TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 339.678 | Formula: C15H8ClF2NO4
H donors: 2 H acceptors: 4 LogP: 3.06 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C1c2ccc(c(c2C(=O)N1Cc1c(F)ccc(c1Cl)F)O)O
InChi: 1S/C15H8ClF2NO4/c16-12-7(8(17)2-3-9(12)18)5-19-14(22)6-1-4-10(20)13(21)11(6)15(19)23/h1-4,20-21H,5H2
InChiKey: UBRJBFPKZQHPLQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Human immunodeficiency virus 1	Integrase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	RNA helicase, putative	Get druggable targets OG5_139608	All targets in OG5_139608
Plasmodium yoelii	integrase-related	Get druggable targets OG5_139608	All targets in OG5_139608
Trypanosoma brucei	RNA helicase, putative	Get druggable targets OG5_139608	All targets in OG5_139608
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_139608	All targets in OG5_139608

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0072	0.1017	0.0779
Echinococcus granulosus	GPCR family 2	0.0033	0.03	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0335	0.0303
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0388	0.0257
Entamoeba histolytica	hypothetical protein	0.0038	0.0388	0.9689
Schistosoma mansoni	hypothetical protein	0.0033	0.03	0.0043
Echinococcus granulosus	sodium and chloride dependent glycine	0.0174	0.2916	0.4549
Onchocerca volvulus		0.0035	0.0335	0.0445
Schistosoma mansoni	sodium/chloride dependent transporter	0.0174	0.2916	0.2729
Toxoplasma gondii	exonuclease III APE	0.0038	0.039	0.4547
Schistosoma mansoni	tar DNA-binding protein	0.0267	0.4658	0.4517
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0335	0.0835
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0038	0.039	0.0392
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0034	0.0311	0.0055
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0034	0.0311	0.0055
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0055	0.0709	0.0971
Onchocerca volvulus		0.0035	0.0335	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0335	0.0303
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0152	0.0119
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0034	0.0311	0.0055
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0335	0.0835
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0034	0.0311	0.0055
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0152	0.2518	0.4261
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0388	0.0133
Toxoplasma gondii	ABC1 family protein	0.0035	0.0335	0.3382
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0175	0.3961
Schistosoma mansoni	hypothetical protein	0.0346	0.6127	0.6025
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0335	0.0167
Plasmodium vivax	SET domain protein, putative	0.0031	0.0258	0.6297
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0174	0.2916	0.2916
Schistosoma mansoni	ap endonuclease	0.0038	0.039	0.0136
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0034	0.0311	0.0126
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0335	0.0291
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0335	0.0835
Leishmania major	hypothetical protein, conserved	0.0026	0.0175	0.004
Mycobacterium ulcerans	hypothetical protein	0.017	0.2839	0.2815
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0335	0.0303
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.03	0.03
Onchocerca volvulus		0.0034	0.0311	0.0388
Schistosoma mansoni	hypothetical protein	0.0038	0.0388	0.0133
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0034	0.0311	0.0091
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.3855	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1017	0.0987
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.039	1
Brugia malayi	hypothetical protein	0.0038	0.0388	0.0388
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.039	0.0225
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0152	0.0152
Loa Loa (eye worm)	TAR-binding protein	0.0267	0.4658	0.464
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0038	0.0396	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0311	0.0279
Loa Loa (eye worm)	norepinephrine transporter	0.0034	0.0311	0.0279
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0038	0.0396	0.0141
Schistosoma mansoni	hypothetical protein	0.0033	0.03	0.0043
Echinococcus multilocularis	ubiquitin specific protease 41	0.0038	0.0396	0.0234
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0396	0.0063
Entamoeba histolytica	hypothetical protein	0.0038	0.0388	0.9689
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0105	0.1635	0.1635
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0335	0.0303
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0335	0.0291
Brugia malayi	Cytochrome P450 family protein	0.0048	0.0567	0.0567
Brugia malayi	Pre-SET motif family protein	0.0031	0.0258	0.0258
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0038	0.0396	0.0402
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0152	0.0119
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.039	0.039
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0033	0.005
Onchocerca volvulus		0.0034	0.0311	0.0388
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0034	0.0311	0.0091
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0175	0.3961
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0034	0.0311	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0152	0.0119
Schistosoma mansoni	hypothetical protein	0.0125	0.2008	0.1796
Brugia malayi	beta-lactamase family protein	0.0035	0.0335	0.0335
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0174	0.2916	0.4529
Schistosoma mansoni	hypothetical protein	0.0033	0.03	0.0043
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0335	0.0835
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0038	0.039	0.0979
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0335	0.0303
Entamoeba histolytica	hypothetical protein	0.0038	0.0388	0.9689
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0335	0.0835
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0038	0.039	0.0392
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0152	0.0119
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.039	0.026
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0038	0.0396	0.027
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.03	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0174	0.2916	0.2893
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0322	0.5675	1
Schistosoma mansoni	glutaminase	0.0554	1	1
Onchocerca volvulus		0.0246	0.4254	1
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0038	0.0396	0.0234
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0152	0.036
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0034	0.0311	0.0126
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0034	0.0311	0.0311
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0152	0.0119
Onchocerca volvulus		0.0031	0.0258	0.0258
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0152	0.0119
Trichomonas vaginalis	set domain proteins, putative	0.0246	0.4254	0.4055
Schistosoma mansoni	hypothetical protein	0.0346	0.6127	0.6025
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0038	0.0396	0.027
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0034	0.0311	0.0055
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0038	0.0396	0.0234
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0335	0.0291
Onchocerca volvulus		0.0035	0.0335	0.0445
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0216	0.3699	0.3678
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0038	0.0396	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0335	0.0835
Entamoeba histolytica	hypothetical protein	0.0038	0.0388	0.9689
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0335	0.0835
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0034	0.0311	0.2883
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0258	0.0036
Brugia malayi	hypothetical protein	0.0026	0.0175	0.0175
Toxoplasma gondii	hypothetical protein	0.0034	0.0311	0.2883
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0258	0.0225
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0034	0.0311	0.0126
Plasmodium vivax	amine transporter, putative	0.0034	0.0311	0.7789
Brugia malayi	RNA recognition motif domain containing protein	0.0267	0.4658	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0311	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0311	0.0279
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0152	0.0152
Onchocerca volvulus		0.0034	0.0311	0.0388
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0258	0.1759
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0034	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0396	0.0363
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0038	0.039	0.0358
Echinococcus granulosus	geminin	0.0346	0.6127	1
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0335	0.0303
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.039	0.9775
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0038	0.039	0.5
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.039	0.0057
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0034	0.0311	0.0055
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0038	0.039	1
Echinococcus multilocularis	tar DNA binding protein	0.0267	0.4658	0.7497
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0335	0.0303
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0335	0.0835
Echinococcus granulosus	ubiquitin specific protease 41	0.0038	0.0396	0.027
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0267	0.4658	0.464
Plasmodium falciparum	transporter, putative	0.0034	0.0311	0.7789
Leishmania major	hypothetical protein, conserved	0.0035	0.0335	0.0331
Brugia malayi	beta-lactamase family protein	0.0035	0.0335	0.0335
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.039	1
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.039	0.0057
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0174	0.2916	0.2893
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1847	0.182
Schistosoma mansoni	tar DNA-binding protein	0.0267	0.4658	0.4517
Trypanosoma brucei	RNA helicase, putative	0.0125	0.2008	0.3333
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	0.0142
Brugia malayi	beta-lactamase	0.0035	0.0335	0.0335
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0045	0.0525	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0335	0.0303
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1847	0.182
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0335	0.0335
Leishmania major	mitochondrial DNA polymerase beta	0.0322	0.5675	1
Schistosoma mansoni	tar DNA-binding protein	0.0267	0.4658	0.4517
Onchocerca volvulus		0.0034	0.0311	0.0388
Schistosoma mansoni	tar DNA-binding protein	0.0267	0.4658	0.4517
Schistosoma mansoni	tar DNA-binding protein	0.0267	0.4658	0.4517
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0311	0.0279
Loa Loa (eye worm)	glutaminase	0.0554	1	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0152	0.0119
Echinococcus multilocularis	serotonin transporter	0.0034	0.0311	0.0091
Schistosoma mansoni	hypothetical protein	0.0033	0.03	0.0043
Schistosoma mansoni	sodium/chloride dependent transporter	0.0174	0.2916	0.2729
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0152	0.0152
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0105	0.1635	0.1635
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0152	0.0119
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0038	0.0396	0.0402
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.0525	0.0636
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0335	0.0131
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0175	0.3961
Brugia malayi	hypothetical protein	0.0034	0.0311	0.0311
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0152	0.036
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0038	0.039	0.0392
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0322	0.5675	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0034	0.0311	0.2883
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0034	0.0311	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0311	0.0279
Schistosoma mansoni	ap endonuclease	0.0038	0.039	0.0136
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0045	0.0525	0.0636
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0335	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0034	0.0311	0.0311
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0335	1
Brugia malayi	MH2 domain containing protein	0.0116	0.1847	0.1847
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0335	0.0079
Echinococcus granulosus	tar DNA binding protein	0.0267	0.4658	0.7506
Loa Loa (eye worm)	hypothetical protein	0.0174	0.2916	0.2893
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0311	0.0279
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0105	0.1635	0.1607
Echinococcus multilocularis	geminin	0.0346	0.6127	1
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0038	0.0396	0.0402
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.03	0.0267
Trichomonas vaginalis	glutaminase, putative	0.0554	1	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0034	0.0311	0.0055
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0311	0.7789
Mycobacterium ulcerans	lipase LipD	0.0035	0.0335	0.0303
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0335	0.0079
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0174	0.2916	0.4529
Mycobacterium ulcerans	glutaminase	0.0554	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0152	0.0119
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.03	0.03
Toxoplasma gondii	hypothetical protein	0.0034	0.0311	0.2883
Brugia malayi	RNA binding protein	0.0267	0.4658	0.4658
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0038	0.0396	0.0063
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0034	0.0311	0.0091
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0038	0.0396	0.0441
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0034	0.0311	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1635	0.1607
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0152	0.2518	0.4284
Loa Loa (eye worm)	RNA binding protein	0.0267	0.4658	0.464
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0335	0.0303
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0152	0.2518	0.4261
Loa Loa (eye worm)	hypothetical protein	0.0033	0.03	0.0267
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0034	0.0311	0.0279
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0335	0.0303
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0038	0.0396	1
Plasmodium falciparum	amino acid transporter, putative	0.0034	0.0311	0.7789
Echinococcus granulosus	sodium and chloride dependent glycine	0.0174	0.2916	0.4549
Toxoplasma gondii	hypothetical protein	0.0052	0.0649	1
Brugia malayi	glutaminase DH11.1	0.0554	1	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.03	0.0071
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0335	0.0303
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0335	0.0835
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.03	0.0107
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.0525	0.0636
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0034	0.0311	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0034	0.0311	0.0311
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0388	0.0222
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.039	0.0358
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.03	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0311	0.0279
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0335	0.8452
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0034	0.0311	0.0279
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0034	0.0311	0.0055
Loa Loa (eye worm)	cytochrome P450 family protein	0.0048	0.0567	0.0535
Mycobacterium tuberculosis	Conserved hypothetical protein	0.017	0.2839	0.7355
Loa Loa (eye worm)	serotonin transporter b	0.0034	0.0311	0.0279
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0322	0.5675	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.1017	0.1017
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0038	0.0396	0.0396
Echinococcus granulosus	serotonin transporter	0.0034	0.0311	0.0126
Brugia malayi	TAR-binding protein	0.0267	0.4658	0.4658
Schistosoma mansoni	sodium/chloride dependent transporter	0.0034	0.0311	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0311	0.0279
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0034	0.0311	0.2883
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0335	0.0303
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0335	0.0835
Brugia malayi	Pre-SET motif family protein	0.0216	0.3699	0.3699
Echinococcus multilocularis	GPCR, family 2	0.0033	0.03	0.0071
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0038	0.039	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0152	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0152	0.0119
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0038	0.0396	0.0063

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4 uM	Inhibition of HIV1 integrase strand transfer activity in presence of magnesium	ChEMBL.	19364649
IC50 (binding)	= 34 uM	Inhibition of HIV1 integrase 3'-processing activity in presence of magnesium	ChEMBL.	19364649

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL550978

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1049891