Detailed information for compound 1051784

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 308.335 | Formula: C17H16N4O2
  • H donors: 1 H acceptors: 3 LogP: 3.4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C(/c1cccnc1Oc1ccc(cc1)CC)\n1cncc1
  • InChi: 1S/C17H16N4O2/c1-2-13-5-7-14(8-6-13)23-17-15(4-3-9-19-17)16(20-22)21-11-10-18-12-21/h3-12,22H,2H2,1H3/b20-16-
  • InChiKey: YXNYFXGRYSOUAK-SILNSSARSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0067 0.0207
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0089 0.6488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0145 0.0737 0.1827
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.0137 0.0126
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0459 0.1685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0145 0.0737 0.1827
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0097
Echinococcus granulosus cathepsin L 0.002 0.0034 0.0083
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0137 0.0988
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0095 0.0084
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0704 0.3883 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.011 0.0209
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0075 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.011 0.0098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0137 0.0988
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0459 0.1685
Loa Loa (eye worm) cysteine protease 0.0038 0.0137 0.0126
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0098
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0265 0.0254
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0459 0.0949
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0459 0.341
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0137 0.0269
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.011 0.037
Trypanosoma cruzi cysteine peptidase, putative 0.0145 0.0737 0.1827
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.011 0.037
Echinococcus granulosus cathepsin l cysteine peptidase 0.0038 0.0137 0.0473
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.011 0.0209
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0022 0.004
Plasmodium vivax SET domain protein, putative 0.0033 0.0109 0.7909
Echinococcus multilocularis dnaJ subfamily B 0.0488 0.2668 0.5632
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0145 0.0737 0.1827
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0137 0.0472
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.011 0.0098
Schistosoma mansoni nuclear hormone receptor 0.0033 0.011 0.037
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0145 0.05
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0034 0.0022
Entamoeba histolytica hypothetical protein 0.0038 0.0137 0.2425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0145 0.0737 0.1827
Brugia malayi Cathepsin L-like cysteine proteinase 0.0025 0.0067 0.0055
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0459 0.1105
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0459 0.341
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0124 0.0238
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0137 0.0988
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0154 0.0301
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0459 0.341
Echinococcus granulosus geminin 0.0381 0.2064 0.7728
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0145 0.0737 0.1827
Trypanosoma cruzi cysteine peptidase, putative 0.0145 0.0737 0.1827
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.011 0.0209
Echinococcus multilocularis cathepsin L 0.002 0.0034 0.0047
Onchocerca volvulus Alhambra homolog 0.0029 0.0089 0.0585
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.011 0.037
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0704 0.3883 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0145 0.0737 0.1827
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.011 0.0743
Brugia malayi Cathepsin L-like precursor 0.0038 0.0137 0.0126
Toxoplasma gondii histone lysine methyltransferase SET1 0.0123 0.0618 1
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0022 0.0011
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0021 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0109 0.0365
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0089 0.0078
Schistosoma mansoni hypothetical protein 0.0488 0.2668 1
Schistosoma mansoni cpg binding protein 0.0068 0.0307 0.1113
Toxoplasma gondii cathepsin CPL 0.0038 0.0137 0.0913
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0137 0.0988
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0137 0.0988
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0137 0.0988
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.011 0.0098
Schistosoma mansoni hypothetical protein 0.0381 0.2064 0.7728
Onchocerca volvulus 0.0038 0.0137 0.095
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.011 0.0098
Brugia malayi Bromodomain containing protein 0.0029 0.0089 0.0078
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0011
Echinococcus granulosus cathepsin l1 0.0025 0.0067 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0137 0.0988
Echinococcus granulosus cathepsin L cysteine protease 0.002 0.0034 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.011 0.0098
Schistosoma mansoni hypothetical protein 0.0038 0.0137 0.0472
Loa Loa (eye worm) hypothetical protein 0.1793 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0137 0.2433
Onchocerca volvulus Cathepsin F homolog 0.0038 0.0137 0.095
Loa Loa (eye worm) hypothetical protein 0.005 0.0207 0.0196
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0189 0.1376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0145 0.0737 0.1827
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0021 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0067 0.0457
Leishmania major cathepsin L-like protease 0.0145 0.0737 0.1602
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0137 0.095
Loa Loa (eye worm) CXXC zinc finger family protein 0.0065 0.0287 0.0275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0137 0.0988
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0022 0.004
Schistosoma mansoni thyroid hormone receptor 0.0033 0.011 0.037
Brugia malayi ecdysteroid receptor 0.0033 0.011 0.0098
Brugia malayi Pre-SET motif family protein 0.0221 0.1165 0.1154
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.011 0.037
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0354 0.1288
Onchocerca volvulus 0.0038 0.0137 0.095
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.011 0.037
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.011 0.037
Trypanosoma cruzi cruzipain precursor, putative 0.0145 0.0737 0.1827
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0089 0.0292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0137 0.0988
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.011 0.037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.011 0.0098
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0011
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0137 0.095
Echinococcus granulosus FTZ F1 alpha 0.0033 0.011 0.037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0137 0.0988
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0137 0.0266
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0137 0.0473
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0034 0.0083
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0137 0.0988
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0137 0.0988
Echinococcus multilocularis cysteine protease 0.0038 0.0137 0.0267
Brugia malayi steroid hormone receptor 0.0033 0.011 0.0098
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0137 0.0267
Schistosoma mansoni hypothetical protein 0.0381 0.2064 0.7728
Brugia malayi Pre-SET motif family protein 0.0033 0.0109 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.011 0.0098
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.011 0.0743
Echinococcus granulosus dnaJ subfamily B 0.0488 0.2668 1
Schistosoma mansoni kinase 0.0048 0.0196 0.0694
Plasmodium falciparum cysteine proteinase falcipain 1 0.002 0.0034 0.2464
Onchocerca volvulus 0.0038 0.0137 0.095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0137 0.0988
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.011 0.0098
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.011 0.0743
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0704 0.3883 1
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0043 0.0031
Onchocerca volvulus 0.0251 0.1335 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0459 0.341
Onchocerca volvulus 0.0038 0.0137 0.095
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0038 0.0137 0.0126
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.011 0.0098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0137 0.0988
Brugia malayi Cathepsin L-like precursor 0.0025 0.0067 0.0055
Trypanosoma cruzi cysteine peptidase, putative 0.0145 0.0737 0.1827
Trypanosoma cruzi major cysteine proteinase, putative 0.0114 0.0563 0.1375
Echinococcus granulosus cpg binding protein 0.0068 0.0307 0.1113
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.011 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0145 0.0737 0.1827
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0145 0.05
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0034 0.0083
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.011 0.0209
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0109 0.0365
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.011 0.037
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0038 0.0137 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0459 0.0448
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0109 0.0369
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.011 0.0098
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0138 0.07 0.2591
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0109 0.0206
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0109 0.0365
Echinococcus multilocularis cpg binding protein 0.0068 0.0307 0.0627
Schistosoma mansoni thyroid hormone receptor 0.0033 0.011 0.037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.011 0.0098
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0067 0.0457
Brugia malayi hypothetical protein 0.0017 0.0022 0.0011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0145 0.05
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0034 0.0083
Giardia lamblia Kinase, PLK 0.0095 0.0459 1
Schistosoma mansoni coup transcription factor 0.0033 0.011 0.037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.011 0.037
Brugia malayi Cathepsin L-like precursor 0.0038 0.0137 0.0126
Onchocerca volvulus 0.0038 0.0137 0.095
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0067 0.0774
Brugia malayi jmjC domain containing protein 0.0039 0.0145 0.0133
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.1793 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0011
Schistosoma mansoni cpg binding protein 0.0065 0.0287 0.1035
Plasmodium falciparum phd finger protein, putative 0.0029 0.0089 0.6488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0145 0.0737 0.1827
Plasmodium vivax vivapain-3 0.002 0.0034 0.2464
Brugia malayi nuclear hormone receptor 0.0033 0.011 0.0098
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0022 0.0011
Onchocerca volvulus 0.0033 0.0109 0.0733
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.011 0.037
Brugia malayi Cathepsin L-like precursor 0.0038 0.0137 0.0126
Plasmodium vivax vivapain-1 0.002 0.0034 0.2464
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0109 0.0365
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0011
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0038 0.0137 1
Loa Loa (eye worm) fibroinase 0.0038 0.0137 0.0126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0137 0.0988
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0137 0.0472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0137 0.0988
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0109 0.0206
Echinococcus multilocularis geminin 0.0381 0.2064 0.4353
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0043 0.0116
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0043 0.0066
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0137 0.0267
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.011 0.037
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.011 0.0209
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.011 0.0098
Echinococcus granulosus cysteine protease 0.002 0.0034 0.0083
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0021 0.0019
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0137 0.0267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.011 0.0098
Schistosoma mansoni hypothetical protein 0.0029 0.0089 0.0292
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0459 0.0448
Entamoeba histolytica hypothetical protein 0.0038 0.0137 0.2425
Echinococcus granulosus peregrin 0.0029 0.0089 0.0292
Leishmania major cathepsin L-like protease 0.0145 0.0737 0.1602
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0089 0.0292
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.011 0.0098
Brugia malayi PHD-finger family protein 0.0029 0.0089 0.0078
Leishmania major malonyl-coa decarboxylase-like protein 0.0704 0.3883 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0855 0.4728 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.011 0.0098
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0459 0.341
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.011 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0137 0.0988
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0137 0.0473
Brugia malayi CXXC zinc finger family protein 0.0065 0.0287 0.0275
Onchocerca volvulus 0.0033 0.011 0.0743
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.011 0.0098
Brugia malayi Cathepsin L-like precursor 0.0038 0.0137 0.0126
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.011 0.0098
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0098
Echinococcus granulosus cathepsin L cysteine proteinase 0.0038 0.0137 0.0473
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0109 0.0365
Onchocerca volvulus 0.0065 0.0287 0.2078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0137 0.0988
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0098
Brugia malayi jmjC domain containing protein 0.0096 0.0465 0.0454
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0132 0.0667 0.1644
Brugia malayi Cathepsin L-like precursor 0.0038 0.0137 0.0126
Entamoeba histolytica cysteine protease, putative 0.0038 0.0137 0.2433
Echinococcus granulosus cathepsin l1 0.0038 0.0137 0.0473
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0137 0.0988
Onchocerca volvulus 0.0038 0.0137 0.095
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0022 0.004
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0145 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.011 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.011 0.0098
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.011 0.037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.011 0.0098
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0465 0.0961
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0154 0.0535
Trichomonas vaginalis set domain proteins, putative 0.0251 0.1335 1
Echinococcus multilocularis peregrin 0.0029 0.0089 0.0164
Onchocerca volvulus 0.0025 0.0067 0.0416
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0145 0.0737 0.1827
Loa Loa (eye worm) hypothetical protein 0.0038 0.0137 0.0126
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0034 0.0022
Brugia malayi Cathepsin L-like precursor 0.0025 0.0067 0.0055
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0022 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0459 0.341
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0459 0.341
Leishmania major cathepsin L-like protease 0.0145 0.0737 0.1602
Plasmodium vivax vivapain-2 0.0038 0.0137 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0137 0.0988
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.011 0.0209
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0459 0.086
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0021 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.011 0.0098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0137 0.0988
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0098
Entamoeba histolytica hypothetical protein 0.0038 0.0137 0.2425
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0459 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0137 0.0267
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0089 0.0164
Brugia malayi nuclear receptor RXR 0.0017 0.0022 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0055
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.011 0.0098
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.011 0.037
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0137 0.2433
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0137 0.0988
Brugia malayi Cathepsin L-like precursor 0.0038 0.0137 0.0126
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0098
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.011 0.037
Entamoeba histolytica hypothetical protein 0.0038 0.0137 0.2425
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.011 0.0209
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0055
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0078
Onchocerca volvulus 0.0038 0.0137 0.095
Plasmodium vivax vivapain-2 0.0038 0.0137 1
Brugia malayi hypothetical protein 0.0038 0.0137 0.0125
Brugia malayi nuclear receptor NHR-88 0.0033 0.011 0.0098
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0055
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0465 0.1707
Brugia malayi cathepsin L-like precursor 0.0025 0.0067 0.0055
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.011 0.037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.011 0.0098
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0189 0.1376
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.011 0.037
Brugia malayi hypothetical protein 0.0017 0.0022 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0137 0.0988
Trypanosoma brucei polo-like protein kinase 0.0095 0.0459 0.1105
Plasmodium falciparum cysteine proteinase falcipain 3 0.0038 0.0137 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.011 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0137 0.0988
Plasmodium vivax unspecified product 0.002 0.0034 0.2464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0145 0.0737 0.1827
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0137 0.0988
Schistosoma mansoni cpg binding protein 0.0068 0.0307 0.1113
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.1165 0.1154
Loa Loa (eye worm) ctsf protein 0.0038 0.0137 0.0126
Echinococcus multilocularis cysteine protease 0.0038 0.0137 0.0267
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0459 0.1105
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0094 0.0311
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0137 0.0126
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0459 0.3382
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.011 0.037

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 3 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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