Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 30.26 uM | Inhibition of human xanthine oxidase | ChEMBL. | 17379526 |
IC50 (binding) | = 30.26 uM | Inhibition of human xanthine oxidase | ChEMBL. | 17379526 |
IC50 (binding) | = 144.9 uM | Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding site | ChEMBL. | 2165159 |
IC50 (binding) | = 144.9 uM | Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding site | ChEMBL. | 2165159 |
Inhibition (binding) | = 49.8 % | Inhibition of human xanthine oxidase at 30 uM | ChEMBL. | 17379526 |
Inhibition (binding) | = 49.8 % | Inhibition of human xanthine oxidase at 30 uM | ChEMBL. | 17379526 |
Ki (binding) | = 99.9 uM | Binding affinity (Ki) against human phosphatidylinositol 4-kinase | ChEMBL. | 2165159 |
Ki (binding) | = 99.9 uM | Binding affinity (Ki) against human phosphatidylinositol 4-kinase | ChEMBL. | 2165159 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
10 literature references were collected for this gene.