Detailed information for compound 1049943

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 353.445 | Formula: C17H19N7S
  • H donors: 2 H acceptors: 4 LogP: 3.69 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1cnc2c1nc(Nc1ccc3c(c1)scn3)nc2NC(C)(C)C
  • InChi: 1S/C17H19N7S/c1-17(2,3)23-14-13-15(24(4)8-18-13)22-16(21-14)20-10-5-6-11-12(7-10)25-9-19-11/h5-9H,1-4H3,(H2,20,21,22,23)
  • InChiKey: ILWBVRYQNMSUSZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Uncoordinated protein 44 0.0046 0.052 0.0488
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0079 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0416 0.0383
Brugia malayi nuclear hormone receptor 0.004 0.0416 0.0383
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0113 0.0052
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0132 0.1892 0.5278
Echinococcus granulosus nuclear factor of activated T cells 5 0.0238 0.3577 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0173 0.0173
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.2212 0.6174
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0307 0.0835
Loa Loa (eye worm) acetylcholinesterase 1 0.0071 0.0916 0.0916
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0112 0.0112
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0416 0.0383
Echinococcus granulosus netrin receptor unc 5 0.0046 0.052 0.1433
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0508 0.1749
Loa Loa (eye worm) hypothetical protein 0.0033 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0079
Brugia malayi Carboxylesterase family protein 0.0071 0.0916 0.0885
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0132 0.1892 0.5278
Loa Loa (eye worm) intermediate filament protein 0.003 0.0256 0.0256
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0416 0.0416
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus granulosus Ankyrin 0.0047 0.0526 0.145
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0079
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0434 0.3329
Entamoeba histolytica hypothetical protein 0.0081 0.1079 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0173 0.4849
Brugia malayi tailless protein 0.0019 0.0079 0.0045
Loa Loa (eye worm) hypothetical protein 0.004 0.0416 0.0416
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0029 0.0237 0.0204
Echinococcus multilocularis serine protein kinase ATM 0.0029 0.0237 0.064
Schistosoma mansoni hypothetical protein 0.0081 0.1079 0.4082
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0079
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0287 0.0781
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0079 0.0198
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0307 0.0835
Echinococcus granulosus carboxylesterase 5A 0.0071 0.0916 0.2544
Echinococcus granulosus intermediate filament protein 0.003 0.0256 0.0692
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0079 0.0045
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0416 0.1142
Onchocerca volvulus 0.0073 0.0945 0.2222
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0079 0.0198
Loa Loa (eye worm) hypothetical protein 0.004 0.0416 0.0416
Loa Loa (eye worm) hypothetical protein 0.0071 0.0916 0.0916
Brugia malayi nuclear hormone receptor 0.0019 0.0079 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0416 0.0383
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0508 0.1399
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0416 0.0416
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0416 0.0383
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0079 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0416 0.0383
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0416 0.1375
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0079 0.0045
Schistosoma mansoni ankyrin 23/unc44 0.0046 0.052 0.1799
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0079 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0416 0.0383
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0416 0.1142
Brugia malayi Cytochrome P450 family protein 0.0028 0.022 0.0187
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0009
Brugia malayi nuclear receptor NHR-67 0.0019 0.0079 0.0045
Schistosoma mansoni coup transcription factor 0.004 0.0416 0.1375
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0079 0.0045
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.009 0.1224 0.1224
Brugia malayi nuclear receptor RXR 0.0019 0.0079 0.0045
Brugia malayi Protein kinase domain containing protein 0.0046 0.052 0.0488
Echinococcus granulosus acetylcholinesterase 0.0071 0.0916 0.2544
Loa Loa (eye worm) hypothetical protein 0.004 0.0416 0.0416
Echinococcus multilocularis jun protein 0.0093 0.1265 0.352
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0416 0.1142
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0115 0.0082
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.2212 0.2185
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0416 0.0864
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0115 0.0147
Onchocerca volvulus 0.0263 0.3977 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0508 0.1399
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0416 0.1142
Brugia malayi hypothetical protein 0.0021 0.0115 0.0082
Schistosoma mansoni hypothetical protein 0.0132 0.1892 0.7397
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0079 0.0198
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0494 0.0989
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0237 0.0323
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0416 0.1142
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0021 0.0112 0.029
Echinococcus granulosus acetylcholinesterase 0.0071 0.0916 0.2544
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0508 0.1749
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0079
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0416 0.1142
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0434 0.5
Brugia malayi nuclear receptor RXR 0.0021 0.0115 0.0082
Onchocerca volvulus 0.004 0.0416 0.0864
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0416 0.0864
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0021 0.0112 0.029
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0416 0.1142
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0416 0.1375
Brugia malayi Death domain containing protein 0.0046 0.052 0.0488
Schistosoma mansoni intermediate filament proteins 0.003 0.0256 0.072
Loa Loa (eye worm) hypothetical protein 0.0047 0.0526 0.0526
Echinococcus multilocularis netrin receptor unc 5 0.0046 0.052 0.1433
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0416 0.1375
Brugia malayi conserved hypotetical protein 0.0019 0.0079 0.0045
Schistosoma mansoni thyroid hormone receptor 0.0172 0.253 1
Loa Loa (eye worm) carboxylesterase 0.0071 0.0916 0.0916
Echinococcus multilocularis acetylcholinesterase 0.0071 0.0916 0.2544
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0021 0.0112 0.0135
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0046 0.052 0.1433
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0416 0.1142
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0508 0.0508
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0079 0.0198
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0079
Echinococcus multilocularis lamin dm0 0.003 0.0256 0.0692
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0416 0.0383
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0029 0.0237 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0416 0.1375
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0416 0.0864
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0416 0.0416
Schistosoma mansoni thyroid hormone receptor 0.0172 0.253 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0021 0.0112 0.029
Schistosoma mansoni netrin receptor unc5 0.0046 0.052 0.1798
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0034 0.0034
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0494 0.0989
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0494 0.136
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0416 0.1375
Brugia malayi nuclear receptor NHR-88 0.004 0.0416 0.0383
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0416 0.1142
Schistosoma mansoni transcription factor LCR-F1 0.0081 0.1079 0.4082
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0416 0.0383
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0021 0.0112 0.0135
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0079 0.0198
Brugia malayi hypothetical protein 0.0073 0.0945 0.0914
Entamoeba histolytica hypothetical protein 0.0081 0.1079 1
Brugia malayi steroid hormone receptor 0.004 0.0416 0.0383
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0494 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0416 0.0416
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0416 0.0383
Trichomonas vaginalis set domain proteins, putative 0.0262 0.397 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0256 0.0256
Onchocerca volvulus Netrin receptor homolog 0.0046 0.052 0.1131
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0256 0.0256
Onchocerca volvulus 0.003 0.0256 0.0453
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0029 0.0237 0.0644
Echinococcus granulosus lamin 0.003 0.0256 0.0692
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0307 0.0928
Brugia malayi intermediate filament protein 0.003 0.0256 0.0222
Toxoplasma gondii FATC domain-containing protein 0.0029 0.0237 0.3269
Loa Loa (eye worm) acetyltransferase 0.0152 0.2212 0.2212
Echinococcus multilocularis Ankyrin 0.0047 0.0526 0.145
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0508 0.0475
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.3461 0.3461
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0115 0.0299
Entamoeba histolytica hypothetical protein 0.0029 0.0237 0.129
Schistosoma mansoni nuclear hormone receptor 0.004 0.0416 0.1375
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0093 0.1265 0.352
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0079 0.0045
Onchocerca volvulus 0.0033 0.0307 0.0584
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0081 0.1079 0.3001
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.2212 0.8702
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0307 0.5092
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.022 0.022
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0046 0.052 0.1433
Brugia malayi Pre-SET motif family protein 0.0033 0.0307 0.0274
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0416 0.1142
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0079 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0416 0.0383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0416 0.0416
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0416 0.1142
Brugia malayi hypothetical protein 0.0019 0.0079 0.0045
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0115 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0416 0.0383
Brugia malayi hypothetical protein 0.0081 0.1079 0.1049
Brugia malayi ecdysteroid receptor 0.004 0.0416 0.0383
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0416 0.0383
Echinococcus granulosus serine protein kinase ATM 0.0029 0.0237 0.064
Brugia malayi bZIP transcription factor family protein 0.0093 0.1265 0.1235
Brugia malayi hypothetical protein 0.0019 0.0079 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.004 0.0416 0.0416
Loa Loa (eye worm) hypothetical protein 0.0639 1 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0115 0.0299
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0079 0.0045
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0093 0.1265 0.352
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0416 0.1375
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0416 0.1142
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0029 0.0237 1
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0079 0.0079
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0416 0.1375
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0416 0.1142
Schistosoma mansoni hypothetical protein 0.0076 0.0986 0.3701
Schistosoma mansoni lamin 0.003 0.0256 0.072
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0021 0.0112 0.029
Brugia malayi nuclear receptor NHR-88 0.0019 0.0079 0.0045
Loa Loa (eye worm) DR-78 0.0019 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0029 0.0247 0.0247
Entamoeba histolytica hypothetical protein 0.0081 0.1079 1
Echinococcus multilocularis lamin 0.003 0.0256 0.0692
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0416 0.0416
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0508 0.1399
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.052 0.0488
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0079 0.0045
Loa Loa (eye worm) hypothetical protein 0.004 0.0416 0.0416
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0256 0.0222
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0047 0.0526 0.1824
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0112 0.0112
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0079 0.0198
Brugia malayi Carboxylesterase family protein 0.0071 0.0916 0.0885
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0416 0.1142
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0307 0.0928
Entamoeba histolytica hypothetical protein 0.0081 0.1079 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0115 0.0082
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0046 0.052 0.052
Echinococcus granulosus death domain containing protein 0.0046 0.052 0.1433
Echinococcus multilocularis thyroid hormone receptor alpha 0.0172 0.253 0.7065
Echinococcus multilocularis musashi 0.003 0.0256 0.0692
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0079
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0494 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0416 0.1375
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0112 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0307 0.0928
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.0916 0.3416
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0416 0.1142
Loa Loa (eye worm) hypothetical protein 0.0046 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0079
Echinococcus granulosus jun protein 0.0093 0.1265 0.352
Brugia malayi Pre-SET motif family protein 0.023 0.3461 0.3439
Brugia malayi hypothetical protein 0.0021 0.0115 0.0082
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0307 0.0835
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0416 0.0383
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0079 0.0198
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0416 0.0383
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0416 0.1375
Echinococcus granulosus lamin dm0 0.003 0.0256 0.0692
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0416 0.0416
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.2143 0.5983
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0307 0.0928
Schistosoma mansoni lamin 0.003 0.0256 0.072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0508 0.1749
Onchocerca volvulus 0.003 0.0256 0.0453
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0508 0.1399
Echinococcus granulosus FTZ F1 alpha 0.004 0.0416 0.1142
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0416 0.0383
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0434 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0416 0.0416
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0113 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0079 0.0079
Brugia malayi ecdysone receptor 0.0019 0.0079 0.0045
Loa Loa (eye worm) hypothetical protein 0.0071 0.0916 0.0916
Loa Loa (eye worm) hypothetical protein 0.004 0.0416 0.0416
Schistosoma mansoni jun-related protein 0.0076 0.0986 0.3701
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0115 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0416 0.0416
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0079 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0416 0.0383
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0112 0.0079
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0238 0.3577 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0079 0.0079
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0494 1
Echinococcus multilocularis acetylcholinesterase 0.0071 0.0916 0.2544
Schistosoma mansoni hypothetical protein 0.0046 0.052 0.1798
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0416 0.1142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.004 0.0416 0.0416
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0081 0.1079 0.3001
Echinococcus multilocularis carboxylesterase 5A 0.0071 0.0916 0.2544

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 7 % Inhibition of ATPase activity of human topoisomerase 2 alpha at 10 uM ChEMBL. 19560355

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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