Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0164 | 0.1373 | 0.1363 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0149 | 0.1223 | 0.3645 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.0044 | 0.0156 | 0.0266 |
Toxoplasma gondii | hypothetical protein | 0.0107 | 0.079 | 1 |
Onchocerca volvulus | 0.0149 | 0.1223 | 0.5867 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0044 | 0.0156 | 0.0266 |
Echinococcus multilocularis | tumor protein p63 | 0.1017 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.1791 | 0.4175 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0072 | 0.0144 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0106 | 0.078 | 0.2241 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.008 | 0.0521 | 0.1197 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 0.2318 | 1 |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.0044 | 0.0156 | 0.0146 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0521 | 0.0766 |
Leishmania major | cathepsin L-like protease | 0.0132 | 0.1051 | 0.156 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0044 | 0.0156 | 0.0266 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0121 | 0.0935 | 0.1376 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0072 | 0.0144 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0092 | 0.0244 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0149 | 0.1223 | 0.1833 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0064 | 0.0125 |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0044 | 0.0156 | 0.0266 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0044 | 0.0156 | 0.0156 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0044 | 0.0156 | 0.0266 |
Onchocerca volvulus | 0.0044 | 0.0156 | 0.0704 | |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0044 | 0.0156 | 0.0341 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.0917 | 0.2126 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0156 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1223 | 0.2844 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0132 | 0.1051 | 0.1549 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 0.2318 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0011 | 0.0011 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0044 | 0.0156 | 0.1868 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0072 | 0.0144 |
Brugia malayi | AMP-binding enzyme family protein | 0.0044 | 0.0156 | 0.0341 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0132 | 0.1051 | 0.156 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0173 | 0.1459 | 0.3397 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0169 | 0.1423 | 0.683 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.0177 | 0.1502 | 0.3499 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0072 | 0.0144 |
Brugia malayi | AMP-binding enzyme family protein | 0.0044 | 0.0156 | 0.0341 |
Brugia malayi | TAR-binding protein | 0.0451 | 0.4274 | 1 |
Leishmania major | cathepsin L-like protease | 0.0132 | 0.1051 | 0.156 |
Echinococcus granulosus | tar DNA binding protein | 0.0451 | 0.4274 | 0.4274 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.0044 | 0.0156 | 0.0266 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0044 | 0.0156 | 0.0146 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0072 | 0.0788 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0035 | 0.0064 | 0.0053 |
Mycobacterium leprae | Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) | 0.0044 | 0.0156 | 0.073 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0106 | 0.078 | 0.2241 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1223 | 0.2844 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0093 | 0.0652 | 0.0917 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0113 | 0.0857 | 0.1254 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.1423 | 0.6026 |
Onchocerca volvulus | 0.0044 | 0.0156 | 0.0704 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0072 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1502 | 0.3499 |
Mycobacterium tuberculosis | PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0038 | 0.0095 | 0.0071 |
Onchocerca volvulus | 0.0036 | 0.0072 | 0.0297 | |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0521 | 0.0766 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 0.2318 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0092 | 0.0244 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0521 | 0.0766 |
Echinococcus multilocularis | tar DNA binding protein | 0.0451 | 0.4274 | 0.4267 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0044 | 0.0156 | 0.0266 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0035 | 0.0064 | 0.0125 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0044 | 0.0156 | 0.0796 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0072 | 0.0144 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0044 | 0.0156 | 0.0266 |
Leishmania major | cathepsin L-like protease | 0.0132 | 0.1051 | 0.156 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0132 | 0.1051 | 0.156 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.1423 | 0.6026 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0092 | 0.0244 |
Onchocerca volvulus | 0.0035 | 0.0064 | 0.0257 | |
Echinococcus multilocularis | cysteine protease | 0.0035 | 0.0064 | 0.0053 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0104 | 0.0765 | 0.1107 |
Mycobacterium ulcerans | hypothetical protein | 0.0348 | 0.323 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0064 | 0.0125 |
Trichomonas vaginalis | set domain proteins, putative | 0.0234 | 0.2078 | 0.8932 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0132 | 0.1051 | 0.1549 |
Onchocerca volvulus | Cathepsin L homolog | 0.0035 | 0.0064 | 0.0257 |
Schistosoma mansoni | tar DNA-binding protein | 0.0451 | 0.4274 | 0.6397 |
Echinococcus multilocularis | GPCR, family 2 | 0.008 | 0.0521 | 0.0511 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.008 | 0.0521 | 0.1197 |
Onchocerca volvulus | 0.0035 | 0.0064 | 0.0257 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0132 | 0.1051 | 0.1549 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.1423 | 0.6026 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0072 | 0.0013 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0035 | 0.0064 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0842 | 0.1949 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0842 | 0.1949 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0044 | 0.0156 | 0.0218 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0044 | 0.0156 | 0.0266 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0044 | 0.0156 | 0.0146 |
Mycobacterium leprae | POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0044 | 0.0156 | 0.073 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0044 | 0.0156 | 0.0341 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0044 | 0.0156 | 0.0146 |
Toxoplasma gondii | propionate-CoA ligase | 0.0044 | 0.0156 | 0.1868 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0064 | 0.0125 |
Brugia malayi | AMP-binding enzyme family protein | 0.0149 | 0.1223 | 0.2844 |
Onchocerca volvulus | Cathepsin L homolog | 0.0035 | 0.0064 | 0.0257 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0132 | 0.1051 | 0.1549 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0842 | 0.1949 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0044 | 0.0156 | 0.0146 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0689 | 0.6675 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0909 | 0.8908 | 0.8908 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0092 | 0.0191 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0044 | 0.0156 | 0.0266 |
Onchocerca volvulus | 0.0044 | 0.0156 | 0.0704 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0149 | 0.1223 | 0.2844 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0035 | 0.0064 | 0.0125 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0072 | 0.0072 |
Onchocerca volvulus | 0.0035 | 0.0064 | 0.0257 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0072 | 0.0013 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0044 | 0.0156 | 0.1868 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.1423 | 0.6026 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0044 | 0.0156 | 0.0266 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.1423 | 0.6026 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0149 | 0.1223 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0451 | 0.4274 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0149 | 0.1223 | 0.3645 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.0044 | 0.0156 | 0.0266 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0044 | 0.0156 | 0.0266 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0072 | 0.0739 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0044 | 0.0156 | 0.0266 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0348 | 0.323 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0106 | 0.078 | 0.2241 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0149 | 0.1223 | 0.3645 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.008 | 0.0521 | 0.0511 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0044 | 0.0156 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0092 | 0.0122 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0072 | 0.0144 |
Onchocerca volvulus | 0.0036 | 0.0072 | 0.0297 | |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0044 | 0.0156 | 0.0266 |
Mycobacterium ulcerans | acetyl-CoA synthetase | 0.0044 | 0.0156 | 0.0266 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0178 | 0.1515 | 0.6434 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0064 | 0.0125 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0258 | 0.2318 | 0.5413 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0064 | 0.0125 |
Plasmodium vivax | vivapain-2 | 0.0035 | 0.0064 | 0.064 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0172 | 0.1453 | 0.6163 |
Toxoplasma gondii | cathepsin CPL | 0.0035 | 0.0064 | 0.0683 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0044 | 0.0156 | 0.0266 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1459 | 0.2173 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0092 | 0.0082 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0072 | 0.0037 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.008 | 0.0521 | 0.0511 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0112 | 0.0842 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.0917 | 0.2126 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0521 | 0.0766 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.1423 | 0.6026 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 0.2318 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0072 | 0.0144 |
Onchocerca volvulus | 0.0035 | 0.0064 | 0.0257 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0451 | 0.4274 | 0.6397 |
Onchocerca volvulus | Cathepsin F homolog | 0.0035 | 0.0064 | 0.0257 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0156 | 0.0341 |
Loa Loa (eye worm) | RNA binding protein | 0.0451 | 0.4274 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0149 | 0.1223 | 0.1833 |
Onchocerca volvulus | 0.0035 | 0.0064 | 0.0257 | |
Leishmania major | acetyl-CoA synthetase, putative | 0.0044 | 0.0156 | 0.0146 |
Echinococcus granulosus | cathepsin l1 | 0.0035 | 0.0064 | 0.0064 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0132 | 0.1051 | 0.1549 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0132 | 0.1051 | 0.156 |
Loa Loa (eye worm) | fibroinase | 0.0035 | 0.0064 | 0.0125 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0149 | 0.1223 | 0.3645 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1219 | 0.2833 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0132 | 0.1051 | 0.1549 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0035 | 0.0064 | 0.0053 |
Brugia malayi | AMP-binding enzyme family protein | 0.0044 | 0.0156 | 0.0341 |
Plasmodium vivax | vivapain-2 | 0.0035 | 0.0064 | 0.064 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0064 | 0.0125 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 0.2318 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0044 | 0.0156 | 0.0146 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.008 | 0.0521 | 0.0521 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0689 | 0.6675 | 0.6675 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0842 | 0.1949 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0044 | 0.0156 | 0.0266 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0064 | 0.0125 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.1423 | 0.6026 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0044 | 0.0156 | 0.0266 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0132 | 0.1051 | 0.1549 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0035 | 0.0064 | 0.008 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0093 | 0.0652 | 0.0929 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.008 | 0.0521 | 0.0521 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0072 | 0.0037 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0149 | 0.1223 | 0.1833 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0092 | 0.0244 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.1791 | 0.4175 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0035 | 0.0064 | 0.008 |
Brugia malayi | Latrophilin receptor protein 2 | 0.008 | 0.0521 | 0.1197 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0072 | 0.0037 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0258 | 0.2318 | 0.5413 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0842 | 0.1949 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0072 | 0.0144 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0044 | 0.0156 | 0.1187 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0093 | 0.0652 | 0.0929 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0035 | 0.0064 | 0.0125 |
Echinococcus granulosus | GPCR family 2 | 0.008 | 0.0521 | 0.0521 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 0.2318 | 1 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0044 | 0.0156 | 0.0266 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0112 | 0.0842 | 0.2436 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0044 | 0.0156 | 0.0341 |
Echinococcus granulosus | geminin | 0.0164 | 0.1373 | 0.1373 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0149 | 0.1223 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0035 | 0.0064 | 0.0064 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0132 | 0.1051 | 0.156 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0044 | 0.0156 | 0.0341 |
Mycobacterium ulcerans | O-succinylbenzoic acid--CoA ligase | 0.0044 | 0.0156 | 0.0266 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0909 | 0.8908 | 0.8907 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0044 | 0.0156 | 0.0266 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0112 | 0.0842 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.2009 | 0.6134 |
Loa Loa (eye worm) | oxidoreductase | 0.0044 | 0.0156 | 0.0341 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0044 | 0.0156 | 0.0133 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0149 | 0.1219 | 0.1812 |
Brugia malayi | AMP-binding enzyme family protein | 0.0149 | 0.1223 | 0.2844 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0132 | 0.1051 | 0.1549 |
Onchocerca volvulus | 0.0234 | 0.2078 | 1 | |
Onchocerca volvulus | 0.0035 | 0.0064 | 0.0257 | |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0072 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0072 | 0.0144 |
Schistosoma mansoni | tar DNA-binding protein | 0.0451 | 0.4274 | 0.6397 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0253 | 0.2267 | 0.5293 |
Loa Loa (eye worm) | cysteine protease | 0.0035 | 0.0064 | 0.0125 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0092 | 0.0092 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0149 | 0.1223 | 0.3645 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0313 | 0.2873 | 0.444 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0044 | 0.0156 | 0.0266 |
Schistosoma mansoni | tar DNA-binding protein | 0.0451 | 0.4274 | 0.6397 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0093 | 0.0652 | 0.0929 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0149 | 0.1223 | 0.3645 |
Brugia malayi | AMP-binding enzyme family protein | 0.0044 | 0.0156 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0072 | 0.0144 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0132 | 0.1051 | 0.1549 |
Onchocerca volvulus | 0.0044 | 0.0156 | 0.0704 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0072 | 0.0092 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0149 | 0.1223 | 0.3645 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0132 | 0.1051 | 0.1549 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0451 | 0.4274 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0044 | 0.0156 | 0.0266 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0106 | 0.078 | 0.2241 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0689 | 0.6675 | 0.6671 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0072 | 0.0013 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.066 | 0.639 | 1 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.0044 | 0.0156 | 0.0266 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0044 | 0.0156 | 0.041 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0072 | 0.0037 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0149 | 0.1223 | 0.3645 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0149 | 0.1223 | 0.3645 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0132 | 0.1051 | 0.1549 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0149 | 0.1223 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0072 | 0.0144 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.066 | 0.639 | 1 |
Onchocerca volvulus | 0.0035 | 0.0064 | 0.0257 | |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0521 | 0.1197 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0044 | 0.0156 | 0.0266 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0313 | 0.2873 | 0.444 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.0917 | 0.2126 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0178 | 0.1515 | 0.6434 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0072 | 0.0092 |
Mycobacterium ulcerans | hypothetical protein | 0.0149 | 0.1223 | 0.3645 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0149 | 0.1223 | 1 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0044 | 0.0156 | 0.1752 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1373 | 0.2044 |
Echinococcus multilocularis | cysteine protease | 0.0035 | 0.0064 | 0.0053 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0072 | 0.0144 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0253 | 0.2267 | 0.5293 |
Onchocerca volvulus | 0.0149 | 0.1219 | 0.5844 | |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0044 | 0.0156 | 0.0266 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.0044 | 0.0156 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.2267 | 0.5293 |
Mycobacterium leprae | POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) | 0.0044 | 0.0156 | 0.073 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0044 | 0.0156 | 0.0146 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0072 | 0.0037 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0451 | 0.4274 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0035 | 0.0064 | 0.0053 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0044 | 0.0156 | 0.041 |
Echinococcus granulosus | neuropeptide s receptor | 0.0909 | 0.8908 | 0.8908 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.1459 | 0.3397 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0112 | 0.0842 | 0.2436 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0253 | 0.2267 | 0.5293 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0092 | 0.0122 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0112 | 0.0842 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1373 | 0.2044 |
Brugia malayi | RNA binding protein | 0.0451 | 0.4274 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0035 | 0.0064 | 0.0125 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.066 | 0.639 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0451 | 0.4274 | 0.6397 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0035 | 0.0064 | 0.0064 |
Leishmania major | mitochondrial DNA polymerase beta | 0.066 | 0.639 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0313 | 0.2873 | 0.4433 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1223 | 0.2844 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0909 | 0.8908 | 0.8907 |
Onchocerca volvulus | 0.0036 | 0.0072 | 0.0297 | |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0149 | 0.1223 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 5 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.