Detailed information for compound 1050465

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 405.397 | Formula: C23H17F2N3O2
  • H donors: 2 H acceptors: 2 LogP: 5.19 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C(/c1ccc(nc1)Oc1ccc2c(c1)cccc2)\NCc1cc(F)ccc1F
  • InChi: 1S/C23H17F2N3O2/c24-19-7-9-21(25)18(11-19)14-27-23(28-29)17-6-10-22(26-13-17)30-20-8-5-15-3-1-2-4-16(15)12-20/h1-13,29H,14H2,(H,27,28)
  • InChiKey: YFTMXPKDYDELCF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0159 0.1973 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0041 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0046
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0744 0.3642
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0332 0.0303
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0041 0.0337
Brugia malayi hypothetical protein 0.0105 0.1222 0.1397
Trichomonas vaginalis chromobox protein, putative 0.0071 0.075 0.0735
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0041 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0041 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0041 0.0001
Schistosoma mansoni hypothetical protein 0.0035 0.0238 0.0216
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0072 0.0044
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0072 0.0043
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0159 0.1973 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0041 0.0001
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.3149 0.3129
Schistosoma mansoni microtubule-associated protein tau 0.0708 0.9674 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.1248 0.1263
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0283 0.0263
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0041 0.0012
Schistosoma mansoni hypothetical protein 0.0261 0.3401 0.3496
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0041 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0041 0.0001
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0104 0.1206 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0467 0.0548
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0353 0.0323
Onchocerca volvulus 0.0107 0.1249 0.1251
Loa Loa (eye worm) hypothetical protein 0.0243 0.3149 0.3707
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0238 0.0278
Schistosoma mansoni hypothetical protein 0.0021 0.0045 0.0016
Schistosoma mansoni chromobox protein 0.0071 0.075 0.0747
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0104 0.1206 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0089 0.1002 0.0975
Loa Loa (eye worm) hypothetical protein 0.0039 0.03 0.0351
Loa Loa (eye worm) oxidoreductase 0.0021 0.0041 0.0045
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0956 0.0929
Loa Loa (eye worm) hypothetical protein 0.0071 0.0744 0.0874
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0744 0.0832
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0041 0.0046
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0041 0.0012
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0055 0.0515 0.2453
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0353 0.0323
Onchocerca volvulus 0.0021 0.0041 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0452 0.3745
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0041 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0452 0.3745
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0101 0.1166 0.1179
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0041 0.0337
Brugia malayi Bromodomain containing protein 0.0039 0.0299 0.0306
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.1248 0.1263
Brugia malayi PHD-finger family protein 0.003 0.0168 0.015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0041 0.0012
Brugia malayi steroid hormone receptor 0.0021 0.0041 0.0001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0515 0.2453
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.1222 0.6113
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0041 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0614 0.0721
Loa Loa (eye worm) hypothetical protein 0.0053 0.0492 0.0577
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1465 0.1723
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0041 0.0012
Echinococcus multilocularis peptidase Clp (S14 family) 0.0104 0.1206 0.118
Trichomonas vaginalis set domain proteins, putative 0.071 0.97 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0041 0.0012
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.075 0.0881
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0041 0.0011
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0168 0.0195
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0409 0.038
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0041 0.0001
Toxoplasma gondii LsmAD domain-containing protein 0.0105 0.1222 0.6113
Brugia malayi Pre-SET motif family protein 0.0089 0.1002 0.1138
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.3149 0.3129
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0041 0.0046
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0744 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0159 0.1973 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0041 0.0046
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.031 0.0279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0041 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0041 0.0001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0041 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0744 0.0832
Schistosoma mansoni peptidase Clp (S14 family) 0.0159 0.1973 0.2014
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0492 0.2338
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0261 0.3401 0.3382
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0041 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0452 0.3745
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0089 0.1002 0.4978
Schistosoma mansoni cellular tumor antigen P53 0.0107 0.1249 0.1264
Loa Loa (eye worm) hypothetical protein 0.0107 0.1248 0.1467
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0041 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.1002 0.1008
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0744 0.3642
Echinococcus granulosus chromobox protein 1 0.0071 0.075 0.0723
Brugia malayi nuclear receptor NHR-88 0.0021 0.0041 0.0001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0041 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0046
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0041 0.0001
Echinococcus multilocularis thyroid hormone receptor alpha 0.0281 0.3695 0.3676
Echinococcus granulosus histone lysine methyltransferase setb 0.0107 0.1248 0.1222
Loa Loa (eye worm) hypothetical protein 0.004 0.031 0.0362
Brugia malayi chromobox protein homolog 3 0.004 0.031 0.0319
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0744 0.0832
Brugia malayi Pre-SET motif family protein 0.0624 0.8492 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0041 0.0337
Plasmodium vivax hypothetical protein, conserved 0.003 0.0168 0.0657
Schistosoma mansoni hypothetical protein 0.0047 0.0409 0.0393
Brugia malayi PHD-finger family protein 0.0026 0.0107 0.0078
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0041 0.0012
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0041 0.0337
Echinococcus multilocularis chromobox protein 1 0.0071 0.075 0.0723
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0492 0.4082
Brugia malayi nuclear hormone receptor 0.0021 0.0041 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0744 0.3642
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0442 0.0475
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0041 0.0012
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0607 0.0579
Schistosoma mansoni chromobox protein 0.0071 0.075 0.0747
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0041 0.0011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0744 0.3642
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0492 0.2338
Echinococcus granulosus peptidase Clp S14 family 0.0104 0.1206 0.118
Onchocerca volvulus 0.0031 0.0189 0.0153
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.1222 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0041 0.0337
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0159 0.1973 0.1949
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0283 0.0331
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0159 0.1973 0.5
Schistosoma mansoni thyroid hormone receptor 0.0281 0.3695 0.38
Brugia malayi jmjC domain containing protein 0.0038 0.0283 0.0287
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0041 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0744 0.5958
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0146 0.0109
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0261 0.3401 0.3382
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.1222 0.6113
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0041 0.0001
Echinococcus multilocularis microtubule associated protein 2 0.0708 0.9674 0.9673
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0041 0.0337
Brugia malayi Bromodomain containing protein 0.0077 0.0827 0.093
Schistosoma mansoni survival motor neuron protein 0.0049 0.0442 0.0427
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0072 0.0043
Echinococcus multilocularis chromobox protein 1 0.0071 0.075 0.0723
Loa Loa (eye worm) hypothetical protein 0.0071 0.0744 0.0874
Schistosoma mansoni bromodomain containing protein 0.0065 0.0658 0.0652
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0283 0.0263
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0332 0.0303
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0046
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0041 0.0337
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0744 0.3642
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0046
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1465 0.1723
Loa Loa (eye worm) hypothetical protein 0.0159 0.1973 0.2321
Loa Loa (eye worm) hypothetical protein 0.0053 0.0492 0.0577
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0041 0.0012
Onchocerca volvulus 0.0071 0.0744 0.0728
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0744 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0041 0.0045
Onchocerca volvulus 0.0101 0.1166 0.1165
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.0744 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0041 0.0012
Loa Loa (eye worm) hypothetical protein 0.0053 0.0492 0.0577
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0465 0.0502
Loa Loa (eye worm) hypothetical protein 0.0053 0.0492 0.0577
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0159 0.1973 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0146 0.0109
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0168 0.0138
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0168 0.0657
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0265 0.0236
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0744 0.3642
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0465 0.0545
Onchocerca volvulus 0.071 0.97 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0189 0.0219
Onchocerca volvulus Alhambra homolog 0.003 0.0168 0.0131
Plasmodium vivax SET domain protein, putative 0.0089 0.1002 0.4978
Brugia malayi Bromodomain containing protein 0.0032 0.0202 0.019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0041 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0041 0.0001
Plasmodium falciparum phd finger protein, putative 0.003 0.0168 0.0657
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0159 0.1973 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0041 0.0012
Schistosoma mansoni hypothetical protein 0.003 0.0168 0.0143
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0607 0.0579
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0159 0.1973 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0195
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0041 0.0012
Brugia malayi hypothetical protein 0.0068 0.0699 0.0779
Echinococcus granulosus peregrin 0.0032 0.0202 0.0172
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0452 0.3745
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0839 0.0839
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.1122 0.1095
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0159 0.1973 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0465 0.0545
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0492 0.2338
Brugia malayi Heterochromatin protein 1 0.0071 0.075 0.084
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0041 0.0337
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0159 0.1973 0.1949
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0041 0.0046
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0041 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0041 0.0001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0465 0.0502
Loa Loa (eye worm) hypothetical protein 0.0071 0.0744 0.0874
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0168 0.0138
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0041 0.0012
Schistosoma mansoni hypothetical protein 0.0049 0.0442 0.0427
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0041 0.0012
Echinococcus multilocularis tumor protein p63 0.0731 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0041 0.0012
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0041 0.0001
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0055 0.0515 0.2453
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0041 0.0046
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0159 0.1973 1
Leishmania major hypothetical protein, conserved 0.0105 0.1222 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0041 0.0012
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0159 0.1973 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0624 0.8492 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0041 0.0337
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0283 0.0254
Plasmodium vivax ataxin-2 like protein, putative 0.0105 0.1222 0.6113
Loa Loa (eye worm) hypothetical protein 0.0042 0.0334 0.0391
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0041 0.0012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0353 0.0323
Onchocerca volvulus 0.0049 0.0442 0.0415
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0744 0.3642
Brugia malayi hypothetical protein 0.0243 0.3149 0.3678
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0168 0.0143
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0238 0.0234
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0041 0.0337
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0744 0.5958
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0041 0.0012
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0256 0.0227
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0159 0.1973 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0041 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0041 0.0001
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.1222 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0041 0.0337
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0046
Toxoplasma gondii hypothetical protein 0.0055 0.0515 0.2453
Trypanosoma brucei PAB1-binding protein , putative 0.0105 0.1222 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0041 0.0011
Echinococcus granulosus chromobox protein 1 0.0071 0.075 0.0723
Trichomonas vaginalis conserved hypothetical protein 0.004 0.031 0.0279
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0041 0.0001
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0104 0.1206 0.6033
Loa Loa (eye worm) hypothetical protein 0.0073 0.0765 0.0899
Schistosoma mansoni thyroid hormone receptor 0.0281 0.3695 0.38
Giardia lamblia PHD finger protein 15 0.003 0.0168 0.5
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0041 0.0045
Trichomonas vaginalis chromobox protein, putative 0.0071 0.075 0.0735
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0107 0.1248 0.1222
Brugia malayi jmjC domain containing protein 0.0098 0.1122 0.1279
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0744 0.3642
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0041 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0046
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0744 0.5958
Brugia malayi ecdysteroid receptor 0.0021 0.0041 0.0001
Echinococcus granulosus microtubule associated protein 2 0.0708 0.9674 0.9673
Loa Loa (eye worm) hypothetical protein 0.0053 0.0492 0.0577
Brugia malayi Probable ClpP-like protease 0.0159 0.1973 0.2286
Loa Loa (eye worm) hypothetical protein 0.0105 0.1222 0.1436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0041 0.0046
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0168 0.0657
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0744 0.617
Loa Loa (eye worm) hypothetical protein 0.0044 0.0362 0.0423
Schistosoma mansoni coup transcription factor 0.0021 0.0041 0.0012
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0265 0.0236
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0046
Echinococcus multilocularis peregrin 0.0032 0.0202 0.0172
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.1122 0.1095
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0041 0.0012
Loa Loa (eye worm) hypothetical protein 0.0107 0.1249 0.1468
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0409 0.038
Brugia malayi MH2 domain containing protein 0.0122 0.1465 0.1686
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0041 0.0012
Mycobacterium ulcerans hypothetical protein 0.0071 0.0744 0.3642
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0744 0.617
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0744 0.3642
Trichomonas vaginalis conserved hypothetical protein 0.004 0.031 0.0279
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0045 0.005
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0041 0.0012

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 31 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.