Detailed information for compound 1051253

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 544.497 | Formula: C24H29N6O7P
  • H donors: 3 H acceptors: 4 LogP: 1.96 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(OC(=O)[C@@H](NP(=O)(Oc1cccc2c1cccc2)OCCOCn1cnc2c1nc(N)[nH]c2=O)C)C
  • InChi: 1S/C24H29N6O7P/c1-15(2)36-23(32)16(3)29-38(33,37-19-10-6-8-17-7-4-5-9-18(17)19)35-12-11-34-14-30-13-26-20-21(30)27-24(25)28-22(20)31/h4-10,13,15-16H,11-12,14H2,1-3H3,(H,29,33)(H3,25,27,28,31)/t16-,38?/m0/s1
  • InChiKey: SKCXLYIEEYIVAU-NRTNLVKCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi heat shock protein 85, putative 0.0087 0.0439 0.1061
Schistosoma mansoni DNA helicase recq5 0.0055 0.0181 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.0173 0.1128 0.2892
Trypanosoma brucei DNA polymerase kappa, putative 0.0106 0.0594 0.1471
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.2013 0.4789
Trichomonas vaginalis heat shock protein, putative 0.0087 0.0439 0.0977
Trichomonas vaginalis rotamase, putative 0.0037 0.004 0.0011
Schistosoma mansoni hypothetical protein 0.1285 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0173 0.1128 0.2892
Echinococcus granulosus GTP binding nuclear protein Ran 0.007 0.0304 0.0304
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Leishmania major GTP-binding protein, putative 0.007 0.0304 0.0703
Mycobacterium ulcerans DNA polymerase IV 0.0173 0.1128 0.2776
Echinococcus granulosus smad 0.0071 0.0315 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0427 0.0949
Brugia malayi ImpB/MucB/SamB family protein 0.0143 0.0889 0.1096
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.005 0.0144 0.0144
Brugia malayi MH1 domain containing protein 0.004 0.006 0.0075
Mycobacterium ulcerans glutaminase 0.0296 0.211 0.5426
Schistosoma mansoni transcription factor LCR-F1 0.0352 0.2554 0.2554
Toxoplasma gondii LsmAD domain-containing protein 0.0112 0.0635 0.1452
Loa Loa (eye worm) glutaminase 2 0.0296 0.211 0.2599
Echinococcus granulosus chromobox protein 1 0.0222 0.152 0.152
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0036 0.0036 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0004 0.0004
Echinococcus multilocularis chromobox protein 2 0.0036 0.0036 0.0036
Echinococcus granulosus dna polymerase eta 0.0283 0.2006 0.2006
Loa Loa (eye worm) hypothetical protein 0.0033 0.0004 0.0006
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0004 0.0015
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0086 0.0432 0.096
Echinococcus granulosus protein C ets 2 0.0036 0.0034 0.0034
Brugia malayi polk-prov protein 0.0074 0.0339 0.0418
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0173 0.1128 0.2647
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0004 0.0006
Brugia malayi MH2 domain containing protein 0.0071 0.0315 0.0389
Loa Loa (eye worm) hypothetical protein 0.0543 0.4076 0.5022
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.007 0.0304 0.0502
Trypanosoma brucei DNA polymerase kappa, putative 0.0173 0.1128 0.2892
Loa Loa (eye worm) hypothetical protein 0.0074 0.0339 0.0418
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0044
Brugia malayi Fli-1 protein 0.0757 0.5789 0.7133
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.2194 0.5724
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0004 0.0004
Echinococcus multilocularis dna polymerase kappa 0.0173 0.1128 0.1128
Echinococcus granulosus GPCR family 2 0.0172 0.1115 0.1115
Loa Loa (eye worm) hypothetical protein 0.0666 0.5062 0.6238
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0004 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0414 0.305 0.305
Loa Loa (eye worm) hypothetical protein 0.0033 0.0004 0.0006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0172 0.1115 0.1374
Brugia malayi MH2 domain containing protein 0.1049 0.8116 1
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0332 0.2396 0.6198
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0106 0.0594 0.1471
Loa Loa (eye worm) hypothetical protein 0.0172 0.1115 0.1374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0004 0.0006
Trypanosoma brucei heat shock protein, putative 0.0102 0.0556 0.1372
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0125 0.074 0.2425
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0004 0.0004
Schistosoma mansoni endoplasmin 0.0102 0.0556 0.0556
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0203 0.1363 0.1363
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0086 0.0432 0.1042
Echinococcus multilocularis geminin 0.1285 1 1
Brugia malayi hypothetical protein 0.0159 0.1013 0.1248
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0227 0.1557 0.1557
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Loa Loa (eye worm) RecQ helicase 0.0132 0.0801 0.0987
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0045 0.0106 0.0177
Echinococcus multilocularis jumonji domain containing protein 0.0128 0.0765 0.0765
Trypanosoma brucei Heat shock protein 83, putative 0.0102 0.0556 0.1372
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0004 0.0004
Trypanosoma brucei 6-phosphogluconolactonase 0.0045 0.0106 0.0177
Loa Loa (eye worm) MH2 domain-containing protein 0.0071 0.0315 0.0389
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0086 0.0432 0.0432
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0509 0.3803 1
Echinococcus multilocularis Chromobox protein 3 0.0036 0.0036 0.0036
Schistosoma mansoni gabp alpha 0.0249 0.1736 0.1736
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0004 0.0005
Trichomonas vaginalis chromobox protein, putative 0.0222 0.152 0.3594
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0036 0.0036 0.0036
Trichomonas vaginalis heat shock protein, putative 0.0102 0.0556 0.1261
Trichomonas vaginalis DNA helicase recq, putative 0.0132 0.0801 0.1855
Echinococcus multilocularis protein C ets 2 0.0036 0.0034 0.0034
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0089 0.0131
Echinococcus multilocularis GA binding protein alpha chain 0.0249 0.1736 0.1736
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0077 0.0361 0.0789
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0203 0.1363 0.1363
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0036 0.0036 0.00000000052059
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0332 0.2396 0.5716
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0449 0.1002
Loa Loa (eye worm) hypothetical protein 0.0095 0.0505 0.0622
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0116 0.0674 0.1683
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.0812 0.1001
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0509 0.3803 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0116 0.0673 0.1544
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0092 0.0478 0.0478
Echinococcus granulosus TGF beta signal transducer SmadC 0.0071 0.0315 0.0315
Entamoeba histolytica recQ family helicase, putative 0.0071 0.0309 0.0909
Schistosoma mansoni hypothetical protein 0.0172 0.1115 0.1115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0004 0.0006
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0036 0.0036 0.0036
Schistosoma mansoni jumonji domain containing protein 0.0239 0.1653 0.1653
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0055 0.0181 0.0181
Echinococcus granulosus dna polymerase kappa 0.0173 0.1128 0.1128
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0509 0.3803 1
Schistosoma mansoni smad1 5 8 and 0.0071 0.0315 0.0315
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Trichomonas vaginalis glutaminase, putative 0.0296 0.211 0.5023
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0036 0.00000000052059
Trypanosoma cruzi DNA polymerase eta, putative 0.0184 0.1217 0.3127
Trypanosoma brucei chrX additional, unordered contigs 0.0045 0.01 0.016
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0904 0.2296
Brugia malayi MH1 domain containing protein 0.004 0.006 0.0075
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.009 0.0459 0.1026
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.2194 0.5724
Schistosoma mansoni hypothetical protein 0.0055 0.0181 0.0181
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0052 0.016 0.03
Brugia malayi Latrophilin receptor protein 2 0.0172 0.1115 0.1374
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0044
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0044
Echinococcus granulosus Chromo domain 0.0036 0.0036 0.0036
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0509 0.3803 0.3803
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0143 0.0889 0.0889
Trypanosoma brucei DNA damage repair protein, putative 0.0045 0.01 0.016
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0071 0.0309 0.0716
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0151 0.0949 0.7665
Brugia malayi Steroid receptor seven-up type 2 0.0227 0.1557 0.1919
Trichomonas vaginalis CAMK family protein kinase 0.0414 0.305 0.73
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0116 0.0674 0.1683
Plasmodium falciparum importin beta, putative 0.0095 0.0505 0.1137
Trichomonas vaginalis DNA helicase recq, putative 0.0071 0.0309 0.0663
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0203 0.1363 0.168
Echinococcus granulosus ewsr:fli fusion protein type 0.0036 0.0034 0.0034
Brugia malayi M-phase phosphoprotein, mpp8 0.0036 0.0036 0.0044
Schistosoma mansoni DNA polymerase eta 0.0283 0.2006 0.2006
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0554 0.4165 1
Schistosoma mansoni smad1 5 8 and 0.0071 0.0315 0.0315
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0148 0.0926 0.0926
Trichomonas vaginalis importin beta-1, putative 0.0077 0.0361 0.0789
Trypanosoma cruzi PAB1-binding protein , putative 0.0112 0.0635 0.1581
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0086 0.0432 0.1042
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.2013 0.4789
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0036 0.00000000052059
Brugia malayi CHD4 protein 0.0036 0.0036 0.0044
Loa Loa (eye worm) hypothetical protein 0.0112 0.0635 0.0782
Toxoplasma gondii isocitrate dehydrogenase 0.0086 0.0432 0.096
Echinococcus multilocularis snurportin 1 0.1017 0.7858 0.7858
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0036 0.0036 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0151 0.0949 0.2415
Echinococcus multilocularis lysine specific demethylase 5A 0.0111 0.0632 0.0632
Trypanosoma brucei DNA polymerase kappa, putative 0.0173 0.1128 0.2892
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1233 0.29
Giardia lamblia Kinase, PLK 0.0414 0.305 0.7257
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0036 0.00000000052059
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0086 0.0427 0.0949
Brugia malayi TAR-binding protein 0.0134 0.0812 0.1001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0004 0.0006
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0068 0.0284 0.0931
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.007 0.0304 0.0703
Loa Loa (eye worm) hypothetical protein 0.0283 0.2006 0.2472
Echinococcus multilocularis heat shock protein 0.0102 0.0556 0.0556
Schistosoma mansoni glutaminase 0.0296 0.211 0.211
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1233 0.29
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.1035 0.8652
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.2194 0.5724
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0044
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0165 0.0332
Echinococcus multilocularis PHD finger protein rhinoceros 0.0092 0.0478 0.0478
Brugia malayi jmjC domain containing protein 0.0111 0.0632 0.0779
Brugia malayi Hsp90 protein 0.0068 0.0284 0.035
Entamoeba histolytica hypothetical protein 0.0352 0.2554 0.8355
Trypanosoma brucei heat shock protein 90, putative 0.0102 0.0556 0.1372
Trichomonas vaginalis rotamase, putative 0.0038 0.0047 0.0028
Trichomonas vaginalis chromobox protein, putative 0.0222 0.152 0.3594
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0044
Plasmodium falciparum heat shock protein 90 0.0102 0.0556 0.1261
Trichomonas vaginalis heat shock protein, putative 0.0095 0.0507 0.1141
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0427 0.0949
Echinococcus granulosus flap endonuclease 1 0.0116 0.0674 0.0674
Leishmania major glucosamine-6-phosphate isomerase, putative 0.0045 0.0106 0.0177
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0086 0.0432 0.1757
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0278 0.0481
Loa Loa (eye worm) D-ets-2 protein 0.0036 0.0034 0.0042
Brugia malayi glutaminase DH11.1 0.0296 0.211 0.2599
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0004 0.0006
Entamoeba histolytica Flap nuclease, putative 0.0116 0.0674 0.2117
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0352 0.2554 0.2554
Brugia malayi PHD-finger family protein 0.0092 0.0478 0.0589
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0414 0.305 0.305
Brugia malayi Flap endonuclease-1 0.0116 0.0674 0.083
Leishmania major DNA polymerase eta, putative 0.0283 0.2006 0.5224
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0427 0.0949
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0427 0.0949
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.2013 0.4789
Echinococcus granulosus heat shock protein 0.0102 0.0556 0.0556
Entamoeba histolytica hypothetical protein 0.0036 0.0036 0.00000000071311
Loa Loa (eye worm) RNA binding protein 0.0134 0.0812 0.1001
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0143 0.0889 0.0889
Trypanosoma cruzi polo-like protein kinase, putative 0.0414 0.305 0.7998
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.01 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0427 0.0949
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0004 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0173 0.1128 0.2892
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0554 0.4165 1
Echinococcus granulosus chromobox protein 2 0.0036 0.0036 0.0036
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0086 0.0432 0.0432
Brugia malayi SET domain containing protein 0.0039 0.0054 0.0067
Echinococcus multilocularis survival motor neuron protein 1 0.0268 0.1881 0.1881
Schistosoma mansoni hypothetical protein 0.0036 0.0036 0.0036
Schistosoma mansoni heat shock protein 0.0068 0.0284 0.0284
Entamoeba histolytica hypothetical protein 0.0352 0.2554 0.8355
Schistosoma mansoni ets-related 0.0036 0.0034 0.0034
Brugia malayi Bloom's syndrome protein homolog 0.0132 0.0801 0.0987
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0184 0.1217 0.2861
Giardia lamblia DINP protein human, muc B family 0.0151 0.0949 0.2087
Loa Loa (eye worm) fli-1 protein 0.0757 0.5789 0.7133
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0554 0.4165 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0055 0.0181 0.0223
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0086 0.0432 0.096
Trypanosoma brucei unspecified product 0.0099 0.0534 0.1313
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0004 0.0004
Loa Loa (eye worm) jmjC domain-containing protein 0.019 0.1259 0.1551
Echinococcus granulosus ETS transcription factor Elf 5 0.0036 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0077 0.0361 0.1081
Brugia malayi Valyl-tRNA synthetase 0.0036 0.0036 0.0044
Loa Loa (eye worm) flap endonuclease-1 0.0116 0.0674 0.083
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.0045 0.0106 0.0177
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0116 0.0674 0.1545
Plasmodium falciparum heat shock protein 90, putative 0.0059 0.0217 0.0439
Treponema pallidum heat shock protein 90 0.0095 0.0507 0.1082
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0045 0.0106 0.0106
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0036 0.00000000052059
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0812 0.0812
Brugia malayi ecdysteroid receptor 0.0033 0.0004 0.0006
Loa Loa (eye worm) endoplasmin 0.0102 0.0556 0.0686
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0004 0.0006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0036 0.00000000052059
Onchocerca volvulus 0.0098 0.0525 0.1721
Echinococcus multilocularis ETS transcription factor Elf 2 0.0036 0.0034 0.0034
Echinococcus multilocularis ets variant gene 4 0.0036 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0427 0.0949
Loa Loa (eye worm) hypothetical protein 0.0125 0.074 0.0912
Loa Loa (eye worm) glutaminase 0.0296 0.211 0.2599
Schistosoma mansoni chromobox protein 0.0222 0.152 0.152
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0004 0.0004
Leishmania major 6-phosphogluconolactonase 0.0045 0.0106 0.0177
Toxoplasma gondii PHD-finger domain-containing protein 0.0092 0.0478 0.1072
Brugia malayi steroid hormone receptor 0.0033 0.0004 0.0006
Brugia malayi heat shock protein 90 0.0102 0.0556 0.0686
Trypanosoma brucei heat shock protein 90, putative 0.0102 0.0556 0.1372
Brugia malayi serine/threonine-protein kinase plk-2 0.0414 0.305 0.3758
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.007 0.0304 0.0651
Mycobacterium ulcerans heat shock protein 90 0.0095 0.0507 0.1097
Trypanosoma brucei unspecified product 0.0099 0.0534 0.1313
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0172 0.1115 0.1115
Trichomonas vaginalis CAMK family protein kinase 0.0414 0.305 0.73
Mycobacterium ulcerans 6-phosphogluconolactonase 0.0045 0.0106 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0812 0.0812
Trypanosoma cruzi heat shock protein 85, putative 0.0102 0.0556 0.1372
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0071 0.0309 0.0716
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.007 0.0304 0.0703
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0037 0.004 0.0015
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0278 0.0633
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0004 0.0006
Onchocerca volvulus Glucosylceramidase homolog 0.0186 0.1233 0.4043
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0227 0.1557 0.1557
Trypanosoma brucei DNA polymerase IV, putative 0.0166 0.1069 0.2734
Schistosoma mansoni SET domain protein 0.0071 0.0311 0.0311
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0004 0.0006
Plasmodium falciparum phd finger protein, putative 0.0092 0.0478 0.1072
Echinococcus granulosus bloom syndrome protein 0.0132 0.0801 0.0801
Schistosoma mansoni DNA helicase recq1 0.0055 0.0181 0.0181
Brugia malayi latrophilin 2 splice variant baaae 0.0371 0.2706 0.3334
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0036 0.00000000052059
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0148 0.0926 0.0926
Leishmania major DNA damage repair protein, putative 0.0045 0.01 0.016
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0284 0.2013 0.2481
Schistosoma mansoni amine GPCR 0.0342 0.2475 0.2475
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0278 0.0278
Trypanosoma cruzi heat shock protein 85, putative 0.0102 0.0556 0.1372
Trypanosoma brucei heat shock protein 84, putative 0.0068 0.0284 0.0648
Loa Loa (eye worm) MH1 domain-containing protein 0.0071 0.0315 0.0389
Giardia lamblia Grp94/Hsp90 0.0095 0.0507 0.1
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0036 0.0034 0.0034
Echinococcus granulosus heat shock protein 90 0.0102 0.0556 0.0556
Trichomonas vaginalis heat shock protein, putative 0.0059 0.0217 0.0439
Brugia malayi Heterochromatin protein 1 0.0222 0.152 0.1872
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0036 0.00000000052059
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0543 0.4076 0.5022
Schistosoma mansoni ets 0.0036 0.0034 0.0034
Onchocerca volvulus 0.0159 0.1013 0.3321
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0352 0.2554 0.2554
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0086 0.0432 0.0432
Trypanosoma cruzi Heat shock protein 83, putative 0.0102 0.0556 0.1372
Toxoplasma gondii hypothetical protein 0.0049 0.014 0.0253
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0004 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0278 0.0481
Trypanosoma cruzi heat shock protein 90, putative 0.0087 0.0439 0.1061
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0045 0.0106 0.0177
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0004 0.0006
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0004 0.0004
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0098 0.0525 0.0525
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0036 0.0036 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0427 0.0949
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0004 0.0004
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0055 0.0181 0.0223
Echinococcus multilocularis tar DNA binding protein 0.0134 0.0812 0.0812
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0427 0.0949
Trypanosoma brucei heat shock protein, putative 0.0102 0.0556 0.1372
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0089 0.0131
Entamoeba histolytica hypothetical protein 0.0352 0.2554 0.8355
Plasmodium vivax hypothetical protein, conserved 0.0092 0.0478 0.1072
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0414 0.305 0.3758
Echinococcus multilocularis ewsr:fli fusion protein type 0.0036 0.0034 0.0034
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0045 0.0106 0.0015
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0095 0.0507 0.5
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0554 0.4165 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0301 0.2146 0.2146
Loa Loa (eye worm) hypothetical protein 0.0098 0.0525 0.0647
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0036 0.0036 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0039 0.0054 0.0054
Giardia lamblia Sgs1 DNA helicase, putative 0.0055 0.0181 0.0199
Echinococcus granulosus heat shock protein 90 0.0087 0.0439 0.0439
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0055 0.0181 0.0181
Trypanosoma brucei importin beta-1 subunit, putative 0.0095 0.0505 0.1236
Brugia malayi MH1 domain containing protein 0.0071 0.0315 0.0389
Echinococcus multilocularis isocitrate dehydrogenase 0.0086 0.0432 0.0432
Onchocerca volvulus 0.0033 0.0004 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0427 0.0949
Schistosoma mansoni hypothetical protein 0.1285 1 1
Schistosoma mansoni smad1 5 8 and 0.0071 0.0315 0.0315
Leishmania major DNA polymerase kappa, putative 0.0151 0.0949 0.2415
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.2013 0.4789
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0077 0.0361 0.0789
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0301 0.2146 0.2146
Toxoplasma gondii heat shock protein 75, putative 0.0068 0.0284 0.0602
Trypanosoma brucei DNA polymerase kappa, putative 0.0106 0.0594 0.1471
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0278 0.0481
Echinococcus multilocularis chromobox protein 1 0.0222 0.152 0.152
Trypanosoma brucei DNA polymerase kappa, putative 0.0173 0.1128 0.2892
Trichomonas vaginalis CAMK family protein kinase 0.0414 0.305 0.73
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0036 0.0034 0.0034
Brugia malayi RNA, U transporter 1 0.0271 0.1906 0.2349
Echinococcus granulosus 6 phosphogluconolactonase 0.0045 0.0106 0.0106
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.0904 0.2296
Toxoplasma gondii peptidylprolyl isomerase 0.0037 0.004 0.0011
Loa Loa (eye worm) heterochromatin protein 1 0.0222 0.152 0.1872
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0143 0.0889 0.0889
Trypanosoma brucei hypothetical protein, conserved 0.0045 0.01 0.016
Brugia malayi Ets-domain containing protein 0.0249 0.1736 0.2139
Schistosoma mansoni elf1 0.0036 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0004 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.2013 0.4789
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0086 0.0432 0.1042
Leishmania major hypothetical protein, conserved 0.0112 0.0635 0.1581
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0044
Echinococcus multilocularis ETS transcription factor Elf 1 0.0036 0.0034 0.0034
Trichomonas vaginalis endoplasmin, putative 0.0074 0.0334 0.0723
Loa Loa (eye worm) hypothetical protein 0.0158 0.1002 0.1235
Schistosoma mansoni flap endonuclease-1 0.0105 0.0584 0.0584
Toxoplasma gondii isocitrate dehydrogenase 0.0086 0.0432 0.096
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0004 0.0004
Loa Loa (eye worm) ets-domain-containing protein 0.0036 0.0034 0.0042
Loa Loa (eye worm) jmjC domain-containing protein 0.0111 0.0632 0.0779
Schistosoma mansoni hypothetical protein 0.0172 0.1115 0.1115
Loa Loa (eye worm) hypothetical protein 0.0033 0.0004 0.0006
Plasmodium vivax importin-beta 2, putative 0.0095 0.0505 0.1137
Entamoeba histolytica hypothetical protein 0.0352 0.2554 0.8355
Trypanosoma cruzi DNA damage repair protein, putative 0.0045 0.01 0.016
Onchocerca volvulus Alhambra homolog 0.0092 0.0478 0.1568
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0004 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0004 0.0006
Loa Loa (eye worm) isocitrate dehydrogenase 0.0086 0.0432 0.0532
Schistosoma mansoni hypothetical protein 0.1017 0.7858 0.7858
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.005 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0172 0.1115 0.1115
Trypanosoma cruzi DNA polymerase kappa, putative 0.0173 0.1128 0.2892
Trypanosoma cruzi DNA polymerase kappa, putative 0.0173 0.1128 0.2892
Leishmania major importin beta-1 subunit, putative 0.0077 0.0361 0.0854
Echinococcus multilocularis ETS transcription factor Elf 5 0.0036 0.0034 0.0034
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0071 0.0309 0.0716
Schistosoma mansoni kinase 0.021 0.1425 0.1425
Brugia malayi Importin beta-1 subunit 0.0095 0.0505 0.0622
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0004 0.0004
Trichomonas vaginalis DNA polymerase eta, putative 0.0173 0.1128 0.2647
Schistosoma mansoni hypothetical protein 0.0352 0.2554 0.2554
Trichomonas vaginalis chromobox protein, putative 0.0134 0.0815 0.1888
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0249 0.1736 0.2139
Schistosoma mansoni chromobox protein 0.0222 0.152 0.152
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0509 0.3803 0.4687
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0509 0.3803 0.3803
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Plasmodium falciparum ataxin-2 like protein, putative 0.0112 0.0635 0.1452
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Brugia malayi jmjC domain containing protein 0.0301 0.2146 0.2645
Plasmodium vivax ataxin-2 like protein, putative 0.0112 0.0635 0.1452
Echinococcus granulosus Chromobox protein 3 0.0036 0.0036 0.0036
Echinococcus multilocularis chromobox protein 1 0.0222 0.152 0.152
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.01 0.0157
Loa Loa (eye worm) hypothetical protein 0.0212 0.1435 0.1768
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0509 0.3803 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0004 0.0004
Trypanosoma brucei heat shock protein, putative 0.0102 0.0556 0.1372
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0004 0.0004
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0284 0.2013 0.2481
Echinococcus granulosus GA binding protein alpha chain 0.0249 0.1736 0.1736
Echinococcus granulosus lysine specific demethylase 5A 0.0111 0.0632 0.0632
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0086 0.0432 0.0432
Echinococcus granulosus expressed protein 0.0038 0.0047 0.0047
Brugia malayi Smad1 0.0071 0.0315 0.0389
Loa Loa (eye worm) hypothetical protein 0.0033 0.0004 0.0006
Echinococcus multilocularis flap endonuclease 1 0.0116 0.0674 0.0674
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1233 0.29
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0004 0.0004
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0087 0.0439 0.0439
Brugia malayi Isocitrate dehydrogenase 0.0086 0.0432 0.0532
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0004 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0812 0.0812
Onchocerca volvulus Matrix metalloproteinase homolog 0.0042 0.0082 0.027
Schistosoma mansoni chromobox protein 0.0036 0.0036 0.0036
Brugia malayi glucose-6-phosphate dehydrogenase 0.0509 0.3803 0.4687
Trypanosoma brucei unspecified product 0.0166 0.1069 0.2734
Echinococcus multilocularis heat shock protein 90 0.0087 0.0439 0.0439
Loa Loa (eye worm) heat shock protein 90 0.0102 0.0556 0.0686
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0089 0.0131
Schistosoma mansoni heat shock protein 0.0102 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0159 0.1013 0.1248
Loa Loa (eye worm) hypothetical protein 0.0033 0.0004 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0203 0.1363 0.1363
Echinococcus granulosus tar DNA binding protein 0.0134 0.0812 0.0812
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.1381 0.3259
Schistosoma mansoni smad 0.0071 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0268 0.1881 0.2318
Plasmodium falciparum endoplasmin, putative 0.0074 0.0334 0.0723
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.007 0.0304 0.0375
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0095 0.0507 0.2609
Loa Loa (eye worm) matrixin family protein 0.0125 0.074 0.0912
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0004 0.0006
Leishmania major DNA polymerase kappa, putative 0.0045 0.01 0.016
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0036 0.00000000052059
Schistosoma mansoni hypothetical protein 0.0036 0.0034 0.0034
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0554 0.4165 1
Loa Loa (eye worm) nuclear hormone receptor 0.021 0.142 0.175
Schistosoma mansoni 6-phosphogluconolactonase 0.0045 0.0106 0.0106
Entamoeba histolytica Ran family GTPase 0.007 0.0304 0.0892
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0004 0.0004
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0055 0.0181 0.0223
Brugia malayi nuclear hormone receptor 0.0033 0.0004 0.0006
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0169 0.109 0.279
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0554 0.4165 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0036 0.00000000052059
Brugia malayi transcription factor E74 isoform 0.0036 0.0034 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0427 0.0949
Trichomonas vaginalis heat shock protein, putative 0.0074 0.0334 0.0723
Schistosoma mansoni Smad4 0.0071 0.0315 0.0315
Giardia lamblia Heat shock protein HSP 90-alpha 0.0087 0.0439 0.0834
Loa Loa (eye worm) matrixin family protein 0.0042 0.0082 0.0101
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0143 0.0889 0.1096
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0004 0.0006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.0632 0.0632
Trypanosoma cruzi importin beta-1 subunit, putative 0.0077 0.0361 0.0854
Onchocerca volvulus Matrilysin homolog 0.0121 0.071 0.2328
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0004 0.0006
Trypanosoma brucei heat shock protein, putative 0.0102 0.0556 0.1372
Trypanosoma brucei DNA polymerase kappa, putative 0.0173 0.1128 0.2892
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0278 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.0074 0.0339 0.0795
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0036 0.00000000052059
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0055 0.0181 0.0353
Trypanosoma cruzi heat shock protein, putative 0.0068 0.0284 0.0648
Brugia malayi Ets-domain containing protein 0.0036 0.0034 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0004 0.0004
Brugia malayi hypothetical protein 0.0352 0.2554 0.3147
Giardia lamblia Heat shock protein HSP 90-alpha 0.0102 0.0556 0.1122
Echinococcus multilocularis heat shock protein 90 0.0102 0.0556 0.0556
Loa Loa (eye worm) heat shock protein 75 0.0068 0.0284 0.035
Loa Loa (eye worm) latrophilin receptor protein 2 0.0172 0.1115 0.1374
Echinococcus granulosus mothers against decapentaplegic 5 0.0071 0.0315 0.0315
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0004 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.074 0.1705
Loa Loa (eye worm) hypothetical protein 0.0033 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0042
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.007 0.0304 0.0651
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0427 0.0949
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0427 0.0949
Schistosoma mansoni hypothetical protein 0.0371 0.2706 0.2706
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.1017 0.7858 0.9682
Brugia malayi hypothetical protein 0.0036 0.0036 0.0044
Trypanosoma brucei DNA polymerase IV, putative 0.0173 0.1128 0.2892
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0257 0.0536
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0278 0.0278
Onchocerca volvulus 0.0036 0.0036 0.0116
Loa Loa (eye worm) hypothetical protein 0.0098 0.0525 0.0647
Trypanosoma cruzi PAB1-binding protein , putative 0.0112 0.0635 0.1581
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0004 0.0006
Toxoplasma gondii HEAT repeat-containing protein 0.0095 0.0505 0.1137
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0089 0.0131
Trypanosoma brucei polo-like protein kinase 0.0414 0.305 0.7998
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0004 0.0004
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0045 0.0106 0.0172
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Trichomonas vaginalis DNA helicase recq1, putative 0.0132 0.0801 0.1855
Schistosoma mansoni importin beta-1 0.0095 0.0505 0.0505
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1233 0.29
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0036 0.00000000071311
Echinococcus granulosus ETS transcription factor Elf 1 0.0036 0.0034 0.0034
Loa Loa (eye worm) CHromoDomain protein family member 0.0036 0.0036 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0004 0.0006
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0038 0.0047 0.0058
Echinococcus multilocularis GPCR, family 2 0.0172 0.1115 0.1115
Trypanosoma cruzi DNA polymerase kappa, putative 0.0173 0.1128 0.2892
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0088 0.0451 0.1006
Plasmodium falciparum DNA repair protein REV1, putative 0.0045 0.01 0.0157
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0278 0.0278
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0181 0.0223
Leishmania major heat shock protein, putative 0.0068 0.0284 0.0648
Echinococcus granulosus Smad4 0.0071 0.0315 0.0315
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0045 0.0106 0.0177
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.007 0.0304 0.0703
Entamoeba histolytica serine/threonine protein kinase, putative 0.0414 0.305 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0478 0.0589
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0055 0.0181 0.0181
Loa Loa (eye worm) Smad1 0.0071 0.0315 0.0389
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0554 0.4165 1
Plasmodium vivax heat shock protein 86, putative 0.0102 0.0556 0.1261
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0095 0.0507 0.124
Brugia malayi Matrixin family protein 0.0125 0.074 0.0912
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0203 0.1363 0.1363
Trichomonas vaginalis CAMK family protein kinase 0.0414 0.305 0.73
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0509 0.3803 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0044
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.007 0.0304 0.0375
Trypanosoma cruzi DNA polymerase eta, putative 0.0283 0.2006 0.5224
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Giardia lamblia NADPH oxidoreductase, putative 0.0086 0.0427 0.0805
Echinococcus multilocularis GTP binding nuclear protein Ran 0.007 0.0304 0.0304
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0004 0.0004
Brugia malayi chromobox protein homolog 3 0.0125 0.074 0.0912
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0086 0.0432 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.0173 0.1128 0.2892
Schistosoma mansoni ran 0.007 0.0304 0.0304
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0004 0.0006
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0036 0.00000000071311
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.1313 0.3095
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0116 0.0674 0.1683
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0036 0.00000000052059
Schistosoma mansoni chromobox protein 0.0036 0.0036 0.0036
Echinococcus granulosus PHD finger protein rhinoceros 0.0092 0.0478 0.0478
Echinococcus multilocularis Smad4 0.0071 0.0315 0.0315
Mycobacterium ulcerans DNA polymerase IV 0.0173 0.1128 0.2776
Trypanosoma brucei DNA polymerase IV, putative 0.0173 0.1128 0.2892
Brugia malayi hypothetical protein 0.0072 0.032 0.0394
Schistosoma mansoni coup transcription factor 0.0033 0.0004 0.0004
Echinococcus multilocularis mothers against decapentaplegic 5 0.0071 0.0315 0.0315
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0509 0.3803 0.3803
Loa Loa (eye worm) hypothetical protein 0.0033 0.0004 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0449 0.1002
Trichomonas vaginalis CAMK family protein kinase 0.0414 0.305 0.73
Echinococcus multilocularis smad 0.0071 0.0315 0.0315
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0036 0.0034 0.0042
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0004 0.0015
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.0632 0.0632
Brugia malayi Protein cec-1. 0.0036 0.0036 0.0044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0036 0.00000000052059
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0278 0.0588
Loa Loa (eye worm) hypothetical protein 0.004 0.006 0.0075
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0068 0.0284 0.0284
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0004 0.0004
Brugia malayi DNA-binding protein D-ETS-3 0.0036 0.0034 0.0042
Toxoplasma gondii PHD-finger domain-containing protein 0.0092 0.0478 0.1072
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0055 0.0181 0.0353
Loa Loa (eye worm) MH2 domain-containing protein 0.1049 0.8116 1
Onchocerca volvulus 0.0036 0.0036 0.0116
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0045 0.0106 0.0015
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0038 0.0047 0.0058
Echinococcus granulosus peregrin 0.0112 0.0643 0.0643
Echinococcus multilocularis 6 phosphogluconolactonase 0.0045 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0055 0.0181 0.0223
Brugia malayi hypothetical protein 0.0112 0.0635 0.0782
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0045 0.0106 0.0177
Plasmodium falciparum heat shock protein 90, putative 0.0385 0.282 0.6743
Trypanosoma brucei importin beta-1 subunit, putative 0.0095 0.0505 0.1236
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0004 0.0004
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0033 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.0036 0.0034 0.0034
Entamoeba histolytica heat shock protein 90, putative 0.0102 0.0556 0.1728
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0068 0.0284 0.0824
Mycobacterium ulcerans hypothetical protein 0.0162 0.1035 0.2524
Trypanosoma cruzi polo-like protein kinase, putative 0.0414 0.305 0.7998
Trypanosoma cruzi DNA polymerase kappa, putative 0.0173 0.1128 0.2892
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0036 0.00000000052059
Loa Loa (eye worm) transcription factor SMAD2 0.1049 0.8116 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0143 0.0889 0.6987
Schistosoma mansoni hypothetical protein 0.0092 0.0478 0.0478
Brugia malayi 6-phosphogluconolactonase family protein 0.0045 0.0106 0.0131
Trypanosoma brucei heat shock protein, putative 0.0102 0.0556 0.1372
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0371 0.2706 0.3334
Trichomonas vaginalis flap endonuclease-1, putative 0.0116 0.0674 0.1545
Loa Loa (eye worm) hypothetical protein 0.0213 0.1447 0.1783
Trypanosoma cruzi heat shock protein 90, putative 0.0043 0.0085 0.0119
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.007 0.0304 0.0651
Schistosoma mansoni heat shock protein 0.0102 0.0556 0.0556
Plasmodium vivax flap endonuclease 1, putative 0.0116 0.0674 0.1545
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0071 0.0311 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0173 0.1128 0.2892
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0172 0.1115 0.1115
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0172 0.1115 0.1115
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0036 0.0036 0.0036
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0509 0.3803 1
Schistosoma mansoni rotamase 0.0038 0.0047 0.0047
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0086 0.0432 0.1042
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0164 0.1051 0.2686
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0543 0.4076 0.5022
Schistosoma mansoni hypothetical protein 0.005 0.0144 0.0144
Echinococcus multilocularis importin subunit beta 1 0.0095 0.0505 0.0505
Echinococcus granulosus survival motor neuron protein 1 0.0268 0.1881 0.1881
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0036 0.00000000071311
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1233 0.29
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0036 0.0036
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0414 0.305 0.305
Trypanosoma cruzi DNA damage repair protein, putative 0.0045 0.01 0.016
Entamoeba histolytica deoxycytidyl transferase, putative 0.0143 0.0889 0.2833
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0055 0.0181 0.0353
Echinococcus granulosus endoplasmin 0.0095 0.0507 0.0507
Onchocerca volvulus 0.0039 0.0054 0.0179
Trichomonas vaginalis chromobox protein, putative 0.0134 0.0815 0.1888
Trichomonas vaginalis CAMK family protein kinase 0.0414 0.305 0.73
Brugia malayi Ets-domain containing protein 0.0249 0.1736 0.2139
Giardia lamblia NADPH oxidoreductase, putative 0.0086 0.0427 0.0805
Echinococcus granulosus chromobox protein 1 0.0222 0.152 0.152
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0004 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0004 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0812 0.0812
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0004 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0047 0.0028
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0176 0.1153 1
Plasmodium vivax endoplasmin, putative 0.0102 0.0556 0.1261
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0045 0.0106 0.0131
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0045 0.0106 0.0235
Brugia malayi nuclear receptor NHR-88 0.0033 0.0004 0.0006
Schistosoma mansoni survival motor neuron protein 0.0055 0.0181 0.0181
Trypanosoma brucei PAB1-binding protein , putative 0.0112 0.0635 0.1581
Brugia malayi RNA binding protein 0.0134 0.0812 0.1001
Giardia lamblia PHD finger protein 15 0.0092 0.0478 0.093
Echinococcus multilocularis endoplasmin 0.0095 0.0507 0.0507
Schistosoma mansoni 6-phosphogluconolactonase 0.0045 0.0106 0.0106
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Echinococcus granulosus ETS transcription factor Elf 2 0.0036 0.0034 0.0034
Brugia malayi Associated with TFs and helicases family protein 0.0036 0.0036 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.1381 0.3259
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0086 0.0432 0.0432
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0203 0.1363 0.1363
Entamoeba histolytica heat shock protein 90, putative 0.0102 0.0556 0.1728
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0036 0.00000000052059
Schistosoma mansoni blooms syndrome DNA helicase 0.0105 0.0579 0.0579
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0004 0.0004
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0134 0.0815 0.2673
Echinococcus multilocularis dna polymerase eta 0.0283 0.2006 0.2006
Toxoplasma gondii heat shock protein HSP90 0.0102 0.0556 0.1261
Brugia malayi hypothetical protein 0.0268 0.1881 0.2318
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.01 0.016
Schistosoma mansoni endoplasmin 0.0102 0.0556 0.0556
Echinococcus multilocularis expressed protein 0.0038 0.0047 0.0047
Brugia malayi MH2 domain containing protein 0.0071 0.0315 0.0389
Trypanosoma brucei DNA polymerase kappa, putative 0.0074 0.0339 0.0795
Loa Loa (eye worm) helicase 0.0036 0.0036 0.0044
Giardia lamblia NADPH oxidoreductase, putative 0.0086 0.0427 0.0805
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0203 0.1363 0.168
Schistosoma mansoni ets-related 0.0757 0.5789 0.5789
Trypanosoma cruzi heat shock protein 90, putative 0.0102 0.0556 0.1372
Echinococcus multilocularis ETS transcription factor Elf 2 0.0036 0.0034 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0414 0.305 0.73
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0071 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0042
Trypanosoma brucei heat shock protein, putative 0.0102 0.0556 0.1372
Trypanosoma brucei DNA damage repair protein, putative 0.0045 0.01 0.016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0004 0.0006
Loa Loa (eye worm) PHD-finger family protein 0.0092 0.0478 0.0589
Toxoplasma gondii heat shock protein 90, putative 0.0102 0.0556 0.1261
Schistosoma mansoni ran 0.007 0.0304 0.0304
Brugia malayi Calcitonin receptor-like protein seb-1 0.0543 0.4076 0.5022
Loa Loa (eye worm) TAR-binding protein 0.0134 0.0812 0.1001
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1233 0.29
Plasmodium falciparum flap endonuclease 1 0.0116 0.0674 0.1545
Plasmodium falciparum ataxin-2 like protein, putative 0.0112 0.0635 0.1452
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0904 0.2296
Trichomonas vaginalis ran, putative 0.007 0.0304 0.0651
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0203 0.1363 0.1363
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0151 0.0949 0.2415
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0172 0.1115 0.1115
Trypanosoma brucei hypothetical protein, conserved 0.0045 0.01 0.016
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0036 0.0034 0.0042
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0086 0.0432 0.1042
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0004 0.0004
Echinococcus multilocularis bloom syndrome protein 0.0132 0.0801 0.0801
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0004 0.0004
Trypanosoma brucei heat shock protein, putative 0.0102 0.0556 0.1372
Trichomonas vaginalis heat shock protein, putative 0.0095 0.0507 0.1141
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0071 0.0315 0.0315
Plasmodium vivax heat shock protein, putative 0.0385 0.282 0.6743
Schistosoma mansoni terminal deoxycytidyl transferase 0.0143 0.0889 0.0889
Plasmodium vivax DNA repair protein REV1, putative 0.0045 0.01 0.0157
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0086 0.0427 0.0949
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0036 0.0036 0.00000000052059
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0071 0.0311 0.0311
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0068 0.0284 0.0284
Onchocerca volvulus 0.0055 0.0181 0.0593
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0086 0.0427 0.0949
Toxoplasma gondii Hsp90 domain-containing protein 0.0385 0.282 0.6743
Brugia malayi Bromodomain containing protein 0.0092 0.0478 0.0589
Schistosoma mansoni DNA polymerase IV / kappa 0.0045 0.01 0.01
Trypanosoma brucei DNA polymerase eta, putative 0.0283 0.2006 0.5224
Trypanosoma cruzi heat shock protein 85, putative 0.0102 0.0556 0.1372
Echinococcus granulosus ETS transcription factor Elf 2 0.0036 0.0034 0.0034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0203 0.1363 0.1363
Brugia malayi isocitrate dehydrogenase 0.0086 0.0432 0.0532
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.074 0.1705
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0095 0.0507 1
Loa Loa (eye worm) nuclear factor I 0.004 0.006 0.0075
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Leishmania major DNA polymerase eta, putative 0.0184 0.1217 0.3127
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1233 0.29
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0055 0.0181 0.0181
Brugia malayi Endoplasmin precursor 0.0102 0.0556 0.0686
Echinococcus granulosus snurportin 1 0.1017 0.7858 0.7858
Echinococcus granulosus ETS domain containing protein Elk 1 0.0036 0.0034 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.2013 0.4789
Brugia malayi MH1 domain containing protein 0.0071 0.0315 0.0389
Leishmania major heat shock protein 83-1 0.0102 0.0556 0.1372
Plasmodium vivax heat shock protein 90, putative 0.0068 0.0284 0.0602
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0427 0.0949
Trypanosoma brucei heat shock protein, putative 0.0102 0.0556 0.1372
Schistosoma mansoni hypothetical protein 0.0172 0.1115 0.1115
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.1313 0.3095
Echinococcus granulosus importin subunit beta 1 0.0095 0.0505 0.0505
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0414 0.305 0.7998
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.0812 0.1001
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.2194 0.5724
Brugia malayi ImpB/MucB/SamB family protein 0.0283 0.2006 0.2472
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0812 0.0812
Echinococcus granulosus jumonji domain containing protein 0.0128 0.0765 0.0765
Echinococcus multilocularis peregrin 0.0112 0.0643 0.0643
Giardia lamblia Flap structure-specific endonuclease 0.0116 0.0674 0.141
Onchocerca volvulus Serine\/threonine kinase homolog 0.0414 0.305 1
Echinococcus multilocularis Chromo domain 0.0036 0.0036 0.0036

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) > 150 uM Cytotoxicity against human MT4 cells assessed as inhibition of cell proliferation ChEMBL. 19645484
IC50 (ADMET) = 36 uM Cytotoxicity against human CEM cells assessed as decrease in cell viability ChEMBL. 19645484
IC50 (ADMET) = 72.5 uM Cytotoxicity against human MT4 cells assessed as decrease in cell viability ChEMBL. 19645484
IC50 (ADMET) > 100 uM Cytotoxicity against HEL cells assessed as inhibition of cell proliferation ChEMBL. 19645484
MCC (ADMET) > 50 uM Cytotoxicity against HEL cells assessed as concentration required to cause alteration in cell alteration by microscopically ChEMBL. 19645484

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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