Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0159 | 0.1973 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0021 | 0.0041 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.0046 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0071 | 0.0744 | 0.3642 |
Echinococcus granulosus | jumonji domain containing protein | 0.0042 | 0.0332 | 0.0303 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0021 | 0.0041 | 0.0337 |
Brugia malayi | hypothetical protein | 0.0105 | 0.1222 | 0.1397 |
Trichomonas vaginalis | chromobox protein, putative | 0.0071 | 0.075 | 0.0735 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0021 | 0.0041 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.0045 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.0041 | 0.0001 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0041 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0238 | 0.0216 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0072 | 0.0044 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0072 | 0.0043 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0159 | 0.1973 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0041 | 0.0001 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0243 | 0.3149 | 0.3129 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0708 | 0.9674 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0107 | 0.1248 | 0.1263 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0283 | 0.0263 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0021 | 0.0041 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0261 | 0.3401 | 0.3496 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0041 | 0.0001 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0041 | 0.0001 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0104 | 0.1206 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0467 | 0.0548 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.0353 | 0.0323 |
Onchocerca volvulus | 0.0107 | 0.1249 | 0.1251 | |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3149 | 0.3707 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0238 | 0.0278 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0045 | 0.0016 |
Schistosoma mansoni | chromobox protein | 0.0071 | 0.075 | 0.0747 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0104 | 0.1206 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0089 | 0.1002 | 0.0975 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.03 | 0.0351 |
Loa Loa (eye worm) | oxidoreductase | 0.0021 | 0.0041 | 0.0045 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0086 | 0.0956 | 0.0929 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0744 | 0.0874 |
Brugia malayi | AMP-binding enzyme family protein | 0.0071 | 0.0744 | 0.0832 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0041 | 0.0046 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0021 | 0.0041 | 0.0012 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0055 | 0.0515 | 0.2453 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.0353 | 0.0323 |
Onchocerca volvulus | 0.0021 | 0.0041 | 0.0001 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.005 | 0.0452 | 0.3745 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0041 | 0.0046 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.005 | 0.0452 | 0.3745 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0101 | 0.1166 | 0.1179 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0021 | 0.0041 | 0.0337 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0299 | 0.0306 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0107 | 0.1248 | 0.1263 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0168 | 0.015 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0041 | 0.0012 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.0041 | 0.0001 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0055 | 0.0515 | 0.2453 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0105 | 0.1222 | 0.6113 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0041 | 0.0012 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.0614 | 0.0721 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0492 | 0.0577 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.1465 | 0.1723 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0021 | 0.0041 | 0.0012 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0104 | 0.1206 | 0.118 |
Trichomonas vaginalis | set domain proteins, putative | 0.071 | 0.97 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0041 | 0.0012 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0071 | 0.075 | 0.0881 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0021 | 0.0041 | 0.0011 |
Loa Loa (eye worm) | PHD-finger family protein | 0.003 | 0.0168 | 0.0195 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0047 | 0.0409 | 0.038 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0.0041 | 0.0001 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0105 | 0.1222 | 0.6113 |
Brugia malayi | Pre-SET motif family protein | 0.0089 | 0.1002 | 0.1138 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0243 | 0.3149 | 0.3129 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.0041 | 0.0046 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0071 | 0.0744 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0159 | 0.1973 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.0046 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0041 | 0.0046 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.004 | 0.031 | 0.0279 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0041 | 0.0046 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0041 | 0.0001 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0041 | 0.0001 |
Brugia malayi | AMP-binding enzyme family protein | 0.0071 | 0.0744 | 0.0832 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0159 | 0.1973 | 0.2014 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0053 | 0.0492 | 0.2338 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0261 | 0.3401 | 0.3382 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0041 | 0.0012 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.005 | 0.0452 | 0.3745 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0089 | 0.1002 | 0.4978 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0107 | 0.1249 | 0.1264 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1248 | 0.1467 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0041 | 0.0001 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0089 | 0.1002 | 0.1008 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0071 | 0.0744 | 0.3642 |
Echinococcus granulosus | chromobox protein 1 | 0.0071 | 0.075 | 0.0723 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0041 | 0.0001 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0041 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.0046 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.0041 | 0.0001 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0281 | 0.3695 | 0.3676 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0107 | 0.1248 | 0.1222 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.031 | 0.0362 |
Brugia malayi | chromobox protein homolog 3 | 0.004 | 0.031 | 0.0319 |
Brugia malayi | AMP-binding enzyme family protein | 0.0071 | 0.0744 | 0.0832 |
Brugia malayi | Pre-SET motif family protein | 0.0624 | 0.8492 | 1 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0021 | 0.0041 | 0.0337 |
Plasmodium vivax | hypothetical protein, conserved | 0.003 | 0.0168 | 0.0657 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0409 | 0.0393 |
Brugia malayi | PHD-finger family protein | 0.0026 | 0.0107 | 0.0078 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0021 | 0.0041 | 0.0012 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0021 | 0.0041 | 0.0337 |
Echinococcus multilocularis | chromobox protein 1 | 0.0071 | 0.075 | 0.0723 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0053 | 0.0492 | 0.4082 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.0041 | 0.0001 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0071 | 0.0744 | 0.3642 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0442 | 0.0475 |
Echinococcus granulosus | FTZ F1 alpha | 0.0021 | 0.0041 | 0.0012 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.0607 | 0.0579 |
Schistosoma mansoni | chromobox protein | 0.0071 | 0.075 | 0.0747 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0021 | 0.0041 | 0.0011 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0071 | 0.0744 | 0.3642 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0053 | 0.0492 | 0.2338 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0104 | 0.1206 | 0.118 |
Onchocerca volvulus | 0.0031 | 0.0189 | 0.0153 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0105 | 0.1222 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0021 | 0.0041 | 0.0337 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0159 | 0.1973 | 0.1949 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0038 | 0.0283 | 0.0331 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0159 | 0.1973 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0281 | 0.3695 | 0.38 |
Brugia malayi | jmjC domain containing protein | 0.0038 | 0.0283 | 0.0287 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0.0041 | 0.0001 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0071 | 0.0744 | 0.5958 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0146 | 0.0109 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0261 | 0.3401 | 0.3382 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0105 | 0.1222 | 0.6113 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0041 | 0.0001 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0708 | 0.9674 | 0.9673 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0021 | 0.0041 | 0.0337 |
Brugia malayi | Bromodomain containing protein | 0.0077 | 0.0827 | 0.093 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0442 | 0.0427 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0072 | 0.0043 |
Echinococcus multilocularis | chromobox protein 1 | 0.0071 | 0.075 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0744 | 0.0874 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.0658 | 0.0652 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0283 | 0.0263 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0042 | 0.0332 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.0046 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0021 | 0.0041 | 0.0337 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0071 | 0.0744 | 0.3642 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.0046 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.1465 | 0.1723 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1973 | 0.2321 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0492 | 0.0577 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0021 | 0.0041 | 0.0012 |
Onchocerca volvulus | 0.0071 | 0.0744 | 0.0728 | |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0071 | 0.0744 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0021 | 0.0041 | 0.0045 |
Onchocerca volvulus | 0.0101 | 0.1166 | 0.1165 | |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0071 | 0.0744 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0021 | 0.0041 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0492 | 0.0577 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0465 | 0.0502 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0492 | 0.0577 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0159 | 0.1973 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0146 | 0.0109 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.003 | 0.0168 | 0.0138 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.0168 | 0.0657 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0265 | 0.0236 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0071 | 0.0744 | 0.3642 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0465 | 0.0545 |
Onchocerca volvulus | 0.071 | 0.97 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0189 | 0.0219 |
Onchocerca volvulus | Alhambra homolog | 0.003 | 0.0168 | 0.0131 |
Plasmodium vivax | SET domain protein, putative | 0.0089 | 0.1002 | 0.4978 |
Brugia malayi | Bromodomain containing protein | 0.0032 | 0.0202 | 0.019 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0041 | 0.0001 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0041 | 0.0001 |
Plasmodium falciparum | phd finger protein, putative | 0.003 | 0.0168 | 0.0657 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0159 | 0.1973 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0021 | 0.0041 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0168 | 0.0143 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.0607 | 0.0579 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0159 | 0.1973 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0168 | 0.0195 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0041 | 0.0012 |
Brugia malayi | hypothetical protein | 0.0068 | 0.0699 | 0.0779 |
Echinococcus granulosus | peregrin | 0.0032 | 0.0202 | 0.0172 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.005 | 0.0452 | 0.3745 |
Schistosoma mansoni | jumonji domain containing protein | 0.0078 | 0.0839 | 0.0839 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0098 | 0.1122 | 0.1095 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0159 | 0.1973 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0465 | 0.0545 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0053 | 0.0492 | 0.2338 |
Brugia malayi | Heterochromatin protein 1 | 0.0071 | 0.075 | 0.084 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0021 | 0.0041 | 0.0337 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0159 | 0.1973 | 0.1949 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0041 | 0.0046 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0041 | 0.0012 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0041 | 0.0001 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0465 | 0.0502 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0744 | 0.0874 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.003 | 0.0168 | 0.0138 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0041 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0442 | 0.0427 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0021 | 0.0041 | 0.0012 |
Echinococcus multilocularis | tumor protein p63 | 0.0731 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0041 | 0.0012 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0.0041 | 0.0001 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0055 | 0.0515 | 0.2453 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.0041 | 0.0046 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0159 | 0.1973 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0105 | 0.1222 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.0041 | 0.0012 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0159 | 0.1973 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0624 | 0.8492 | 1 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0021 | 0.0041 | 0.0337 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0038 | 0.0283 | 0.0254 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0105 | 0.1222 | 0.6113 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0334 | 0.0391 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0021 | 0.0041 | 0.0012 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.0353 | 0.0323 |
Onchocerca volvulus | 0.0049 | 0.0442 | 0.0415 | |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0071 | 0.0744 | 0.3642 |
Brugia malayi | hypothetical protein | 0.0243 | 0.3149 | 0.3678 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.003 | 0.0168 | 0.0143 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0238 | 0.0234 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0021 | 0.0041 | 0.0337 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0071 | 0.0744 | 0.5958 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0021 | 0.0041 | 0.0012 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0256 | 0.0227 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0159 | 0.1973 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0021 | 0.0041 | 0.0012 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0041 | 0.0001 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0105 | 0.1222 | 1 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0021 | 0.0041 | 0.0337 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.0046 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.0515 | 0.2453 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0105 | 0.1222 | 1 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0021 | 0.0041 | 0.0011 |
Echinococcus granulosus | chromobox protein 1 | 0.0071 | 0.075 | 0.0723 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.031 | 0.0279 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.0041 | 0.0001 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0104 | 0.1206 | 0.6033 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0765 | 0.0899 |
Schistosoma mansoni | thyroid hormone receptor | 0.0281 | 0.3695 | 0.38 |
Giardia lamblia | PHD finger protein 15 | 0.003 | 0.0168 | 0.5 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0021 | 0.0041 | 0.0045 |
Trichomonas vaginalis | chromobox protein, putative | 0.0071 | 0.075 | 0.0735 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0107 | 0.1248 | 0.1222 |
Brugia malayi | jmjC domain containing protein | 0.0098 | 0.1122 | 0.1279 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0071 | 0.0744 | 0.3642 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.0041 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.0046 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0071 | 0.0744 | 0.5958 |
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.0041 | 0.0001 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0708 | 0.9674 | 0.9673 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0492 | 0.0577 |
Brugia malayi | Probable ClpP-like protease | 0.0159 | 0.1973 | 0.2286 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1222 | 0.1436 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0041 | 0.0046 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.0168 | 0.0657 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0071 | 0.0744 | 0.617 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0362 | 0.0423 |
Schistosoma mansoni | coup transcription factor | 0.0021 | 0.0041 | 0.0012 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0265 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.0046 |
Echinococcus multilocularis | peregrin | 0.0032 | 0.0202 | 0.0172 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0098 | 0.1122 | 0.1095 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0021 | 0.0041 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1249 | 0.1468 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0047 | 0.0409 | 0.038 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.1465 | 0.1686 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0021 | 0.0041 | 0.0012 |
Mycobacterium ulcerans | hypothetical protein | 0.0071 | 0.0744 | 0.3642 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0071 | 0.0744 | 0.617 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0071 | 0.0744 | 0.3642 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.031 | 0.0279 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0045 | 0.005 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0041 | 0.0012 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 31 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.