0.0964 0.178 0.7571
Schistosoma mansoni nuclear hormone receptor 0.0187 0.0307 0.1307
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.0059 0.0453
Leishmania major hypothetical protein, conserved 0.0056 0.0059 0.0453
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0302 0.0527 0.224
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0046 0.0218
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0011 0.0047
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0187 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0189 0.0311 0.0872
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0088 0.0121 0.0121
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0066 0.008 0.008
Trichomonas vaginalis importin beta-1, putative 0.0073 0.0093 0.0435
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0059 0.0453
Schistosoma mansoni hypothetical protein 0.0116 0.0173 0.0736
Echinococcus multilocularis peregrin 0.003 0.0011 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0048 0.0127
Brugia malayi nuclear receptor NHR-88 0.0088 0.0121 0.0323
Schistosoma mansoni nuclear receptor 0.0088 0.0121 0.0513
Echinococcus multilocularis thyroid hormone receptor alpha 0.1266 0.2351 0.2351
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0189 0.0311 0.1323
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0088 0.0121 0.0323
Onchocerca volvulus 0.0187 0.0307 0.2131
Echinococcus granulosus ecdysone induced protein 78C 0.0187 0.0307 0.1538
Onchocerca volvulus Bile acid receptor homolog 0.0187 0.0307 0.2131
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.0059 0.1606
Loa Loa (eye worm) DR-78 0.0088 0.0121 0.0338
Brugia malayi photoreceptor-specific nuclear receptor 0.0187 0.0307 0.0823
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0116 0.0173 0.0173
Echinococcus granulosus tar DNA binding protein 0.0125 0.0191 0.0955
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0283 0.049 0.1312
Mycobacterium leprae Probable lipase LipE 0.0189 0.0311 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0093 0.0435
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0345 0.0607 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0135 0.0209 0.0889
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.0544 0.3733
Loa Loa (eye worm) hypothetical protein 0.0099 0.0141 0.0394
Brugia malayi jmjC domain containing protein 0.0099 0.0141 0.0377
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0066 0.0569
Mycobacterium tuberculosis Conserved protein 0.0189 0.0311 0.112
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0964 0.178 0.4991
Toxoplasma gondii HEAT repeat-containing protein 0.009 0.0125 0.3801
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0049 0.0281
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0046 0.0218
Loa Loa (eye worm) hypothetical protein 0.0189 0.0311 0.0872
Trypanosoma brucei importin beta-1 subunit, putative 0.009 0.0125 0.1602
Loa Loa (eye worm) MH2 domain-containing protein 0.0357 0.0629 0.1764
Schistosoma mansoni hypothetical protein 0.0049 0.0048 0.0202
Loa Loa (eye worm) hypothetical protein 0.0088 0.0121 0.0338
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0191 0.0811
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0033 0.0033
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0672 0.1226 0.3437
Echinococcus multilocularis cpg binding protein 0.0065 0.0078 0.0078
Onchocerca volvulus 0.0088 0.0121 0.0788
Mycobacterium ulcerans hypothetical protein 0.0182 0.0298 0.9452
Loa Loa (eye worm) hypothetical protein 0.0088 0.0121 0.0338
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0156 0.0418
Loa Loa (eye worm) hypothetical protein 0.0099 0.0141 0.0394
Schistosoma mansoni retinoic acid receptor RXR 0.0187 0.0307 0.1307
Schistosoma mansoni ap endonuclease 0.006 0.0068 0.0291
Onchocerca volvulus Glucosylceramidase homolog 0.0186 0.0306 0.2119
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0042 0.0042
Brugia malayi ecdysteroid receptor 0.0187 0.0307 0.0823
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0187 0.0307 0.0861
Loa Loa (eye worm) hypothetical protein 0.0088 0.0121 0.0338
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0191 0.0811
Schistosoma mansoni hypothetical protein 0.0049 0.0048 0.0202
Echinococcus granulosus GTP binding nuclear protein Ran 0.0066 0.008 0.04
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0302 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0156 0.025 0.07
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0068 0.0192
Onchocerca volvulus 0.0189 0.0311 0.2158
Echinococcus multilocularis tar DNA binding protein 0.0125 0.0191 0.0191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.0544 0.3733
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0191 0.0811
Mycobacterium ulcerans esterase/lipase LipP 0.0189 0.0311 1
Brugia malayi hypothetical protein 0.0088 0.0121 0.0323
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0187 0.0307 0.1538
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0141 0.0141
Brugia malayi Nuclear hormone receptor E75 0.0088 0.0121 0.0323
Loa Loa (eye worm) TAR-binding protein 0.0125 0.0191 0.0535
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0066 0.008 0.2296
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0102 0.0435
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0189 0.0311 0.0872
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0054 0.0271
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0187 0.0307 0.2131
Brugia malayi RNA binding protein 0.0125 0.0191 0.0511
Brugia malayi beta-lactamase family protein 0.0189 0.0311 0.0833
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0093 0.0129 0.0648
Brugia malayi ecdysone receptor 0.0088 0.0121 0.0323
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0088 0.0121 0.0338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0139 0.059
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0097 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.009 0.0125 0.0351
Giardia lamblia Fructose-bisphosphate aldolase 0.0312 0.0544 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0093 0.0435
Brugia malayi nuclear receptor NHR-67 0.0088 0.0121 0.0323
Schistosoma mansoni alpha-glucosidase 0.0162 0.0261 0.1112
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0073 0.0181
Leishmania major mitochondrial DNA polymerase beta 0.0345 0.0607 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0187 0.0307 0.0861
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0187 0.0307 0.1307
Loa Loa (eye worm) hypothetical protein 0.1897 0.3547 0.9944
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0046 0.0042 0.0118
Onchocerca volvulus 0.0189 0.0311 0.2158
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0302 0.0527 0.1411
Brugia malayi hypothetical protein 0.0099 0.0141 0.0377
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0187 0.0307 0.1538
Schistosoma mansoni hypothetical protein 0.0049 0.0048 0.0202
Brugia malayi nuclear receptor RXR 0.0099 0.0141 0.0377
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0088 0.0121 0.0788
Schistosoma mansoni hypothetical protein 0.048 0.0863 0.3672
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0187 0.0307 0.0823
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0187 0.0307 0.0823
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0189 0.0311 0.1323
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0088 0.0121 0.0788
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0054 0.0054
Brugia malayi hypothetical protein 0.051 0.092 0.2464
Echinococcus multilocularis FTZ F1 alpha 0.0187 0.0307 0.0307
Brugia malayi hypothetical protein 0.0088 0.0121 0.0323
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.0544 0.3733
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0163 0.0263 0.4005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0187 0.0307 0.1307
Echinococcus multilocularis geminin 0.0358 0.0631 0.0631
Entamoeba histolytica hypothetical protein 0.0116 0.0173 0.2735
Brugia malayi MH2 domain containing protein 0.0357 0.0629 0.1685
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0187 0.0307 0.1538
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0066 0.008 0.0214
Brugia malayi hypothetical protein 0.0116 0.0173 0.0463
Loa Loa (eye worm) hypothetical protein 0.0056 0.0059 0.0166
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0042 0.0179
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0068 0.0688
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0189 0.0311 0.0833
Schistosoma mansoni alpha glucosidase 0.0042 0.0033 0.0141
Brugia malayi nuclear hormone receptor family member nhr-6 0.0088 0.0121 0.0323
Echinococcus granulosus FTZ F1 alpha 0.0187 0.0307 0.1538
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0033 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0187 0.0307 0.0823
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0187 0.0307 0.0861
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0049 0.0118
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0048 0.0127
Loa Loa (eye worm) hypothetical protein 0.0049 0.0048 0.0133
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0187 0.0307 0.0307
Schistosoma mansoni cpg binding protein 0.0065 0.0078 0.0331
Schistosoma mansoni hypothetical protein 0.0107 0.0156 0.0664
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0139 0.059
Treponema pallidum fructose-bisphosphate aldolase 0.0312 0.0544 1
Echinococcus multilocularis GPCR, family 2 0.0049 0.0048 0.0048
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0504 0.0908 0.2545
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0073 0.0309
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0008 0.0036
Echinococcus granulosus peregrin 0.003 0.0011 0.0055
Brugia malayi Nuclear hormone receptor-like 1 0.1908 0.3567 0.9554
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0066 0.008 0.2296
Toxoplasma gondii exonuclease III APE 0.006 0.0068 0.1912
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0042 0.0223
Entamoeba histolytica hypothetical protein 0.0116 0.0173 0.2735
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1205 0.2235 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0302 0.0527 0.1477
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0068 0.0342
Brugia malayi Nuclear hormone receptor E75 0.0088 0.0121 0.0323
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0099 0.0141 0.0598
Schistosoma mansoni coup transcription factor 0.0187 0.0307 0.1307
Brugia malayi Cytochrome P450 family protein 0.0029 0.001 0.0026
Schistosoma mansoni hypothetical protein 0.0025 0.0001 0.0005
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0088 0.0121 0.0513
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.0544 0.3733
Entamoeba histolytica hypothetical protein 0.0073 0.0093 0.1164
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0187 0.0307 0.0823
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0187 0.0307 0.0307
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0066 0.008 0.0224
Loa Loa (eye worm) hypothetical protein 0.0121 0.0183 0.0514
Schistosoma mansoni hypothetical protein 0.003 0.0011 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0187 0.0307 0.0307
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0073 0.0073
Onchocerca volvulus 0.0046 0.0042 0.0223
Onchocerca volvulus 0.0764 0.1401 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0073 0.0689
Brugia malayi hypothetical protein 0.0036 0.0022 0.0059
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0048 0.0238
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0042 0.0179
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.0544 1
Brugia malayi orphan nuclear receptor NR2E1 0.0088 0.0121 0.0323
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0042 0.021
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0049 0.0118
Mycobacterium ulcerans hypothetical protein 0.0189 0.0311 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0189 0.0311 0.112
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0049 0.0281
Echinococcus granulosus neuropeptide s receptor 0.093 0.1715 0.8584
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0116 0.0173 0.0866
Schistosoma mansoni ran 0.0066 0.008 0.034
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0068 0.1076
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0048 0.0238
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0049 0.1277
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0073 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0187 0.0307 0.0861
Echinococcus multilocularis neuropeptide s receptor 0.093 0.1715 0.1715
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0033 0.0167
Mycobacterium tuberculosis Probable lipase LipE 0.0189 0.0311 0.112
Onchocerca volvulus 0.0097 0.0139 0.0918
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.0263 0.4005
Trypanosoma brucei protein kinase, putative 0.005 0.0049 0.0281
Loa Loa (eye worm) hypothetical protein 0.0088 0.0121 0.0338
Loa Loa (eye worm) steroid hormone receptor 0.0187 0.0307 0.0861
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0031
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0049 0.0049
Entamoeba histolytica hypothetical protein 0.0116 0.0173 0.2735
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0302 0.0527 0.224
Plasmodium falciparum importin beta, putative 0.009 0.0125 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.003 0.0126
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0049 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0187 0.0307 0.0861
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.003 0.0149
Loa Loa (eye worm) hypothetical protein 0.0088 0.0121 0.0338
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0187 0.0307 0.1307
Loa Loa (eye worm) hypothetical protein 0.0187 0.0307 0.0861
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0187 0.0307 0.0861
Schistosoma mansoni ran 0.0066 0.008 0.034
Loa Loa (eye worm) hypothetical protein 0.0298 0.0519 0.1455
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0187 0.0307 0.0823
Onchocerca volvulus 0.0189 0.0311 0.2158
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0049 0.0281
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0049 0.0281
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0325 0.2129
Brugia malayi tailless protein 0.0088 0.0121 0.0323
Schistosoma mansoni nuclear receptor nhr-48 0.0088 0.0121 0.0513
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0141 0.0705
Trypanosoma cruzi hypothetical protein, conserved 0.0189 0.0311 0.4845
Echinococcus granulosus dnaJ subfamily B 0.048 0.0863 0.4321
Echinococcus granulosus geminin 0.0358 0.0631 0.3161
Brugia malayi TAR-binding protein 0.0125 0.0191 0.0511
Mycobacterium tuberculosis Conserved protein 0.0189 0.0311 0.112
Brugia malayi follicle stimulating hormone receptor 0.0504 0.0908 0.2431
Brugia malayi conserved hypotetical protein 0.0088 0.0121 0.0323
Schistosoma mansoni nuclear hormone receptor 0.0088 0.0121 0.0513
Mycobacterium ulcerans lipase LipD 0.0189 0.0311 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0189 0.0311 0.112
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0099 0.0141 0.0704
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0049 0.021
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0054 0.023
Loa Loa (eye worm) hypothetical protein 0.0097 0.0139 0.0389
Echinococcus granulosus beta LACTamase domain containing family member 0.0189 0.0311 0.1557
Leishmania major hypothetical protein, conserved 0.0189 0.0311 0.4845
Loa Loa (eye worm) hypothetical protein 0.0088 0.0121 0.0338
Onchocerca volvulus 0.0104 0.0151 0.1007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0187 0.0307 0.1538
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0187 0.0307 0.0823
Loa Loa (eye worm) hypothetical protein 0.051 0.092 0.2579
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0059 0.0453
Loa Loa (eye worm) RNA binding protein 0.0125 0.0191 0.0535
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0071 0.0199
Echinococcus multilocularis ecdysone induced protein 78C 0.0187 0.0307 0.0307
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.0242 0.0802
Brugia malayi steroid hormone receptor 0.0187 0.0307 0.0823
Loa Loa (eye worm) hypothetical protein 0.0088 0.0121 0.0338
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0073 0.0309
Brugia malayi nuclear hormone receptor family member odr-7 0.0088 0.0121 0.0323

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 2.4 mg kg-1 Effective dose required to potentiate yohimbine hydrochloride induced lethality in mice, administered intraperitoneally ChEMBL. 4067998
ED50 (functional) = 2.4 mg kg-1 Compound(administered intraperitoneally) was tested for yohimbine lethality potentiation ChEMBL. 4067998
ED50 (functional) = 9.3 mg kg-1 Effective dose required to prevent reserpine ptosis in mice, administered intraperitoneally ChEMBL. 4067998
ED50 (functional) = 10.8 mg kg-1 Effective dose required to prevent reserpine ptosis in mice, administered (po)orally ChEMBL. 4067998
LD50 (ADMET) = 60 mg kg-1 Lethal dose of the compound was determined in mouse i.p. ChEMBL. 4067998
LD50 (ADMET) = 215 mg kg-1 Lethal dose of the compound was determined in mouse p.o. ChEMBL. 4067998

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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