Detailed information for compound 1050852

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 412.5 | Formula: C23H29FN4O2
  • H donors: 1 H acceptors: 2 LogP: 3.95 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C(/c1ccc(nc1OCc1ccccc1F)C)\N1CCN(CC1)C1CCCC1
  • InChi: 1S/C23H29FN4O2/c1-17-10-11-20(23(25-17)30-16-18-6-2-5-9-21(18)24)22(26-29)28-14-12-27(13-15-28)19-7-3-4-8-19/h2,5-6,9-11,19,29H,3-4,7-8,12-16H2,1H3/b26-22-
  • InChiKey: IBMAQIKVADNBEX-ROMGYVFFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.3594 0.2589
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.3594 0.5
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0166 0.8816 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.017 0.9033 0.9012
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.1457 0.3059
Schistosoma mansoni growth factor receptor-bound protein 0.017 0.9033 0.9015
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.1457 0.1272
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.8816 0.879
Trypanosoma brucei aldo-keto reductase, putative 0.0166 0.8816 1
Entamoeba histolytica protein kinase, putative 0.009 0.4258 0.4813
Echinococcus granulosus tyrosine protein kinase Lyn 0.0074 0.3317 0.3172
Brugia malayi Variant SH3 domain containing protein 0.0036 0.1075 0.0977
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.8816 0.879
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.4664 0.5046
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.8816 1
Trypanosoma brucei prostaglandin f synthase 0.0166 0.8816 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0048 0.177 0.4076
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.4664 0.4548
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.8816 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.009 0.4258 0.4586
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.177 0.0425
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.8816 1
Schistosoma mansoni jumonji domain containing protein 0.0061 0.2544 0.2403
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0074 0.3289 0.3143
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.2544 0.2382
Schistosoma mansoni tyrosine kinase 0.0074 0.3289 0.3162
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0549 0.0108
Echinococcus granulosus aldo keto reductase 0.0166 0.8816 0.879
Loa Loa (eye worm) oxidoreductase 0.0166 0.8816 0.9753
Loa Loa (eye worm) hypothetical protein 0.0036 0.1075 0.0977
Schistosoma mansoni potassium channel beta 0.0048 0.177 0.1615
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0074 0.3289 0.3143
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.8816 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0166 0.8816 0.9753
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.8816 1
Brugia malayi Variant SH3 domain containing protein 0.0036 0.1075 0.0977
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.8816 1
Onchocerca volvulus 0.0166 0.8816 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.3594 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0074 0.3289 0.3143
Onchocerca volvulus 0.0022 0.0212 0.0241
Entamoeba histolytica aldose reductase, putative 0.0166 0.8816 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.8816 0.879
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0074 0.3289 0.3143
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.8816 0.879
Echinococcus granulosus tyrosine protein kinase Fyn 0.0074 0.3289 0.3143
Trypanosoma cruzi aldo-keto reductase 0.0166 0.8816 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0166 0.8816 1
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0048 0.177 0.1766
Entamoeba histolytica alcohol dehydrogenase, putative 0.0048 0.177 0.1983
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0074 0.3289 0.3143
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.1457 0.1135
Onchocerca volvulus 0.0022 0.0212 0.0241
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0074 0.3289 0.3143
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.8816 0.879
Schistosoma mansoni tyrosine kinase 0.0074 0.3289 0.3162
Toxoplasma gondii aldo-keto reductase 0.0048 0.177 0.1512
Loa Loa (eye worm) oxidoreductase 0.0166 0.8816 0.9753
Loa Loa (eye worm) oxidoreductase 0.0166 0.8816 0.9753
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.3594 0.2589
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0166 0.8816 1
Echinococcus granulosus hypothetical protein 0.0166 0.8816 0.879
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.8816 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0166 0.8816 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.3594 0.3455
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0166 0.8816 0.9753
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0166 0.8816 0.9753
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.4664 0.4563
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.8816 0.879
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.1457 0.1135
Entamoeba histolytica protein kinase domain containing protein 0.009 0.4258 0.4813
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.4258 0.4486
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.1976 0.0292
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.8816 0.879
Schistosoma mansoni pol-related 0.0166 0.8816 0.8793
Echinococcus multilocularis aldo keto reductase 0.0166 0.8816 0.879
Schistosoma mansoni tyrosine kinase 0.004 0.1287 0.1123
Echinococcus multilocularis aldo keto reductase 0.0166 0.8816 0.879
Echinococcus granulosus tyrosine protein kinase Fyn 0.0074 0.3289 0.3143
Schistosoma mansoni adapter molecule crk 0.0036 0.1075 0.0906
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.2544 0.2382
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0549 0.0108
Entamoeba histolytica hypothetical protein 0.009 0.4258 0.4813
Leishmania major prostaglandin f synthase, putative 0.0166 0.8816 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0074 0.3289 0.3143
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.2214 0.2045
Loa Loa (eye worm) TK protein kinase 0.0056 0.2214 0.2269
Echinococcus granulosus c src tyrosine kinase 0.004 0.1287 0.1098
Echinococcus multilocularis c src tyrosine kinase 0.004 0.1287 0.1098
Onchocerca volvulus 0.0022 0.0212 0.0241
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.009 0.4258 0.4486
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.3594 0.3473
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0036 0.1075 0.0906
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.2662 0.2586
Onchocerca volvulus 0.0022 0.0212 0.0241
Onchocerca volvulus 0.0048 0.177 0.2008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.4664 0.4548
Echinococcus granulosus tyrosine protein kinase Blk 0.0056 0.2214 0.2045
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.2662 0.1266
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.8816 0.879
Echinococcus multilocularis NCK adaptor protein 0.0036 0.1075 0.0881
Schistosoma mansoni aldo-keto reductase 0.0166 0.8816 0.8793
Echinococcus granulosus tyrosine protein kinase Btk29A 0.004 0.1287 0.1098
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.2662 0.2503
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.2662 0.2503
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.1976 0.1802
Echinococcus granulosus growth factor receptor bound protein 2 0.017 0.9033 0.9012
Loa Loa (eye worm) oxidoreductase 0.0166 0.8816 0.9753
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.2544 0.2403
Schistosoma mansoni tyrosine kinase 0.0022 0.0212 0.0028
Entamoeba histolytica protein kinase, putative 0.009 0.4258 0.4813
Onchocerca volvulus 0.0022 0.0212 0.0241
Entamoeba histolytica alcohol dehydrogenase, putative 0.0048 0.177 0.1983
Entamoeba histolytica protein kinase, putative 0.0037 0.1112 0.1234
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0074 0.3289 0.3143
Trichomonas vaginalis aldo/keto reductase, putative 0.0166 0.8816 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.2662 0.1266
Loa Loa (eye worm) SRC-1 0.0074 0.3289 0.3488
Trypanosoma cruzi aldo/keto reductase, putative 0.0166 0.8816 1
Mycobacterium leprae Conserved hypothetical protein 0.0118 0.5943 0.6539
Onchocerca volvulus 0.0166 0.8816 1
Echinococcus granulosus aldehyde reductase 0.0118 0.5943 0.5855
Plasmodium falciparum aldo-keto reductase, putative 0.0048 0.177 0.4076
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.3594 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0074 0.3289 0.3143
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.2662 0.2524
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.2662 0.2524
Echinococcus granulosus tyrosine protein kinase Src42A 0.0074 0.3289 0.3143
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.8816 0.879
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.8816 0.879
Echinococcus multilocularis geminin 0.0186 1 1
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0048 0.177 0.1592
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0074 0.3289 0.3143
Loa Loa (eye worm) hypothetical protein 0.0166 0.8816 0.9753
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.3594 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0056 0.2214 0.2045
Loa Loa (eye worm) hypothetical protein 0.0089 0.423 0.4554
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.1976 0.0292
Echinococcus granulosus aldo keto reductase 0.0166 0.8816 0.879
Trichomonas vaginalis aldo-keto reductase, putative 0.0048 0.177 0.0425
Loa Loa (eye worm) hypothetical protein 0.0028 0.0549 0.0381
Brugia malayi Protein kinase domain containing protein 0.009 0.4258 0.4586
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.4664 0.4548
Onchocerca volvulus 0.0022 0.0212 0.0241
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.3594 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.8816 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0074 0.3289 0.3143
Echinococcus granulosus tyrosine protein kinase HCK 0.0037 0.1112 0.0919
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0549 0.004
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.004 0.1287 0.1123
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.3594 0.3709
Trypanosoma cruzi aldo/keto reductase, putative 0.0048 0.177 0.1477
Brugia malayi Probable ClpP-like protease 0.0079 0.3594 0.3834
Echinococcus granulosus voltage gated potassium channel subunit 0.0048 0.177 0.1592
Loa Loa (eye worm) TK protein kinase 0.0037 0.1112 0.1019
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0052 0.2001 0.1828
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.4664 0.4563
Echinococcus granulosus tyrosine protein kinase Src42A 0.0052 0.2001 0.1828
Entamoeba histolytica aldose reductase, putative 0.0166 0.8816 1
Schistosoma mansoni growth factor receptor-bound protein 0.017 0.9033 0.9015
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0166 0.8816 0.9753
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0048 0.177 0.1512
Schistosoma mansoni tyrosine kinase 0.0022 0.0212 0.0028
Giardia lamblia Aldose reductase 0.0166 0.8816 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.3594 0.3709
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.2662 0.1266
Echinococcus multilocularis tyrosine protein kinase HCK 0.0037 0.1112 0.0919
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.2544 0.2382
Echinococcus multilocularis dual specificity 0.009 0.4258 0.4133
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.2544 0.2403
Echinococcus multilocularis tyrosine protein kinase Abl 0.004 0.1287 0.1098
Giardia lamblia Aldose reductase 0.0166 0.8816 1
Brugia malayi SRC-1 0.0074 0.3289 0.3488
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0166 0.8816 1
Mycobacterium ulcerans oxidoreductase 0.0166 0.8816 1
Echinococcus granulosus NCK adaptor protein 0.0036 0.1075 0.0881
Trichomonas vaginalis aldo-keto reductase, putative 0.0048 0.177 0.0425
Schistosoma mansoni nck2/grb4 0.0036 0.1075 0.0906
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.1244 0.2366
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0074 0.3289 0.3143
Loa Loa (eye worm) acetyltransferase 0.0146 0.7603 0.8378
Onchocerca volvulus 0.0166 0.8816 1
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.2544 0.2382
Trichomonas vaginalis aldo/keto reductase, putative 0.0166 0.8816 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0048 0.177 0.1766
Echinococcus granulosus tyrosine kinase 0.0056 0.2214 0.2045
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0036 0.1075 0.0977
Echinococcus multilocularis aldehyde reductase 0.0118 0.5943 0.5855
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.2544 0.2643
Echinococcus multilocularis voltage gated potassium channel subunit 0.0048 0.177 0.1592
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.7603 0.8378
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.8816 0.879
Loa Loa (eye worm) sex muscle abnormal protein 5 0.017 0.9033 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.8816 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0166 0.8816 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.2662 0.2556
Loa Loa (eye worm) hypothetical protein 0.0089 0.423 0.4554
Echinococcus multilocularis tyrosine protein kinase Srms 0.0056 0.2214 0.2045
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0056 0.2214 0.2045
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.8816 0.879
Trichomonas vaginalis aldo-keto reductase, putative 0.0048 0.177 0.0425
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.1244 0.1384
Brugia malayi protein-tyrosine kinase 0.0056 0.2214 0.2269
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.8816 0.879
Toxoplasma gondii aldose reductase, putative 0.0166 0.8816 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.4664 0.4548
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.3594 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.8816 0.879
Brugia malayi hypothetical protein 0.0028 0.0549 0.0381
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.8816 0.879
Schistosoma mansoni hypothetical protein 0.0186 1 1
Loa Loa (eye worm) oxidoreductase 0.0166 0.8816 0.9753
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.1976 0.1802
Trypanosoma brucei aldo/keto reductase, putative 0.0048 0.177 0.1477
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.7603 0.7551
Brugia malayi Tyrosine-protein kinase abl-1 0.004 0.1287 0.1219
Brugia malayi Sex muscle abnormal protein 5 0.017 0.9033 1
Plasmodium falciparum aldehyde reductase, putative 0.0048 0.177 0.4076
Brugia malayi jmjC domain containing protein 0.0061 0.2544 0.2643
Brugia malayi jmjC domain containing protein 0.0061 0.2544 0.2643
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.004 0.1287 0.1098
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.8816 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0022 0.0212 0.0211
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.8816 0.879
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.8816 0.879
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.1976 0.176
Echinococcus granulosus dual specificity 0.009 0.4258 0.4133
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0166 0.8816 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.009 0.4258 0.4486
Echinococcus granulosus aldo keto reductase 0.0166 0.8816 0.879
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0549 0.0108
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.4664 0.5046
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.8816 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.3594 0.3709
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.4664 0.4563
Loa Loa (eye worm) hypothetical protein 0.0079 0.3594 0.3834
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.4258 0.4486
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.2662 0.1266
Onchocerca volvulus 0.0166 0.8816 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.7603 0.7557
Plasmodium vivax aldehyde reductase, putative 0.0048 0.177 0.4076
Echinococcus multilocularis aldo keto reductase 0.0166 0.8816 0.879
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0048 0.177 0.1512
Brugia malayi NADH-dependent xylose reductase 0.0048 0.177 0.1766
Schistosoma mansoni tyrosine kinase 0.004 0.1287 0.1123
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.8816 0.879
Schistosoma mansoni aldo-keto reductase 0.0166 0.8816 0.8793
Leishmania major aldo-keto reductase-like protein 0.0166 0.8816 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0048 0.177 0.0425
Schistosoma mansoni hypothetical protein 0.0186 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.8816 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.3594 0.3455
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.8816 0.879
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0074 0.3289 0.3143
Echinococcus multilocularis aldo keto reductase 0.0166 0.8816 0.879
Schistosoma mansoni serine/threonine protein kinase 0.009 0.4258 0.4149
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0166 0.8816 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.8816 0.879
Entamoeba histolytica aldose reductase, putative 0.0166 0.8816 1
Onchocerca volvulus 0.0166 0.8816 1
Mycobacterium leprae Possible oxidoreductase 0.0048 0.177 0.1512
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.7358 0.7301
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0048 0.177 0.1477
Onchocerca volvulus 0.0166 0.8816 1

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 1 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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