Detailed information for compound 1050708

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 371.271 | Formula: C19H19BrN2O
  • H donors: 1 H acceptors: 1 LogP: 4.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)CCNCc1coc(n1)c1ccccc1Br
  • InChi: 1S/C19H19BrN2O/c1-14-6-8-15(9-7-14)10-11-21-12-16-13-23-19(22-16)17-4-2-3-5-18(17)20/h2-9,13,21H,10-12H2,1H3
  • InChiKey: YXZGALVYICPXHA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0963 0.3449
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0018 0.0196 0.0348
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0646 0.2314
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0963 0.0982
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0963 0.3449
Onchocerca volvulus 0.016 0.5634 0.6241
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0018 0.0196 0.0196
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0196 0.0196
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0255 0.026
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0646 0.2314
Giardia lamblia DINP protein human, muc B family 0.0038 0.0963 1
Trypanosoma brucei metacaspase MCA2 0.0026 0.0509 0.1822
Loa Loa (eye worm) hypothetical protein 0.0038 0.096 0.0979
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0018 0.0196 0.02
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.092 0.3295
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0196 0.02
Trypanosoma brucei metacaspase 5, putative 0.0026 0.0509 0.1822
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0196 0.0348
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0196 0.02
Trypanosoma brucei unspecified product 0.0026 0.0511 0.1832
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.1923 0.6888
Loa Loa (eye worm) hypothetical protein 0.0031 0.0693 0.0707
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0646 0.2314
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.7769 0.7919
Echinococcus granulosus protein tyrosine phosphatase n9 0.0018 0.0196 0.0348
Trichomonas vaginalis set domain proteins, putative 0.0245 0.891 0.9082
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0196 0.0348
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0018 0.0196 0.02
Trypanosoma cruzi metacaspase, putative 0.0026 0.0509 0.1822
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0646 0.2314
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0963 0.3449
Echinococcus granulosus caspase 0.0026 0.0509 0.0903
Loa Loa (eye worm) hypothetical protein 0.0087 0.2829 0.2884
Echinococcus multilocularis disco interacting protein 2 0.0038 0.096 0.1704
Loa Loa (eye worm) pip kinase 2 0.016 0.5634 0.5743
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0196 0.0348
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0196 0.0348
Leishmania major metacaspase, putative 0.0026 0.0509 0.1822
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0963 0.0982
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0018 0.0196 0.2034
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0019 0.0253 0.0448
Echinococcus granulosus dna polymerase eta 0.0063 0.1923 0.3413
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Trypanosoma brucei metacaspase 0.0026 0.0509 0.1822
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.092 0.3295
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0196 0.02
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0018 0.0196 0.0348
Toxoplasma gondii exonuclease III APE 0.0019 0.0255 0.0913
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0196 0.02
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0086 0.2792 0.3347
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0196 0.0348
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0963 0.0982
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0509 0.0518
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0196 0.02
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Trypanosoma brucei protein tyrosine phosphatase 1 0.0018 0.0196 0.0701
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0019 0.0253 0.0905
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0196 0.0348
Trypanosoma brucei DNA polymerase eta, putative 0.0063 0.1923 0.6888
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0509 0.0518
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Toxoplasma gondii DNA methyltransferase 2, putative 0.0019 0.0253 0.0905
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0195 0.6998 0.8897
Plasmodium falciparum glutathione reductase 0.0086 0.2792 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0963 0.0963
Onchocerca volvulus 0.0245 0.891 1
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0019 0.0253 0.0905
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Loa Loa (eye worm) hypothetical protein 0.0087 0.2829 0.2884
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0511 0.1832
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0771 0.0786
Brugia malayi Disco-interacting protein 2 homolog 0.0038 0.096 0.0979
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0646 0.2314
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0509 0.1822
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0018 0.0196 0.0348
Trichomonas vaginalis glutaminase, putative 0.0268 0.9811 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0196 0.0348
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0646 0.0516
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Schistosoma mansoni ap endonuclease 0.0019 0.0255 0.0255
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0963 0.3449
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0646 1
Leishmania major trypanothione reductase 0.0086 0.2792 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0511 0.1832
Brugia malayi glutathione reductase 0.0086 0.2792 0.2846
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0693 0.123
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0255 0.0913
Brugia malayi hypothetical protein 0.0018 0.0196 0.02
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0196 0.0196
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0255 0.0452
Leishmania major tyrosine specific protein phosphatase, putative 0.0018 0.0196 0.0701
Plasmodium vivax SET domain protein, putative 0.0031 0.0693 0.2483
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0196 0.02
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0019 0.0253 0.2624
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0693 0.123
Giardia lamblia Protein tyrosine phosphatase 0.0018 0.0196 0.2034
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0018 0.0196 0.0348
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.1923 0.196
Brugia malayi Pre-SET motif family protein 0.0215 0.7769 0.7919
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0963 0.0963
Brugia malayi Thioredoxin reductase 0.0086 0.2792 0.2846
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0196 0.0348
Echinococcus granulosus caspase 2 0.0026 0.0509 0.0903
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0963 0.3449
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0646 0.2314
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0196 0.0701
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0196 0.0348
Brugia malayi hypothetical protein 0.0018 0.0196 0.02
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0255 0.0913
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0196 0.0348
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0196 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0509 0.0518
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0018 0.0196 0.0348
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0509 0.1822
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0195 0.6998 0.8897
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0509 0.0518
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0963 0.3449
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0646 0.2314
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0196 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0963 0.3449
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0963 0.0934
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0018 0.0196 0.2034
Plasmodium vivax glutathione reductase, putative 0.0086 0.2792 1
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0963 0.0741
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0018 0.0196 0.0348
Echinococcus multilocularis thioredoxin glutathione reductase 0.0086 0.2812 0.4991
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0963 0.1709
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0963 0.3449
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0196 0.0348
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0196 0.0348
Loa Loa (eye worm) protein tyrosine phosphatase 0.0018 0.0196 0.02
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0018 0.0196 0.0348
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0196 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0509 0.0518
Leishmania major DNA polymerase eta, putative 0.0063 0.1923 0.6888
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0509 0.1822
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0196 0.0348
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0255 0.026
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0196 0.0348
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0196 0.02
Brugia malayi hypothetical protein 0.0087 0.2829 0.2884
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.0196 0.0196
Brugia malayi CXXC zinc finger family protein 0.0033 0.0771 0.0786
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0196 0.0348
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0509 0.1822
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0509 0.0518
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0646 0.2314
Loa Loa (eye worm) glutathione reductase 0.0086 0.2792 0.2846
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0196 0.02
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0646 0.2314
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0963 0.3449
Leishmania major modification methylase-like protein 0.0019 0.0253 0.0905
Echinococcus multilocularis caspase 8 0.0026 0.0509 0.0903
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0963 0.0741
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0019 0.0253 0.0905
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0646 0.041
Echinococcus granulosus caspase 8 0.0026 0.0509 0.0903
Onchocerca volvulus 0.0033 0.0771 0.066
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0196 0.0348
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.016 0.5634 1
Schistosoma mansoni glutaminase 0.0268 0.9811 0.9811
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0018 0.0196 0.02
Schistosoma mansoni ap endonuclease 0.0019 0.0255 0.0255
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0693 0.0693
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0018 0.0196 0.0348
Brugia malayi hypothetical protein 0.0018 0.0196 0.02
Schistosoma mansoni DNA polymerase eta 0.0063 0.1923 0.1923
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.0196 0.0196
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0196 0.0701
Trichomonas vaginalis pten, drome, putative 0.0018 0.0196 0.02
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0646 0.1147
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0255 0.026
Leishmania major DNA polymerase kappa, putative 0.0038 0.0963 0.3449
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0646 0.2314
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0509 0.0509
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0255 0.2646
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0018 0.0196 0.0348
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Trypanosoma cruzi trypanothione reductase, putative 0.0086 0.2792 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0196 0.0348
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0018 0.0196 0.0196
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0195 0.6998 0.8897
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0646 0.2314
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0255 0.0913
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0196 0.0348
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0026 0.0509 0.0518
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0196 0.0348
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0646 0.0659
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0026 0.0509 0.0903
Schistosoma mansoni cpg binding protein 0.0033 0.0771 0.0771
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0646 0.671
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0963 0.3449
Toxoplasma gondii thioredoxin reductase 0.0086 0.2792 1
Toxoplasma gondii hypothetical protein 0.0083 0.2697 0.9662
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.065 0.1153
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0196 0.02
Loa Loa (eye worm) hypothetical protein 0.0063 0.1923 0.196
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Loa Loa (eye worm) hypothetical protein 0.016 0.5634 0.5743
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0646 0.2314
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Plasmodium vivax metacaspase 1, putative 0.0026 0.0509 0.1822
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0196 0.0348
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Echinococcus multilocularis 0.0018 0.0196 0.0348
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0018 0.0196 0.0196
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0255 0.0913
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0196 0.02
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Trypanosoma brucei metacaspase MCA3 0.0026 0.0509 0.1822
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0255 0.0452
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0646 0.0659
Loa Loa (eye worm) hypothetical protein 0.0026 0.0509 0.0518
Loa Loa (eye worm) glutaminase 2 0.0268 0.9811 1
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0196 0.02
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0646 0.2314
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0963 0.1709
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0646 0.2314
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0196 0.0348
Plasmodium falciparum thioredoxin reductase 0.0086 0.2792 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0018 0.0196 0.02
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0646 0.2314
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0018 0.0196 0.0196
Trypanosoma brucei unspecified product 0.0038 0.0963 0.3449
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0196 0.0348
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0018 0.0196 0.0348
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0646 0.0659
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0217 0.7834 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0646 0.2314
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0511 0.1832
Plasmodium vivax thioredoxin reductase, putative 0.0086 0.2792 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0646 0.2314
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0963 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Echinococcus multilocularis caspase 2 0.0026 0.0509 0.0903
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0083 0.2697 0.9662
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0196 0.02
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0646 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0963 0.3449
Leishmania major DNA polymerase eta, putative 0.0037 0.092 0.3295
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0195 0.6998 0.8897
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0693 0.123
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0646 0.2314
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Brugia malayi hypothetical protein 0.0018 0.0196 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0509 0.0518
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0509 0.0509
Trypanosoma brucei trypanothione reductase 0.0086 0.2792 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0646 0.0646
Echinococcus multilocularis dna polymerase eta 0.0063 0.1923 0.3413
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.016 0.5634 1
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0963 0.1709
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0509 0.0518
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0693 0.0693
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.016 0.5634 0.5634
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0344 0.0351
Schistosoma mansoni caspase-3 (C14 family) 0.0026 0.0509 0.0509
Schistosoma mansoni pcd6 interacting protein-related 0.0018 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Echinococcus granulosus dna polymerase kappa 0.0038 0.0963 0.1709
Plasmodium falciparum glutathione reductase 0.003 0.0646 0.2314
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Echinococcus multilocularis cpg binding protein 0.0033 0.0771 0.1369
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0018 0.0196 0.0196
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0693 0.2483
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0963 0.3449
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0509 0.0518
Trypanosoma cruzi metacaspase, putative 0.0026 0.0509 0.1822
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0026 0.0509 0.0903
Loa Loa (eye worm) thioredoxin reductase 0.0086 0.2792 0.2846
Echinococcus granulosus DNA methyltransferase 2, putative 0.0019 0.0253 0.0448
Plasmodium falciparum metacaspase-like protein 0.0026 0.0509 0.1822
Plasmodium falciparum metacaspase 1 0.0026 0.0509 0.1822
Onchocerca volvulus 0.0031 0.0693 0.0571
Trypanosoma brucei unspecified product 0.0026 0.0511 0.1832
Trypanosoma brucei Metacaspase-4 0.0026 0.0509 0.1822
Mycobacterium ulcerans glutaminase 0.0268 0.9811 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0086 0.2812 0.4991
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0255 0.2646
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0018 0.0196 0.0196
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0196 0.0348
Brugia malayi hypothetical protein 0.0018 0.0196 0.02
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0019 0.0253 0.0905
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0038 0.096 0.096
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0196 0.0196
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0019 0.0253 0.0253
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0018 0.0196 0.0348
Brugia malayi Protein-tyrosine phosphatase 1 0.0018 0.0196 0.02
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0646 0.2314
Onchocerca volvulus Cell death protein 3 homolog 0.0026 0.0509 0.0359
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0196 0.0348
Loa Loa (eye worm) hypothetical protein 0.0026 0.0509 0.0518
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0255 0.0913
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0646 0.041
Schistosoma mansoni eyes absent homolog 0.0087 0.2829 0.2829
Onchocerca volvulus 0.0038 0.096 0.0877
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0196 0.0196
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0196 0.0196
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0196 0.02
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0255 0.026
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0646 0.1147
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0963 0.3449
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0196 0.0348
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0646 0.2314
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0018 0.0196 0.02
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0196 0.0348
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0693 0.0693
Schistosoma mansoni cpg binding protein 0.0033 0.0771 0.0771
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0646 0.041
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0509 0.0518
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0646 0.2314
Brugia malayi Pre-SET motif family protein 0.0031 0.0693 0.0707
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0196 0.02
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0963 0.0934
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0509 0.0518
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0509 0.0518
Mycobacterium tuberculosis Probable reductase 0.0195 0.6998 0.8897
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0196 0.0348
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0196 0.02
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0196 0.0348
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0217 0.7834 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0344 0.0351
Trypanosoma cruzi metacaspase, putative 0.0026 0.0509 0.1822
Echinococcus multilocularis hypothetical protein 0.0018 0.0196 0.0348
Trypanosoma cruzi metacaspase, putative 0.0026 0.0509 0.1822
Brugia malayi Cell death protein 3 precursor 0.0026 0.0509 0.0518
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0026 0.0509 0.0509
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0196 0.02
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0646 0.2314
Brugia malayi Pip kinase protein 2 0.016 0.5634 0.5743
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0196 0.0196
Mycobacterium tuberculosis Probable oxidoreductase 0.0217 0.7834 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0509 0.1822
Echinococcus multilocularis caspase 0.0026 0.0509 0.0903
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.016 0.5634 0.5634
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0196 0.02
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0018 0.0196 0.2034
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0963 0.3449
Echinococcus granulosus cpg binding protein 0.0033 0.0771 0.1369
Brugia malayi glutaminase DH11.1 0.0268 0.9811 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0963 0.3449
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0509 0.0518
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0646 0.2314
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0255 0.0913
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0509 0.0518
Treponema pallidum NADH oxidase 0.003 0.0646 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0509 0.0518
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0018 0.0196 0.02
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0963 0.3449
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0509 0.1822
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0963 0.3449
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0693 0.0693
Loa Loa (eye worm) glutaminase 0.0268 0.9811 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0646 0.5
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0196 0.0196
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0963 0.0982
Plasmodium falciparum thioredoxin reductase 0.003 0.0646 0.2314
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0018 0.0196 0.0196
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0196 0.02
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0217 0.7834 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0196 0.02
Mycobacterium tuberculosis Probable dehydrogenase 0.0195 0.6998 0.8897
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0963 0.3449
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0018 0.0196 0.0196
Schistosoma mansoni cpg binding protein 0.0033 0.0771 0.0771
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0018 0.0196 0.0701
Echinococcus granulosus disco interacting protein 2 0.0038 0.096 0.1704

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 13 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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