Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0032 | 0.0032 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0039 | 0.1657 | 0.4887 |
Echinococcus multilocularis | Phosphatidylinositol 4 phosphate 5 kinase type 1 | 0.0014 | 0.0085 | 0.0085 |
Echinococcus multilocularis | muscleblind protein 1 | 0.016 | 0.9127 | 0.9127 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1606 | 0.1578 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.148 | 0.1443 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0467 | 0.0436 |
Entamoeba histolytica | phosphatidylinositol-4-phosphate 5-kinase, putative | 0.0014 | 0.0085 | 0.0262 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0027 | 0.09 | 0.2597 |
Plasmodium vivax | phosphatidylinositol-4-phosphate 5-kinase, putative | 0.0014 | 0.0085 | 0.0997 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0837 | 0.0837 |
Brugia malayi | Muscleblind-like protein | 0.016 | 0.9127 | 0.9123 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | pip kinase 2 | 0.0174 | 1 | 1 |
Echinococcus multilocularis | phosphatidylinositol 5 phosphate 4 kinase type 2 | 0.0174 | 1 | 1 |
Schistosoma mansoni | nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) | 0.0013 | 0.0042 | 0.001 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0266 | 0.0234 |
Trypanosoma cruzi | phosphatidylinositol-4-phosphate 5-kinase-like, putative | 0.0014 | 0.0085 | 0.0128 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0467 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.3346 | 0.3346 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0467 | 0.2629 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1606 | 0.9682 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0837 | 0.0798 |
Loa Loa (eye worm) | FYVE zinc finger family protein | 0.0014 | 0.0085 | 0.0085 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0467 | 0.0436 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0027 | 0.09 | 0.2597 |
Trypanosoma cruzi | phosphatidylinositol-4-phosphate 5-kinase, putative | 0.0014 | 0.0085 | 0.0128 |
Echinococcus multilocularis | dna polymerase eta | 0.0066 | 0.3346 | 0.3346 |
Toxoplasma gondii | phosphatidylinositol-4-phosphate 5-kinase | 0.0014 | 0.0085 | 0.0261 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0039 | 0.1657 | 0.163 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.1606 | 0.1578 |
Brugia malayi | Pip kinase protein 1 | 0.0014 | 0.0085 | 0.0043 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0266 | 0.0266 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0039 | 0.1657 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0266 | 0.0266 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0066 | 0.3346 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0039 | 0.1657 | 0.4887 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0467 | 0.1284 |
Leishmania major | phosphatidylinositol-4-phosphate 5-kinase-like protein | 0.0014 | 0.0085 | 0.0128 |
Leishmania major | phosphatidylinositol-4-phosphate 5-kinase-like, putative | 0.0014 | 0.0085 | 0.0128 |
Schistosoma mansoni | DNA polymerase eta | 0.0066 | 0.3346 | 0.3325 |
Echinococcus granulosus | dna polymerase kappa | 0.0039 | 0.1657 | 0.1657 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0039 | 0.1657 | 0.1657 |
Echinococcus granulosus | lamin | 0.0026 | 0.0837 | 0.0837 |
Onchocerca volvulus | 0.0174 | 1 | 1 | |
Echinococcus granulosus | phosphatidylinositol phosphate 5 kinase type III | 0.0014 | 0.0085 | 0.0085 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.2526 | 0.2494 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0837 | 0.0837 |
Echinococcus multilocularis | muscleblind protein | 0.016 | 0.9127 | 0.9127 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0128 | 0.7138 | 0.7138 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0266 | 0.0224 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0467 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.9127 | 0.9127 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0128 | 0.7138 | 0.7138 |
Trypanosoma brucei | phosphatidylinositol-4-phosphate 5-kinase, putative | 0.0014 | 0.0085 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0266 | 0.0266 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0039 | 0.1657 | 1 |
Toxoplasma gondii | phosphatidylinositol-4-phosphate 5-Kinase | 0.0014 | 0.0085 | 0.0261 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.1657 | 0.4887 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0039 | 0.1657 | 0.4887 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0039 | 0.1657 | 1 |
Trypanosoma brucei | unspecified product | 0.0039 | 0.1657 | 0.4887 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0266 | 0.0266 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.1657 | 0.4887 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate 5-kinase type II | 0.0174 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.1657 | 0.4887 |
Trypanosoma cruzi | phosphatidylinositol-4-phosphate 5-kinase type II beta, putative | 0.0014 | 0.0085 | 0.0128 |
Echinococcus granulosus | muscleblind protein | 0.016 | 0.9127 | 0.9127 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate 5-kinase type I | 0.0014 | 0.0085 | 0.0053 |
Plasmodium vivax | hypothetical protein, conserved | 0.0014 | 0.0085 | 0.0997 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0039 | 0.1657 | 0.4887 |
Leishmania major | phosphatidylinositol-4-phosphate-5-kinase-likep ro tein | 0.0014 | 0.0085 | 0.0128 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0837 | 0.0837 |
Giardia lamblia | Phosphatidylinositol-4-phosphate 5-kinase, putative | 0.0014 | 0.0085 | 0.0262 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.1606 | 0.1606 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.2526 | 0.2526 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.1657 | 0.4887 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0086 | 0.0086 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0039 | 0.1657 | 0.4887 |
Brugia malayi | FYVE finger-containing phosphoinositide kinase, putative | 0.0014 | 0.0085 | 0.0043 |
Trypanosoma brucei | unspecified product | 0.0027 | 0.09 | 0.2597 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0042 | 0.0042 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.1606 | 0.1606 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1606 | 0.9682 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.1657 | 0.4887 |
Echinococcus granulosus | CTD small phosphatase protein like | 0.0013 | 0.0042 | 0.0042 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0039 | 0.1657 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.148 | 0.148 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0467 | 0.0467 |
Leishmania major | DNA polymerase eta, putative | 0.0066 | 0.3346 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0039 | 0.1657 | 0.1657 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0039 | 0.1657 | 0.4887 |
Trypanosoma brucei | phosphatidylinositol (3,5) kinase, putative | 0.0014 | 0.0085 | 0.0128 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.1657 | 0.4887 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0837 | 0.0837 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0837 | 0.0837 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0039 | 0.1657 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0837 | 0.0837 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0467 | 0.1284 |
Trypanosoma cruzi | phosphatidylinositol-4-phosphate 5-kinase, putative | 0.0014 | 0.0085 | 0.0128 |
Leishmania major | phosphatidylinositol (3,5) kinase, putative | 0.0014 | 0.0085 | 0.0128 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0467 | 0.2629 |
Loa Loa (eye worm) | FYVE finger-containing phosphoinositide kinase | 0.0014 | 0.0085 | 0.0085 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.1657 | 0.4887 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0086 | 0.0044 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0266 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.9127 | 0.9127 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0467 | 0.1284 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate 5-kinase type II | 0.0014 | 0.0085 | 0.0053 |
Trichomonas vaginalis | phosphatidylinositol-4-phosphate 5-kinase type II, putative | 0.0014 | 0.0085 | 0.0262 |
Echinococcus granulosus | Phosphatidylinositol 4 phosphate 5 kinase type 1 | 0.0014 | 0.0085 | 0.0085 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0039 | 0.1657 | 0.1621 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0837 | 0.0798 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0467 | 0.0467 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0837 | 0.0837 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0807 | 0.0807 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0467 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0467 | 0.0467 |
Schistosoma mansoni | lamin | 0.0026 | 0.0837 | 0.0807 |
Echinococcus multilocularis | Carboxy terminal domain RNA polymerase II | 0.0013 | 0.0042 | 0.0042 |
Trypanosoma cruzi | phosphatidylinositol (3,5) kinase, putative | 0.0014 | 0.0085 | 0.0128 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0467 | 0.2615 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate-5-kinaseputativ e | 0.0014 | 0.0085 | 0.0053 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0039 | 0.1657 | 0.163 |
Echinococcus multilocularis | phosphatidylinositol phosphate 5 kinase type III | 0.0014 | 0.0085 | 0.0085 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0266 | 0.0266 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0039 | 0.1657 | 0.4887 |
Echinococcus granulosus | phosphatidylinositol 5 phosphate 4 kinase type 2 | 0.0174 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0027 | 0.09 | 0.2597 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1606 | 0.9682 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0266 | 0.0234 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0066 | 0.3346 | 0.3318 |
Echinococcus multilocularis | 0.0013 | 0.0042 | 0.0042 | |
Giardia lamblia | Hypothetical protein | 0.0014 | 0.0085 | 0.0262 |
Brugia malayi | hypothetical protein | 0.0038 | 0.1606 | 0.157 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0066 | 0.3346 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0039 | 0.1657 | 0.4887 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0467 | 0.0426 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0039 | 0.1665 | 0.4912 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.1657 | 0.4887 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0467 | 0.2629 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2526 | 0.2526 |
Trypanosoma cruzi | phosphatidylinositol 4-phosphate 5-kinase alpha, putative | 0.0014 | 0.0085 | 0.0128 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1606 | 0.9682 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.148 | 0.1452 |
Trichomonas vaginalis | phosphatidylinositol-4-phosphate 5-kinase type II, putative | 0.0014 | 0.0085 | 0.0262 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0039 | 0.1657 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0039 | 0.1657 | 0.4887 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0266 | 0.0266 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0467 | 1 |
Schistosoma mansoni | lamin | 0.0026 | 0.0837 | 0.0807 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate 5-kinase type II | 0.0174 | 1 | 1 |
Echinococcus granulosus | Carboxy terminal domain RNA polymerase II | 0.0013 | 0.0042 | 0.0042 |
Schistosoma mansoni | nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) | 0.0013 | 0.0042 | 0.001 |
Plasmodium falciparum | phosphatidylinositol-4-phosphate 5-kinase | 0.0014 | 0.0085 | 0.0997 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0467 | 0.2629 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0027 | 0.09 | 0.2597 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0039 | 0.1657 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0066 | 0.3346 | 0.3346 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate 5-kinase type II | 0.0014 | 0.0085 | 0.0053 |
Toxoplasma gondii | phosphatidylinositol-4-phosphate 5-Kinase | 0.0014 | 0.0085 | 0.0261 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0266 | 0.0224 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0039 | 0.1665 | 1 |
Trypanosoma brucei | phosphatidylinositol phosphate kinase alpha | 0.0014 | 0.0085 | 0.0128 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0039 | 0.1657 | 0.1657 |
Trypanosoma brucei | phosphatidylinositol-4-phosphate 5-kinase, putative | 0.0014 | 0.0085 | 0.0128 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.1657 | 0.4887 |
Loa Loa (eye worm) | pip kinase 1 | 0.0014 | 0.0085 | 0.0085 |
Trypanosoma cruzi | phosphatidylinositol-4-phosphate 5-kinase, putative | 0.0014 | 0.0085 | 0.0128 |
Echinococcus multilocularis | dna polymerase kappa | 0.0039 | 0.1657 | 0.1657 |
Entamoeba histolytica | phosphoinositide kinase, putative | 0.0014 | 0.0085 | 0.0262 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0467 | 0.1284 |
Trypanosoma cruzi | phosphatidylinositol-4-phosphate 5-kinase-like, putative | 0.0014 | 0.0085 | 0.0128 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0266 | 0.0234 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0837 | 0.0837 |
Brugia malayi | MH2 domain containing protein | 0.0128 | 0.7138 | 0.7125 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.2526 | 0.2494 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0837 | 0.0807 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0266 | 0.0266 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.1657 | 0.4887 |
Giardia lamblia | DINP protein human, muc B family | 0.0039 | 0.1657 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0039 | 0.1665 | 0.4912 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 1839 uM | Cytotoxicity against human PBMC by XTT assay | ChEMBL. | 19581097 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.