Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | wingless-type MMTV integration site family, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Wnt-2 protein precursor | wingless-type MMTV integration site family, member 3 | 355 aa | 358 aa | 37.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 1 | 1 |
Echinococcus multilocularis | wnt family member wnt11 2 | 0.0016 | 0.2078 | 0.1798 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.2078 | 0.2078 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.2078 | 0.2078 |
Echinococcus multilocularis | protein Wnt 2 | 0.0016 | 0.2078 | 0.1798 |
Echinococcus granulosus | protein Wnt 1 | 0.0016 | 0.2078 | 0.1798 |
Brugia malayi | wnt family protein | 0.0016 | 0.2078 | 0.086 |
Echinococcus multilocularis | WNT | 0.0016 | 0.2078 | 0.1798 |
Brugia malayi | Wnt-4 protein precursor | 0.0016 | 0.2078 | 0.086 |
Echinococcus granulosus | protein Wnt 2 | 0.0016 | 0.2078 | 0.1798 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.2078 | 0.2078 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.2078 | 0.2078 |
Echinococcus multilocularis | wingless type MMTV integration site family | 0.0016 | 0.2078 | 0.1798 |
Loa Loa (eye worm) | Wnt2 protein | 0.0016 | 0.2078 | 0.2078 |
Loa Loa (eye worm) | wnt-4 protein | 0.0016 | 0.2078 | 0.2078 |
Brugia malayi | wnt family protein | 0.0016 | 0.2078 | 0.086 |
Brugia malayi | wnt family protein | 0.0016 | 0.2078 | 0.086 |
Echinococcus multilocularis | protein Wnt 1 | 0.0016 | 0.2078 | 0.1798 |
Echinococcus granulosus | Protein Wnt-111 | 0.0016 | 0.2078 | 0.1798 |
Schistosoma mansoni | lamin | 0.0028 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 1 | 1 |
Echinococcus granulosus | Protein Wnt-11b | 0.0016 | 0.2078 | 0.1798 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 1 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.9658 | 0.9658 |
Echinococcus granulosus | lamin | 0.0028 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 1 | 1 |
Echinococcus granulosus | Protein Wnt-5 | 0.0016 | 0.2078 | 0.1798 |
Loa Loa (eye worm) | CWN-2 protein | 0.0016 | 0.2078 | 0.2078 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.2078 | 0.2078 |
Echinococcus multilocularis | lamin | 0.0028 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 1 | 1 |
Brugia malayi | wnt family protein | 0.0016 | 0.2078 | 0.086 |
Onchocerca volvulus | 0.0028 | 1 | 0.5 | |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.1333 | 0.1333 |
Echinococcus granulosus | Protein Wnt-04 | 0.0016 | 0.2078 | 0.1798 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0342 | 0.0342 |
Echinococcus multilocularis | musashi | 0.0028 | 1 | 1 |
Brugia malayi | Wnt-2 protein precursor | 0.0016 | 0.2078 | 0.086 |
Schistosoma mansoni | lamin | 0.0028 | 1 | 1 |
Echinococcus multilocularis | WNT | 0.0016 | 0.2078 | 0.1798 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 4 uM | Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay | ChEMBL. | 19410457 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.