TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 345.848 | Formula: C13H20ClN5O2S
H donors: 5 H acceptors: 4 LogP: -0.11 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCSCC1NC(C(C1O)O)c1c[nH]c2c1ncnc2N.Cl
InChi: 1S/C13H19N5O2S.ClH/c1-2-21-4-7-11(19)12(20)9(18-7)6-3-15-10-8(6)16-5-17-13(10)14;/h3,5,7,9,11-12,15,18-20H,2,4H2,1H3,(H2,14,16,17);1H
InChiKey: XJZAUBHVIDJLLS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	methylthioadenosine phosphorylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	methylthioadenosine phosphorylase, putative	Get druggable targets OG5_128424	All targets in OG5_128424
Schistosoma mansoni	methylthioadenosine phosphorylase	Get druggable targets OG5_128424	All targets in OG5_128424
Mycobacterium ulcerans	5'-methylthioadenosine phosphorylase	Get druggable targets OG5_128424	All targets in OG5_128424
Schistosoma mansoni	methylthioadenosine phosphorylase	Get druggable targets OG5_128424	All targets in OG5_128424
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	Get druggable targets OG5_128424	All targets in OG5_128424
Brugia malayi	MTAP	Get druggable targets OG5_128424	All targets in OG5_128424
Leishmania major	methylthioadenosine phosphorylase, putative	Get druggable targets OG5_128424	All targets in OG5_128424
Candida albicans	ADH2 expression	Get druggable targets OG5_128424	All targets in OG5_128424
Trypanosoma congolense	methylthioadenosine phosphorylase, putative	Get druggable targets OG5_128424	All targets in OG5_128424
Trypanosoma brucei gambiense	methylthioadenosine phosphorylase, putative	Get druggable targets OG5_128424	All targets in OG5_128424
Echinococcus multilocularis	methylthioadenosine phosphorylase	Get druggable targets OG5_128424	All targets in OG5_128424
Mycobacterium tuberculosis	Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase)	Get druggable targets OG5_128424	All targets in OG5_128424
Loa Loa (eye worm)	S-methyl-5'-thioadenosine phosphorylase MTAP	Get druggable targets OG5_128424	All targets in OG5_128424
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	Get druggable targets OG5_128424	All targets in OG5_128424
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	Get druggable targets OG5_128424	All targets in OG5_128424
Leishmania donovani	methylthioadenosine phosphorylase, putative	Get druggable targets OG5_128424	All targets in OG5_128424
Schistosoma japonicum	ko:K00772 5'-methylthioadenosine phosphorylase [EC2.4.2.28], putative	Get druggable targets OG5_128424	All targets in OG5_128424
Candida albicans	ADH2 expression	Get druggable targets OG5_128424	All targets in OG5_128424
Leishmania braziliensis	methylthioadenosine phosphorylase, putative	Get druggable targets OG5_128424	All targets in OG5_128424
Leishmania mexicana	methylthioadenosine phosphorylase, putative	Get druggable targets OG5_128424	All targets in OG5_128424
Echinococcus granulosus	methylthioadenosine phosphorylase	Get druggable targets OG5_128424	All targets in OG5_128424

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	methylthioadenosine phosphorylase	283 aa	259 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0092	0.0219	0.071
Treponema pallidum	fructose-bisphosphate aldolase	0.1206	0.5867	0.5
Echinococcus granulosus	titin	0.0056	0.0035	0.006
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0042	0.0042
Brugia malayi	Fibronectin type III domain containing protein	0.0105	0.0284	0.0266
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0092	0.0219	0.071
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0056	0.0035	0.0017
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0611	0.2848	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0258	0.1058	0.3676
Loa Loa (eye worm)	TK/Met protein kinase	0.0258	0.1058	0.1058
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0611	0.2848	1
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Echinococcus multilocularis	SHC transforming protein 3	0.0353	0.1543	0.5388
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0258	0.1058	0.3676
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Onchocerca volvulus		0.0258	0.1058	0.1073
Plasmodium falciparum	protein kinase, putative	0.0258	0.1058	0.5
Brugia malayi	SH2 domain containing protein	0.0353	0.1543	0.1528
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0258	0.1058	0.3676
Schistosoma mansoni	cell adhesion molecule	0.0141	0.0467	0.1587
Schistosoma mansoni	signal transduction protein lnk-related	0.0353	0.1543	0.5388
Brugia malayi	Variant SH3 domain containing protein	0.0353	0.1543	0.1528
Schistosoma mansoni	hypothetical protein	0.0194	0.0735	0.2534
Onchocerca volvulus		0.0258	0.1058	0.1073
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Loa Loa (eye worm)	MH2 domain-containing protein	0.0137	0.0445	0.0445
Entamoeba histolytica	protein kinase, putative	0.0353	0.1543	0.1008
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Brugia malayi	Raf kinase	0.0258	0.1058	0.1042
Brugia malayi	SRC-1	0.0611	0.2848	0.2835
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0258	0.1058	0.1058
Schistosoma mansoni	adapter molecule crk	0.0353	0.1543	0.5388
Echinococcus multilocularis	c src tyrosine kinase	0.0611	0.2848	1
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Brugia malayi	hypothetical protein	0.0258	0.1058	0.1042
Echinococcus multilocularis	roundabout 2	0.0092	0.0219	0.071
Echinococcus granulosus	tyrosine protein kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0611	0.2848	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0258	0.1058	0.3676
Echinococcus granulosus	twitchin	0.0106	0.0289	0.0959
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0065	0.0081	0.0081
Echinococcus granulosus	geminin	0.0194	0.0735	0.2534
Loa Loa (eye worm)	TK/FER protein kinase	0.0611	0.2848	0.2848
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0284	0.0284
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0092	0.0219	0.071
Brugia malayi	SH2 domain containing protein	0.0353	0.1543	0.1528
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0081	0.0081
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0056	0.0035	0.0035
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0353	0.1543	0.1582
Loa Loa (eye worm)	CAMK protein kinase	0.0056	0.0035	0.0035
Loa Loa (eye worm)	TK protein kinase	0.0258	0.1058	0.1058
Schistosoma mansoni	protein kinase	0.0258	0.1058	0.3676
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0353	0.1543	0.5388
Schistosoma mansoni	roundabout	0.0065	0.0081	0.0222
Toxoplasma gondii	protein kinase domain-containing protein	0.0258	0.1058	0.5
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0064	0.0075	0.0201
Brugia malayi	Protein kinase domain containing protein	0.0611	0.2848	0.2835
Toxoplasma gondii	protein kinase	0.0258	0.1058	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.1058	0.1058
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0353	0.1543	0.1528
Schistosoma mansoni	neuroglian	0.0092	0.0219	0.071
Schistosoma mansoni	cell adhesion molecule	0.0092	0.0219	0.071
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1206	0.5867	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0258	0.1058	0.1042
Loa Loa (eye worm)	TK/ABL protein kinase	0.0611	0.2848	0.2848
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0172	0.0625	0.2143
Plasmodium falciparum	protein kinase, putative	0.0258	0.1058	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0258	0.1058	0.3676
Onchocerca volvulus		0.0353	0.1543	0.1582
Echinococcus granulosus	activin receptor type	0.0258	0.1058	0.3676
Loa Loa (eye worm)	transcription factor SMAD2	0.0137	0.0445	0.0445
Echinococcus multilocularis	protein kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0611	0.2848	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0258	0.1058	0.1058
Echinococcus granulosus	roundabout 2	0.0092	0.0219	0.071
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0329	0.0329
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0258	0.1058	0.3676
Brugia malayi	jmjC domain containing protein	0.0093	0.0225	0.0207
Brugia malayi	Variant SH3 domain containing protein	0.0353	0.1543	0.1528
Echinococcus granulosus	natriuretic peptide receptor 1	0.0258	0.1058	0.3676
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0258	0.1058	0.3676
Echinococcus granulosus	tyrosine protein kinase pr2	0.0258	0.1058	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1058	0.1058
Brugia malayi	Variant SH3 domain containing protein	0.0353	0.1543	0.1528
Echinococcus multilocularis	tensin	0.0353	0.1543	0.5388
Echinococcus granulosus	tyrosine protein kinase Srms	0.0611	0.2848	1
Schistosoma mansoni	cell adhesion molecule	0.0056	0.0035	0.006
Echinococcus granulosus	epidermal growth factor receptor	0.0258	0.1058	0.3676
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0064	0.0075	0.0201
Echinococcus granulosus	peroxidasin	0.0065	0.0081	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1543	0.1543
Echinococcus granulosus	methylthioadenosine phosphorylase	0.0172	0.0625	0.2143
Schistosoma mansoni	cell adhesion molecule	0.0092	0.0219	0.071
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0056	0.0035	0.0017
Echinococcus multilocularis	tyrosine kinase	0.0611	0.2848	1
Schistosoma mansoni	serine/threonine RGC	0.0258	0.1058	0.3676
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0065	0.0081	0.0222
Onchocerca volvulus		0.0258	0.1058	0.1073
Echinococcus granulosus	ephrin type A receptor 4 A	0.0258	0.1058	0.3676
Schistosoma mansoni	hypothetical protein	0.0194	0.0735	0.2534
Echinococcus granulosus	kinase suppressor of Ras 1	0.0258	0.1058	0.3676
Echinococcus granulosus	growth factor receptor bound protein 2	0.0353	0.1543	0.5388
Schistosoma mansoni	growth factor receptor-bound protein	0.0353	0.1543	0.5388
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0353	0.1543	0.5388
Loa Loa (eye worm)	SH2 domain-containing protein	0.0353	0.1543	0.1543
Echinococcus multilocularis	tumor protein p63	0.0274	0.1141	0.3967
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0258	0.1058	1
Loa Loa (eye worm)	TK protein kinase	0.0258	0.1058	0.1058
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0258	0.1058	0.1058
Schistosoma mansoni	septate junction protein	0.0065	0.0081	0.0222
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0064	0.0075	0.0075
Echinococcus granulosus	titin	0.0056	0.0035	0.006
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0611	0.2848	1
Brugia malayi	Sex muscle abnormal protein 5	0.0353	0.1543	0.1528
Plasmodium falciparum	tyrosine kinase-like protein	0.0258	0.1058	0.5
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Echinococcus multilocularis	FL cytokine receptor	0.0258	0.1058	0.3676
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.1058	0.1058
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0353	0.1543	0.1543
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Echinococcus multilocularis	protein kinase	0.0258	0.1058	0.3676
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0258	0.1058	0.3676
Schistosoma mansoni	titin	0.0056	0.0035	0.006
Loa Loa (eye worm)	TK/CSK protein kinase	0.0258	0.1058	0.1058
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0589	0.274	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0353	0.1543	0.5388
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1543	0.1543
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1543	0.1543
Loa Loa (eye worm)	TK/FER protein kinase	0.0611	0.2848	0.2848
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0258	0.1058	0.3676
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0258	0.1058	0.5
Loa Loa (eye worm)	TK/ACK protein kinase	0.0258	0.1058	0.1058
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0258	0.1058	0.1042
Echinococcus multilocularis	transfer RNA-Thr	0.0258	0.1058	0.3676
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0611	0.2848	1
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0258	0.1058	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1543	0.1543
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0353	0.1543	0.5388
Loa Loa (eye worm)	TK/FER protein kinase	0.0611	0.2848	0.2848
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0611	0.2848	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0353	0.1543	0.1543
Schistosoma mansoni	protein kinase	0.0258	0.1058	0.3676
Onchocerca volvulus		0.0611	0.2848	0.2951
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0353	0.1543	0.5388
Echinococcus granulosus	epidermal growth factor receptor	0.0258	0.1058	0.3676
Echinococcus granulosus	protein tyrosine kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0353	0.1543	0.5388
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0353	0.1543	0.5388
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0353	0.1543	0.1582
Schistosoma mansoni	tyrosine kinase	0.0611	0.2848	1
Loa Loa (eye worm)	TK protein kinase	0.0258	0.1058	0.1058
Onchocerca volvulus		0.0258	0.1058	0.1073
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0258	0.1058	0.3676
Echinococcus granulosus	tyrosine protein kinase csk	0.0258	0.1058	0.3676
Schistosoma mansoni	protein kinase	0.0258	0.1058	0.3676
Schistosoma mansoni	tyrosine kinase	0.0611	0.2848	1
Echinococcus granulosus	tumor protein p63	0.0274	0.1141	0.3967
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0611	0.2848	1
Echinococcus multilocularis	NCK adaptor protein	0.0353	0.1543	0.5388
Schistosoma mansoni	GTPase activating protein	0.0353	0.1543	0.5388
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Loa Loa (eye worm)	TK/EPH protein kinase	0.0258	0.1058	0.1058
Onchocerca volvulus		0.0353	0.1543	0.1582
Schistosoma mansoni	protein kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	TK/FAK protein kinase	0.0258	0.1058	0.1058
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0284	0.0284
Echinococcus granulosus	tyrosine kinase	0.0258	0.1058	0.3676
Schistosoma mansoni	shc transforming protein	0.0353	0.1543	0.5388
Echinococcus granulosus	SHC transforming protein 3	0.0353	0.1543	0.5388
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1206	0.5867	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0092	0.0219	0.0219
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0589	0.274	0.5
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0042	0.0042
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0258	0.1058	0.1042
Onchocerca volvulus		0.0258	0.1058	0.1073
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0353	0.1543	0.5388
Echinococcus multilocularis	protein tyrosine kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1543	0.1543
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Schistosoma mansoni	cell adhesion molecule	0.0065	0.0081	0.0222
Brugia malayi	C-terminal src kinase protein 1	0.0258	0.1058	0.1042
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0611	0.2848	1
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0284	0.0284
Schistosoma mansoni	nephrin	0.0092	0.0219	0.071
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0081	0.0081
Loa Loa (eye worm)	TK/FER protein kinase	0.0611	0.2848	0.2848
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0285	0.1197	0.4164
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Brugia malayi	Guanylyl cyclase protein 23	0.0258	0.1058	0.1042
Echinococcus multilocularis	epidermal growth factor receptor	0.0258	0.1058	0.3676
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0258	0.1058	0.3676
Schistosoma mansoni	SH2A	0.0353	0.1543	0.5388
Schistosoma mansoni	tensin-related	0.0353	0.1543	0.5388
Echinococcus multilocularis	methylthioadenosine phosphorylase	0.0172	0.0625	0.2143
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.0128	0.0388
Onchocerca volvulus		0.0353	0.1543	0.1582
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0258	0.1058	0.1042
Loa Loa (eye worm)	SH2 domain-containing protein	0.0353	0.1543	0.1543
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0258	0.1058	0.5
Onchocerca volvulus		0.0258	0.1058	0.1073
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0258	0.1058	0.3676
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0353	0.1543	0.5388
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0473	0.0473
Brugia malayi	SH2 domain containing protein	0.0611	0.2848	0.2835
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0258	0.1058	0.3676
Brugia malayi	Furin-like cysteine rich region family protein	0.0258	0.1058	0.1042
Schistosoma mansoni	protein kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	TK protein kinase	0.0258	0.1058	0.1058
Echinococcus granulosus	hemicentin 1	0.0065	0.0081	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1058	0.1058
Loa Loa (eye worm)	TK/FER protein kinase	0.0611	0.2848	0.2848
Echinococcus granulosus	activated cdc42 kinase 1	0.0258	0.1058	0.3676
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0258	0.1058	0.1042
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0353	0.1543	0.5388
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.1206	0.5867	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0353	0.1543	0.1543
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0081	0.0081
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0258	0.1058	0.1058
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0056	0.0035	0.006
Echinococcus granulosus	insulin receptor	0.0258	0.1058	0.3676
Schistosoma mansoni	hypothetical protein	0.0258	0.1058	0.3676
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0258	0.1058	0.1058
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0258	0.1058	0.1058
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1543	0.1543
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1058	0.1058
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0056	0.0035	0.0035
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0258	0.1058	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1543	0.1543
Loa Loa (eye worm)	STAT protein	0.0353	0.1543	0.1543
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0258	0.1058	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1058	0.1058
Schistosoma mansoni	serine/threonine protein kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0258	0.1058	0.1058
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0065	0.0081	0.0063
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0092	0.0219	0.0201
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.1058	0.1058
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0065	0.0081	0.0222
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0065	0.0081	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1543	0.1543
Schistosoma mansoni	cell adhesion molecule	0.0056	0.0035	0.006
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1058	0.1058
Echinococcus granulosus	SH2 motif	0.0353	0.1543	0.5388
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0353	0.1543	0.5388
Brugia malayi	integrin-linked kinase	0.0258	0.1058	0.1042
Schistosoma mansoni	hypothetical protein	0.0056	0.0035	0.006
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0258	0.1058	0.1058
Schistosoma mansoni	tyrosine kinase	0.0611	0.2848	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0611	0.2848	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0065	0.0081	0.0063
Loa Loa (eye worm)	TK protein kinase	0.0286	0.1202	0.1202
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0092	0.0219	0.071
Schistosoma mansoni	protein kinase	0.0258	0.1058	0.3676
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0353	0.1543	0.5388
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0077	0.0145	0.045
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0258	0.1058	0.5
Echinococcus granulosus	NCK adaptor protein	0.0353	0.1543	0.5388
Brugia malayi	Tyrosine-protein kinase PR2	0.0258	0.1058	0.1042
Brugia malayi	SH2 domain containing protein	0.0353	0.1543	0.1528
Brugia malayi	Tyrosine-protein kinase abl-1	0.0611	0.2848	0.2835
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0611	0.2848	1
Loa Loa (eye worm)	projectin	0.0056	0.0035	0.0035
Brugia malayi	Variant SH3 domain containing protein	0.0353	0.1543	0.1528
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0056	0.0035	0.0017
Brugia malayi	Tensin	0.0353	0.1543	0.1528
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0258	0.1058	0.1073
Echinococcus granulosus	integrin linked protein kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	SH2 domain containing protein 7	0.0353	0.1543	0.5388
Plasmodium vivax	protein kinase, putative	0.0258	0.1058	0.5
Echinococcus granulosus	hypothetical protein	0.0353	0.1543	0.5388
Brugia malayi	MTAP	0.0172	0.0625	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0081	0.0081
Schistosoma mansoni	tyrosine kinase	0.0611	0.2848	1
Echinococcus multilocularis	tyrosine protein kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0286	0.1202	0.4184
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0258	0.1058	1
Echinococcus multilocularis	Immunoglobulin	0.0077	0.0145	0.045
Loa Loa (eye worm)	TK protein kinase	0.0258	0.1058	0.1058
Echinococcus granulosus	neuroglian	0.0106	0.0289	0.0959
Loa Loa (eye worm)	TK/FER protein kinase	0.0611	0.2848	0.2848
Schistosoma mansoni	hypothetical protein	0.0353	0.1543	0.5388
Echinococcus multilocularis		0.0353	0.1543	0.5388
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0056	0.0035	0.0017
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1206	0.5867	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.1058	0.1058
Schistosoma mansoni	ephrin receptor	0.0258	0.1058	0.3676
Loa Loa (eye worm)	TK/FER protein kinase	0.0611	0.2848	0.2848
Schistosoma mansoni	myosin-binding protein-related	0.0056	0.0035	0.006
Loa Loa (eye worm)	TK/ALK protein kinase	0.0258	0.1058	0.1058
Echinococcus granulosus	Immunoglobulin	0.0077	0.0145	0.045
Echinococcus granulosus	contactin	0.0092	0.0219	0.071
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	lachesin	0.0065	0.0081	0.0222
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0065	0.0081	0.0048
Loa Loa (eye worm)	TK/FER protein kinase	0.0611	0.2848	0.2848
Onchocerca volvulus		0.0258	0.1058	0.1073
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.1058	0.1058
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0056	0.0035	0.0035
Schistosoma mansoni	tyrosine kinase	0.0322	0.1386	0.4834
Brugia malayi	hypothetical protein	0.0258	0.1058	0.1042
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Onchocerca volvulus		0.0611	0.2848	0.2951
Loa Loa (eye worm)	TK/FER protein kinase	0.0611	0.2848	0.2848
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0258	0.1058	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0258	0.1058	0.3676
Echinococcus multilocularis	SH2 motif	0.0353	0.1543	0.5388
Echinococcus granulosus	tyrosine kinase	0.0611	0.2848	1
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1058	0.1058
Echinococcus multilocularis	hemicentin 1	0.0065	0.0081	0.0222
Echinococcus multilocularis	activin receptor type	0.0258	0.1058	0.3676
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.0225	0.073
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0258	0.1058	0.1058
Trypanosoma brucei	protein kinase, putative	0.0258	0.1058	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0353	0.1543	0.5388
Brugia malayi	protein unc-22	0.0056	0.0035	0.0017
Schistosoma mansoni	hemicentin	0.0056	0.0035	0.006
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1058	0.1058
Brugia malayi	MH2 domain containing protein	0.0137	0.0445	0.0428
Onchocerca volvulus		0.0611	0.2848	0.2951
Loa Loa (eye worm)	TK protein kinase	0.0258	0.1058	0.1058
Echinococcus multilocularis	activated cdc42 kinase 1	0.0258	0.1058	0.3676
Brugia malayi	protein-tyrosine kinase	0.0611	0.2848	0.2835
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0145	0.0145
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0353	0.1543	0.5388
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0611	0.2848	1
Echinococcus granulosus	SH2 motif	0.0353	0.1543	0.5388
Schistosoma mansoni	ephrin receptor	0.0285	0.1197	0.4164
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0114	0.0329	0.1099
Echinococcus multilocularis	roundabout 2	0.0169	0.0611	0.2096
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0258	0.1058	0.1058
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1543	0.1543
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0056	0.0035	0.0017
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0258	0.1058	0.3676
Brugia malayi	SH2 domain containing protein	0.0353	0.1543	0.1528
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0353	0.1543	0.5388
Loa Loa (eye worm)	hypothetical protein	0.0611	0.2848	0.2848
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0353	0.1543	0.5388
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1206	0.5867	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0258	0.1058	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0035	0.0035
Echinococcus multilocularis	transfer RNA-Phe	0.0056	0.0035	0.006
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1058	0.1058
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.1058	0.1058
Echinococcus granulosus	tyrosine protein kinase csk	0.0258	0.1058	0.3676
Echinococcus granulosus	tyrosine kinase	0.0611	0.2848	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0258	0.1058	0.1042
Loa Loa (eye worm)	SH2 domain-containing protein	0.0353	0.1543	0.1543
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0353	0.1543	0.5388
Schistosoma mansoni	titin	0.0056	0.0035	0.006
Schistosoma mansoni	protein kinase	0.0258	0.1058	0.3676
Schistosoma mansoni	growth factor receptor-bound protein	0.0353	0.1543	0.5388
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1206	0.5867	1
Schistosoma mansoni	serine/threonine protein kinase	0.0258	0.1058	0.3676
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0258	0.1058	0.3676
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0353	0.1543	0.1543
Loa Loa (eye worm)	SRC-1	0.0611	0.2848	0.2848
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1543	0.1543
Loa Loa (eye worm)	TK protein kinase	0.0258	0.1058	0.1058
Echinococcus multilocularis	peroxidasin	0.0065	0.0081	0.0222
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0286	0.1202	0.1186
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0611	0.2848	1
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0219	0.0219
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0611	0.2848	0.3722
Echinococcus granulosus	defective proboscis extension response	0.0077	0.0145	0.045
Onchocerca volvulus		0.0353	0.1543	0.1582
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0353	0.1543	0.5388
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.005	0.005
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Echinococcus granulosus	tensin	0.0353	0.1543	0.5388
Echinococcus granulosus	lachesin	0.0065	0.0081	0.0222
Schistosoma mansoni	protein tyrosine kinase	0.0258	0.1058	0.3676
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0611	0.2848	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0056	0.0035	0.0017
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0353	0.1543	0.1528
Schistosoma mansoni	protein kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	TK protein kinase	0.0611	0.2848	0.2848
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0077	0.0145	0.045
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1543	0.1543
Echinococcus multilocularis	insulin receptor	0.0258	0.1058	0.3676
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0611	0.2848	1
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0258	0.1058	0.3676
Echinococcus granulosus	raf serine:threonine protein kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	N chimaerin	0.0353	0.1543	0.5388
Echinococcus multilocularis	tyrosine protein kinase csk	0.0258	0.1058	0.3676
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0285	0.1197	0.4164
Onchocerca volvulus		0.0611	0.2848	0.2951
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0353	0.1543	0.1543
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0258	0.1058	0.3676
Echinococcus multilocularis	tyrosine protein kinase otk	0.0065	0.0081	0.0222
Schistosoma mansoni	tensin	0.0353	0.1543	0.5388
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0258	0.1058	0.3676
Echinococcus multilocularis	tyrosine protein kinase csk	0.0258	0.1058	0.3676
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1058	0.1058
Echinococcus granulosus	activated cdc42 kinase 1	0.0258	0.1058	0.3676
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0258	0.1058	0.3676
Echinococcus granulosus	tyrosine protein kinase shark	0.0611	0.2848	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0035	0.0035
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0353	0.1543	0.5388
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0353	0.1543	0.5388
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.1058	0.1058
Brugia malayi	Prion-like-	0.0065	0.0081	0.0063
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0258	0.1058	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.2022	1	1
Schistosoma mansoni	nck2/grb4	0.0353	0.1543	0.5388
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1543	0.1543
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0077	0.0145	0.045
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1058	0.1058
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0258	0.1058	0.1058
Loa Loa (eye worm)	serine/threonine protein kinase	0.0258	0.1058	0.1058
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0258	0.1058	0.3676
Echinococcus granulosus	expressed conserved protein	0.0353	0.1543	0.5388
Echinococcus multilocularis	heat shock protein 70	0.0258	0.1058	0.3676
Onchocerca volvulus		0.0353	0.1543	0.1582
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0258	0.1058	0.3676
Brugia malayi	SH2 domain containing protein	0.0611	0.2848	0.2835
Brugia malayi	SH2 domain containing protein	0.0353	0.1543	0.1528
Brugia malayi	Protein kinase domain containing protein	0.0611	0.2848	0.2835
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1206	0.5867	1
Onchocerca volvulus		0.0353	0.1543	0.1582
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1206	0.5867	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1206	0.5867	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0258	0.1058	0.3676
Echinococcus granulosus	tyrosine protein kinase Blk	0.0611	0.2848	1
Brugia malayi	hypothetical protein	0.0353	0.1543	0.1528
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0258	0.1058	0.3676
Echinococcus granulosus	signal transduction protein lnk realted	0.0353	0.1543	0.5388
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0172	0.0625	0.2143
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0611	0.2848	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0353	0.1543	0.5388
Echinococcus granulosus	tyrosine protein kinase HCK	0.0258	0.1058	0.3676
Brugia malayi	Receptor family ligand binding region containing protein	0.0258	0.1058	0.1042
Schistosoma mansoni	tensin-related	0.0353	0.1543	0.5388
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0611	0.2848	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0258	0.1058	0.1058
Onchocerca volvulus		0.0611	0.2848	0.2951
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0611	0.2848	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0353	0.1543	0.5388
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0042	0.0024
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0286	0.1202	0.4184
Schistosoma mansoni	vesicular amine transporter	0.0077	0.0145	0.045
Echinococcus multilocularis	SH2 motif	0.0353	0.1543	0.5388
Onchocerca volvulus		0.1651	0.8118	0.8479
Echinococcus multilocularis	integrin linked protein kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	S-methyl-5'-thioadenosine phosphorylase MTAP	0.0172	0.0625	0.0625
Echinococcus multilocularis	signal transduction protein lnk realted	0.0353	0.1543	0.5388
Echinococcus multilocularis	geminin	0.0194	0.0735	0.2534
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0255	0.1048	0.2567
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0589	0.274	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0258	0.1058	0.5
Echinococcus granulosus	nephrin	0.0056	0.0035	0.006
Leishmania major	protein kinase, putative	0.0258	0.1058	1
Echinococcus granulosus	roundabout 2	0.0092	0.0219	0.071
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0353	0.1543	0.1528
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0258	0.1058	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0145	0.0145
Giardia lamblia	Fructose-bisphosphate aldolase	0.1206	0.5867	1
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Trypanosoma cruzi	protein kinase, putative	0.0258	0.1058	1
Schistosoma mansoni	serine/threonine protein kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0611	0.2848	1
Schistosoma mansoni	titin	0.0065	0.0081	0.0222
Brugia malayi	SH2 domain containing protein	0.0353	0.1543	0.1528
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0258	0.1058	0.1058
Loa Loa (eye worm)	TK protein kinase	0.0258	0.1058	0.1058
Schistosoma mansoni	protein kinase	0.0258	0.1058	0.3676
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	SH2 motif	0.0353	0.1543	0.5388
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0611	0.2848	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0258	0.1058	0.1042
Loa Loa (eye worm)	TK/INSR protein kinase	0.0258	0.1058	0.1058
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0353	0.1543	0.5388
Loa Loa (eye worm)	TK/ROR protein kinase	0.0286	0.1202	0.1202
Brugia malayi	Peroxidasin	0.0065	0.0081	0.0063
Schistosoma mansoni	tensin	0.0353	0.1543	0.5388
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0065	0.0081	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1543	0.1543
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0056	0.0035	0.0017
Echinococcus granulosus	N chimaerin	0.0353	0.1543	0.5388
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0353	0.1543	0.5388
Brugia malayi	Protein kinase domain containing protein	0.0611	0.2848	0.2835
Schistosoma mansoni	tyrosine protein kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	tyrosine protein kinase shark	0.0611	0.2848	1
Brugia malayi	hypothetical protein	0.0105	0.0284	0.0266
Echinococcus multilocularis	tyrosine protein kinase csk	0.0258	0.1058	0.3676
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0353	0.1543	0.1543
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.0225	0.073
Echinococcus granulosus	receptor type guanylyl cyclase	0.0258	0.1058	0.3676
Brugia malayi	hypothetical protein	0.0611	0.2848	0.2835
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0353	0.1543	0.5388
Onchocerca volvulus	Tyrosine kinase homolog	0.1937	0.9568	1
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Plasmodium falciparum	protein kinase, putative	0.0258	0.1058	0.5
Echinococcus granulosus	neuroglian	0.0092	0.0219	0.071
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0042	0.0024
Echinococcus multilocularis	neuroglian	0.0092	0.0219	0.071
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0258	0.1058	0.3676
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0611	0.2848	1
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0611	0.2848	1
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	hemicentin 1	0.0065	0.0081	0.0222
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0611	0.2848	1
Schistosoma mansoni	tyrosine kinase	0.0611	0.2848	1
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1058	0.1058
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0064	0.0075	0.0057
Trypanosoma brucei	Pseudokinase, putative	0.0258	0.1058	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0092	0.0219	0.071
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0258	0.1058	0.3676
Leishmania major	hypothetical protein, conserved	0.0258	0.1058	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0092	0.0219	0.0201
Leishmania major	protein kinase, putative	0.0258	0.1058	1
Echinococcus granulosus	tyrosine protein kinase otk	0.0065	0.0081	0.0222
Toxoplasma gondii	STE kinase	0.0258	0.1058	0.5
Echinococcus multilocularis	Immunoglobulin	0.0077	0.0145	0.045
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0258	0.1058	0.3676
Onchocerca volvulus		0.0611	0.2848	0.2951
Brugia malayi	RhoGAP domain containing protein	0.0353	0.1543	0.1528
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0092	0.0219	0.0219
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0353	0.1543	0.5388
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0611	0.2848	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0258	0.1058	0.3676
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0258	0.1058	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	neuroglian	0.0106	0.0289	0.0959
Brugia malayi	Protein kinase domain containing protein	0.0611	0.2848	0.2835
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0611	0.2848	1
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0092	0.0219	0.071
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0145	0.0145
Brugia malayi	Protein kinase domain containing protein	0.0611	0.2848	0.2835
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1543	0.1543
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0065	0.0081	0.0063
Echinococcus granulosus	protein kinase	0.0258	0.1058	0.3676
Schistosoma mansoni	protein kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	tyrosine kinase	0.0258	0.1058	0.3676
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0353	0.1543	0.1008
Schistosoma mansoni	hypothetical protein	0.0353	0.1543	0.5388
Echinococcus multilocularis	tensin	0.0353	0.1543	0.5388
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0105	0.0284	0.0266
Echinococcus granulosus	roundabout 2	0.0169	0.0611	0.2096
Echinococcus multilocularis	titin	0.0056	0.0035	0.006
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	tyrosine protein kinase csk	0.0258	0.1058	0.3676
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0611	0.2848	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0353	0.1543	0.1528
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0065	0.0081	0.0063
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0258	0.1058	0.1058
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0611	0.2848	1
Schistosoma mansoni	tyrosine kinase	0.0258	0.1058	0.3676
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0473	0.0473
Loa Loa (eye worm)	TK/DDR protein kinase	0.0258	0.1058	0.1058
Trypanosoma cruzi	protein kinase, putative	0.0258	0.1058	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0258	0.1058	0.3676
Schistosoma mansoni	vav2	0.0353	0.1543	0.5388
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0081	0.0081
Echinococcus granulosus	c src tyrosine kinase	0.0611	0.2848	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0258	0.1058	1
Onchocerca volvulus		0.0258	0.1058	0.1073
Onchocerca volvulus		0.0258	0.1058	0.1073
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0258	0.1058	0.3676
Echinococcus multilocularis	epidermal growth factor receptor	0.0258	0.1058	0.3676
Echinococcus multilocularis	roundabout 2	0.0092	0.0219	0.071
Schistosoma mansoni	serine/threonine protein kinase	0.0258	0.1058	0.3676
Schistosoma mansoni	septate junction protein	0.0065	0.0081	0.0222
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0065	0.0081	0.0081
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0258	0.1058	0.3676
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0258	0.1058	0.1073
Entamoeba histolytica	SH2 domain containing protein	0.0353	0.1543	0.1008
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0258	0.1058	0.3676
Schistosoma mansoni	protein kinase	0.0258	0.1058	0.3676
Brugia malayi	ephrin receptor 1 precursor	0.0258	0.1058	0.1042
Schistosoma mansoni	suppressor of cytokine signaling	0.0353	0.1543	0.5388
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.1206	0.5867	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0611	0.2848	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0092	0.0219	0.0201
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0611	0.2848	1
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1058	0.1058
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0056	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1543	0.1543
Schistosoma mansoni	serine/threonine protein kinase	0.0056	0.0035	0.006
Brugia malayi	Protein kinase domain containing protein	0.0258	0.1058	0.1042
Schistosoma mansoni	tensin	0.0353	0.1543	0.5388
Schistosoma mansoni	nephrin	0.0133	0.0428	0.1447
Brugia malayi	SH2 domain containing protein	0.0353	0.1543	0.1528
Loa Loa (eye worm)	TK/FER protein kinase	0.0611	0.2848	0.2848
Schistosoma mansoni	tyrosine kinase	0.0611	0.2848	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0258	0.1058	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0081	0.0081

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.266 nM	Equilibrium dissociation constant towards human 5'-methylthioadenosine phosphorylase	ChEMBL.	15163207
Ki (binding)	= 9.2 nM	Initial dissociation constant towards human 5'-methylthioadenosine phosphorylase	ChEMBL.	15163207

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL554965

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1049612