TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 387.434 | Formula: C22H21N5O2
H donors: 2 H acceptors: 4 LogP: 2.3 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: N#CCNC(=O)[C@@H](NC(=O)c1ccccc1)Cc1cccc(c1)c1ccnn1C
InChi: 1S/C22H21N5O2/c1-27-20(10-12-25-27)18-9-5-6-16(14-18)15-19(22(29)24-13-11-23)26-21(28)17-7-3-2-4-8-17/h2-10,12,14,19H,13,15H2,1H3,(H,24,29)(H,26,28)/t19-/m0/s1
InChiKey: OBUDLVVVWDLOTN-IBGZPJMESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin V	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin S	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin V	334 aa	357 aa	29.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0291	0.0207
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0483	0.0586
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0036	0.033	0.033
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0524	0.142
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0113	0.3694	0.3694
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.3694	0.5375
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0186	0.6874	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0113	0.3694	0.364
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0077	0.214	0.3113
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0061	0.1415	0.3829
Leishmania major	cathepsin L-like protease	0.0113	0.3694	1
Brugia malayi	Papain family cysteine protease containing protein	0.0113	0.3694	0.3694
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.3694	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0483	0.0586
Echinococcus granulosus	cathepsin L	0.0061	0.1415	0.1341
Schistosoma mansoni	survival motor neuron protein	0.0053	0.1065	0.1443
Loa Loa (eye worm)	hypothetical protein	0.0077	0.214	0.214
Leishmania major	cathepsin L-like protease	0.0113	0.3694	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1415	0.29
Schistosoma mansoni	hypothetical protein	0.0184	0.6819	0.9919
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.3694	1
Leishmania major	cathepsin L-like protease	0.0113	0.3694	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.3694	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.3694	1
Onchocerca volvulus	Cathepsin L homolog	0.0113	0.3694	0.801
Onchocerca volvulus		0.0113	0.3694	0.801
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.3694	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0291	0.0207
Toxoplasma gondii	ABC1 family protein	0.004	0.0524	0.142
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1415	0.29
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0113	0.3694	1
Mycobacterium leprae	Probable lipase LipE	0.004	0.0524	0.5
Plasmodium vivax	vivapain-2	0.0113	0.3694	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0075	0.2029	0.5493
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.3694	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.1415	0.1958
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.0524	0.5
Brugia malayi	Cathepsin L-like precursor	0.0113	0.3694	0.3694
Giardia lamblia	Cathepsin B precursor	0.0075	0.2029	0.5
Onchocerca volvulus	Cathepsin F homolog	0.0113	0.3694	0.801
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0113	0.3694	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0053	0.1065	0.1065
Schistosoma mansoni	hypothetical protein	0.0035	0.0291	0.0302
Entamoeba histolytica	cysteine proteinase 2	0.0061	0.1415	0.29
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.1415	0.2808
Plasmodium vivax	unspecified product	0.0036	0.033	0.0894
Onchocerca volvulus	Huntingtin homolog	0.0133	0.4591	1
Loa Loa (eye worm)	ctsf protein	0.0113	0.3694	0.3694
Echinococcus granulosus	survival motor neuron protein 1	0.0257	1	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0291	0.0291
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.3694	0.5375
Schistosoma mansoni	cathepsin s	0.0036	0.033	0.036
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.3694	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0524	0.0524
Echinococcus granulosus	cathepsin l1	0.0077	0.214	0.2072
Entamoeba histolytica	cysteine proteinase 1, putative	0.0061	0.1415	0.29
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0524	0.0647
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.1415	0.3829
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.3694	1
Loa Loa (eye worm)	cysteine protease	0.0113	0.3694	0.3694
Loa Loa (eye worm)	hypothetical protein	0.0133	0.4591	0.4591
Onchocerca volvulus		0.0053	0.1065	0.2174
Brugia malayi	Cathepsin L-like precursor	0.0077	0.214	0.214
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0524	0.0763
Giardia lamblia	Cathepsin B precursor	0.0075	0.2029	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.033	0.033
Toxoplasma gondii	cathepsin CPL	0.0113	0.3694	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.3694	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0061	0.1415	0.2058
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0086	0.0086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.3694	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.3694	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.214	0.214
Loa Loa (eye worm)	beta-lactamase	0.004	0.0524	0.0524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.3694	1
Plasmodium vivax	unspecified product	0.0061	0.1415	0.3829
Echinococcus multilocularis	cysteine protease	0.0113	0.3694	0.364
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1415	0.29
Loa Loa (eye worm)	hypothetical protein	0.003	0.0086	0.0086
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0113	0.3694	0.364
Brugia malayi	beta-lactamase family protein	0.004	0.0524	0.0524
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0075	0.2029	0.2952
Brugia malayi	intermediate filament protein	0.003	0.0086	0.0086
Onchocerca volvulus		0.0113	0.3694	0.801
Entamoeba histolytica	cysteine proteinase, putative	0.0113	0.3694	1
Echinococcus granulosus	cathepsin b	0.0186	0.6874	0.6847
Trypanosoma cruzi	cysteine peptidase, putative	0.0061	0.1415	0.2058
Trypanosoma cruzi	cysteine proteinase, putative	0.0061	0.1415	0.2058
Loa Loa (eye worm)	hypothetical protein	0.0186	0.6874	0.6874
Leishmania major	cathepsin L-like protease	0.0113	0.3694	1
Onchocerca volvulus	Huntingtin homolog	0.0133	0.4591	1
Leishmania major	cathepsin L-like protease	0.0113	0.3694	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.3694	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1415	0.29
Onchocerca volvulus	Cathepsin L homolog	0.0113	0.3694	0.801
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1415	0.29
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.3694	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0524	0.0524
Echinococcus multilocularis	cysteine protease	0.0113	0.3694	0.364
Plasmodium vivax	vivapain-1	0.0061	0.1415	0.3829
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.3694	1
Brugia malayi	Cathepsin L-like precursor	0.0036	0.033	0.033
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.3694	1
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1415	0.29
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0291	0.0291
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.3694	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1415	0.29
Trypanosoma cruzi	cysteine peptidase, putative	0.0036	0.033	0.048
Brugia malayi	Cathepsin L-like precursor	0.0113	0.3694	0.3694
Echinococcus granulosus	geminin	0.0184	0.6819	0.6791
Loa Loa (eye worm)	hypothetical protein	0.0036	0.033	0.033
Echinococcus multilocularis	cathepsin b	0.0186	0.6874	0.6847
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.3694	1
Mycobacterium ulcerans	lipase LipD	0.004	0.0524	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.3694	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.3694	1
Brugia malayi	Cathepsin L-like precursor	0.0113	0.3694	0.3694
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0291	0.0207
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0075	0.2029	0.2864
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0524	0.0763
Schistosoma mansoni	hypothetical protein	0.0035	0.0291	0.0302
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0186	0.6874	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1415	0.29
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.033	0.033
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0291	0.0207
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.3694	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0075	0.2029	0.5493
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.3694	1
Mycobacterium ulcerans	beta-lactamase	0.004	0.0524	0.5
Brugia malayi	Cathepsin L-like precursor	0.0113	0.3694	0.3694
Brugia malayi	Calcitonin receptor-like protein seb-1	0.011	0.3563	0.3563
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.0524	0.5
Onchocerca volvulus		0.0113	0.3694	0.801
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1415	0.29
Brugia malayi	cathepsin B-like cysteine proteinase	0.0186	0.6874	0.6874
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1415	0.29
Schistosoma mansoni	cathepsin F (C01 family)	0.0113	0.3694	0.5316
Onchocerca volvulus		0.0113	0.3694	0.801
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0483	0.0401
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0483	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0036	0.033	0.033
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0062	0.0062
Echinococcus granulosus	cysteine protease	0.0061	0.1415	0.1341
Plasmodium vivax	vivapain-3	0.0061	0.1415	0.3829
Echinococcus granulosus	GPCR family 2	0.0035	0.0291	0.0207
Brugia malayi	beta-lactamase family protein	0.004	0.0524	0.0524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.3694	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.1415	0.1958
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0113	0.3694	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0036	0.033	0.048
Giardia lamblia	Cathepsin B precursor	0.0075	0.2029	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.3694	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.1415	0.3829
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.3694	0.5375
Echinococcus multilocularis	cathepsin L cysteine protease	0.0113	0.3694	0.364
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1415	0.29
Entamoeba histolytica	cysteine proteinase, putative	0.0077	0.214	0.5159
Brugia malayi	Papain family cysteine protease containing protein	0.0061	0.1415	0.1415
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.3694	1
Schistosoma mansoni	hypothetical protein	0.0184	0.6819	0.9919
Leishmania major	cathepsin L-like protease	0.0113	0.3694	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.1415	0.1958
Onchocerca volvulus		0.004	0.0524	0.0974
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0291	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0524	0.0524
Mycobacterium leprae	conserved hypothetical protein	0.004	0.0524	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.6874	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0524	0.0443
Onchocerca volvulus		0.004	0.0524	0.0974
Mycobacterium ulcerans	hypothetical protein	0.004	0.0524	0.5
Loa Loa (eye worm)	cathepsin B	0.0075	0.2029	0.2029
Loa Loa (eye worm)	MH2 domain-containing protein	0.013	0.4442	0.4442
Echinococcus granulosus	cathepsin b	0.0186	0.6874	0.6847
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0524	0.0524
Brugia malayi	hypothetical protein	0.0133	0.4591	0.4591
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1415	0.29
Echinococcus multilocularis	survival motor neuron protein 1	0.0257	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.3694	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.3694	0.3694
Brugia malayi	Cathepsin L-like precursor	0.0113	0.3694	0.3694
Brugia malayi	beta-lactamase	0.004	0.0524	0.0524
Schistosoma mansoni	cathepsin F (C01 family)	0.0077	0.214	0.3027
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0075	0.2029	0.4748
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0524	0.0647
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0524	0.0443
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1415	0.29
Brugia malayi	Cathepsin L-like precursor	0.0113	0.3694	0.3694
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.3694	0.5375
Loa Loa (eye worm)	hypothetical protein	0.0257	1	1
Onchocerca volvulus		0.0113	0.3694	0.801
Leishmania major	hypothetical protein, conserved	0.004	0.0524	0.142
Brugia malayi	Cathepsin L-like precursor	0.0077	0.214	0.214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	0.214	0.5097
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.3694	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.3694	1
Echinococcus multilocularis	cathepsin b	0.0186	0.6874	0.6847
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.6874	1
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0086	0.0086
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0113	0.3694	0.364
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.3694	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.011	0.3563	0.3563
Loa Loa (eye worm)	fibroinase	0.0113	0.3694	0.3694
Plasmodium vivax	vivapain-2	0.0113	0.3694	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.011	0.3563	0.3563
Entamoeba histolytica	cysteine proteinase, putative	0.0113	0.3694	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0113	0.3694	1
Echinococcus granulosus	cathepsin l1	0.0113	0.3694	0.364
Loa Loa (eye worm)	hypothetical protein	0.0133	0.4591	0.4591
Onchocerca volvulus		0.004	0.0524	0.0974
Toxoplasma gondii	cathepsin B	0.0075	0.2029	0.5493
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0291	0.0291
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0086	0.0086
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1415	0.29
Brugia malayi	hypothetical protein	0.0039	0.0483	0.0483
Trypanosoma cruzi	cysteine proteinase, putative	0.0061	0.1415	0.2058
Echinococcus granulosus	cathepsin L cysteine protease	0.0061	0.1415	0.1341
Leishmania major	cysteine peptidase A (CPA)	0.0113	0.3694	1
Echinococcus multilocularis	cathepsin L	0.0061	0.1415	0.1341
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0256	0.9948	1
Brugia malayi	cathepsin L-like precursor	0.0077	0.214	0.214
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0113	0.3694	0.3694
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.3694	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.2048	0.2048
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.3694	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.6874	1
Schistosoma mansoni	hypothetical protein	0.0053	0.1065	0.1443
Loa Loa (eye worm)	hypothetical protein	0.0075	0.2048	0.2048
Onchocerca volvulus		0.0077	0.214	0.456
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0524	0.142
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0113	0.3694	1
Trypanosoma cruzi	cysteine protease, putative	0.0061	0.1415	0.2058
Entamoeba histolytica	cysteine protease, putative	0.0113	0.3694	1
Leishmania major	cathepsin L-like protease	0.0113	0.3694	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	0.214	0.5097
Echinococcus multilocularis	cathepsin L cysteine protease	0.0113	0.3694	0.364
Echinococcus multilocularis	geminin	0.0184	0.6819	0.6791
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.1415	0.2808
Schistosoma mansoni	hypothetical protein	0.0075	0.2048	0.2892
Schistosoma mansoni	hypothetical protein	0.0035	0.0291	0.0302
Trypanosoma cruzi	cruzipain precursor, putative	0.0113	0.3694	0.5375
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1415	0.29
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0113	0.3694	0.364
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.3694	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0077	0.214	0.214
Loa Loa (eye worm)	hypothetical protein	0.011	0.3563	0.3563
Leishmania major	cathepsin L-like protease	0.0113	0.3694	1
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1415	0.29
Brugia malayi	MH2 domain containing protein	0.013	0.4442	0.4442
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0291	0.0291
Schistosoma mansoni	hypothetical protein	0.0035	0.0291	0.0302
Loa Loa (eye worm)	transcription factor SMAD2	0.013	0.4442	0.4442
Loa Loa (eye worm)	hypothetical protein	0.004	0.0524	0.0524
Loa Loa (eye worm)	hypothetical protein	0.004	0.0524	0.0524
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.3694	1
Onchocerca volvulus		0.0113	0.3694	0.801
Loa Loa (eye worm)	hypothetical protein	0.0077	0.214	0.214
Onchocerca volvulus		0.0113	0.3694	0.801
Loa Loa (eye worm)	hypothetical protein	0.004	0.0524	0.0524
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0524	0.0524
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.3694	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0036	0.033	0.033
Brugia malayi	Papain family cysteine protease containing protein	0.0061	0.1415	0.1415
Schistosoma mansoni	cathepsin F (C01 family)	0.0113	0.3694	0.5316
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1415	0.29

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 5	Inhibition of cathepsin K assessed as inhibition of fluorogenic substrate cleavage	ChEMBL.	19616430
IC50 (binding)	= 5.1	Inhibition of human liver cathepsin B assessed as inhibition of fluorogenic substrate cleavage	ChEMBL.	19616430
IC50 (binding)	= 5.5	Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavage	ChEMBL.	19616430
IC50 (binding)	= 5.5	Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage	ChEMBL.	19616430
IC50 (binding)	= 6.5	Inhibition of cathepsin S assessed as inhibition of fluorogenic substrate cleavage	ChEMBL.	19616430

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL559248

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1051391