Detailed information for compound 1050149

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 568.085 | Formula: C25H34ClN5O6S
  • H donors: 4 H acceptors: 5 LogP: 0.23 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(C[C@H]1ON([C@H](C1)c1ccc(cc1)C(=N)N)C(C)C)NC[C@@H](C(=O)O)NS(=O)(=O)c1cccc(c1)C.Cl
  • InChi: 1S/C25H33N5O6S.ClH/c1-15(2)30-22(17-7-9-18(10-8-17)24(26)27)12-19(36-30)13-23(31)28-14-21(25(32)33)29-37(34,35)20-6-4-5-16(3)11-20;/h4-11,15,19,21-22,29H,12-14H2,1-3H3,(H3,26,27)(H,28,31)(H,32,33);1H/t19-,21-,22+;/m0./s1
  • InChiKey: HRDJIFWLTVRIOM-PQYKPJTCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi diacylglycerol acyltransferase 0.0022 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.0071 0.0495 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.013 0.013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0073 0.0073
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0495 0.0495
Echinococcus multilocularis importin subunit beta 1 0.003 0.0081 0.0081
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0023 0.0462
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0142 0.2865
Echinococcus multilocularis lamin 0.0029 0.0073 0.0073
Echinococcus granulosus excitatory amino acid transporter 2 0.1008 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0495 0.0495
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0495 0.0051
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.004 0.0184 0.0184
Onchocerca volvulus 0.0071 0.0495 0.0492
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0495 0.0051
Onchocerca volvulus 0.0029 0.0073 0.007
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0073 0.0073
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1008 1 1
Mycobacterium tuberculosis Conserved protein 0.0071 0.0495 0.0051
Echinococcus multilocularis excitatory amino acid transporter 2 0.1008 1 1
Mycobacterium ulcerans hypothetical protein 0.0071 0.0495 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0495 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0454 0.4376 0.4113
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0022 0.0003 0.0003
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0003 0.0163
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1008 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0239 0.0239
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0022 0.0003 0.0003
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0184 0.3718
Schistosoma mansoni intermediate filament proteins 0.0029 0.0073 0.0073
Schistosoma mansoni alpha-glucosidase 0.014 0.1198 0.1198
Echinococcus multilocularis lamin dm0 0.0029 0.0073 0.0073
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0022 0.0003 0.0373
Brugia malayi MBOAT family protein 0.0022 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.0022 0.0003 0.0061
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0495 1
Echinococcus granulosus neutral amino acid transporter A 0.1008 1 1
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0022 0.0003 0.0003
Echinococcus granulosus lamin dm0 0.0029 0.0073 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0142 0.2865
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0022 0.0003 0.0003
Onchocerca volvulus 0.0094 0.0731 0.0728
Brugia malayi hypothetical protein 0.0035 0.013 0.013
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0022 0.0003 0.0061
Schistosoma mansoni hypothetical protein 0.0322 0.3039 0.3039
Leishmania major glycerol uptake protein, putative 0.0022 0.0003 0.0061
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0142 0.2865
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0081 0.163
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.013 0.013
Echinococcus granulosus muscleblind protein 0.0149 0.1291 0.1291
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1428 0.1428
Chlamydia trachomatis glutamate symporter 0.1008 1 1
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1008 1 0.5
Leishmania major importin beta-1 subunit, putative 0.0024 0.0023 0.0462
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0022 0.0003 0.0003
Trypanosoma cruzi GUP1, putative 0.0022 0.0003 0.0061
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1008 1 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0184 0.3718
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0495 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0003 0.0003
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0495 1
Loa Loa (eye worm) hypothetical protein 0.0258 0.2391 0.2391
Brugia malayi MH2 domain containing protein 0.0119 0.0986 0.0986
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0309 0.0309
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.013 0.013
Schistosoma mansoni zinc finger protein 0.0022 0.0003 0.0003
Echinococcus granulosus neutral amino acid transporter A 0.1008 1 1
Onchocerca volvulus 0.0053 0.0309 0.0306
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0447 0.0447
Leishmania major glycerol uptake protein, putative 0.0022 0.0003 0.0061
Echinococcus granulosus Excitatory amino acid transporter 0.1008 1 1
Echinococcus granulosus microtubule associated protein 2 0.0753 0.741 0.741
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0495 0.0051
Brugia malayi intermediate filament protein 0.0029 0.0073 0.0073
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0142 0.0142
Echinococcus granulosus excitatory amino acid transporter 2 0.1008 1 1
Echinococcus multilocularis muscleblind protein 0.0149 0.1291 0.1291
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.1428 0.1428
Echinococcus multilocularis neutral amino acid transporter A 0.1008 1 1
Brugia malayi beta-lactamase 0.0071 0.0495 0.0495
Toxoplasma gondii hypothetical protein 0.0022 0.0003 0.0061
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0142 0.2865
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0022 0.0003 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0495 1
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.7037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0003 0.0003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0495 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0003 0.0061
Echinococcus multilocularis sterol O acyltransferase 1 0.023 0.2109 0.2109
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0447 0.4307 0.4307
Trypanosoma brucei glycerol uptake protein, putative 0.0022 0.0003 0.0061
Echinococcus granulosus importin subunit beta 1 0.003 0.0081 0.0081
Mycobacterium tuberculosis Conserved protein 0.0071 0.0495 0.0051
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0022 0.0003 0.0003
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0003 0.0163
Schistosoma mansoni microtubule-associated protein tau 0.0753 0.741 0.741
Schistosoma mansoni lamin 0.0029 0.0073 0.0073
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0142 0.2865
Schistosoma mansoni sterol O-acyltransferase 1 0.023 0.2109 0.2109
Schistosoma mansoni alpha-glucosidase 0.014 0.1198 0.1198
Echinococcus granulosus lamin 0.0029 0.0073 0.0073
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0447 0.9022
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.1428 0.1428
Loa Loa (eye worm) hypothetical protein 0.0071 0.0495 0.0495
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0073 0.0073
Leishmania major glycerol uptake protein, putative 0.0022 0.0003 0.0061
Entamoeba histolytica hypothetical protein, conserved 0.0022 0.0003 0.0163
Loa Loa (eye worm) hypothetical protein 0.0029 0.0073 0.0073
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0184 0.0184
Echinococcus multilocularis Excitatory amino acid transporter 0.1008 1 1
Trypanosoma brucei glucosidase, putative 0.0036 0.0142 0.2865
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0495 0.0051
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0071 0.0495 0.0495
Echinococcus granulosus neutral amino acid transporter 0.1008 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0239 0.0239
Schistosoma mansoni importin beta-1 0.003 0.0081 0.0081
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0495 0.0051
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0184 0.0184
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0003 0.0163
Echinococcus granulosus sodium:dicarboxylate symporter 0.1008 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0986 0.0986
Loa Loa (eye worm) hypothetical protein 0.0071 0.0495 0.0495
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0495 0.0495
Echinococcus multilocularis neutral amino acid transporter A 0.1008 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0495 0.0495
Mycobacterium ulcerans beta-lactamase 0.0071 0.0495 1
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0495 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0142 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0184 0.3718
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0022 0.0003 0.0003
Trichomonas vaginalis porcupine, putative 0.0022 0.0003 0.0061
Echinococcus multilocularis excitatory amino acid transporter 3 0.1008 1 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0184 0.3718
Loa Loa (eye worm) hypothetical protein 0.0029 0.0068 0.0068
Treponema pallidum glutamate/aspartate transporter 0.0447 0.4307 1
Schistosoma mansoni hypothetical protein 0.0022 0.0003 0.0003
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0023 0.0462
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0003 0.0061
Loa Loa (eye worm) excitatory amino acid transporter 0.1008 1 1
Leishmania major glycerol uptake protein, putative 0.0022 0.0003 0.0061
Loa Loa (eye worm) hypothetical protein 0.0149 0.1291 0.1291
Treponema pallidum glutamate transporter 0.0447 0.4307 1
Trichomonas vaginalis esterase, putative 0.0071 0.0495 1
Echinococcus granulosus excitatory amino acid transporter 3 0.1008 1 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0142 0.2865
Mycobacterium ulcerans lipase LipD 0.0071 0.0495 1
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0022 0.0003 0.0003
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0322 0.3039 0.3039
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0447 0.9022
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0184 0.0184
Plasmodium vivax importin-beta 2, putative 0.003 0.0081 0.163
Brugia malayi beta-lactamase family protein 0.0071 0.0495 0.0495
Schistosoma mansoni lamin 0.0029 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0208 0.1881 0.1881
Brugia malayi Muscleblind-like protein 0.0149 0.1291 0.1291
Leishmania major glycerol uptake protein, putative 0.0022 0.0003 0.0061
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0447 0.4307 0.4307
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0495 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0142 0.2865
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0184 0.0184
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0184 0.0184
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0003 0.0003
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0003 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0495 1
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0022 0.0003 0.0061
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0022 0.0003 0.0061
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0142 0.7705
Echinococcus multilocularis musashi 0.0029 0.0073 0.0073
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0495 1
Onchocerca volvulus 0.0071 0.0495 0.0492
Brugia malayi beta-lactamase family protein 0.0071 0.0495 0.0495
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0184 0.3718
Schistosoma mansoni hypothetical protein 0.0053 0.0309 0.0309
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0495 0.0495
Echinococcus granulosus sterol O acyltransferase 1 0.023 0.2109 0.2109
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1428 0.1428
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0003 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0239 0.0239
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0022 0.0003 0.0003
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0447 0.4307 0.4307
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0003 0.0061
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0022 0.0003 0.0003
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1008 1 1
Trypanosoma brucei glycerol uptake protein, putative 0.0022 0.0003 0.0061
Brugia malayi MBOAT family protein 0.0022 0.0003 0.0003
Echinococcus granulosus survival motor neuron protein 1 0.0258 0.2391 0.2391
Onchocerca volvulus 0.0071 0.0495 0.0492
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0239 0.0239
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0142 0.2865
Brugia malayi follicle stimulating hormone receptor 0.0232 0.2125 0.2125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0239 0.0239
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0142 0.0142
Onchocerca volvulus 0.0029 0.0073 0.007
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0003 0.0003
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0184 0.3718
Brugia malayi MBOAT family protein 0.0022 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0149 0.1291 0.1291
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1291 0.1291
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0495 1
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0081 0.163
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0447 0.0447
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0239 0.0239
Echinococcus multilocularis excitatory amino acid transporter 2 0.1008 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0986 0.0986
Echinococcus multilocularis microtubule associated protein 2 0.0753 0.741 0.741
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0022 0.0003 0.0003
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0184 1
Entamoeba histolytica vacuolar protein sorting 26 0.0022 0.0003 0.0163
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0003 0.0003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0239 0.0239
Mycobacterium tuberculosis Conserved protein 0.0071 0.0495 0.0051
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0081 0.163
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.7037
Entamoeba histolytica hypothetical protein 0.0024 0.0023 0.1244
Toxoplasma gondii ABC1 family protein 0.0071 0.0495 1
Echinococcus multilocularis survival motor neuron protein 1 0.0258 0.2391 0.2391
Plasmodium falciparum importin beta, putative 0.003 0.0081 1
Trypanosoma cruzi GUP1, putative 0.0022 0.0003 0.0061
Trichomonas vaginalis transmembrane protein nessy, putative 0.0022 0.0003 0.0061
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0003 0.0003
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0184 0.3718
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0142 0.2865
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0003 0.0061
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0022 0.0003 0.0003
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0142 0.2865
Brugia malayi MBOAT family protein 0.0022 0.0003 0.0003
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0003 0.0003
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0022 0.0003 0.0003
Echinococcus multilocularis Excitatory amino acid transporter 0.1008 1 1
Mycobacterium leprae Probable lipase LipE 0.0071 0.0495 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0081
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0184 1
Schistosoma mansoni survival motor neuron protein 0.0053 0.0309 0.0309
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0239 0.0239
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0447 0.0447
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0142 0.2865
Loa Loa (eye worm) hypothetical protein 0.0071 0.0495 0.0495
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0003 0.0061
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0447 0.4307 0.4307
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.7037
Loa Loa (eye worm) hypothetical protein 0.0071 0.0495 0.0495
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0003 0.0003
Loa Loa (eye worm) beta-lactamase 0.0071 0.0495 0.0495
Echinococcus granulosus Excitatory amino acid transporter 0.1008 1 1
Brugia malayi MBOAT family protein 0.0022 0.0003 0.0003
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0184 0.0184
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.0022 0.0003 0.0003
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0023 0.0462
Loa Loa (eye worm) hypothetical protein 0.023 0.2109 0.2109
Brugia malayi Hhat protein 0.0022 0.0003 0.0003
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0184 0.0184
Brugia malayi RNA, U transporter 1 0.0086 0.0644 0.0644
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0142 0.2865
Echinococcus multilocularis neutral amino acid transporter A 0.1008 1 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0495 0.0051
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.1428 0.1428
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0022 0.0003 0.0003
Loa Loa (eye worm) hhat protein 0.0022 0.0003 0.0003
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1008 1 1
Brugia malayi hypothetical protein 0.0258 0.2391 0.2391
Echinococcus granulosus snurportin 1 0.0322 0.3039 0.3039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0239 0.0239
Schistosoma mansoni hypothetical protein 0.0035 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0071 0.0495 0.0495
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.7037
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0495 0.0051
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0142 0.0142
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0184 0.0184
Brugia malayi Importin beta-1 subunit 0.003 0.0081 0.0081
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0142 0.7705
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0184 0.0184
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0003 0.0003
Echinococcus granulosus intermediate filament protein 0.0029 0.0073 0.0073
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0142 0.2865
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0023 0.0462
Schistosoma mansoni alpha glucosidase 0.0036 0.0142 0.0142
Loa Loa (eye worm) hhat protein 0.0022 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0022 0.0003 0.0163
Echinococcus multilocularis snurportin 1 0.0322 0.3039 0.3039
Loa Loa (eye worm) hypothetical protein 0.0022 0.0003 0.0003
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.2125 0.2125
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0495 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.14 uM Compound was tested for its invitro activity in the inhibition of platelet aggregation using human platelet rich plasma ChEMBL. 9990456

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 9990456

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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