Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0265 | 0.1542 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0145 | 0.1716 | 1 |
Echinococcus multilocularis | sentrin specific protease 7 | 0.0145 | 0.1716 | 0.1716 |
Loa Loa (eye worm) | Ulp1 protease | 0.0013 | 0.0032 | 0.0105 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0138 | 0.1628 | 0.1628 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0138 | 0.1628 | 0.949 |
Echinococcus granulosus | expressed conserved protein | 0.0132 | 0.1554 | 0.9061 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0379 | 0.221 |
Trypanosoma cruzi | SUMO1/Ulp2, putative | 0.0013 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.11 | 0.3637 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0092 | 1 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C48, putative | 0.0013 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0167 | 0.0551 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.032 | 0.1712 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.1116 | 0.3689 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0265 | 0.1542 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0265 | 0.0265 |
Echinococcus multilocularis | sentrin specific protease 1 | 0.0013 | 0.0032 | 0.0032 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0013 | 0.0032 | 0.0184 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0167 | 1 |
Onchocerca volvulus | 0.0023 | 0.0167 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0167 | 0.0551 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0167 | 0.0802 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0013 | 0.0032 | 0.0184 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0398 | 0.1316 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0092 | 1 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0013 | 0.0032 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0092 | 0.0303 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0013 | 0.0032 | 0.0105 |
Onchocerca volvulus | 0.0013 | 0.0032 | 0.1898 | |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0379 | 0.221 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.032 | 0.1712 |
Echinococcus multilocularis | expressed conserved protein | 0.0091 | 0.1026 | 0.1026 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0398 | 0.2321 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0167 | 0.0802 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0167 | 0.0551 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.3025 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0167 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0265 | 0.0874 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0097 | 0.11 | 0.6346 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0013 | 0.0032 | 0.0105 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0167 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0091 | 0.1026 | 0.5979 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0097 | 0.11 | 0.11 |
Trypanosoma cruzi | hypothetical protein | 0.0013 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0032 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0092 | 0.0303 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0092 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0167 | 0.0551 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0032 | 0.0105 |
Toxoplasma gondii | Ulp1 protease family, C-terminal catalytic domain-containing protein | 0.0013 | 0.0032 | 0.5 |
Echinococcus granulosus | sentrin specific protease 1 | 0.0013 | 0.0032 | 0.0184 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0167 | 1 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0398 | 0.2321 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0722 | 0.4208 |
Echinococcus multilocularis | sentrin specific protease 8 | 0.0013 | 0.0032 | 0.0032 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0167 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0092 | 0.0303 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0248 | 0.3025 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.032 | 0.1057 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0265 | 0.1542 |
Trypanosoma brucei | SUMO1/Ulp2, putative | 0.0013 | 0.0032 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0265 | 0.0874 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0379 | 0.221 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0265 | 0.0874 |
Toxoplasma gondii | Ulp1 protease family, C-terminal catalytic domain-containing protein | 0.0013 | 0.0032 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0265 | 0.1542 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0013 | 0.0032 | 0.0184 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.032 | 0.1865 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0167 | 1 |
Entamoeba histolytica | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0145 | 0.1716 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0167 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.032 | 0.1865 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0167 | 0.0802 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0398 | 0.0398 |
Toxoplasma gondii | Ulp1 protease family, C-terminal catalytic domain-containing protein | 0.0013 | 0.0032 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0265 | 0.0874 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.032 | 0.1865 |
Echinococcus granulosus | sentrin specific protease 8 | 0.0013 | 0.0032 | 0.0184 |
Echinococcus multilocularis | expressed conserved protein | 0.0132 | 0.1554 | 0.1554 |
Echinococcus granulosus | sentrin specific protease 7 | 0.0145 | 0.1716 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0167 | 1 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0398 | 0.1316 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.1116 | 0.3689 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0098 | 0.1119 | 0.6524 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0517 | 0.1709 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0167 | 1 |
Loa Loa (eye worm) | Ulp1 protease | 0.0013 | 0.0032 | 0.0105 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0167 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0167 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0097 | 0.11 | 0.6413 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0032 | 0.0105 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0092 | 0.139 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0379 | 0.221 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.0473 | 0.0473 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0265 | 0.1542 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0167 | 0.0551 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.1116 | 0.3689 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0167 | 0.0551 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.032 | 0.1712 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0167 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0092 | 0.0303 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.0722 | 0.2386 |
Giardia lamblia | Sentrin specific protease, putative | 0.0013 | 0.0032 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0167 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0265 | 0.1542 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0398 | 0.1316 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0097 | 0.11 | 0.3637 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0167 | 1 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0398 | 0.0398 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0265 | 0.0265 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0013 | 0.0032 | 0.0105 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0265 | 0.1542 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0722 | 0.2386 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.032 | 0.1712 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0398 | 0.2321 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0398 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.1116 | 0.3689 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0167 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.032 | 0.032 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0092 | 0.0303 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0265 | 0.0265 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 45 uM | Cytotoxicity against human MT4 cells assessed as inhibition of cell proliferation | ChEMBL. | 19645484 |
IC50 (ADMET) | = 40 uM | Cytotoxicity against human CEM cells assessed as decrease in cell viability | ChEMBL. | 19645484 |
IC50 (ADMET) | = 140 uM | Cytotoxicity against human MT4 cells assessed as decrease in cell viability | ChEMBL. | 19645484 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.