Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0015 | 0.0028 | 1 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0015 | 0.0028 | 0.0028 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0015 | 0.0028 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0015 | 0.0028 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0015 | 0.0028 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 0.3215 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0028 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 0.3215 | 1 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0015 | 0.0028 | 0.0029 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0015 | 0.0028 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0015 | 0.0028 | 1 |
Onchocerca volvulus | 0.0015 | 0.0028 | 0.5 | |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 0.3215 | 0.5 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0654 | 0.9796 | 0.9796 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0667 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 0.3215 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0015 | 0.0028 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0015 | 0.0028 | 1 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0015 | 0.0028 | 0.0028 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 0.3215 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0223 | 0.3215 | 1 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0654 | 0.9796 | 1 |
Schistosoma mansoni | dihydropteridine reductase | 0.0015 | 0.0028 | 0.0029 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0015 | 0.0028 | 0.5 |
Echinococcus granulosus | ankyrin repeat protein | 0.0654 | 0.9796 | 0.9796 |
Trypanosoma brucei | pteridine reductase 1 | 0.0015 | 0.0028 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 0.3215 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0015 | 0.0028 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 0.3215 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0015 | 0.0028 | 0.5 |
Onchocerca volvulus | 0.0015 | 0.0028 | 0.5 | |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0015 | 0.0028 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0015 | 0.0028 | 0.5 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0015 | 0.0028 | 1 |
Leishmania major | pteridine reductase 1 | 0.0015 | 0.0028 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 0.3215 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0015 | 0.0028 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.37 uM | Inhibition of Mycobacterium tuberculosis InhA | ChEMBL. | 19428156 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.