Detailed information for compound 1050842

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 408.45 | Formula: C22H24N4O4
  • H donors: 0 H acceptors: 3 LogP: 3.63 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1c1occ(n1)CN1CCN(CC1)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C22H24N4O4/c1-2-29-21-6-4-3-5-20(21)22-23-17(16-30-22)15-24-11-13-25(14-12-24)18-7-9-19(10-8-18)26(27)28/h3-10,16H,2,11-15H2,1H3
  • InChiKey: QYLWFMIFNDEVFW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0018
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0025 0.0025
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.1621 0.2817
Echinococcus multilocularis geminin 0.0166 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0018
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.1161 0.1179
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.3525 0.6485
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.535 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0025 0.0018
Plasmodium falciparum thioredoxin reductase 0.0016 0.0326 0.1376
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.2279 0.2279
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0013 0.0159 0.0154
Schistosoma mansoni cpg binding protein 0.003 0.1248 0.1225
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0326 0.0323
Echinococcus multilocularis peregrin 0.0029 0.1161 0.1161
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0025 0.0018
Mycobacterium tuberculosis Probable reductase 0.0105 0.6108 0.8837
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0025 0.0018
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0025 0.0025
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.3525 0.3595
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0503 0.2156
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0326 0.0323
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0503 0.0506
Trypanosoma brucei polo-like protein kinase 0.0094 0.535 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.1621 0.1621
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0326 0.0323
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.535 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0326 0.0326
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.3525 0.3525
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0025 0.0018
Brugia malayi CXXC zinc finger family protein 0.0029 0.1142 0.1159
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.229 0.4106
Brugia malayi jmjC domain containing protein 0.0095 0.5416 0.5527
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.166 0.1639
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0326 0.0323
Schistosoma mansoni ap endonuclease 0.0019 0.0503 0.0479
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0025 0.0025
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.1161 0.1161
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.6108 0.8837
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0326 0.0323
Trypanosoma brucei trypanothione reductase 0.0046 0.2279 0.4085
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0326 0.1376
Toxoplasma gondii thioredoxin reductase 0.0046 0.2279 0.7901
Plasmodium falciparum thioredoxin reductase 0.0046 0.2279 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.2279 0.2279
Echinococcus multilocularis jumonji domain containing protein 0.004 0.1893 0.1893
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.535 0.535
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.4225 0.4225
Loa Loa (eye worm) hypothetical protein 0.005 0.2497 0.2544
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0025 0.0018
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0025 0.0025
Brugia malayi steroid hormone receptor 0.0011 0.0025 0.0018
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0025 0.0018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.4225 0.4225
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.6868 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.1621 0.5239
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0025 0.0025
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.1621 0.2817
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.2239 0.222
Toxoplasma gondii exonuclease III APE 0.0019 0.0503 0.0715
Brugia malayi Bromodomain containing protein 0.0029 0.1161 0.1179
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.3525 0.6485
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.535 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0326 0.0323
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0018
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.9793 0.9793
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0025 0.0018
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.1142 0.1159
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0025 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0025 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0025 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0025 0.0018
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0503 0.0663
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.535 1
Brugia malayi Thioredoxin reductase 0.0046 0.2279 0.2322
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.1161 0.3376
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.1621 0.2817
Onchocerca volvulus 0.0094 0.5365 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0052 0.0045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0018
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.3525 0.6485
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0326 0.0323
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.2279 0.2322
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0467 0.047
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.535 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.6108 0.8837
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0025 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.535 1
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0025 0.0025
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.2239 0.2281
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.9793 0.9793
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.1621 0.1649
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.3217 0.32
Plasmodium vivax glutathione reductase, putative 0.0046 0.2279 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0503 0.0663
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.9793 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0326 0.0323
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0326 0.0323
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.2239 0.2239
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.5416 0.5416
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0362 0.0338
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.535 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.2239 0.2281
Schistosoma mansoni ap endonuclease 0.0019 0.0503 0.0479
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.166 0.1639
Brugia malayi nuclear receptor NHR-88 0.0011 0.0025 0.0018
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.3525 0.3525
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0025 0.0025
Entamoeba histolytica hypothetical protein 0.0076 0.4225 0.7833
Echinococcus granulosus peregrin 0.0029 0.1161 0.1161
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0025 0.0025
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.2798 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0503 0.0663
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.2279 1
Giardia lamblia Kinase, PLK 0.0094 0.535 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.2239 0.2239
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0326 0.0323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0025 0.0018
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.166 0.1689
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.3525 0.6485
Brugia malayi jmjC domain containing protein 0.0037 0.166 0.1689
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0326 0.1376
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.1161 0.1161
Entamoeba histolytica hypothetical protein 0.0076 0.4225 0.7833
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.1621 0.2817
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0025 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0025 0.0025
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.6868 1
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.1742 0.1742
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0326 0.5
Schistosoma mansoni cpg binding protein 0.003 0.1248 0.1225
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.1621 0.2817
Schistosoma mansoni hypothetical protein 0.0166 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0326 0.0323
Brugia malayi glutathione reductase 0.0046 0.2279 0.2322
Plasmodium falciparum glutathione reductase 0.0046 0.2279 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.6108 0.8837
Schistosoma mansoni alpha-glucosidase 0.014 0.833 0.8326
Echinococcus granulosus cpg binding protein 0.003 0.1248 0.1248
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.3525 0.6485
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.3525 0.3595
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1621 0.2817
Loa Loa (eye worm) hypothetical protein 0.0029 0.1161 0.1179
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0159 0.025
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0025 0.0025
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0052 0.0045
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0326 0.1376
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.6868 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.535 0.546
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.229 0.4106
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1621 0.2817
Schistosoma mansoni hypothetical protein 0.0166 1 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0326 0.0326
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.5416 0.5416
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.1161 0.1139
Brugia malayi nuclear hormone receptor 0.0011 0.0025 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0018
Plasmodium vivax hypothetical protein, conserved 0.0029 0.1161 0.5061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0025 0.0018
Echinococcus granulosus transcription factor Dp 1 0.0038 0.1742 0.1742
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0503 0.0663
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0503 0.0663
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.3525 0.3509
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0025 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.1621 0.2817
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.1621 0.2817
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.1621 0.2817
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0503 0.0506
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0326 0.0326
Echinococcus multilocularis cpg binding protein 0.003 0.1248 0.1248
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0025 0.0018
Schistosoma mansoni alpha-glucosidase 0.014 0.833 0.8326
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.6108 0.8837
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.2279 0.2985
Brugia malayi ecdysteroid receptor 0.0011 0.0025 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0326 0.0323
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0326 0.0323
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.9793 0.9793
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0159 0.0154
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0503 0.0663
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.1621 0.1649
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.2239 0.2239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0025 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0018
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.4225 0.4211
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0326 0.0323
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0503 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0025 0.0025
Echinococcus granulosus jumonji domain containing protein 0.004 0.1893 0.1893
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0503 0.0503
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.535 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0025 0.0018
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0326 0.0323
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0025 0.0025
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0025 0.0025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.2239 0.2239
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.1621 0.1621
Trypanosoma brucei glucosidase, putative 0.0036 0.1621 0.2817
Plasmodium falciparum phd finger protein, putative 0.0029 0.1161 0.5061
Schistosoma mansoni hypothetical protein 0.0076 0.4225 0.4211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0025 0.0018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0503 0.2156
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0326 0.0323
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0025 0.0025
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0025 0.0018
Loa Loa (eye worm) glutathione reductase 0.0046 0.2279 0.2322
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.6108 0.8837
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.166 0.166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.2239 0.222
Onchocerca volvulus 0.0029 0.1142 0.2092
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0326 0.0302
Brugia malayi PHD-finger family protein 0.0029 0.1161 0.1179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0025 0.0018
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0503 0.0663
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.1621 0.2817
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.535 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.2239 0.222
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0503 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.1621 0.2817
Giardia lamblia PHD finger protein 15 0.0029 0.1161 0.1661
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.535 0.9972
Entamoeba histolytica hypothetical protein 0.0076 0.4225 0.7833
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0025 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.535 0.5338
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0025 0.0018
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0503 0.0352
Leishmania major trypanothione reductase 0.0046 0.2279 0.4085
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.9793 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0326 0.1376
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0503 1
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0025 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0326 0.0323
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.535 0.535
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.1554 0.1554
Plasmodium falciparum glutathione reductase 0.0016 0.0326 0.1376
Schistosoma mansoni cpg binding protein 0.0029 0.1142 0.112
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.6868 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.535 1
Onchocerca volvulus Alhambra homolog 0.0029 0.1161 0.2127
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.3152 0.3214
Schistosoma mansoni hypothetical protein 0.0029 0.1161 0.1139
Entamoeba histolytica hypothetical protein 0.0076 0.4225 0.7833
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0503 0.027
Schistosoma mansoni kinase 0.0048 0.237 0.2351
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0326 0.0323
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.2279 0.4085
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.1621 0.2817
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.535 1
Brugia malayi hypothetical protein 0.0076 0.4225 0.431
Schistosoma mansoni alpha glucosidase 0.0036 0.1621 0.16
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.1621 0.2817
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.535 0.546
Schistosoma mansoni jumonji domain containing protein 0.0075 0.4157 0.4142
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0326 0.0323
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.1161 0.3376
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0025 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0018

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 22 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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