Detailed information for compound 104996

Basic information

Technical information
  • TDR Targets ID: 104996
  • Name: tert-butyl N-[(2S,3R,4R)-4-[(4-ethoxyphenyl)m ethylamino]-3-hydroxy-5-[[(2R)-2-hydroxy-2,3- dihydro-1H-inden-1-yl]amino]-5-oxo-1-phenylpe ntan-2-yl]carbamate
  • MW: 589.722 | Formula: C34H43N3O6
  • H donors: 5 H acceptors: 4 LogP: 4.61 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOc1ccc(cc1)CN[C@H]([C@@H]([C@@H](NC(=O)OC(C)(C)C)Cc1ccccc1)O)C(=O)NC1[C@H](O)Cc2c1cccc2
  • InChi: 1S/C34H43N3O6/c1-5-42-25-17-15-23(16-18-25)21-35-30(32(40)37-29-26-14-10-9-13-24(26)20-28(29)38)31(39)27(19-22-11-7-6-8-12-22)36-33(41)43-34(2,3)4/h6-18,27-31,35,38-39H,5,19-21H2,1-4H3,(H,36,41)(H,37,40)/t27-,28+,29?,30+,31+/m0/s1
  • InChiKey: QLWYZVLNCWQIIO-OIOORBEQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • tert-butyl N-[(1S,2R,3R)-1-benzyl-3-[(4-ethoxyphenyl)methylamino]-2-hydroxy-4-[[(2R)-2-hydroxyindan-1-yl]amino]-4-oxo-butyl]carbamate
  • N-[(1S,2R,3R)-1-benzyl-3-[(4-ethoxyphenyl)methylamino]-2-hydroxy-4-[[(2R)-2-hydroxy-1-indanyl]amino]-4-oxobutyl]carbamic acid tert-butyl ester
  • tert-butyl N-[(2S,3R,4R)-4-[(4-ethoxyphenyl)methylamino]-3-hydroxy-5-[[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxo-1-phenyl-pentan-2-yl]carbamate
  • N-[(1S,2R,3R)-1-benzyl-3-[(4-ethoxybenzyl)amino]-2-hydroxy-4-[[(2R)-2-hydroxyindan-1-yl]amino]-4-keto-butyl]carbamic acid tert-butyl ester
  • tert-butyl N-[(1S,2R,3R)-3-[(4-ethoxyphenyl)methylamino]-2-hydroxy-4-[[(2R)-2-hydroxyindan-1-yl]amino]-4-oxo-1-(phenylmethyl)butyl]carbamate
  • N-[(1S,2R,3R)-3-[(4-ethoxyphenyl)methylamino]-2-hydroxy-4-[[(2R)-2-hydroxy-1-indanyl]amino]-4-oxo-1-(phenylmethyl)butyl]carbamic acid tert-butyl ester
  • N-[(1S,2R,3R)-1-(benzyl)-3-[(4-ethoxybenzyl)amino]-2-hydroxy-4-[[(2R)-2-hydroxyindan-1-yl]amino]-4-keto-butyl]carbamic acid tert-butyl ester
  • [(1S,2S,3R)-1-Benzyl-3-(4-ethoxy-benzylamino)-2-hydroxy-3-((R)-2-hydroxy-indan-1-ylcarbamoyl)-propyl]-carbamic acid tert-butyl ester
  • AIDS-032576
  • AIDS032576

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0048 0.0102 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0102 0.0303
Onchocerca volvulus 0.0048 0.0102 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Brugia malayi Dopamine receptor protein 1 0.0048 0.0102 0.0348
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0102 0.01
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0048 0.0102 0.0303
Onchocerca volvulus 0.0048 0.0102 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0102 0.01
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0023 0.0086
Schistosoma mansoni neuropeptide receptor 0.0048 0.0102 0.01
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.0102 0.0303
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0525 0.2617 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0525 0.2617 0.9652
Brugia malayi TAR-binding protein 0.0062 0.0177 0.0683
Echinococcus granulosus neuropeptide receptor 0.0048 0.0102 0.0303
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0187 0.5008
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0525 0.2617 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0187 0.5008
Brugia malayi hypothetical protein 0.0048 0.0102 0.0348
Plasmodium vivax glutathione reductase, putative 0.0095 0.035 1
Trypanosoma brucei hypothetical protein, conserved 0.0064 0.0187 0.5008
Onchocerca volvulus 0.0048 0.0102 0.5
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0064 0.0187 0.0208
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0059 0.0045
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0048 0.0102 0.0303
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0059 0.0035
Schistosoma mansoni myosin xvIII 0.0048 0.0102 0.01
Loa Loa (eye worm) PDE1B protein 0.0064 0.0187 0.062
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0023 0.0089
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0102 0.0292
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0102 0.01
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0102 0.01
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Giardia lamblia hypothetical protein 0.0064 0.0187 0.0714
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0187 0.5008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0036 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0177 0.0196
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.0196 0.0767
Onchocerca volvulus 0.0048 0.0102 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0048 0.0102 0.0348
Schistosoma mansoni adenoreceptor 0.0048 0.0102 0.01
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Mycobacterium tuberculosis Probable dehydrogenase 0.0216 0.099 0.1359
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Echinococcus granulosus dna polymerase kappa 0.004 0.0059 0.0136
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.1082
Echinococcus multilocularis g-protein coupled receptor 0.0048 0.0102 0.0303
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.0102 0.0303
Brugia malayi hypothetical protein 0.0048 0.0102 0.0348
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0048 0.0102 0.01
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0102 0.01
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0059 0.0136
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0216 0.099 0.1359
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Echinococcus granulosus serotonin receptor 0.0048 0.0102 0.0303
Echinococcus granulosus fmrfamide receptor 0.0048 0.0102 0.0303
Schistosoma mansoni biogenic amine receptor 0.0048 0.0102 0.01
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0048 0.0102 0.01
Brugia malayi hypothetical protein 0.0048 0.0102 0.0348
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0064 0.0187 0.0631
Loa Loa (eye worm) RNA binding protein 0.0062 0.0177 0.0584
Giardia lamblia DINP protein human, muc B family 0.004 0.0059 0.0224
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1925 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.035 0.1259
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 1
Brugia malayi Serotonin receptor 0.0048 0.0102 0.0348
Schistosoma mansoni growth hormone secretagogue receptor 0.0048 0.0102 0.01
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0064 0.0187 0.0208
Schistosoma mansoni neuropeptide receptor 0.0048 0.0102 0.01
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0525 0.2617 1
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0102 0.01
Brugia malayi hypothetical protein 0.0048 0.0102 0.0348
Schistosoma mansoni hypothetical protein 0.0033 0.0026 0.0004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Brugia malayi Tachykinin-like peptides receptor 99D 0.0048 0.0102 0.0348
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0102 0.0303
Brugia malayi G protein-coupled receptor 0.0048 0.0102 0.0348
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0177 0.0683
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0461 0.228 0.8702
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0023 0.0086
Brugia malayi hypothetical protein 0.0048 0.0102 0.0348
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Brugia malayi hypothetical protein 0.0048 0.0102 0.0348
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 1
Echinococcus granulosus dro:myosuppressin receptor 0.0048 0.0102 0.0303
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0543 0.2711 0.2799
Brugia malayi Dopamine receptor protein 2 0.0048 0.0102 0.0348
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0177 0.0584
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.0102 0.0303
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Echinococcus multilocularis somatostatin receptor 0.0048 0.0102 0.0303
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0048 0.0102 0.0303
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0048 0.0102 0.0303
Loa Loa (eye worm) melatonin receptor type 1A 0.0048 0.0102 0.0292
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0108 0.0315
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0048 0.0102 0.0303
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0048 0.0102 0.0303
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 0.5008
Brugia malayi hypothetical protein 0.0035 0.0036 0.0056
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0064 0.0187 0.0631
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0064 0.0187 0.0208
Echinococcus multilocularis fmrfamide receptor 0.0048 0.0102 0.0303
Leishmania major DNA polymerase eta, putative 0.0038 0.0052 0.0893
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0102 0.0303
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.035 0.0459
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0064 0.0187 0.5008
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0064 0.0187 0.0725
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0525 0.2617 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0102 0.01
Echinococcus granulosus geminin 0.034 0.1641 0.6239
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0059 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0187 0.5008
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0059 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0187 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1383 0.7139 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.035 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0525 0.2617 0.3291
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0064 0.0187 0.0631
Echinococcus granulosus somatostatin receptor 0.0048 0.0102 0.0303
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0064 0.0187 0.0208
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0064 0.0187 0.0631
Echinococcus granulosus g protein coupled receptor 0.0048 0.0102 0.0303
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.0102 0.0303
Loa Loa (eye worm) hypothetical protein 0.0064 0.0187 0.062
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0064 0.0187 0.0208
Trypanosoma brucei DNA polymerase eta, putative 0.0066 0.0196 0.5296
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 0.5008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0102 0.0303
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0064 0.0187 0.5008
Brugia malayi Serotonin receptor 0.0048 0.0102 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0187 0.5008
Echinococcus multilocularis serotonin receptor 0.0048 0.0102 0.0303
Leishmania major DNA polymerase kappa, putative 0.004 0.0059 0.1082
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0187 0.5008
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1925 1 1
Brugia malayi Melatonin receptor type 1A 0.0048 0.0102 0.0348
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0059 0.1082
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0059 0.1082
Echinococcus multilocularis G protein coupled receptor 139 0.0048 0.0102 0.0303
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.1314 0.1638
Brugia malayi hypothetical protein 0.0048 0.0102 0.0348
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.1112 0.4192
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0102 0.0303
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 0.5008
Giardia lamblia Hypothetical protein 0.0064 0.0187 0.0714
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0102 0.0303
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0064 0.0187 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0048 0.0102 0.01
Brugia malayi ORL1-like opioid receptor 0.0048 0.0102 0.0348
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0187 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.024 0.1117 0.1538
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0102 0.0303
Echinococcus granulosus 7tm_1 domain containing protein 0.0048 0.0102 0.0303
Schistosoma mansoni alpha-1 adrenergic receptor 0.0048 0.0102 0.01
Onchocerca volvulus 0.0048 0.0102 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0102 0.0303
Echinococcus multilocularis neuropeptide receptor 0.0048 0.0102 0.0303
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.0102 0.0303
Onchocerca volvulus 0.0048 0.0102 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Onchocerca volvulus 0.0048 0.0102 0.5
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1925 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0177 0.0196
Brugia malayi GnHR receptor homolog 0.0048 0.0102 0.0348
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0543 0.2711 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0048 0.0102 0.0303
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0102 0.0292
Loa Loa (eye worm) glutathione reductase 0.0095 0.035 0.125
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0187 0.5008
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0064 0.0187 0.0725
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0048 0.0102 0.0303
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0177 0.0196
Schistosoma mansoni opsin-like receptor 0.0048 0.0102 0.01
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0525 0.2617 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0064 0.0187 0.0631
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0102 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Brugia malayi neuropeptide F receptor 0.0048 0.0102 0.0348
Echinococcus multilocularis fmrfamide receptor 0.0048 0.0102 0.0303
Echinococcus granulosus g protein coupled receptor 0.0048 0.0102 0.0303
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0177 0.0196
Schistosoma mansoni hypothetical protein 0.034 0.1641 0.2053
Schistosoma mansoni hypothetical protein 0.0048 0.0102 0.01
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0064 0.0187 1
Brugia malayi Thioredoxin reductase 0.0095 0.035 0.1447
Echinococcus granulosus tar DNA binding protein 0.0062 0.0177 0.0594
Schistosoma mansoni neuropeptide receptor 0.0048 0.0102 0.01
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0064 0.0187 0.0631
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 0.5008
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 0.5008
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Brugia malayi G-protein coupled receptor 0.0048 0.0102 0.0348
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0108 0.0315
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0064 0.0187 0.0208
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0048 0.0102 0.0292
Toxoplasma gondii thioredoxin reductase 0.0095 0.035 0.129
Schistosoma mansoni amine GPCR 0.0048 0.0102 0.01
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0102 0.0303
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 0.5008
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Onchocerca volvulus 0.0048 0.0102 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0048 0.0102 0.0303
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0064 0.0187 0.0208
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0102 0.0303
Echinococcus granulosus allatostatin A receptor 0.0048 0.0102 0.0303
Brugia malayi Dopamine receptor 0.0048 0.0102 0.0348
Echinococcus multilocularis G-protein coupled receptor, putative 0.0048 0.0102 0.0303
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0048 0.0102 0.01
Loa Loa (eye worm) hypothetical protein 0.0064 0.0187 0.062
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0036 0.0049
Echinococcus granulosus hypothetical protein 0.0048 0.0102 0.0303
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0102 0.0292
Brugia malayi RE15519p 0.0048 0.0102 0.0348
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0048 0.0102 0.0303
Schistosoma mansoni DNA polymerase eta 0.0066 0.0196 0.022
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0059 0.0136
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0048 0.0102 0.0303
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0059 0.0035
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0064 0.0187 0.0208
Loa Loa (eye worm) TYRA-2 protein 0.0048 0.0102 0.0292
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0059 0.3134
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Brugia malayi hypothetical protein 0.0048 0.0102 0.0348
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0177 0.0594
Leishmania major hypothetical protein, conserved 0.0064 0.0187 0.5008
Plasmodium vivax phosphodiesterase gamma, putative 0.0064 0.0187 0.5008
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0102 0.01
Schistosoma mansoni hypothetical protein 0.034 0.1641 0.2053
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0102 0.0303
Schistosoma mansoni biogenic amine receptor 0.0048 0.0102 0.01
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Plasmodium falciparum glutathione reductase 0.0095 0.035 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0064 0.0187 0.5008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.0102 0.0303
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0064 0.0187 0.5008
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Schistosoma mansoni amine GPCR 0.0048 0.0102 0.01
Brugia malayi MH2 domain containing protein 0.0239 0.1112 0.4824
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0064 0.0187 0.5008
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0048 0.0102 0.0348
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1383 0.7139 1
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0187 0.5008
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0177 0.0584
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.035 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0059 0.0125
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.1082
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0196 0.0657
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.0102 0.0303
Echinococcus multilocularis neuropeptide receptor 0.0048 0.0102 0.0303
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0102 0.01
Leishmania major DNA polymerase eta, putative 0.0066 0.0196 0.5296
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0064 0.0187 0.5008
Onchocerca volvulus 0.0048 0.0102 0.5
Echinococcus multilocularis serotonin receptor 0.0048 0.0102 0.0303
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Schistosoma mansoni hypothetical protein 0.0048 0.0102 0.01
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0102 0.01
Onchocerca volvulus 0.0048 0.0102 0.5
Brugia malayi hypothetical protein 0.0048 0.0102 0.0348
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Echinococcus granulosus neuropeptide receptor A26 0.0048 0.0102 0.0303
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0064 0.0187 0.5008
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.0102 0.0303
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.035 0.125
Echinococcus multilocularis neuropeptide FF receptor 2 0.0048 0.0102 0.0303
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0064 0.0187 0.0631
Echinococcus granulosus neuropeptide s receptor 0.0048 0.0102 0.0303
Schistosoma mansoni neuropeptide receptor 0.0048 0.0102 0.01
Trypanosoma cruzi DNA polymerase eta, putative 0.0066 0.0196 0.5296
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0048 0.0102 0.0292
Brugia malayi hypothetical protein 0.0048 0.0102 0.0348
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0177 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Onchocerca volvulus 0.0048 0.0102 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Echinococcus multilocularis geminin 0.034 0.1641 0.6239
Trypanosoma brucei unspecified product 0.004 0.0059 0.1082
Schistosoma mansoni neuropeptide f receptor 76f 0.0048 0.0102 0.01
Brugia malayi putative neuropeptide receptor 0.0048 0.0102 0.0348
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0108 0.0374
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0064 0.0187 0.0725
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.0102 0.0303
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Loa Loa (eye worm) hypothetical protein 0.0525 0.2617 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.0102 0.0303
Echinococcus granulosus g-protein coupled receptor 0.0048 0.0102 0.0303
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Echinococcus multilocularis allatostatin A receptor 0.0048 0.0102 0.0303
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0048 0.0102 0.0292
Echinococcus granulosus sex peptide receptor 0.0048 0.0102 0.0303
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0216 0.099 0.1359
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0102 0.0303
Echinococcus multilocularis neuropeptide receptor A26 0.0048 0.0102 0.0303
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0048 0.0102 0.0292
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.035 0.1259
Echinococcus multilocularis orexin receptor type 2 0.0048 0.0102 0.0303
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0102 0.01
Leishmania major trypanothione reductase 0.0095 0.035 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0048 0.0102 0.0292
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0052 0.0193
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0048 0.0102 0.0303
Echinococcus granulosus 7TM GPCR rhodopsin 0.0048 0.0102 0.0303
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0048 0.0102 0.01
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0543 0.2711 0.2694
Leishmania major hypothetical protein, conserved 0.0064 0.0187 0.5008
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0064 0.0187 0.0631
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0102 0.0303
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0064 0.0187 0.0631
Plasmodium falciparum phosphodiesterase delta, putative 0.0064 0.0187 0.5008
Echinococcus multilocularis sex peptide receptor 0.0048 0.0102 0.0303
Echinococcus granulosus orexin receptor type 2 0.0048 0.0102 0.0303
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Brugia malayi follicle stimulating hormone receptor 0.0048 0.0102 0.0348
Schistosoma mansoni amine GPCR 0.0048 0.0102 0.01
Onchocerca volvulus 0.0048 0.0102 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0048 0.0102 0.0303
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0102 0.0303
Echinococcus multilocularis dna polymerase eta 0.0066 0.0196 0.0667
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0102 0.0303
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0052 0.0893
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Mycobacterium tuberculosis Probable oxidoreductase 0.024 0.1117 0.1538
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0048 0.0102 0.0303
Brugia malayi putative neuropeptide receptor NPR1 0.0048 0.0102 0.0348
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.0102 0.0303
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0064 0.0187 0.0631
Brugia malayi RNA binding protein 0.0062 0.0177 0.0683
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0048 0.0102 0.0348
Schistosoma mansoni histamine h1 receptor 0.0048 0.0102 0.01
Echinococcus granulosus G protein coupled receptor 139 0.0048 0.0102 0.0303
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.0102 0.0303
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0064 0.0187 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0064 0.0187 0.5008
Echinococcus multilocularis neuropeptide s receptor 0.0048 0.0102 0.0303
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0064 0.0187 0.0208
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0102 0.0303
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0102 0.01
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0216 0.099 0.1359
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.1112 0.4192
Loa Loa (eye worm) hypothetical protein 0.0064 0.0187 0.062
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 1
Onchocerca volvulus 0.0048 0.0102 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0048 0.0102 0.01
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.024 0.1117 0.1538
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0102 0.0303
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0064 0.0187 0.0208
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0102 0.0303
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0064 0.0187 0.0725
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Plasmodium falciparum phosphodiesterase gamma, putative 0.0064 0.0187 0.5008
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0064 0.0187 0.062
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0048 0.0102 0.01
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 1
Schistosoma mansoni amine GPCR 0.0048 0.0102 0.01
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0048 0.0102 0.0303
Schistosoma mansoni hypothetical protein 0.0048 0.0102 0.01
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0064 0.0187 0.5008
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Echinococcus granulosus neuropeptide FF receptor 2 0.0048 0.0102 0.0303
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0064 0.0187 0.5008
Schistosoma mansoni hypothetical protein 0.0035 0.0036 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0102 0.0303
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.0102 0.0303
Onchocerca volvulus 0.0048 0.0102 0.5
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0102 0.0303
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0187 1
Echinococcus multilocularis dna polymerase kappa 0.004 0.0059 0.0136
Brugia malayi larval opioid receptor 0.0048 0.0102 0.0348
Brugia malayi sulfakinin receptor protein 0.0048 0.0102 0.0348
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0102 0.0303
Schistosoma mansoni amine GPCR 0.0048 0.0102 0.01
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0461 0.228 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.1082
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0064 0.0187 0.0631
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0048 0.0102 0.0303
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0108 0.0374
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Schistosoma mansoni opsin-like receptor 0.0048 0.0102 0.01
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0102 0.01
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 1
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0461 0.228 0.87
Onchocerca volvulus Neuropeptide F receptor homolog 0.0048 0.0102 0.5
Schistosoma mansoni biogenic amine receptor 0.0048 0.0102 0.01
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0461 0.228 0.8702
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0059 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0048 0.0102 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Plasmodium falciparum thioredoxin reductase 0.0095 0.035 1
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0059 0.3134
Echinococcus granulosus g protein coupled receptor 0.0048 0.0102 0.0303
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0048 0.0102 0.0303
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0187 0.0689
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0064 0.0187 0.0725
Onchocerca volvulus 0.0048 0.0102 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0102 0.01
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0036 0.0016
Brugia malayi G-protein coupled receptor 0.0048 0.0102 0.0348
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0187 0.5008
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Schistosoma mansoni opsin-like receptor 0.0048 0.0102 0.01
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0023 0.1241
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0026 0.0013
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0187 0.5008
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0048 0.0102 0.01
Trypanosoma brucei trypanothione reductase 0.0095 0.035 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0102 0.01
Brugia malayi AKH receptor 0.0048 0.0102 0.0348
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.1082
Onchocerca volvulus 0.0048 0.0102 0.5
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0543 0.2711 0.2694
Echinococcus granulosus dna polymerase eta 0.0066 0.0196 0.0667
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0102 0.0303
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0059 0.0045
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.7904 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0048 0.0102 0.0348
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0102 0.0303
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0102 0.01
Brugia malayi glutathione reductase 0.0095 0.035 0.1447
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0048 0.0102 0.0348
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.024 0.1117 0.0207
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0023 0.1241
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0064 0.0187 0.5008
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0059 0.1082
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0064 0.0187 0.5008
Echinococcus granulosus neuropeptide receptor 0.0048 0.0102 0.0303
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0102 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0187 0.5008
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0064 0.0187 0.0725
Brugia malayi neuropeptide F receptor 0.0048 0.0102 0.0348
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0059 0.005
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Mycobacterium tuberculosis Probable reductase 0.0216 0.099 0.1359
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0187 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0292
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0216 0.099 0.1359
Schistosoma mansoni hypothetical protein 0.0048 0.0102 0.01
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0102 0.0303
Onchocerca volvulus 0.0048 0.0102 0.5
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0059 0.1082
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.0102 0.0303
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0102 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1082
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0064 0.0187 0.0631

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) d 0 nM Antiviral Activity of the compound against HIV-1, IIIB, in MT-4 Cells; d indicates no activity at 10 uM ChEMBL. 8642565
Ki (binding) = 92 nM Binding affinity against HIV-1 protease ChEMBL. 8642565
Ki (binding) = 92 nM Binding affinity against HIV-1 protease ChEMBL. 8642565

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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