Detailed information for compound 104984

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 393.31 | Formula: C19H22Cl2N4O
  • H donors: 0 H acceptors: 2 LogP: 5.76 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(c1cc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)OC
  • InChi: 1S/C19H22Cl2N4O/c1-5-6-9-24(26-4)17-10-12(2)22-19-18(13(3)23-25(17)19)15-8-7-14(20)11-16(15)21/h7-8,10-11H,5-6,9H2,1-4H3
  • InChiKey: ZBACGSNTPXKOKJ-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens corticotropin releasing hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 1 444 aa 445 aa 25.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.053 0.2724 1
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0197 0.975
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0065 0.02 0.053
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0065 0.02 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Trypanosoma brucei trypanothione reductase 0.0047 0.0106 0.3325
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0433 0.0529
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0065 0.02 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0177 0.0509
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0059 0.042
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0204 0.0958 0.3371
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1873 1 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Leishmania major hypothetical protein, conserved 0.0065 0.02 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0065 0.02 0.053
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0177 0.0442
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.02 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0059 0.2956
Loa Loa (eye worm) hypothetical protein 0.0065 0.02 0.053
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0106 0.0066
Plasmodium falciparum phosphodiesterase delta, putative 0.0065 0.02 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0204 0.0958 0.3371
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0499 0.0621
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0001 0.0036
Echinococcus granulosus geminin 0.0169 0.0766 0.2653
Leishmania major DNA polymerase eta, putative 0.0064 0.0197 0.976
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0065 0.02 0.061
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.02 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0065 0.02 0.061
Toxoplasma gondii thioredoxin reductase 0.0047 0.0106 0.0387
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0065 0.02 0.053
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0065 0.02 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0466 0.2374 0.8688
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0433 0.0529
Loa Loa (eye worm) hypothetical protein 0.0065 0.02 0.053
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0065 0.02 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0065 0.02 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.053 0.2724 1
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0197 0.0595
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0106 0.0176
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0065 0.02 0.053
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0059 0.042
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0528 0.2712 0.3398
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0065 0.02 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0065 0.02 0.053
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0065 0.02 0.053
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0197 0.976
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0001 0.0036
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0065 0.02 0.061
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0065 0.02 0.053
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0059 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0433 0.0529
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0065 0.02 0.053
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0065 0.02 1
Giardia lamblia DINP protein human, muc B family 0.0038 0.0059 0.0215
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0528 0.2712 0.2668
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0065 0.02 0.053
Echinococcus multilocularis geminin 0.0169 0.0766 0.2653
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0065 0.02 0.053
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0065 0.02 0.053
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0466 0.2374 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0059 0.042
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Echinococcus multilocularis dna polymerase eta 0.0064 0.0197 0.0517
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0106 0.0176
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.02 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0065 0.02 0.053
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0065 0.02 0.053
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.02 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0245 0.1181 0.4844
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0466 0.2374 0.8688
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.053 0.2724 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Schistosoma mansoni DNA polymerase eta 0.0064 0.0197 0.0517
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Loa Loa (eye worm) PDE1B protein 0.0065 0.02 0.053
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0496 0.1638
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.02 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0065 0.02 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0065 0.02 0.053
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0496 0.1638
Schistosoma mansoni hypothetical protein 0.0041 0.0074 0.0054
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0528 0.2712 0.9956
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0065 0.02 0.061
Echinococcus granulosus dna polymerase eta 0.0064 0.0197 0.0517
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Brugia malayi MH2 domain containing protein 0.0119 0.0496 0.1886
Loa Loa (eye worm) hypothetical protein 0.0064 0.0197 0.0517
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1873 1 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0065 0.02 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0065 0.02 0.053
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Schistosoma mansoni hypothetical protein 0.0169 0.0766 0.2653
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.053 0.2724 1
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1873 1 0.5
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.053 0.2724 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.02 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0059 0.042
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0433 0.0529
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0106 0.0176
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0065 0.02 0.053
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0433 0.0529
Loa Loa (eye worm) hypothetical protein 0.0065 0.02 0.053
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0065 0.02 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Trypanosoma brucei hypothetical protein, conserved 0.0065 0.02 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0065 0.02 1
Giardia lamblia Hypothetical protein 0.0065 0.02 0.0733
Brugia malayi glutathione reductase 0.0047 0.0106 0.0203
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Brugia malayi Thioredoxin reductase 0.0047 0.0106 0.0203
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Mycobacterium tuberculosis Probable reductase 0.0108 0.0433 0.0529
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0065 0.02 0.053
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.02 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0065 0.02 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0074 0.0063
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0065 0.02 0.061
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0074 0.0054
Leishmania major hypothetical protein, conserved 0.0065 0.02 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0065 0.02 0.053
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.02 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0065 0.02 0.053
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0059 0.042
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0065 0.02 0.061
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.053 0.2724 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.053 0.2724 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1345 0.7139 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0065 0.02 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.053 0.2724 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0065 0.02 0.053
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0065 0.02 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0065 0.02 0.053
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0065 0.02 0.053
Loa Loa (eye worm) hypothetical protein 0.0245 0.1181 0.4208
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0499 0.0097
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1345 0.7139 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0466 0.2374 0.8688
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0059 0.2956
Giardia lamblia hypothetical protein 0.0065 0.02 0.0733
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0499 0.0621
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0065 0.02 1
Trichomonas vaginalis MYB, putative 0.0028 0.0001 0.0036
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0065 0.02 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0065 0.02 1
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.02 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0065 0.02 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0065 0.02 1
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0106 0.3605
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0053 0.0192
Loa Loa (eye worm) glutathione reductase 0.0047 0.0106 0.0176
Plasmodium vivax phosphodiesterase gamma, putative 0.0065 0.02 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0065 0.02 1
Schistosoma mansoni hypothetical protein 0.0169 0.0766 0.2653
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.02 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0065 0.02 0.053
Leishmania major trypanothione reductase 0.0047 0.0106 0.3605
Leishmania major DNA polymerase kappa, putative 0.0038 0.0059 0.042
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.02 0.0733
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0499 0.0621
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0065 0.02 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 216 nM Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells ChEMBL. 9873487
Ki (binding) = 216 nM Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells ChEMBL. 9873487

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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