Detailed information for compound 1051368

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 336.427 | Formula: C21H24N2O2
  • H donors: 1 H acceptors: 1 LogP: 4 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1c1occ(n1)CN[C@@H](c1ccc(cc1)C)C
  • InChi: 1S/C21H24N2O2/c1-4-24-20-8-6-5-7-19(20)21-23-18(14-25-21)13-22-16(3)17-11-9-15(2)10-12-17/h5-12,14,16,22H,4,13H2,1-3H3/t16-/m1/s1
  • InChiKey: OHAUFCGJZQSWJV-MRXNPFEDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0044 0.0014 0.0053
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0028 0.0111
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Brugia malayi cathepsin L-like cysteine proteinase 0.0419 0.0279 0.1093
Schistosoma mansoni hypothetical protein 0.0037 0.0008 0.0012
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.001 0.0005
Onchocerca volvulus 0.0044 0.0014 0.0119
Brugia malayi cathepsin F-like cysteine proteinase 0.0279 0.018 0.0703
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0419 0.0279 0.1093
Brugia malayi beta-lactamase family protein 0.0039 0.001 0.0039
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0028 0.0041
Brugia malayi RNA binding protein 0.0065 0.0028 0.011
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Leishmania major cathepsin L-like protease 0.1106 0.0767 0.3557
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0044 0.0014 0.0053
Loa Loa (eye worm) hypothetical protein 0.0148 0.0087 0.034
Plasmodium vivax vivapain-3 0.0697 0.0477 0.6171
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0028 0.0112
Giardia lamblia Cathepsin L precursor 0.0419 0.0279 0.1022
Giardia lamblia Cysteine protease 0.0419 0.0279 0.1022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0419 0.0279 0.1282
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0028 0.0094
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0044 0.0014 0.002
Mycobacterium leprae conserved hypothetical protein 0.0039 0.001 0.0014
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1886 0.132 1
Trypanosoma cruzi DNA repair protein, putative 0.0138 0.008 0.0297
Giardia lamblia Hypothetical protein 0.0419 0.0279 0.1022
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0028 0.0112
Echinococcus multilocularis ecdysone induced protein 78C 0.0044 0.0014 0.0053
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0028 0.0041
Plasmodium vivax aspartyl protease, putative 0.0572 0.0388 0.4993
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.001 0.0025
Giardia lamblia Cathepsin B precursor 0.0419 0.0279 0.1022
Trypanosoma cruzi cysteine peptidase, putative 0.0697 0.0477 0.1851
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0008 0.0017
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0119 0.0067 0.029
Toxoplasma gondii cathepsin B 0.3052 0.2148 1
Onchocerca volvulus 0.1106 0.0767 1
Brugia malayi Muscleblind-like protein 0.0148 0.0087 0.034
Schistosoma mansoni Replicative DNA helicase 0.161 0.1125 0.1647
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0279 0.018 0.0703
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0049 0.0072
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0116 0.0521
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.3629 0.2556 0.3745
Schistosoma mansoni cathepsin F (C01 family) 0.0827 0.0569 0.0834
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.001 0.0039
Loa Loa (eye worm) hypothetical protein 0.0054 0.0021 0.008
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0044 0.0014 0.002
Giardia lamblia Cathepsin L-like protease 0.0419 0.0279 0.1022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0021 0.008
Leishmania major cysteine peptidase A (CPA) 0.1106 0.0767 0.3557
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Plasmodium falciparum plasmepsin II 0.0791 0.0544 0.7009
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0791 0.0544 0.2127
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.0047 0.0182
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0419 0.0279 0.1022
Plasmodium vivax aspartyl protease, putative 0.0572 0.0388 0.4993
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0189 0.0116 0.0454
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0119 0.0067 0.0098
Echinococcus granulosus cathepsin b 0.3629 0.2556 1
Chlamydia trachomatis replicative DNA helicase 0.161 0.1125 1
Echinococcus granulosus cysteine protease 0.0697 0.0477 0.1866
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.001 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0697 0.0477 0.2204
Giardia lamblia Cysteine protease 0.0419 0.0279 0.1022
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0321 0.021 0.0959
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Brugia malayi Eukaryotic aspartyl protease family protein 0.0572 0.0388 0.1517
Loa Loa (eye worm) hypothetical protein 0.0572 0.0388 0.1517
Onchocerca volvulus Protein ultraspiracle homolog 0.0044 0.0014 0.0119
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0921 0.0636 0.5636
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0021 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0419 0.0279 0.1282
Giardia lamblia Encystation-specific protease 0.0419 0.0279 0.1022
Schistosoma mansoni memapsin-2 (A01 family) 0.9647 0.6826 1
Entamoeba histolytica hypothetical protein 0.0419 0.0279 0.2089
Entamoeba histolytica cysteine protease, putative 0.0419 0.0279 0.2089
Leishmania major cathepsin L-like protease 0.1106 0.0767 0.3557
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0028 0.0111
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0119 0.0067 0.029
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0116 0.0521
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0572 0.0388 0.1517
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Onchocerca volvulus 0.0039 0.001 0.007
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0028 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0094 0.0049 0.0072
Brugia malayi Cathepsin L-like precursor 0.1106 0.0767 0.2999
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.0065 0.0254
Giardia lamblia Cathepsin B precursor 0.0419 0.0279 0.1022
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0189 0.0116 0.0521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0014 0.0055
Entamoeba histolytica cysteine proteinase, putative 0.0697 0.0477 0.3591
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.001 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0044 0.0014 0.0053
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Trypanosoma cruzi cysteine peptidase, putative 0.1579 0.1102 0.4302
Leishmania major cathepsin L-like protease 0.1106 0.0767 0.3557
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0021 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Entamoeba histolytica cysteine protease, putative 0.0419 0.0279 0.2089
Brugia malayi nuclear hormone receptor 0.0044 0.0014 0.0053
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3629 0.2556 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.001 0.0025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.001 0.0015
Plasmodium falciparum serine repeat antigen 8 0.0419 0.0279 0.3465
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0419 0.0279 0.1022
Echinococcus multilocularis muscleblind protein 0.0148 0.0087 0.034
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Entamoeba histolytica cysteine proteinase, putative 0.1106 0.0767 0.5794
Mycobacterium leprae Conserved hypothetical protein 0.4747 0.335 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0044 0.0014 0.0053
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.161 0.1125 1
Loa Loa (eye worm) twinkle helicase 0.046 0.0309 0.1207
Echinococcus granulosus muscleblind protein 0.0148 0.0087 0.034
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1106 0.0767 0.3557
Onchocerca volvulus Huntingtin homolog 0.0121 0.0068 0.0833
Mycobacterium ulcerans hypothetical protein 0.0039 0.001 0.0048
Loa Loa (eye worm) hypothetical protein 0.0037 0.0008 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0419 0.0279 0.1282
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0049 0.0072
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0031 0.0005 0.0007
Echinococcus multilocularis microtubule associated protein 2 0.2271 0.1593 0.6232
Brugia malayi Steroid receptor seven-up type 2 0.0044 0.0014 0.0053
Loa Loa (eye worm) hypothetical protein 0.0038 0.0009 0.0037
Echinococcus multilocularis thyroid hormone receptor alpha 0.0044 0.0014 0.0053
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0009 0.0035
Entamoeba histolytica cysteine proteinase, putative 0.0827 0.0569 0.4292
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0039
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.0065 0.0254
Schistosoma mansoni aldehyde dehydrogenase 0.0321 0.021 0.0308
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3629 0.2556 0.3745
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0419 0.0279 0.0409
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0419 0.0279 0.356
Trypanosoma cruzi major cysteine proteinase, putative 0.0892 0.0615 0.2392
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0044 0.0014 0.0053
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0049 0.0192
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0791 0.0544 0.2504
Echinococcus granulosus ecdysone induced protein 78C 0.0044 0.0014 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0044 0.0014 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0419 0.0279 0.1282
Toxoplasma gondii aspartyl protease ASP3 0.0572 0.0388 0.1775
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0419 0.0279 0.0409
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0419 0.0279 0.1022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0116 0.0521
Mycobacterium tuberculosis Conserved protein 0.0039 0.001 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0044 0.0014 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0419 0.0279 0.1282
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0044 0.0014 0.0053
Giardia lamblia Fructose-bisphosphate aldolase 0.1886 0.132 0.6024
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0014 0.0055
Loa Loa (eye worm) beta-lactamase 0.0039 0.001 0.0039
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0419 0.0279 0.1093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0419 0.0279 0.1282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0044 0.0014 0.0053
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0008 0.0032
Echinococcus granulosus tar DNA binding protein 0.0065 0.0028 0.011
Schistosoma mansoni cathepsin S (C01 family) 0.0419 0.0279 0.0409
Brugia malayi fibroinase precursor 0.0419 0.0279 0.1093
Echinococcus granulosus cathepsin l1 0.1106 0.0767 0.2999
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0014 0.0055
Brugia malayi Pepsin A precursor 0.0572 0.0388 0.1517
Plasmodium vivax vivapain-2 0.1106 0.0767 1
Onchocerca volvulus 0.0748 0.0513 0.6665
Mycobacterium ulcerans recombinase A 0.045 0.0301 0.2649
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.001 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Echinococcus granulosus microtubule associated protein 2 0.2271 0.1593 0.6232
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0008 0.0032
Echinococcus granulosus tumor protein p63 0.0262 0.0168 0.0657
Brugia malayi hypothetical protein 0.0572 0.0388 0.1517
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0419 0.0279 0.1282
Giardia lamblia Cathepsin B precursor 0.0419 0.0279 0.1022
Plasmodium vivax aspartyl protease, putative 0.0572 0.0388 0.4993
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0419 0.0279 0.1282
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Giardia lamblia Cathepsin L precursor 0.0419 0.0279 0.1022
Loa Loa (eye worm) hypothetical protein 0.0119 0.0067 0.0261
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0014 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0049 0.0072
Giardia lamblia Cathepsin B precursor 0.0419 0.0279 0.1022
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0116 0.0521
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0044 0.0014 0.0053
Trypanosoma cruzi cysteine peptidase, putative 0.0279 0.018 0.0687
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0697 0.0477 0.2204
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0419 0.0279 0.356
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0014 0.0055
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Plasmodium vivax unspecified product 0.0279 0.018 0.2245
Schistosoma mansoni aldehyde dehydrogenase 0.0321 0.021 0.0308
Trypanosoma brucei cysteine peptidase C (CPC) 0.3052 0.2148 1
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0021 0.0146
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0028 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0419 0.0279 0.1282
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0419 0.0279 0.1093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0279 0.018 0.0703
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0094 0.0049 0.0192
Echinococcus granulosus neuropeptide s receptor 0.0501 0.0338 0.1322
Schistosoma mansoni inositol monophosphatase 0.0036 0.0008 0.0012
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0419 0.0279 0.2089
Echinococcus granulosus cathepsin L cysteine proteinase 0.1106 0.0767 0.2999
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0419 0.0279 0.1282
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Plasmodium falciparum serine repeat antigen 6 0.0419 0.0279 0.3465
Brugia malayi hypothetical protein 0.0121 0.0068 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1106 0.0767 0.3557
Toxoplasma gondii ABC1 family protein 0.0039 0.001 0.0008
Brugia malayi aspartic protease BmAsp-2, identical 0.0572 0.0388 0.1517
Plasmodium vivax vivapain-1 0.0697 0.0477 0.6171
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Loa Loa (eye worm) hypothetical protein 0.0055 0.0021 0.0082
Brugia malayi cathepsin F-like cysteine proteinase 0.0419 0.0279 0.1093
Echinococcus granulosus cathepsin l1 0.0827 0.0569 0.2226
Loa Loa (eye worm) hypothetical protein 0.0827 0.0569 0.2226
Loa Loa (eye worm) cysteine protease 0.1106 0.0767 0.2999
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0419 0.0279 0.1282
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0031 0.0005 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Loa Loa (eye worm) cathepsin B 0.3052 0.2148 0.8401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0697 0.0477 0.2204
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0119 0.0067 0.0261
Onchocerca volvulus 0.0419 0.0279 0.3605
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Echinococcus granulosus cathepsin L 0.0419 0.0279 0.1093
Giardia lamblia Cysteine protease 0.0419 0.0279 0.1022
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0419 0.0279 0.356
Plasmodium falciparum plasmepsin IX 0.0572 0.0388 0.4919
Giardia lamblia Cathepsin B precursor 0.3052 0.2148 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0419 0.0279 0.356
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0697 0.0477 0.0699
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0189 0.0116 0.0454
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0044 0.0014 0.0053
Loa Loa (eye worm) hypothetical protein 0.0791 0.0544 0.2127
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Trypanosoma cruzi cruzipain precursor, putative 0.1579 0.1102 0.4302
Echinococcus multilocularis neuropeptide receptor A26 0.0501 0.0338 0.1322
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0419 0.0279 0.0409
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0039
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0044 0.0014 0.0053
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0044 0.0014 0.0053
Entamoeba histolytica cysteine proteinase, putative 0.0697 0.0477 0.3591
Brugia malayi hypothetical protein 0.0572 0.0388 0.1517
Echinococcus granulosus cathepsin L 0.0697 0.0477 0.1866
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0811 0.0558 0.2181
Schistosoma mansoni cathepsin C 0.0419 0.0279 0.0409
Toxoplasma gondii preprocathepsin c precursor, putative 0.0419 0.0279 0.1268
Plasmodium falciparum serine repeat antigen 5 0.0419 0.0279 0.3465
Echinococcus multilocularis neuropeptide s receptor 0.0501 0.0338 0.1322
Schistosoma mansoni microtubule-associated protein tau 0.2271 0.1593 0.2334
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Leishmania major cathepsin L-like protease 0.1579 0.1102 0.5123
Echinococcus multilocularis FTZ F1 alpha 0.0044 0.0014 0.0053
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1106 0.0767 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0014 0.0021
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0419 0.0279 0.0409
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0044 0.0014 0.0053
Plasmodium falciparum plasmepsin X 0.0572 0.0388 0.4919
Schistosoma mansoni inositol monophosphatase 0.0036 0.0008 0.0012
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0119 0.0067 0.0098
Echinococcus multilocularis ubiquitin specific protease 41 0.0119 0.0067 0.0261
Entamoeba histolytica cysteine protease, putative 0.0419 0.0279 0.2089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Treponema pallidum fructose-bisphosphate aldolase 0.1886 0.132 1
Schistosoma mansoni kinase 0.0096 0.005 0.0074
Schistosoma mansoni lipoxygenase 0.0081 0.004 0.0059
Entamoeba histolytica cysteine protease, putative 0.1106 0.0767 0.5794
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0572 0.0388 0.1775
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0119 0.0067 0.029
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0119 0.0067 0.029
Onchocerca volvulus 0.0572 0.0388 0.5028
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0014 0.002
Echinococcus granulosus cathepsin l cysteine peptidase 0.1106 0.0767 0.2999
Loa Loa (eye worm) fibroinase 0.1106 0.0767 0.2999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Loa Loa (eye worm) aminopeptidase N 0.0031 0.0005 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0419 0.0279 0.1282
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0119 0.0067 0.0243
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0049 0.0191
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0657 0.0448 0.1753
Giardia lamblia Cysteine protease 0.0419 0.0279 0.1022
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0039
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0039
Brugia malayi aspartic protease BmAsp-1, identical 0.0572 0.0388 0.1517
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0021 0.006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0014 0.0053
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 1.296 0.9177 0.9176
Mycobacterium tuberculosis Conserved protein 0.0039 0.001 0.0005
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3052 0.2148 0.8398
Schistosoma mansoni lipoxygenase 0.0117 0.0065 0.0095
Plasmodium vivax aspartyl proteinase, putative 0.0791 0.0544 0.7053
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.3052 0.2148 1
Echinococcus multilocularis muscleblind protein 1 0.0148 0.0087 0.034
Plasmodium falciparum cysteine proteinase falcipain 3 0.1106 0.0767 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0419 0.0279 0.356
Echinococcus granulosus histone lysine methyltransferase setb 0.0094 0.0049 0.0192
Loa Loa (eye worm) steroid hormone receptor 0.0044 0.0014 0.0053
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0039
Trypanosoma brucei polo-like protein kinase 0.0189 0.0116 0.0521
Loa Loa (eye worm) MH2 domain-containing protein 0.0368 0.0243 0.0952
Leishmania major cathepsin L-like protease 0.1579 0.1102 0.5123
Mycobacterium ulcerans aldehyde dehydrogenase 0.0321 0.021 0.1835
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0044 0.0014 0.0053
Loa Loa (eye worm) hypothetical protein 0.0279 0.018 0.0703
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0321 0.021 0.0205
Brugia malayi Cathepsin L-like precursor 0.1106 0.0767 0.2999
Plasmodium vivax serine-repeat antigen (SERA) 0.0419 0.0279 0.356
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0014 0.002
Plasmodium falciparum plasmepsin VIII, putative 0.0572 0.0388 0.4919
Brugia malayi Peptidase family M1 containing protein 0.0031 0.0005 0.0018
Brugia malayi Papain family cysteine protease containing protein 0.0697 0.0477 0.1866
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.13 0.0905 0.3528
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0116 0.0521
Trichomonas vaginalis set domain proteins, putative 0.0748 0.0513 0.2371
Brugia malayi Cathepsin L-like precursor 0.0827 0.0569 0.2226
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0044 0.0014 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Echinococcus multilocularis tumor protein p63 0.0262 0.0168 0.0657
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.001 0.0025
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0119 0.0067 0.0243
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0419 0.0279 0.0409
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0021 0.0064
Onchocerca volvulus Bile acid receptor homolog 0.0044 0.0014 0.0119
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.001 0.0039
Onchocerca volvulus 0.0094 0.0049 0.0584
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0008 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0419 0.0279 0.1282
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.3052 0.2148 1
Plasmodium falciparum serine repeat antigen 1 0.0419 0.0279 0.3465
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0028 0.0041
Leishmania major hypothetical protein, conserved 0.0039 0.001 0.0025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0014 0.0053
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Brugia malayi Cathepsin L-like precursor 0.1106 0.0767 0.2999
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0116 0.0521
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0419 0.0279 0.3465
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0791 0.0544 0.2516
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0419 0.0279 0.1282
Plasmodium falciparum serine repeat antigen 2 0.0419 0.0279 0.3465
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0067 0.029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0419 0.0279 0.356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Mycobacterium ulcerans aldehyde dehydrogenase 0.0321 0.021 0.1835
Entamoeba histolytica cysteine proteinase, putative 0.1106 0.0767 0.5794
Onchocerca volvulus 0.0572 0.0388 0.5028
Onchocerca volvulus 0.0039 0.001 0.007
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1106 0.0767 0.2999
Brugia malayi Peptidase family M1 containing protein 0.0031 0.0005 0.0018
Echinococcus multilocularis aminopeptidase N 0.0031 0.0005 0.0018
Plasmodium vivax unspecified product 0.0697 0.0477 0.6171
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0028 0.011
Plasmodium vivax SET domain protein, putative 0.0094 0.0049 0.0517
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.001 0.0025
Giardia lamblia Cathepsin L precursor 0.0419 0.0279 0.1022
Plasmodium falciparum plasmepsin IV 0.0791 0.0544 0.7009
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0119 0.0067 0.0261
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Entamoeba histolytica cysteine proteinase 2 0.0697 0.0477 0.3591
Giardia lamblia Cathepsin L precursor 0.0419 0.0279 0.1022
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0028 0.011
Mycobacterium ulcerans replicative DNA helicase DnaB 0.161 0.1125 1
Leishmania major hypothetical protein, conserved 0.0055 0.0021 0.0077
Giardia lamblia Cathepsin B precursor 0.0419 0.0279 0.1022
Onchocerca volvulus 0.1106 0.0767 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0321 0.021 0.1835
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0697 0.0477 0.0699
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0321 0.021 0.0822
Brugia malayi hypothetical protein 0.0035 0.0007 0.0028
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0014 0.0021
Plasmodium falciparum serine repeat antigen 3 0.0419 0.0279 0.3465
Toxoplasma gondii cathepsin CPC1 0.0419 0.0279 0.1268
Echinococcus multilocularis cysteine protease 0.1106 0.0767 0.2999
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Echinococcus granulosus FTZ F1 alpha 0.0044 0.0014 0.0053
Brugia malayi steroid hormone receptor 0.0044 0.0014 0.0053
Brugia malayi Cathepsin L-like cysteine proteinase 0.0827 0.0569 0.2226
Toxoplasma gondii aldehyde dehydrogenase 0.0321 0.021 0.0944
Echinococcus granulosus ubiquitin specific protease 41 0.0119 0.0067 0.0261
Loa Loa (eye worm) hypothetical protein 0.0121 0.0068 0.0266
Schistosoma mansoni steroid hormone receptor ad4bp 0.0044 0.0014 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.001 0.0025
Brugia malayi hypothetical protein 0.0031 0.0005 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0014 0.0021
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0028 0.011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.001 0.0015
Echinococcus granulosus aminopeptidase N 0.0031 0.0005 0.0018
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0008 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0827 0.0569 0.2635
Trypanosoma cruzi cysteine peptidase, putative 0.1106 0.0767 0.2987
Onchocerca volvulus 0.1106 0.0767 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0049 0.0192
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0044 0.0014 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Loa Loa (eye worm) hypothetical protein 0.0827 0.0569 0.2226
Brugia malayi ecdysteroid receptor 0.0044 0.0014 0.0053
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0697 0.0477 0.0699
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3629 0.2556 0.3745
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0014 0.0053
Plasmodium falciparum plasmepsin I 0.0791 0.0544 0.7009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0419 0.0279 0.1093
Trichomonas vaginalis esterase, putative 0.0039 0.001 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.001 0.0021
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.001 0.0039
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1106 0.0767 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0827 0.0569 0.2635
Onchocerca volvulus 0.0039 0.001 0.007
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0419 0.0279 0.356
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0044 0.0014 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1886 0.132 1
Onchocerca volvulus 0.0827 0.0569 0.7408
Loa Loa (eye worm) hypothetical protein 0.0148 0.0087 0.034
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1106 0.0767 0.2999
Schistosoma mansoni retinoic acid receptor RXR 0.0044 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0419 0.0279 0.1093
Brugia malayi hypothetical protein 0.0055 0.0021 0.0082
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0049 0.0205
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0044 0.0014 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0014 0.002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0419 0.0279 0.0409
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0419 0.0279 0.0409
Entamoeba histolytica cysteine proteinase, putative 0.0697 0.0477 0.3591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Leishmania major cathepsin L-like protease 0.1579 0.1102 0.5123
Plasmodium falciparum plasmepsin V 0.0572 0.0388 0.4919
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Loa Loa (eye worm) aspartyl protease 6 0.0572 0.0388 0.1517
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.0116 0.0437
Giardia lamblia Cathepsin B precursor 0.3052 0.2148 1
Echinococcus multilocularis cysteine protease 0.1106 0.0767 0.2999
Entamoeba histolytica cysteine proteinase 1, putative 0.0697 0.0477 0.3591
Onchocerca volvulus 0.1106 0.0767 1
Brugia malayi cathepsin B-like cysteine proteinase 0.3629 0.2556 1
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.0116 0.017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Loa Loa (eye worm) hypothetical protein 0.1106 0.0767 0.2999
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0044 0.0014 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.0279 0.1282
Toxoplasma gondii aspartyl protease 0.0572 0.0388 0.1775
Loa Loa (eye worm) hypothetical protein 0.0419 0.0279 0.1093
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0028 0.0094
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0044 0.0014 0.002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0014 0.0053
Brugia malayi Cathepsin L-like precursor 0.1106 0.0767 0.2999
Echinococcus granulosus neuropeptide receptor A26 0.0501 0.0338 0.1322
Entamoeba histolytica cysteine protease, putative 0.0419 0.0279 0.2089
Giardia lamblia Cathepsin L-like protease 0.0419 0.0279 0.1022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.001 0.0048
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0021 0.0077
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0697 0.0477 0.1851
Trypanosoma cruzi major cysteine proteinase, putative 0.0419 0.0279 0.1077
Plasmodium vivax vivapain-2 0.1106 0.0767 1
Onchocerca volvulus 0.1106 0.0767 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0419 0.0279 0.1282
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.001 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0116 0.0521
Wolbachia endosymbiont of Brugia malayi recombinase A 0.045 0.0301 0.2625
Loa Loa (eye worm) hypothetical protein 0.0419 0.0279 0.1093
Brugia malayi cathepsin L-like precursor 0.0827 0.0569 0.2226
Leishmania major cathepsin L-like protease 0.1106 0.0767 0.3557
Loa Loa (eye worm) hypothetical protein 0.0419 0.0279 0.1093
Onchocerca volvulus 0.0038 0.0009 0.0064
Onchocerca volvulus Cathepsin L homolog 0.1106 0.0767 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0028 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0014 0.0053
Treponema pallidum replicative DNA helicase (dnaB) 0.161 0.1125 0.8081
Plasmodium falciparum serine repeat antigen 9 0.0419 0.0279 0.3465
Trypanosoma cruzi cysteine proteinase, putative 0.0697 0.0477 0.1851
Schistosoma mansoni cellular tumor antigen P53 0.0038 0.0009 0.0014
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1106 0.0767 0.2999
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0119 0.0067 0.0261
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.001 0.0039
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3052 0.2148 0.3146
Trypanosoma cruzi cysteine proteinase, putative 0.0697 0.0477 0.1851
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0419 0.0279 0.356
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0419 0.0279 0.1282
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0008 0.0017
Schistosoma mansoni cathepsin D (A01 family) 0.1352 0.0942 0.1379
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Plasmodium vivax aspartyl proteinase, putative 0.0572 0.0388 0.4993
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0419 0.0279 0.1282
Echinococcus granulosus cathepsin L cysteine protease 0.0697 0.0477 0.1866
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.001 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0419 0.0279 0.1093
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0419 0.0279 0.2089
Brugia malayi Cathepsin L-like precursor 0.0827 0.0569 0.2226
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0419 0.0279 0.356
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0014 0.0053
Toxoplasma gondii aspartyl protease ASP1 0.0791 0.0544 0.2504
Entamoeba histolytica cysteine protease, putative 0.0419 0.0279 0.2089
Trypanosoma cruzi cysteine protease, putative 0.0697 0.0477 0.1851
Brugia malayi Papain family cysteine protease containing protein 0.1106 0.0767 0.2999
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0044 0.0014 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0014 0.0055
Giardia lamblia Cathepsin B precursor 0.3052 0.2148 1
Plasmodium falciparum plasmepsin VI 0.0791 0.0544 0.7009
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Brugia malayi photoreceptor-specific nuclear receptor 0.0044 0.0014 0.0053
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0791 0.0544 0.2127
Schistosoma mansoni coup transcription factor 0.0044 0.0014 0.002
Trypanosoma cruzi cruzipain precursor, putative 0.0279 0.018 0.0687
Onchocerca volvulus Serine\/threonine kinase homolog 0.0189 0.0116 0.1464
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0014 0.0053
Plasmodium vivax plasmepsin IV, putative 0.0791 0.0544 0.7053
Brugia malayi beta-lactamase family protein 0.0039 0.001 0.0039
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0119 0.0067 0.0261
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Loa Loa (eye worm) hypothetical protein 0.3629 0.2556 1
Schistosoma mansoni cathepsin B (C01 family) 0.0419 0.0279 0.0409
Brugia malayi Cathepsin L-like precursor 0.1106 0.0767 0.2999
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0419 0.0279 0.3465
Entamoeba histolytica cysteine proteinase, putative 0.0697 0.0477 0.3591
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0031 0.0005 0.0018
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.001 0.0005
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.161 0.1125 0.3346
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Plasmodium falciparum plasmepsin VII 0.0572 0.0388 0.4919
Loa Loa (eye worm) ctsf protein 0.1106 0.0767 0.2999
Brugia malayi Cathepsin L-like precursor 0.0279 0.018 0.0703
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0419 0.0279 0.0409
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0321 0.021 0.0822
Plasmodium vivax unspecified product 0.0419 0.0279 0.356
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0039
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0119 0.0067 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.0279 0.1282
Toxoplasma gondii cathepsin CPL 0.1106 0.0767 0.3546
Loa Loa (eye worm) transcription factor SMAD2 0.0368 0.0243 0.0952
Plasmodium vivax plasmepsin V, putative 0.0572 0.0388 0.4993
Schistosoma mansoni cathepsin s 0.0279 0.018 0.0263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Brugia malayi Cathepsin L-like precursor 0.1106 0.0767 0.2999
Plasmodium falciparum serine repeat antigen 7 0.0419 0.0279 0.3465
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Entamoeba histolytica serine/threonine protein kinase, putative 0.0189 0.0116 0.0848
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Onchocerca volvulus Cathepsin L homolog 0.1106 0.0767 1
Plasmodium falciparum serine repeat antigen 4 0.0419 0.0279 0.3465
Brugia malayi cathepsin L precursor 0.0419 0.0279 0.1093
Schistosoma mansoni cathepsin D (A01 family) 0.1352 0.0942 0.1379
Echinococcus multilocularis cathepsin b 0.3629 0.2556 1
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0014 0.002
Brugia malayi TAR-binding protein 0.0065 0.0028 0.011
Plasmodium falciparum plasmepsin III 0.0572 0.0388 0.4919
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0014 0.0053
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0419 0.0279 0.1093
Echinococcus multilocularis cathepsin b 0.3629 0.2556 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0044 0.0014 0.0053
Loa Loa (eye worm) hypothetical protein 0.0279 0.018 0.0703
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Brugia malayi Papain family cysteine protease containing protein 0.0697 0.0477 0.1866
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Plasmodium falciparum cysteine proteinase falcipain 1 0.0697 0.0477 0.6114
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3629 0.2556 0.3745
Leishmania major cathepsin L-like protease 0.1106 0.0767 0.3557
Brugia malayi Papain family cysteine protease containing protein 0.0419 0.0279 0.1093
Echinococcus multilocularis cathepsin L cysteine protease 0.1106 0.0767 0.2999
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0021 0.008
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Echinococcus multilocularis cathepsin L cysteine protease 0.1106 0.0767 0.2999
Trypanosoma cruzi DNA repair protein, putative 0.0138 0.008 0.0297
Schistosoma mansoni cathepsin F (C01 family) 0.1106 0.0767 0.1123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Loa Loa (eye worm) hypothetical protein 0.0121 0.0068 0.0266
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0009 0.0035
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0189 0.0116 0.0454
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0791 0.0544 0.0797
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0119 0.0067 0.0261
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Onchocerca volvulus 0.1106 0.0767 1
Brugia malayi nuclear receptor NHR-88 0.0044 0.0014 0.0053
Onchocerca volvulus 0.1106 0.0767 1
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0138 0.008 0.0354
Loa Loa (eye worm) inositol-1 0.0036 0.0008 0.0032
Brugia malayi Pre-SET motif family protein 0.0094 0.0049 0.0192
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Loa Loa (eye worm) RNA binding protein 0.0065 0.0028 0.011
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0008 0.0027
Brugia malayi Papain family cysteine protease containing protein 0.0419 0.0279 0.1093
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0014 0.0053
Brugia malayi beta-lactamase 0.0039 0.001 0.0039
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0921 0.0636 0.0631
Mycobacterium tuberculosis Conserved protein 0.0039 0.001 0.0005
Giardia lamblia Kinase, PLK 0.0189 0.0116 0.0238
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0044 0.0014 0.002
Brugia malayi cathepsin Z-like cysteine proteinase 0.0419 0.0279 0.1093
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0419 0.0279 0.356
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0419 0.0279 0.3465
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.001 0.0005
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0044 0.0014 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0697 0.0477 0.2204
Echinococcus multilocularis cathepsin L 0.0419 0.0279 0.1093
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0791 0.0544 0.2127
Toxoplasma gondii cathepsin CPC2 0.0419 0.0279 0.1268
Echinococcus granulosus cathepsin b 0.3629 0.2556 1
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.045 0.0301 0.0884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Schistosoma mansoni cathepsin F (C01 family) 0.1106 0.0767 0.1123
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1106 0.0767 0.2999
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0044 0.0014 0.0053
Loa Loa (eye worm) hypothetical protein 0.0279 0.018 0.0703
Mycobacterium ulcerans beta-lactamase 0.0039 0.001 0.0048
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0028 0.0182
Brugia malayi MH2 domain containing protein 0.0368 0.0243 0.0952
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Mycobacterium ulcerans lipase LipD 0.0039 0.001 0.0048
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.0116 0.0437
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0028 0.011
Echinococcus multilocularis cathepsin L 0.0697 0.0477 0.1866
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Brugia malayi cathepsin Z-like cysteine proteinase 0.0419 0.0279 0.1093
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0008 0.0017
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Giardia lamblia Cathepsin L precursor 0.0419 0.0279 0.1022
Entamoeba histolytica cysteine protease, putative 0.0419 0.0279 0.2089
Onchocerca volvulus Cathepsin L homolog 0.0419 0.0279 0.3605
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0419 0.0279 0.1022
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0049 0.0205
Brugia malayi Pre-SET motif family protein 0.0657 0.0448 0.1753
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0028 0.0041
Brugia malayi serine/threonine-protein kinase plk-2 0.0189 0.0116 0.0454
Trypanosoma cruzi cysteine peptidase, putative 0.1579 0.1102 0.4302
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0419 0.0279 0.356
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0921 0.0636 0.1885
Brugia malayi Inositol-1 0.0036 0.0008 0.0032
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0572 0.0388 0.1517
Giardia lamblia Hypothetical protein 0.0419 0.0279 0.1022
Onchocerca volvulus Huntingtin homolog 0.0121 0.0068 0.0833
Loa Loa (eye worm) hypothetical protein 0.0827 0.0569 0.2226
Mycobacterium leprae Probable lipase LipE 0.0039 0.001 0.0014
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0419 0.0279 0.0409
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0014
Schistosoma mansoni RAR-like nuclear receptor 0.0044 0.0014 0.002
Onchocerca volvulus Cathepsin F homolog 0.1106 0.0767 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0044 0.0014 0.0119
Trypanosoma cruzi cysteine peptidase, putative 0.1579 0.1102 0.4302
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0014 0.0055
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0014 0.0053
Brugia malayi Papain family cysteine protease containing protein 0.0419 0.0279 0.1093
Giardia lamblia Cathepsin L precursor 0.0419 0.0279 0.1022
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0028 0.0111

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 10 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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