Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0022 | 0.0156 | 0.0156 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0022 | 0.0156 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0022 | 0.0156 | 0.2657 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0022 | 0.0156 | 0.0156 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.0156 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0022 | 0.0156 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0022 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0156 | 0.0156 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0022 | 0.0156 | 0.0156 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0022 | 0.0156 | 0.0156 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0022 | 0.0156 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0022 | 0.0156 | 0.0156 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0022 | 0.0156 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0022 | 0.0156 | 0.0156 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0022 | 0.0156 | 0.2657 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0022 | 0.0156 | 0.0156 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0022 | 0.0156 | 0.2657 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0156 | 0.0156 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.0156 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0022 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0022 | 0.0156 | 0.0156 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0022 | 0.0156 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0022 | 0.0156 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0.0156 | 0.2657 |
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0.0156 | 0.2657 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0022 | 0.0156 | 0.0156 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.0156 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0588 | 0.0588 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.0156 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0207 | 0.5768 | 0.5768 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0588 | 0.0588 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0022 | 0.0156 | 0.0156 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0022 | 0.0156 | 0.0156 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0022 | 0.0156 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0022 | 0.0156 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0022 | 0.0156 | 0.2657 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5768 | 0.5768 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0022 | 0.0156 | 0.0156 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0022 | 0.0156 | 0.0156 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0022 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0156 | 0.0156 |
Brugia malayi | nuclear receptor NHR-88 | 0.0022 | 0.0156 | 0.0156 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0022 | 0.0156 | 0.0156 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0022 | 0.0156 | 0.0156 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0337 | 0.9712 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0022 | 0.0156 | 0.2657 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0022 | 0.0156 | 0.0156 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.0156 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0022 | 0.0156 | 0.0156 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.0156 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0022 | 0.0156 | 0.2657 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0156 | 0.0156 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.0156 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0022 | 0.0156 | 0.2657 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0.0156 | 0.2657 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0156 | 0.0156 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0.0156 | 0.2657 |
Brugia malayi | steroid hormone receptor | 0.0022 | 0.0156 | 0.0156 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.0156 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0022 | 0.0156 | 0.0156 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0022 | 0.0156 | 0.2657 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.0156 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0022 | 0.0156 | 0.0156 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0022 | 0.0156 | 0.0156 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0588 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0022 | 0.0156 | 0.2657 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.0156 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0022 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1095 | 0.1095 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1095 | 0.1095 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1095 | 0.1095 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1095 | 0.1095 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0207 | 0.5768 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0022 | 0.0156 | 0.0156 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Agonist activity at human PPARdelta ligand binding domain (165-441) expressed in human HuH7 cells co-transfected with Gal4-DBD by luciferase transactivation assay | ChEMBL. | 19394832 | |
Activity (binding) | Agonist activity at human PPARalpha ligand binding domain (189-468) expressed in human HuH7 cells co-transfected with Gal4-DBD by luciferase transactivation assay | ChEMBL. | 19394832 | |
Activity (binding) | Agonist activity at human PPARgamma ligand binding domain (206-477) expressed in human HuH7 cells co-transfected with Gal4-DBD by luciferase transactivation assay | ChEMBL. | 19394832 | |
EC50 (functional) | = 0.068 uM | Induction of ABCA1 mRNA expression in mouse J774A1 cells after 18 hrs by RT-PCR | ChEMBL. | 19394832 |
EC50 (binding) | = 1.16 uM | Agonist activity at human LXRbeta ligand binding domain (219-462) expressed in human HuH7 cells co-transfected with Gal4-DBD by luciferase transactivation assay | ChEMBL. | 19394832 |
EC50 (binding) | = 8.32 uM | Agonist activity at human LXRalpha ligand binding domain (205-448) expressed in human HuH7 cells co-transfected with Gal4-DBD by luciferase transactivation assay | ChEMBL. | 19394832 |
Efficacy (binding) | = 23 % | Agonist activity at human LXRalpha ligand binding domain (205-448) expressed in human HuH7 cells co-transfected with Gal4-DBD by luciferase transactivation assay relative to TO901317 | ChEMBL. | 19394832 |
Efficacy (binding) | = 67 % | Agonist activity at human LXRbeta ligand binding domain (219-462) expressed in human HuH7 cells co-transfected with Gal4-DBD by luciferase transactivation assay relative to TO901317 | ChEMBL. | 19394832 |
Efficacy (functional) | = 109 % | Induction of ABCA1 mRNA expression in mouse J774A1 cells after 18 hrs by RT-PCR relative to TO901317 | ChEMBL. | 19394832 |
IC50 (binding) | = 14 uM | Displacement of [3H]T0901317 from human recombinant N-terminal biotinylated tagged LXRbeta ligand binding domain (154-461) expressed in Escherichia coli | ChEMBL. | 19394832 |
IC50 (binding) | > 1000 uM | Displacement of [3H]T0901317 from human recombinant N-terminal biotinylated tagged LXRalpha ligand binding domain (197-447) expressed in Escherichia coli | ChEMBL. | 19394832 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 19394832 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.