Detailed information for compound 104993

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 480.614 | Formula: C29H37FN2O3
  • H donors: 1 H acceptors: 1 LogP: 4.86 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)CN1CCC2=C(C1)c1c(OC)cc(cc1OC2(C)C)C(CCCc1ccc(cc1)F)C
  • InChi: 1S/C29H37FN2O3/c1-19(7-6-8-20-9-11-22(30)12-10-20)21-15-25(34-5)28-23-17-32(18-27(33)31-4)14-13-24(23)29(2,3)35-26(28)16-21/h9-12,15-16,19H,6-8,13-14,17-18H2,1-5H3,(H,31,33)
  • InChiKey: JYRSFOWXFFRZNP-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Platelet activating factor receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni neuropeptide F-like receptor Platelet activating factor receptor   342 aa 325 aa 22.2 %
Echinococcus granulosus g-protein coupled receptor Platelet activating factor receptor   342 aa 352 aa 22.2 %
Schistosoma mansoni peptide (allatostatin)-like receptor Platelet activating factor receptor   342 aa 344 aa 25.6 %
Echinococcus multilocularis neuropeptide receptor Platelet activating factor receptor   342 aa 303 aa 23.1 %
Schistosoma mansoni neuropeptide receptor Platelet activating factor receptor   342 aa 292 aa 20.5 %
Echinococcus multilocularis g-protein coupled receptor Platelet activating factor receptor   342 aa 351 aa 22.5 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Platelet activating factor receptor   342 aa 340 aa 23.8 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 320 aa 24.7 %
Echinococcus granulosus neuropeptide receptor Platelet activating factor receptor   342 aa 304 aa 23.4 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 295 aa 21.7 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Platelet activating factor receptor   342 aa 283 aa 20.5 %
Onchocerca volvulus Cyclin-dependent kinase 20 homolog Platelet activating factor receptor   342 aa 383 aa 23.8 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 327 aa 21.7 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 319 aa 21.6 %
Schistosoma mansoni opsin-like receptor Platelet activating factor receptor   342 aa 318 aa 21.7 %
Echinococcus granulosus allatostatin A receptor Platelet activating factor receptor   342 aa 334 aa 22.8 %
Echinococcus granulosus rhodopsin orphan GPCR Platelet activating factor receptor   342 aa 278 aa 16.5 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 342 aa 19.6 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 300 aa 21.0 %
Schistosoma mansoni neuropeptide receptor Platelet activating factor receptor   342 aa 338 aa 24.9 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 321 aa 19.6 %
Echinococcus multilocularis rhodopsin orphan GPCR Platelet activating factor receptor   342 aa 278 aa 16.5 %
Echinococcus granulosus tachykinin peptides receptor 99D Platelet activating factor receptor   342 aa 314 aa 21.3 %
Echinococcus multilocularis allatostatin A receptor Platelet activating factor receptor   342 aa 334 aa 23.4 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 394 aa 20.3 %
Loa Loa (eye worm) hypothetical protein Platelet activating factor receptor   342 aa 355 aa 22.5 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0037 0.0048
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0065 0.0191 0.0637
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0065 0.0191 1
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0543 0.2712 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1383 0.7139 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0178 0.0675
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0191 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.053 0.2647 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0065 0.0191 0.5117
Plasmodium falciparum glutathione reductase 0.0095 0.0351 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0065 0.0191 1
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0191 0.5117
Loa Loa (eye worm) hypothetical protein 0.0066 0.0197 0.0649
Entamoeba histolytica hypothetical protein 0.0035 0.0037 0.6176
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.1113 0.4145
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0178 0.0588
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.1082
Trypanosoma brucei hypothetical protein, conserved 0.0065 0.0191 0.5117
Brugia malayi MH2 domain containing protein 0.0239 0.1113 0.477
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0059 0.0035
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0059 0.0124
Schistosoma mansoni DNA polymerase eta 0.0066 0.0197 0.066
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0059 0.0135
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0065 0.0191 0.0637
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0065 0.0191 0.0637
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0065 0.0191 0.0637
Brugia malayi glutathione reductase 0.0095 0.0351 0.1431
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0065 0.0191 0.5117
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0108 0.037
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0059 1
Leishmania major hypothetical protein, conserved 0.0065 0.0191 0.5117
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.1082
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0065 0.0191 0.0637
Mycobacterium tuberculosis Probable oxidoreductase 0.024 0.1118 0.1538
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Mycobacterium tuberculosis Probable dehydrogenase 0.0216 0.0991 0.1359
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0178 0.0588
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.1082
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.0351 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0065 0.0191 0.5117
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0065 0.0191 0.0732
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0065 0.0191 0.5117
Loa Loa (eye worm) hypothetical protein 0.0065 0.0191 0.0627
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 1
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0543 0.2712 0.2799
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.053 0.2647 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0065 0.0191 0.0637
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.024 0.1118 0.1538
Loa Loa (eye worm) RNA binding protein 0.0062 0.0178 0.0577
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0178 0.0588
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0065 0.0191 0.5117
Plasmodium falciparum phosphodiesterase delta, putative 0.0065 0.0191 0.5117
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0065 0.0191 0.0627
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0059 0.0155
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 0.5117
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Schistosoma mansoni hypothetical protein 0.0033 0.0027 0.0011
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 1
Plasmodium vivax glutathione reductase, putative 0.0095 0.0351 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Trichomonas vaginalis MYB, putative 0.0028 0.0001 0.0037
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0065 0.0191 0.0637
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0027 0.0013
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0178 0.0577
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0178 0.0577
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 0.5117
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0178 0.0588
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.1082
Echinococcus granulosus dna polymerase eta 0.0066 0.0197 0.066
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0059 0.1082
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0065 0.0191 0.0637
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.053 0.2647 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0053 0.0193
Brugia malayi hypothetical protein 0.0035 0.0037 0.0056
Trypanosoma brucei DNA polymerase eta, putative 0.0066 0.0197 0.5296
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0065 0.0191 0.0732
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0065 0.0191 0.5117
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0053 0.0893
Loa Loa (eye worm) glutathione reductase 0.0095 0.0351 0.1236
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0178 0.0588
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0059 0.1082
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.053 0.2647 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0065 0.0191 0.5117
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0466 0.2306 0.8702
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0065 0.0191 0.0732
Schistosoma mansoni hypothetical protein 0.034 0.1642 0.6169
Echinococcus granulosus dna polymerase kappa 0.004 0.0059 0.0135
Echinococcus granulosus tar DNA binding protein 0.0062 0.0178 0.0588
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0065 0.0191 0.5117
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 0.5117
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0065 0.0191 0.5117
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0059 0.0135
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Schistosoma mansoni hypothetical protein 0.0035 0.0037 0.0048
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0543 0.2712 0.2694
Leishmania major hypothetical protein, conserved 0.0065 0.0191 0.5117
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0466 0.2306 0.8701
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0065 0.0191 0.0637
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0065 0.0191 0.0637
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0059 0.3101
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0065 0.0191 0.0732
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.053 0.2647 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Loa Loa (eye worm) PDE1B protein 0.0065 0.0191 0.0627
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0059 0.1082
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 0.5117
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 1
Echinococcus granulosus geminin 0.034 0.1642 0.6169
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0065 0.0191 0.5117
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1925 1 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.0351 0.0459
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0178 0.0588
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.1113 0.4145
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0108 0.0311
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0065 0.0191 0.5117
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.0351 0.1236
Mycobacterium tuberculosis Probable reductase 0.0216 0.0991 0.1359
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0065 0.0191 0.0637
Leishmania major trypanothione reductase 0.0095 0.0351 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0065 0.0191 0.0637
Leishmania major DNA polymerase kappa, putative 0.004 0.0059 0.1082
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0037 0.0048
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0065 0.0191 0.5117
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0543 0.2712 0.2694
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0191 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Loa Loa (eye worm) hypothetical protein 0.053 0.2647 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0065 0.0191 0.0637
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1383 0.7139 1
Echinococcus multilocularis geminin 0.034 0.1642 0.6169
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0059 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0059 0.1082
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 1
Echinococcus multilocularis dna polymerase eta 0.0066 0.0197 0.066
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0065 0.0191 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0065 0.0191 0.0732
Leishmania major DNA polymerase eta, putative 0.0038 0.0053 0.0893
Plasmodium falciparum thioredoxin reductase 0.0095 0.0351 1
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0059 0.0035
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0024 0.0088
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.024 0.1118 0.1538
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0065 0.0191 0.0637
Brugia malayi TAR-binding protein 0.0062 0.0178 0.0675
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0065 0.0191 0.5117
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.0197 0.0758
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0191 0.5117
Plasmodium vivax phosphodiesterase gamma, putative 0.0065 0.0191 0.5117
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.053 0.2647 0.976
Entamoeba histolytica hypothetical protein 0.0035 0.0037 0.6176
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0216 0.0991 0.1359
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0059 0.005
Giardia lamblia hypothetical protein 0.0065 0.0191 0.0719
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0024 0.1251
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1925 1 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1925 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0216 0.0991 0.1359
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0065 0.0191 0.0637
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0024 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.0351 0.1245
Loa Loa (eye worm) hypothetical protein 0.0065 0.0191 0.0627
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0065 0.0191 0.0637
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0065 0.0191 0.0637
Trypanosoma cruzi DNA polymerase eta, putative 0.0066 0.0197 0.5296
Leishmania major DNA polymerase eta, putative 0.0066 0.0197 0.5296
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0065 0.0191 0.0637
Entamoeba histolytica hypothetical protein 0.0035 0.0037 0.6176
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0065 0.0191 0.0732
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.0351 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0065 0.0191 0.0637
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0191 0.0627
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0191 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0037 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0191 0.5117
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0059 0.005
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0059 0.0135
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0065 0.0191 0.0637
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Leishmania major cAMP-specific phosphodiesterase, putative 0.0065 0.0191 0.5117
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 0.5117
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0216 0.0991 0.1359
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0108 0.0311
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0065 0.0191 0.5117
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0065 0.0191 0.0637
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0108 0.037
Toxoplasma gondii thioredoxin reductase 0.0095 0.0351 0.129
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Giardia lamblia DINP protein human, muc B family 0.004 0.0059 0.0221
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0001 0.0037
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0466 0.2306 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 0.5117
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.0351 0.1245
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0024 0.1251
Echinococcus multilocularis dna polymerase kappa 0.004 0.0059 0.0135
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0024 0.0086
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0216 0.0991 0.1359
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0191 0.5117
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0065 0.0191 0.5117
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0191 0.0702
Trypanosoma brucei trypanothione reductase 0.0095 0.0351 1
Giardia lamblia Hypothetical protein 0.0065 0.0191 0.0719
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0059 0.3101
Brugia malayi Thioredoxin reductase 0.0095 0.0351 0.1431
Brugia malayi RNA binding protein 0.0062 0.0178 0.0675
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0191 0.5117
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0191 0.5117
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0191 0.5117
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.024 0.1118 0.0207
Schistosoma mansoni hypothetical protein 0.034 0.1642 0.6169
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0065 0.0191 0.5117
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Entamoeba histolytica hypothetical protein 0.0035 0.0037 0.6176
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0001 0.0037
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0466 0.2306 0.8702
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0191 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0065 0.0191 0.0637
Trypanosoma brucei unspecified product 0.004 0.0059 0.1082
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.053 0.2647 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 142 nM In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes ChEMBL. 1317924
Ki (binding) = 142 nM In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes ChEMBL. 1317924

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.