Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0433 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3448 | 0.3365 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.0433 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0433 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0185 | 0.0185 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0185 | 0.0185 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0124 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.144 | 0.1333 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0433 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.5097 | 0.5097 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0172 | 0.5097 | 0.5036 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0172 | 0.5097 | 0.5097 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0172 | 0.5097 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.4263 | 0.4191 |
Brugia malayi | RNA binding protein | 0.0125 | 0.3448 | 0.6683 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0786 | 0.0786 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0185 | 0.0123 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0124 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.144 | 0.2647 |
Onchocerca volvulus | 0.01 | 0.257 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0185 | 0.0062 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0433 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.3448 | 0.3365 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0786 | 0.0786 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0786 | 0.1331 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0185 | 0.0123 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0124 | 0.0124 |
Schistosoma mansoni | hypothetical protein | 0.0313 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0185 | 0.0185 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.3448 | 0.3365 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.0433 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0433 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.3448 | 0.6683 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.3448 | 0.3448 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0786 | 0.067 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0433 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0786 | 0.067 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0061 | 0.1226 | 0.1226 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.4263 | 0.4191 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2522 | 0.2428 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0313 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3448 | 0.3365 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0185 | 0.0062 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3448 | 0.3365 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.2522 | 0.4822 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0185 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0185 | 0.0062 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3448 | 0.3365 |
Echinococcus multilocularis | snurportin 1 | 0.0313 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0038 | 0.0433 | 0.0313 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0038 | 0.0433 | 0.0622 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0038 | 0.0433 | 0.0433 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0786 | 0.067 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0038 | 0.0433 | 0.5 |
Trypanosoma brucei | glucosidase, putative | 0.0038 | 0.0433 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0786 | 0.0786 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0124 | 0.0124 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0185 | 0.0062 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.5097 | 0.5097 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0038 | 0.0433 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3448 | 0.3365 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.144 | 0.1333 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.3448 | 0.6683 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0061 | 0.1226 | 0.1226 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0185 | 0.0062 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0433 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0786 | 0.0786 |
Schistosoma mansoni | alpha glucosidase | 0.0038 | 0.0433 | 0.0313 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0786 | 0.067 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.2522 | 0.4822 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.3448 | 0.3448 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0433 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0433 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0185 | 0.0185 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0185 | 0.0062 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.2522 | 0.2428 |
Brugia malayi | RNA, U transporter 1 | 0.0083 | 0.2006 | 0.3784 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0038 | 0.0433 | 0.0433 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0433 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0185 | 0.0185 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0038 | 0.0433 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0061 | 0.1226 | 0.1116 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.3448 | 0.3365 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 11 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.