Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.003 | 0.001 |
Leishmania major | UDP-galactopyranose mutase | 0.0069 | 0.0586 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.037 | 0.0571 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0155 | 0.1475 | 0.2469 |
Echinococcus multilocularis | protein tyrosine kinase | 0.0256 | 0.2519 | 0.4191 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.003 | 0.005 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.0571 | 0.5762 | 0.5499 |
Schistosoma mansoni | tyrosine kinase | 0.0592 | 0.5976 | 1 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0571 | 0.5762 | 0.5949 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0592 | 0.5976 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0592 | 0.5976 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0069 | 0.0586 | 0.0944 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1562 | 0.2613 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.037 | 0.0619 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.0504 | 0.0844 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.003 | 0.005 |
Brugia malayi | RNA binding protein | 0.0061 | 0.0504 | 0.0797 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0504 | 0.0844 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.003 | 0.001 |
Brugia malayi | SWIRM domain containing protein | 0.0069 | 0.0586 | 0.0935 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0069 | 0.0586 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0015 | 0.0024 | 0.0041 |
Brugia malayi | hypothetical protein | 0.0069 | 0.0586 | 0.0935 |
Echinococcus multilocularis | 0.0069 | 0.0586 | 0.0944 | |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0069 | 0.0586 | 0.0944 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0319 | 0.3161 | 0.527 |
Brugia malayi | Protein kinase domain containing protein | 0.0259 | 0.255 | 0.4238 |
Schistosoma mansoni | tyrosine kinase | 0.0256 | 0.2519 | 0.4215 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0069 | 0.0586 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0069 | 0.0586 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0313 | 0.3107 | 0.5199 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.003 | 0.005 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0069 | 0.0586 | 0.0981 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0982 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.0504 | 0.0797 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0069 | 0.0586 | 0.0981 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0155 | 0.1475 | 0.2431 |
Echinococcus granulosus | protein tyrosine kinase | 0.0256 | 0.2519 | 0.4215 |
Plasmodium vivax | hypothetical protein, conserved | 0.0069 | 0.0586 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0144 | 0.1362 | 0.2279 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0069 | 0.0586 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.003 | 0.001 |
Echinococcus granulosus | insulin receptor | 0.019 | 0.1837 | 0.3073 |
Echinococcus multilocularis | insulin receptor | 0.019 | 0.1837 | 0.3045 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0024 | 0.0041 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.0504 | 0.0844 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.003 | 0.005 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0213 | 0.0307 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0504 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0024 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.037 | 0.0619 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.003 | 0.005 |
Plasmodium vivax | hypothetical protein, conserved | 0.0069 | 0.0586 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.0504 | 0.0797 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0592 | 0.5976 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.003 | 0.005 |
Brugia malayi | Muscleblind-like protein | 0.0144 | 0.1362 | 0.2239 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0586 | 0.0981 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0069 | 0.0586 | 0.5 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0145 | 0.1373 | 1 |
Onchocerca volvulus | 0.0138 | 0.1294 | 0.9002 | |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0069 | 0.0586 | 0.0935 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.003 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0586 | 0.0981 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0213 | 0.0356 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0912 | 0.9287 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0313 | 0.3107 | 0.5199 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0504 | 0.0844 |
Schistosoma mansoni | amine oxidase | 0.0069 | 0.0586 | 0.0981 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.019 | 0.1837 | 0.3073 |
Schistosoma mansoni | tyrosine kinase | 0.0319 | 0.3161 | 0.529 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0069 | 0.0586 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0319 | 0.3161 | 0.529 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0592 | 0.5976 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.0504 | 0.0844 |
Brugia malayi | Protein kinase domain containing protein | 0.019 | 0.1837 | 0.3038 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.003 | 0.005 |
Schistosoma mansoni | tyrosine kinase | 0.0319 | 0.3161 | 0.529 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1562 | 0.2613 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.003 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1362 | 0.2279 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0069 | 0.0586 | 0.0981 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1362 | 0.2279 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0504 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0586 | 0.0981 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0586 | 0.0981 |
Echinococcus multilocularis | geminin | 0.0164 | 0.1562 | 0.2583 |
Loa Loa (eye worm) | TK/FAK protein kinase | 0.0259 | 0.255 | 0.4267 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.0504 | 0.0806 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0069 | 0.0586 | 0.0981 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.019 | 0.1837 | 0.3045 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0504 | 0.0844 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0069 | 0.0586 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0213 | 0.0356 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.019 | 0.1837 | 0.3073 |
Schistosoma mansoni | amine oxidase | 0.0069 | 0.0586 | 0.0981 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0069 | 0.0586 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0069 | 0.0586 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0313 | 0.3107 | 0.5199 |
Schistosoma mansoni | tyrosine kinase | 0.019 | 0.1837 | 0.3073 |
Echinococcus multilocularis | muscleblind protein | 0.0144 | 0.1362 | 0.2247 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0069 | 0.0586 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.0504 | 0.0844 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0144 | 0.1362 | 0.2247 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.037 | 0.0571 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0586 | 0.0981 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0069 | 0.0586 | 0.5 |
Echinococcus granulosus | geminin | 0.0164 | 0.1562 | 0.2613 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0319 | 0.3161 | 0.529 |
Echinococcus multilocularis | 0.0183 | 0.1756 | 0.2909 | |
Schistosoma mansoni | tyrosine kinase | 0.019 | 0.1837 | 0.3073 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0586 | 0.0981 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 1 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.