Detailed information for compound 105189

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 525.598 | Formula: C30H31N5O4
  • H donors: 3 H acceptors: 5 LogP: 3.25 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@@H]1CC(N(C1)C(=O)c1[nH]nc2c1cccc2)C(=O)N[C@@H](C(=O)N(Cc1ccccc1)C)Cc1ccccc1
  • InChi: 1S/C30H31N5O4/c1-34(18-21-12-6-3-7-13-21)29(38)25(16-20-10-4-2-5-11-20)31-28(37)26-17-22(36)19-35(26)30(39)27-23-14-8-9-15-24(23)32-33-27/h2-15,22,25-26,36H,16-19H2,1H3,(H,31,37)(H,32,33)/t22-,25-,26?/m1/s1
  • InChiKey: GESFNPXBWQVSPL-NQXVELOOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Neurokinin 1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04224 tachykinin receptor 3, putative Get druggable targets OG5_137770 All targets in OG5_137770
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Neurokinin 1 receptor   407 aa 373 aa 23.1 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Neurokinin 1 receptor   407 aa 341 aa 26.1 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Neurokinin 1 receptor   407 aa 339 aa 20.6 %
Echinococcus granulosus thyrotropin releasing hormone receptor Neurokinin 1 receptor   407 aa 341 aa 22.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) oxidoreductase 0.0031 0.001 0.0009
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0005 0.0005
Giardia lamblia MRP-like ABC transporter 0.0029 0.0009 0.1736
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0005 0.0005
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0003 0.0009
Mycobacterium ulcerans short chain dehydrogenase 0.0075 0.0032 0.0032
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0011 0.001
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0005 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0012 0.0024
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0031 0.001 0.002
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0005 0.0005
Echinococcus multilocularis ferritin 0.0018 0.0003 0.0003
Mycobacterium ulcerans short chain dehydrogenase 0.0075 0.0032 0.0032
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0022 0.0021
Echinococcus granulosus ferritin 0.0018 0.0003 0.0003
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1637 0.0835 0.0832
Brugia malayi Reduced folate carrier family protein 0.0112 0.0051 0.005
Loa Loa (eye worm) sodium-independent organic anion transporter 0.006 0.0024 0.0023
Leishmania major hypothetical protein, conserved 0.0031 0.001 0.002
Trypanosoma brucei trypanothione reductase 0.0055 0.0022 0.0045
Onchocerca volvulus 0.0112 0.0051 0.0552
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Schistosoma mansoni multidrug resistance protein 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0041 0.0015 0.0014
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0042 0.0016 0.0015
Loa Loa (eye worm) RNA binding protein 0.0146 0.0069 0.0067
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.0034 0.0034
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.001 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.002 0.0386
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0022 0.0019
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0015 0.0014
Echinococcus multilocularis isocitrate dehydrogenase 0.0054 0.0022 0.0021
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0016 0.0016
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.001 0.0007
Leishmania major folylpolyglutamate synthetase 0.0443 0.0221 0.0459
Onchocerca volvulus 0.0075 0.0032 0.0322
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0028 0.0008 0.0017
Echinococcus multilocularis dna polymerase kappa 0.007 0.003 0.0029
Trypanosoma brucei short-chain dehydrogenase, putative 0.0031 0.001 0.002
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0005 0.0005
Onchocerca volvulus Folate transporter 1 homolog 0.0112 0.0051 0.0552
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0009
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0075 0.0032 0.0067
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0054 0.0022 0.0045
Echinococcus granulosus dihydrofolate reductase 1.9479 1 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0005 0.0005
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0019 0.004
Echinococcus multilocularis geminin 0.0554 0.0278 0.0278
Mycobacterium ulcerans short-chain dehydrogenase 0.0031 0.001 0.001
Echinococcus multilocularis phd:f box containing protein 0.0034 0.0011 0.0011
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0027 0.0008 0.0007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0057 0.0023 0.0023
Trypanosoma cruzi metacaspase, putative 0.0051 0.002 0.0041
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0005 0.0004
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0014 0.0014
Schistosoma mansoni rab6-interacting 0.0023 0.0005 0.0005
Toxoplasma gondii endonuclease IV APN 0.0088 0.0039 0.0081
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0008 0.0007
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0031 0.001 0.0009
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0031 0.001 0.0007
Mycobacterium ulcerans dehydrogenase/reductase 0.0031 0.001 0.001
Trypanosoma brucei metacaspase 5, putative 0.0051 0.002 0.0041
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0011 0.0011
Mycobacterium leprae Probable oxidoreductase 0.0031 0.001 0.0007
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.001 0.002
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.006 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0158 0.0075 0.0074
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.0033 0.0032
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0017 0.1702
Leishmania major quinonoid dihydropteridine reductase 0.0031 0.001 0.002
Echinococcus granulosus caspase 2 0.0099 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0006
Leishmania major dehydrogenase-like protein 0.0031 0.001 0.002
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0005 0.0004
Brugia malayi sodium-independent organic anion transporter family protein 0.006 0.0024 0.0024
Entamoeba histolytica ATP-binding cassette protein, putative 0.0029 0.0009 0.0561
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0006 0.0003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.002 0.0386
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0106 0.0048 0.0048
Schistosoma mansoni jumonji domain containing protein 0.0034 0.0011 0.0011
Schistosoma mansoni protein phosphatase 2C 0.0034 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0006
Treponema pallidum thioredoxin 0.0025 0.0007 0.0164
Onchocerca volvulus 0.0106 0.0048 0.0515
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0012 0.0024
Echinococcus multilocularis RUN 0.0023 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0009
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0008 0.0007
Echinococcus granulosus thyroid hormone receptor alpha 0.0027 0.0008 0.0007
Mycobacterium ulcerans endonuclease IV 0.0088 0.0039 0.0039
Echinococcus multilocularis nuclear receptor nhr 48 0.0027 0.0008 0.0007
Schistosoma mansoni short chain dehydrogenase 0.0031 0.001 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0003 0.0007
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.001 0.001
Echinococcus granulosus lamin 0.0031 0.001 0.0009
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0031 0.001 0.0007
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0055 0.0055
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0057 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0112 0.0051 0.005
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0061 0.0025 0.0024
Schistosoma mansoni short chain dehydrogenase 0.0031 0.001 0.001
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0075 0.0032 0.0067
Leishmania major 3-keto-dihydrosphingosine reductase 0.0031 0.001 0.002
Leishmania major hypothetical protein, conserved 0.0034 0.0011 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0005 0.0005
Plasmodium falciparum 1-cys peroxiredoxin 0.0098 0.0044 0.0092
Echinococcus multilocularis steroid dehydrogenase 0.0031 0.001 0.0009
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0008 0.0026
Schistosoma mansoni carbonyl reductase 0.0031 0.001 0.001
Trypanosoma brucei DNA polymerase IV, putative 0.007 0.003 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0057 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0033 0.0011 0.001
Loa Loa (eye worm) RecQ helicase 0.0052 0.0021 0.0019
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0031 0.001 0.002
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0031 0.001 0.0007
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0023 0.0006 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0107 0.0049 0.0047
Schistosoma mansoni multidrug resistance protein 0.0029 0.0009 0.0009
Trypanosoma cruzi folylpolyglutamate synthase, putative 0.0443 0.0221 0.0459
Echinococcus granulosus hypothetical protein 0.0031 0.001 0.0009
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0031 0.001 0.0697
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0146 0.0069 0.0142
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0009
Brugia malayi prostaglandin transporter 0.006 0.0024 0.0024
Brugia malayi PXA domain containing protein 0.0022 0.0005 0.0004
Toxoplasma gondii hypothetical protein 0.0236 0.0115 0.0239
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0023 0.0023
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.001 0.001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0054 0.0022 0.0021
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.002 0.0386
Trypanosoma cruzi metacaspase, putative 0.0051 0.002 0.0041
Onchocerca volvulus 0.0035 0.0012 0.0077
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0075 0.0032 0.0029
Plasmodium falciparum glutathione reductase 0.0019 0.0003 0.0007
Brugia malayi nuclear receptor NHR-88 0.0057 0.0023 0.0022
Echinococcus granulosus agrin 0.0041 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0006
Echinococcus multilocularis multidrug resistance associated protein 1 0.0029 0.0009 0.0008
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0023 0.0006 0.0006
Brugia malayi Cell death protein 3 precursor 0.0099 0.0044 0.0044
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0005 0.0005
Mycobacterium ulcerans short chain dehydrogenase 0.0075 0.0032 0.0032
Trypanosoma brucei short-chain dehydrogenase, putative 0.0031 0.001 0.002
Echinococcus multilocularis JmjC domain containing protein 4 0.0034 0.0011 0.0011
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0029 0.0009 0.0018
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0075 0.0032 0.0032
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0075 0.0032 0.0029
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0002 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0057 0.0023 0.0022
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0005 0.0004
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0146 0.0069 0.0068
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0009 0.0018
Loa Loa (eye worm) multidrug resistance-associated protein 0.0023 0.0006 0.0004
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0042 0.0016 0.0015
Plasmodium falciparum glutathione reductase 0.0055 0.0022 0.0045
Mycobacterium ulcerans dihydrofolate reductase DfrA 1.9479 1 1
Schistosoma mansoni short chain dehydrogenase 0.0031 0.001 0.001
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0005 0.0011
Mycobacterium ulcerans short-chain type oxidoreductase 0.0031 0.001 0.001
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0124 0.0058 0.0055
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0075 0.0032 0.0067
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0025 0.0051
Entamoeba histolytica recQ family helicase, putative 0.0028 0.0008 0.0448
Brugia malayi ABC transporter transmembrane region family protein 0.0029 0.0009 0.0008
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0031 0.001 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0003 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0106 0.0048 0.01
Brugia malayi hypothetical protein 0.0511 0.0256 0.0255
Onchocerca volvulus 0.0033 0.0011 0.0064
Echinococcus multilocularis tumor protein p63 0.039 0.0194 0.0194
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0031 0.001 0.0007
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0031 0.001 0.0697
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0511 0.0256 0.0255
Trypanosoma brucei short-chain dehydrogenase, putative 0.0031 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.0085 0.0038 0.0036
Entamoeba histolytica short chain dehydrogenase family protein 0.0031 0.001 0.0697
Entamoeba histolytica hypothetical protein 0.0031 0.001 0.0697
Schistosoma mansoni steroid dehydrogenase 0.0031 0.001 0.001
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0057 0.0023 0.0022
Loa Loa (eye worm) dehydrogenase 0.0031 0.001 0.0009
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.0134 0.0133
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.001 0.001
Brugia malayi RNA recognition motif domain containing protein 0.0146 0.0069 0.0068
Toxoplasma gondii exonuclease III APE 0.0022 0.0005 0.001
Toxoplasma gondii carbonyl reductase 1, putative 0.0031 0.001 0.002
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0009
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0031 0.001 0.002
Leishmania major quinonoid dihydropteridine reductase 0.0031 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0006
Echinococcus granulosus organic anion transporting polypeptide 30B 0.006 0.0024 0.0024
Giardia lamblia Short-chain dehydrogenase, putative 0.0031 0.001 0.1923
Schistosoma mansoni short chain dehydrogenase 0.0031 0.001 0.001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.001 0.001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0009 0.0009
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0033 0.0068
Schistosoma mansoni nuclear receptor nhr-48 0.0027 0.0008 0.0008
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0011 0.001
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0075 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.0027 0.0008 0.0384
Schistosoma mansoni hypothetical protein 0.0172 0.0082 0.0082
Echinococcus granulosus expressed protein 0.0018 0.0003 0.0003
Brugia malayi glutaminase DH11.1 0.0314 0.0155 0.0154
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.001
Loa Loa (eye worm) oxidoreductase 0.0031 0.001 0.0009
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0146 0.0069 0.0067
Echinococcus multilocularis folate receptor beta 0.0961 0.0488 0.0487
Echinococcus multilocularis caspase 8 0.0051 0.002 0.002
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0003 0.0007
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0028 0.0008 0.0017
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0003 0.0007
Schistosoma mansoni apoferritin-2 0.0018 0.0003 0.0003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0112 0.0051 0.005
Plasmodium falciparum steroid dehydrogenase, putative 0.0031 0.001 0.002
Schistosoma mansoni tar DNA-binding protein 0.0146 0.0069 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0005 0.0047
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0075 0.0032 0.0029
Leishmania major hypothetical protein, conserved 0.0031 0.001 0.002
Onchocerca volvulus 0.0031 0.001 0.0052
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0124 0.0058 0.0055
Echinococcus granulosus caspase 0.0135 0.0063 0.0063
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0055 0.0055
Mycobacterium ulcerans ketoacyl reductase 0.0031 0.001 0.001
Trichomonas vaginalis rotamase, putative 0.0038 0.0013 0.0232
Echinococcus multilocularis carbonyl reductase 1 0.0031 0.001 0.0009
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0005 0.0005
Entamoeba histolytica ATP-binding cassette protein, putative 0.0029 0.0009 0.0561
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0015 0.003
Toxoplasma gondii oxidoreductase, putative 0.0031 0.001 0.002
Schistosoma mansoni steroid dehydrogenase 0.0031 0.001 0.001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0075 0.0032 0.0032
Mycobacterium ulcerans short chain dehydrogenase 0.0075 0.0032 0.0032
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative 0.0387 0.0193 0.0399
Echinococcus multilocularis microtubule associated protein 2 0.0796 0.0403 0.0402
Loa Loa (eye worm) acetyltransferase 0.0167 0.008 0.0079
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0008 0.0007
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0075 0.0032 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0009
Echinococcus granulosus lysine specific demethylase 5A 0.0128 0.0059 0.0059
Onchocerca volvulus 0.006 0.0024 0.0229
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0031 0.001 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0011 0.001
Schistosoma mansoni nuclear receptor 0.0027 0.0008 0.0008
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.001 0.001
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0005 0.001
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.009 0.004 0.004
Schistosoma mansoni carbonyl reductase 0.0031 0.001 0.001
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0008 0.0008
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0005 0.0005
Echinococcus granulosus oxidoreductase 0.0031 0.001 0.0009
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0005 0.0963
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0034 0.0011 0.0023
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0015 0.003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0003 0.0007
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0075 0.0032 0.0029
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0018 0.0003 0.0006
Entamoeba histolytica hypothetical protein 0.0022 0.0005 0.003
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0005 0.0004
Loa Loa (eye worm) steroid hormone receptor 0.0057 0.0023 0.0022
Schistosoma mansoni hypothetical protein 0.0056 0.0022 0.0022
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0029 0.0009 0.0018
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0031 0.001 0.1923
Toxoplasma gondii melibiase subfamily protein 0.0118 0.0055 0.0113
Giardia lamblia Hypothetical protein 0.0031 0.001 0.1923
Schistosoma mansoni loxhd1 0.0023 0.0005 0.0005
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0005 0.0004
Trypanosoma cruzi hypothetical protein 0.0023 0.0005 0.0011
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0005 0.0004
Brugia malayi jmjC domain containing protein 0.0034 0.0011 0.001
Schistosoma mansoni apoferritin-2 0.0018 0.0003 0.0003
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0031 0.001 0.0007
Brugia malayi ecdysteroid receptor 0.0057 0.0023 0.0022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0159 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0008
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0189 0.0091 0.009
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0019 0.0364
Onchocerca volvulus 0.0041 0.0015 0.0111
Echinococcus granulosus hypothetical protein 0.0031 0.001 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.003 0.0061
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0034 0.0011 0.0023
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.009 0.004 0.0083
Toxoplasma gondii isocitrate dehydrogenase 0.0054 0.0022 0.0045
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0053 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0057 0.0023 0.0022
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0025 0.0021
Mycobacterium ulcerans ketoacyl reductase 0.0031 0.001 0.001
Onchocerca volvulus Putative organic anion transporter 0.006 0.0024 0.0229
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0051 0.002 0.0041
Schistosoma mansoni polycystin 1-related 0.0023 0.0005 0.0005
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0005 0.0004
Brugia malayi glutathione reductase 0.0055 0.0022 0.0021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0023 0.0023
Trichomonas vaginalis steroid dehydrogenase, putative 0.0031 0.001 0.0154
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0031 0.001 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0008 0.0007
Trichomonas vaginalis rotamase, putative 0.0037 0.0013 0.0221
Onchocerca volvulus 0.0112 0.0051 0.0552
Trypanosoma cruzi short chain dehydrogenase, putative 0.0031 0.001 0.002
Loa Loa (eye worm) oxidoreductase 0.0031 0.001 0.0009
Schistosoma mansoni lipoxygenase 0.0023 0.0005 0.0005
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0005 0.0084
Mycobacterium tuberculosis Probable reductase 0.0124 0.0058 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.002 0.0386
Echinococcus multilocularis cpg binding protein 0.0035 0.0012 0.0011
Plasmodium vivax peroxiredoxin, putative 0.0098 0.0044 0.0092
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.001 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.003 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.001 0.002
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0031 0.001 0.0053
Plasmodium falciparum thioredoxin reductase 0.0055 0.0022 0.0045
Schistosoma mansoni DNA polymerase eta 0.0068 0.0029 0.0029
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0031 0.001 0.0009
Schistosoma mansoni rab6-interacting 0.0023 0.0005 0.0005
Mycobacterium leprae Possible regulatory protein 0.0018 0.0003 0.0000021514
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0031 0.001 0.002
Schistosoma mansoni steroid dehydrogenase 0.0031 0.001 0.001
Giardia lamblia ABC transporter, putative 0.0029 0.0009 0.1736
Leishmania major quinonoid dihydropteridine reductase 0.0031 0.001 0.002
Brugia malayi isocitrate dehydrogenase 0.0054 0.0022 0.0021
Trypanosoma brucei folylpolyglutamate synthase, putative 0.0443 0.0221 0.0459
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0057 0.0023 0.0022
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0031 0.001 0.0007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0057 0.0023 0.0023
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0064 0.0027 0.0026
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0005 0.0005
Giardia lamblia Multidrug resistance-associated protein 1 0.0029 0.0009 0.1736
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0015 0.1357
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0005 0.0005
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0031 0.001 0.002
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0005 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0005 0.0047
Schistosoma mansoni lamin 0.0031 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0085 0.0038 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0023 0.0023
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0135 0.0063 0.0063
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0075 0.0032 0.0032
Trypanosoma cruzi metacaspase 5, putative 0.0051 0.002 0.0041
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.002
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0005 0.0004
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0002 0.0001
Schistosoma mansoni hypothetical protein 0.0472 0.0236 0.0236
Schistosoma mansoni cpg binding protein 0.0035 0.0012 0.0012
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0031 0.001 0.002
Echinococcus multilocularis multidrug resistance associated protein 7 0.0029 0.0009 0.0008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0057 0.0023 0.0023
Loa Loa (eye worm) oxidoreductase 0.0031 0.001 0.0009
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0015 0.0014
Schistosoma mansoni steroid dehydrogenase 0.0031 0.001 0.001
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0009 0.0018
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0031 0.001 0.0009
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0003 0.0009
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0031 0.001 0.0154
Onchocerca volvulus Sepiapterin reductase homolog 0.0031 0.001 0.0053
Onchocerca volvulus Protein ultraspiracle homolog 0.0057 0.0023 0.0212
Trypanosoma cruzi DNA polymerase kappa, putative 0.007 0.003 0.0061
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0005 0.0005
Schistosoma mansoni dihydrofolate reductase 1.9479 1 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0005 0.0005
Echinococcus multilocularis oxidoreductase 0.0031 0.001 0.0009
Echinococcus multilocularis transcription factor btf3 0.004 0.0015 0.0014
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0005 0.001
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0005 0.0011
Schistosoma mansoni hypothetical protein 0.0554 0.0278 0.0278
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0146 0.0069 0.0069
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.009 0.004 0.0037
Loa Loa (eye worm) hypothetical protein 0.006 0.0024 0.0023
Trypanosoma brucei short-chain dehydrogenase, putative 0.0031 0.001 0.002
Schistosoma mansoni multidrug resistance protein 0.0029 0.0009 0.0009
Onchocerca volvulus 0.0031 0.001 0.0053
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0057 0.0023 0.0022
Mycobacterium tuberculosis Probable dehydrogenase 0.0031 0.001 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Brugia malayi sodium-independent organic anion transporter family protein 0.006 0.0024 0.0024
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0057 0.0023 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0146 0.0069 0.0069
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0126 0.0058 0.0058
Echinococcus multilocularis peptidase Clp (S14 family) 0.0059 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0005 0.0047
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0005 0.0005
Brugia malayi secreted modular calcium-binding protein 1 0.0041 0.0015 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.003 0.0061
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.0015 0.0031
Brugia malayi dehydrogenases, short chain protein 9 0.0031 0.001 0.0009
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.009 0.004 0.1697
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0057 0.0023 0.0023
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0054 0.0022 0.0022
Mycobacterium ulcerans short chain dehydrogenase 0.0075 0.0032 0.0032
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0015 0.003
Trichomonas vaginalis hypothetical protein 0.0075 0.0032 0.0663
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.001 0.0154
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative 0.0387 0.0193 0.0399
Leishmania major basic transcription factor 3a, putative 0.004 0.0015 0.003
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.001 0.0154
Plasmodium vivax SET domain protein, putative 0.0035 0.0012 0.0025
Leishmania major pteridine reductase 1 0.1769 0.0902 0.1871
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.002
Brugia malayi dehydrogenases, short chain protein 2 0.0031 0.001 0.0009
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0054 0.0022 0.0021
Brugia malayi Doublecortin family protein 0.0023 0.0005 0.0005
Echinococcus multilocularis steroid dehydrogenase 0.0031 0.001 0.0009
Mycobacterium ulcerans folylpolyglutamate synthase protein FolC 0.0443 0.0221 0.0221
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.002 0.0386
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0095 0.0043 0.5358
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.001 0.0697
Echinococcus granulosus caspase 8 0.0051 0.002 0.002
Echinococcus granulosus retinol dehydrogenase 11 0.0031 0.001 0.0009
Mycobacterium ulcerans short chain dehydrogenase 0.0075 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0006
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0022 0.0045
Leishmania major dihydrofolate reductase-thymidylate synthase 0.9401 0.4823 1
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0017 0.3307
Schistosoma mansoni short chain dehydrogenase 0.0031 0.001 0.001
Echinococcus multilocularis transient receptor potential cation channel 0.0031 0.001 0.0009
Echinococcus multilocularis muscleblind protein 0.0172 0.0082 0.0082
Echinococcus granulosus tar DNA binding protein 0.0146 0.0069 0.0068
Brugia malayi folate-like transporter 3 0.0112 0.0051 0.005
Loa Loa (eye worm) DR-78 0.0027 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0057 0.0023 0.0022
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0005 0.0945
Toxoplasma gondii bifunctional protein FolC subfamily protein 0.0443 0.0221 0.0459
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0029 0.0009 0.0018
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0057 0.0023 0.0022
Schistosoma mansoni hypothetical protein 0.0034 0.0011 0.0011
Trypanosoma cruzi DNA polymerase kappa, putative 0.007 0.003 0.0061
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0095 0.0043 0.5358
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0057 0.0023 0.0022
Schistosoma mansoni hypothetical protein 0.0355 0.0176 0.0176
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0005 0.0004
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.001 0.0154
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0003 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0057 0.0023 0.0022
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0015 0.003
Mycobacterium ulcerans short chain dehydrogenase 0.0075 0.0032 0.0032
Echinococcus granulosus steroid dehydrogenase 0.0031 0.001 0.0009
Mycobacterium ulcerans DNA polymerase IV 0.007 0.003 0.003
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0003 0.0007
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0005 0.001
Loa Loa (eye worm) ICD-1 protein 0.004 0.0015 0.0013
Brugia malayi small heat shock protein 0.0667 0.0336 0.0335
Brugia malayi nuclear receptor NHR-88 0.0027 0.0008 0.0007
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0031 0.003
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0075 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.0029 0.0009 0.0561
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0075 0.0032 0.0067
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0029 0.0009 0.0018
Trypanosoma cruzi short chain dehydrogenase, putative 0.0031 0.001 0.002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0124 0.0058 0.0055
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0031 0.001 0.002
Leishmania major metacaspase, putative 0.0051 0.002 0.0041
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.002 0.0386
Echinococcus granulosus ecdysone induced protein 78C 0.0057 0.0023 0.0023
Leishmania major p-glycoprotein e 0.0029 0.0009 0.0018
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0075 0.0032 0.0067
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0031 0.001 0.001
Trypanosoma brucei unspecified product 0.0027 0.0008 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0012 0.0024
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0003 0.0003
Brugia malayi hypothetical protein 0.0042 0.0016 0.0015
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0005 0.0005
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0031 0.001 0.0007
Brugia malayi nuclear receptor RXR 0.003 0.0009 0.0008
Onchocerca volvulus 0.0511 0.0256 0.3025
Brugia malayi PXA domain containing protein 0.0022 0.0005 0.0004
Treponema pallidum folylpolyglutamate synthetase (folC) 0.0443 0.0221 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.007 0.003 0.0061
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0042 0.0016 0.0015
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0075 0.0032 0.0032
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0017 0.0002 0.0002
Brugia malayi orphan nuclear receptor NR2E1 0.0027 0.0008 0.0007
Trypanosoma brucei pteridine reductase 1 0.1737 0.0886 0.1838
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0031 0.001 0.0007
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0025 0.0024
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0064 0.0027 0.0026
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0022 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0057 0.0023 0.0022
Onchocerca volvulus 0.0031 0.001 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.003 0.0061
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0008
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0355 0.0176 0.0175
Loa Loa (eye worm) reduced folate carrier family protein 0.0112 0.0051 0.005
Brugia malayi Dehydrogenases, short chain protein 2 0.0031 0.001 0.0009
Schistosoma mansoni steroid hormone receptor ad4bp 0.0057 0.0023 0.0023
Loa Loa (eye worm) oxidoreductase 0.0031 0.001 0.0009
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0005 0.0004
Giardia lamblia Multidrug resistance-associated protein 1 0.0029 0.0009 0.1736
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.001
Echinococcus multilocularis retinol dehydrogenase 11 0.0031 0.001 0.0009
Echinococcus granulosus follistatin 0.0041 0.0015 0.0014
Loa Loa (eye worm) thymidylate synthase 0.1637 0.0835 0.0834
Echinococcus granulosus multidrug resistance associated protein 4 0.0023 0.0005 0.0005
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.002 0.0004 0.0008
Leishmania major protein kinase, putative 0.0018 0.0003 0.0006
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0023 0.0006 0.0005
Mycobacterium ulcerans short-chain dehydrogenase 0.0031 0.001 0.001
Echinococcus multilocularis dna polymerase eta 0.0068 0.0029 0.0028
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0054 0.0022 0.0045
Leishmania major hypothetical protein, conserved 0.0031 0.001 0.002
Schistosoma mansoni cpg binding protein 0.0035 0.0012 0.0012
Trypanosoma brucei short-chain dehydrogenase, putative 0.0031 0.001 0.002
Schistosoma mansoni ferritin 0.0018 0.0003 0.0003
Schistosoma mansoni zinc finger protein 0.0027 0.0008 0.0008
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.001 0.0007
Schistosoma mansoni cpg binding protein 0.0033 0.0011 0.0011
Trypanosoma cruzi metacaspase, putative 0.0051 0.002 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0015 0.026
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0057 0.0023 0.0212
Toxoplasma gondii protease inhibitor PI2 0.0041 0.0015 0.003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0011 0.0011
Trypanosoma brucei multidrug resistance protein E 0.0029 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0024
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0011 0.0023
Onchocerca volvulus 0.006 0.0024 0.0229
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0013 0.0027
Onchocerca volvulus 0.0031 0.001 0.0053
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0031 0.001 0.002
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0008 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0014 0.0013
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0025 0.0025
Mycobacterium ulcerans DNA polymerase IV 0.007 0.003 0.003
Onchocerca volvulus 0.0031 0.001 0.0053
Trichomonas vaginalis dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0443 0.0221 0.4977
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0031 0.0031
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0005 0.0004
Schistosoma mansoni lamin 0.0031 0.001 0.001
Brugia malayi hypothetical protein 0.003 0.0009 0.0008
Toxoplasma gondii hypothetical protein 0.0031 0.001 0.002
Brugia malayi conserved hypotetical protein 0.0027 0.0008 0.0007
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0012 0.0024
Schistosoma mansoni steroid dehydrogenase 0.0031 0.001 0.001
Echinococcus multilocularis ecdysone induced protein 78C 0.0057 0.0023 0.0023
Loa Loa (eye worm) nuclear receptor NHR-67 0.0027 0.0008 0.0006
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0018 0.0003 0.0006
Onchocerca volvulus 0.0027 0.0008 0.0026
Brugia malayi hypothetical protein 0.0042 0.0016 0.0015
Plasmodium falciparum dihydrofolate synthase/folylpolyglutamate synthase 0.0443 0.0221 0.0459
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0003 0.0003
Echinococcus granulosus retinol dehydrogenase 11 0.0031 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0009
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0005 0.0005
Echinococcus granulosus multidrug resistance associated protein 1 0.0029 0.0009 0.0008
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0167 0.008 0.0079
Schistosoma mansoni blooms syndrome DNA helicase 0.0041 0.0015 0.0015
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0172 0.0082 0.0081
Toxoplasma gondii NAC domain-containing protein 0.004 0.0015 0.003
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0014 0.0013
Giardia lamblia DINP protein human, muc B family 0.0047 0.0018 0.3457
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0029 0.0009 0.0018
Schistosoma mansoni hypothetical protein 0.0034 0.0011 0.0011
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.001 0.0154
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0034 0.0011 0.0011
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0012 0.0025
Loa Loa (eye worm) oxidoreductase 0.0031 0.001 0.0009
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0016 0.0016
Onchocerca volvulus Putative organic anion transporter 0.006 0.0024 0.0229
Loa Loa (eye worm) hypothetical protein 0.0041 0.0015 0.0014
Mycobacterium ulcerans thymidylate synthase 0.1637 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0006
Echinococcus granulosus FTZ F1 alpha 0.0057 0.0023 0.0023
Schistosoma mansoni aryl hydrocarbon receptor 0.0018 0.0003 0.0003
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0018 0.0003 0.0006
Echinococcus granulosus phd:f box containing protein 0.0034 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0008
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0034 0.0011 0.0023
Brugia malayi ecdysone receptor 0.0027 0.0008 0.0007
Echinococcus granulosus carbonyl reductase 1 0.0031 0.001 0.0009
Schistosoma mansoni lipoxygenase 0.0064 0.0027 0.0027
Onchocerca volvulus 0.0057 0.0023 0.0213
Loa Loa (eye worm) oxidoreductase 0.0031 0.001 0.0009
Loa Loa (eye worm) retinol dehydrogenase 12 0.0075 0.0032 0.0031
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 1.9479 1 1
Schistosoma mansoni thyroid hormone receptor 0.0057 0.0023 0.0023
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0011 0.0011
Schistosoma mansoni steroid dehydrogenase 0.0031 0.001 0.001
Trichomonas vaginalis glutaminase, putative 0.0314 0.0155 0.346
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.002 0.0386
Loa Loa (eye worm) runx1 0.0064 0.0027 0.0026
Leishmania major short chain dehydrogenase/reductase, putative 0.0031 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0004
Loa Loa (eye worm) glutathione reductase 0.0055 0.0022 0.0021
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0008 0.0104
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0031 0.001 0.0007
Brugia malayi hypothetical protein 0.0085 0.0038 0.0037
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0018 0.0003 0.0003
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative 0.0387 0.0193 0.0399
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 0.0387 0.0193 0.0399
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0031 0.001 0.0007
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0031 0.001 0.002
Leishmania major hypothetical protein, conserved 0.0031 0.001 0.002
Toxoplasma gondii Alpha-galactosidase 0.0017 0.0002 0.0005
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0005 0.0005
Trypanosoma cruzi metacaspase, putative 0.0051 0.002 0.0041
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0003 0.0007
Brugia malayi Muscleblind-like protein 0.0172 0.0082 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.003 0.0061
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0009 0.0008
Trypanosoma brucei DNA polymerase eta, putative 0.0068 0.0029 0.006
Loa Loa (eye worm) hypothetical protein 0.009 0.004 0.0039
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Trypanosoma brucei oxidoreductase-like protein 0.0106 0.0048 0.01
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0027 0.0008 0.0008
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0088 0.0039 0.0081
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0031 0.001 0.0053
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0126 0.0058 0.0058
Echinococcus granulosus cpg binding protein 0.0035 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0172 0.0082 0.0081
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.009 0.004 1
Leishmania major protein kinase, putative 0.0018 0.0003 0.0006
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.0033 0.3965
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0011
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0055 0.0055
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0075 0.0032 0.0029
Echinococcus multilocularis muscleblind protein 1 0.0172 0.0082 0.0082
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0008 0.0016
Brugia malayi hypothetical protein 0.0872 0.0442 0.0441
Brugia malayi Importin beta-1 subunit 0.0033 0.0011 0.001
Brugia malayi steroid hormone receptor 0.0057 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.006 0.0024 0.0023
Schistosoma mansoni phd/f-box containing protein 0.0034 0.0011 0.0011
Mycobacterium tuberculosis Soluble secreted antigen Mpt53 precursor 0.0025 0.0007 0.0004
Toxoplasma gondii redoxin domain-containing protein 0.0098 0.0044 0.0092
Plasmodium vivax importin-beta 2, putative 0.0033 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0018 0.0015
Onchocerca volvulus 0.0274 0.0135 0.1557
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0005 0.0047
Brugia malayi hypothetical protein 0.0022 0.0005 0.0004
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0003 0.0007
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0029 0.0009 0.0018
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0057 0.0023 0.0023
Brugia malayi hypothetical protein 0.0019 0.0003 0.0003
Onchocerca volvulus 0.0061 0.0025 0.0234
Brugia malayi Dehydrogenases, short chain protein 30 0.0031 0.001 0.0009
Echinococcus multilocularis snurportin 1 0.0355 0.0176 0.0176
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.006 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0112 0.0051 0.005
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0031 0.001 0.001
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0031 0.001 0.0007
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.001 0.0154
Onchocerca volvulus 0.0031 0.001 0.0053
Loa Loa (eye worm) hypothetical protein 0.006 0.0024 0.0023
Loa Loa (eye worm) dihydrofolate reductase 1.9479 1 1
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.001
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0029 0.0009 0.0018
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0005 0.0004
Plasmodium falciparum thioredoxin reductase 0.0019 0.0003 0.0007
Schistosoma mansoni caspase-3 (C14 family) 0.0135 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0008
Loa Loa (eye worm) TAR-binding protein 0.0146 0.0069 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0016 0.0033
Mycobacterium ulcerans thiol peroxidase 0.0025 0.0007 0.0007
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0141 0.0066 0.0066
Schistosoma mansoni short chain dehydrogenase 0.0031 0.001 0.001
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0075 0.0032 0.0032
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.003 0.0009 0.0009
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative 0.0387 0.0193 0.0399
Echinococcus multilocularis expressed protein 0.0431 0.0215 0.0215
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0005 0.0004
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0008
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0011 0.0023
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Onchocerca volvulus Protein cycle homolog 0.0042 0.0016 0.0121
Brugia malayi oxidoreductase 0.0031 0.001 0.0009
Onchocerca volvulus 0.1637 0.0835 1
Schistosoma mansoni short chain dehydrogenase 0.0031 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0112 0.0051 0.005
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.009 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0511 0.0256 0.0255
Trichomonas vaginalis DNA helicase recq1, putative 0.0052 0.0021 0.0399
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0049 0.0048
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0031 0.001 0.0007
Echinococcus granulosus aryl hydrocarbon receptor 0.0061 0.0025 0.0024
Brugia malayi hypothetical protein 0.0159 0.0076 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.002 0.0386
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0028 0.0008 0.0017
Echinococcus multilocularis lysine specific demethylase 6a 0.0034 0.0011 0.0011
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.003 0.0009 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0025 0.0025
Mycobacterium ulcerans oxidoreductase 0.0031 0.001 0.001
Leishmania major pentamidine resistance protein 1 0.0029 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.003 0.0061
Onchocerca volvulus 0.0031 0.001 0.0052
Loa Loa (eye worm) glutaminase 0.0314 0.0155 0.0154
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0031 0.001 0.002
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0018 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0041 0.0015 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0003 0.0007
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.003 0.0009 0.0009
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.002
Echinococcus multilocularis carbonyl reductase 1 0.0031 0.001 0.0009
Toxoplasma gondii transporter, major facilitator family protein 0.006 0.0025 0.0051
Loa Loa (eye worm) hypothetical protein 0.0057 0.0023 0.0022
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0025 0.0051
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0012 0.0011
Mycobacterium tuberculosis Probable oxidoreductase 0.0106 0.0048 0.0045
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0075 0.0032 0.0029
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0057 0.0023 0.0023
Loa Loa (eye worm) glutaminase 2 0.0314 0.0155 0.0154
Giardia lamblia Hypothetical protein 0.0112 0.0051 1
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative 0.0387 0.0193 0.0399
Brugia malayi hypothetical protein 0.0027 0.0008 0.0007
Brugia malayi nuclear receptor NHR-67 0.0027 0.0008 0.0007
Entamoeba histolytica short chain dehydrogenase family protein 0.0031 0.001 0.0697
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0031 0.001 0.002
Plasmodium vivax glutathione reductase, putative 0.0055 0.0022 0.0045
Mycobacterium ulcerans ketoacyl reductase 0.0031 0.001 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.001 0.002
Mycobacterium ulcerans dehydrogenase 0.0031 0.001 0.001
Schistosoma mansoni folylpolyglutamate synthase 0.0443 0.0221 0.0221
Plasmodium vivax steroid dehydrogenase, putative 0.0031 0.001 0.002
Chlamydia trachomatis endonuclease IV 0.0088 0.0039 0.0036
Brugia malayi jmjC domain containing protein 0.0128 0.0059 0.0058
Brugia malayi nuclear hormone receptor 0.0057 0.0023 0.0022
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0872 0.0442 1
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0031 0.001 0.0009
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.002 0.0386
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0031 0.001 0.0007
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0008 0.0007
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0118 0.0055 0.0054
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.001 0.0009
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0118 0.0055 0.0054
Onchocerca volvulus 0.0048 0.0018 0.0154
Brugia malayi PAS domain containing protein 0.0018 0.0003 0.0002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0241 0.0118 0.0116
Mycobacterium ulcerans short-chain dehydrogenase 0.0031 0.001 0.001
Giardia lamblia Reductase, putative 0.0031 0.001 0.1923
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0054 0.0022 0.0045
Mycobacterium tuberculosis Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) 0.0443 0.0221 0.0218
Mycobacterium ulcerans oxidoreductase 0.0075 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0005 0.0047
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0054 0.0022 0.0019
Entamoeba histolytica ATP-binding cassette protein, putative 0.0029 0.0009 0.0561
Plasmodium falciparum metacaspase 1 0.0051 0.002 0.0041
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0079 0.0034 0.0711
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0005 0.0004
Loa Loa (eye worm) nuclear hormone receptor 0.0027 0.0008 0.0006
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0035 0.0012 0.0012
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0075 0.0032 0.0029
Schistosoma mansoni transcription factor btf3 0.004 0.0015 0.0015
Giardia lamblia Multidrug resistance-associated protein 1 0.0029 0.0009 0.1712
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0038 0.0013 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0057 0.0023 0.0022
Mycobacterium tuberculosis Probable conserved lipoprotein DsbF 0.0025 0.0007 0.0004
Entamoeba histolytica hypothetical protein 0.0112 0.0051 0.6563
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0138 0.0065 0.0062
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0031 0.001 0.002
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0159 0.0076 1
Entamoeba histolytica multidrug resistance protein, putative 0.0029 0.0009 0.0561
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0005 0.001
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.001 0.0007
Brugia malayi hypothetical protein 0.003 0.0009 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.001 0.002
Schistosoma mansoni short chain dehydrogenase 0.0031 0.001 0.001
Brugia malayi FolC bifunctional protein 0.0443 0.0221 0.022
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0014
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0031 0.001 0.002
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0075 0.0032 0.0032
Echinococcus granulosus dna polymerase kappa 0.007 0.003 0.0029
Schistosoma mansoni caspase-7 (C14 family) 0.0099 0.0044 0.0044
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0075 0.0032 0.0067
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0005 0.0005
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0003 0.0007
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.002 0.0386
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0003 0.0003
Mycobacterium ulcerans hypothetical protein 0.0023 0.0006 0.0006
Entamoeba histolytica ATP-binding cassette protein, putative 0.0029 0.0009 0.0561
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0146 0.0069 0.0068
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0009
Brugia malayi hypothetical protein 0.0273 0.0134 0.0133
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0075 0.0032 0.0031
Echinococcus granulosus WW domain containing oxidoreductase 0.0031 0.001 0.0009
Leishmania major short chain dehydrogenase/reductase, putative 0.0031 0.001 0.002
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0003 0.0007
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0075 0.0032 0.0032
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0005 0.0005
Echinococcus granulosus muscleblind protein 0.0172 0.0082 0.0082
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0008 0.0104
Brugia malayi follicle stimulating hormone receptor 0.0501 0.0251 0.025
Echinococcus multilocularis retinol dehydrogenase 11 0.0031 0.001 0.0009
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0031 0.001 0.0007
Echinococcus granulosus histone acetyltransferase KAT2B 0.0163 0.0077 0.0077
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0011 0.001
Trypanosoma brucei metacaspase 0.0051 0.002 0.0041
Trypanosoma brucei metacaspase MCA2 0.0051 0.002 0.0041
Mycobacterium tuberculosis Probable oxidoreductase 0.0138 0.0065 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.002 0.0386
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0005 0.0005
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0031 0.001 0.0009
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0014 0.0013
Entamoeba histolytica hypothetical protein 0.004 0.0015 0.1357
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0075 0.0032 0.0067
Leishmania major trypanothione reductase 0.0055 0.0022 0.0045
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.001 0.0007
Leishmania major short chain dehydrogenase, putative 0.0031 0.001 0.002
Trypanosoma cruzi multidrug resistance protein E, putative 0.0029 0.0009 0.0018
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0018 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0041 0.0015 0.0014
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0054 0.0022 0.0045
Leishmania major hypothetical protein, conserved 0.0029 0.0009 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0146 0.0069 0.0069
Brugia malayi nuclear receptor RXR 0.0027 0.0008 0.0007
Brugia malayi hypothetical protein 0.0027 0.0008 0.0007
Schistosoma mansoni DNA helicase recq5 0.0022 0.0005 0.0005
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0031 0.001 0.0154
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0011 0.0023
Echinococcus multilocularis musashi 0.0031 0.001 0.0009
Echinococcus multilocularis carbonyl reductase 1 0.0031 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0006
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0009
Echinococcus granulosus carbonyl reductase 1 0.0031 0.001 0.0009
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0015 0.0031
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.9401 0.4823 1
Entamoeba histolytica ABC transporter, putative 0.0029 0.0009 0.0561
Onchocerca volvulus 0.006 0.0024 0.0229
Plasmodium falciparum enoyl-acyl carrier reductase 0.0075 0.0032 0.0067
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0008 0.0007
Leishmania major quinonoid dihydropteridine reductase 0.0031 0.001 0.002
Brugia malayi SPARC precursor 0.0041 0.0015 0.0014
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0075 0.0032 0.3857
Loa Loa (eye worm) hypothetical protein 0.0667 0.0336 0.0335
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Echinococcus multilocularis thymidylate synthase 0.1637 0.0835 0.0834
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0023 0.0023
Trichomonas vaginalis DNA polymerase eta, putative 0.007 0.003 0.0604
Onchocerca volvulus Folate transporter 1 homolog 0.0112 0.0051 0.0552
Echinococcus multilocularis tar DNA binding protein 0.0146 0.0069 0.0068
Schistosoma mansoni eyes absent homolog 0.0085 0.0038 0.0038
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.004 0.0037
Echinococcus granulosus RUN 0.0023 0.0005 0.0005
Echinococcus granulosus lysine specific demethylase 6a 0.0034 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0057 0.0023 0.0022
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0146 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0075 0.0032 0.0031
Schistosoma mansoni glutaminase 0.0314 0.0155 0.0155
Mycobacterium ulcerans short chain dehydrogenase 0.0075 0.0032 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0146 0.0069 0.0069
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0011 0.001
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0005 0.0004
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0011 0.001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0106 0.0048 0.0048
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Onchocerca volvulus 0.0031 0.001 0.0053
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.009 0.004 0.0083
Schistosoma mansoni hypothetical protein 0.0073 0.0031 0.0031
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.001 0.0305
Trichomonas vaginalis set domain proteins, putative 0.0274 0.0135 0.2999
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.001 0.0697
Schistosoma mansoni steroid dehydrogenase 0.0031 0.001 0.001
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0042 0.0016 0.0014
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0088 0.0039 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.001 0.002
Loa Loa (eye worm) agrin synaptic family protein 0.0041 0.0015 0.0014
Brugia malayi Retinol dehydrogenase 12 0.0031 0.001 0.0009
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0025 0.0025
Mycobacterium leprae POSSIBLE MEMBRANE-ANCHORED THIOREDOXIN-LIKE PROTEIN (THIOL-DISULFIDE INTERCHANGE RELATED PROTEIN) 0.0025 0.0007 0.0004
Trypanosoma cruzi folylpolyglutamate synthetase 0.0443 0.0221 0.0459
Schistosoma mansoni organic anion transporter 0.006 0.0024 0.0024
Schistosoma mansoni short chain dehydrogenase 0.0031 0.001 0.001
Trichomonas vaginalis peroxiredoxin, putative 0.0025 0.0007 0.0082
Echinococcus granulosus importin subunit beta 1 0.0033 0.0011 0.001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0057 0.0023 0.0022
Schistosoma mansoni survival motor neuron protein 0.0056 0.0022 0.0022
Schistosoma mansoni dihydropteridine reductase 0.0075 0.0032 0.0032
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0008 0.0007
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0018 0.0037
Brugia malayi CXXC zinc finger family protein 0.0033 0.0011 0.001
Loa Loa (eye worm) isocitrate dehydrogenase 0.0054 0.0022 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.007 0.003 0.0061
Echinococcus granulosus jumonji domain containing 1A 0.0034 0.0011 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0003 0.0007
Plasmodium vivax metacaspase 1, putative 0.0051 0.002 0.0041
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0075 0.0032 0.0032
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.004 0.0083
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0003 0.0007
Loa Loa (eye worm) dehydrogenase 0.0031 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.006 0.0024 0.0023
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0059 0.0024 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.002 0.0386
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0005 0.0042
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.002
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0005 0.0004
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0018 0.0003 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0009
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0088 0.0039 0.0081
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0008 0.0104
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0051 0.002 0.0019
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0003 0.0007
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0053 0.0052
Schistosoma mansoni lozenge 0.0064 0.0027 0.0027
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0038 0.0013 0.0012
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0031 0.001 0.0009
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0106 0.0048 0.01
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.006 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0034 0.0011 0.0011
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0012 0.0011
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0031 0.001 0.001
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Leishmania major oxidoreductase-like protein 0.0106 0.0048 0.01
Loa Loa (eye worm) hypothetical protein 0.0031 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0068 0.0029 0.0028
Schistosoma mansoni hypothetical protein 0.0023 0.0005 0.0005
Trypanosoma cruzi metacaspase 5, putative 0.0051 0.002 0.0041
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0075 0.0032 0.0029
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0005 0.0005
Mycobacterium tuberculosis Possible oxidoreductase 0.0031 0.001 0.0007
Brugia malayi intermediate filament protein 0.0031 0.001 0.0009
Entamoeba histolytica hypothetical protein 0.0159 0.0076 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0126 0.0058 0.0058
Loa Loa (eye worm) FolC protein 0.0443 0.0221 0.022
Echinococcus granulosus nuclear receptor nhr 48 0.0027 0.0008 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.003 0.0061
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0005 0.0005
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0025 0.0024
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0059 0.0024 0.0021
Entamoeba histolytica hypothetical protein 0.0022 0.0005 0.003
Echinococcus multilocularis caspase 3 0.0084 0.0037 0.0036
Echinococcus multilocularis Major facilitator superfamily, general substrate transporter 0.0173 0.0082 0.0082
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0029 0.0009 0.0018
Onchocerca volvulus Cell death protein 3 homolog 0.0099 0.0044 0.047
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0003 0.0003
Mycobacterium tuberculosis Hypothetical protein 0.0872 0.0442 0.0439
Schistosoma mansoni transcription factor LCR-F1 0.0159 0.0076 0.0076
Entamoeba histolytica hypothetical protein 0.0159 0.0076 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0014
Trichomonas vaginalis DNA helicase recq, putative 0.0052 0.0021 0.0399
Brugia malayi nuclear hormone receptor 0.0027 0.0008 0.0007
Echinococcus granulosus intermediate filament protein 0.0031 0.001 0.0009
Mycobacterium ulcerans short chain dehydrogenase 0.0075 0.0032 0.0032
Plasmodium falciparum JmjC domain-containing protein, putative 0.0034 0.0011 0.0023
Trichomonas vaginalis DNA helicase recq, putative 0.0028 0.0008 0.0114
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0936 0.0475 0.0474
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Brugia malayi nuclear hormone receptor family member odr-7 0.0027 0.0008 0.0007
Brugia malayi Melibiase family protein 0.0079 0.0034 0.0033
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0057 0.0023 0.0023
Mycobacterium tuberculosis Possible oxidoreductase 0.0075 0.0032 0.0029
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0003 0.0007
Onchocerca volvulus 0.006 0.0024 0.0229
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0031 0.001 0.0007
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0005 0.0005
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0035 0.0012 0.0025
Echinococcus granulosus folylpolyglutamate synthase, mitochondrial 0.0443 0.0221 0.0221
Leishmania major short chain dehydrogenase, putative 0.0031 0.001 0.002
Brugia malayi beta-NAC-like protein 0.004 0.0015 0.0014
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0018 0.0003 0.0003
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0059 0.0024 0.0021
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0075 0.0032 0.7843
Loa Loa (eye worm) hypothetical protein 0.0057 0.0023 0.0022
Schistosoma mansoni short chain dehydrogenase 0.0031 0.001 0.001
Onchocerca volvulus 0.0031 0.001 0.0053
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0003 0.0107
Echinococcus granulosus peptidase Clp S14 family 0.0059 0.0024 0.0024
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0057 0.0023 0.0023
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0031 0.001 0.002
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1637 0.0835 0.0832
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0004
Echinococcus granulosus GPCR family 2 0.0034 0.0011 0.0011
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0019 0.0019
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0015 0.003
Schistosoma mansoni short chain dehydrogenase 0.0031 0.001 0.001
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1637 0.0835 0.0835
Echinococcus granulosus dna polymerase eta 0.0068 0.0029 0.0028
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0005 0.0047
Brugia malayi Isocitrate dehydrogenase 0.0054 0.0022 0.0021
Entamoeba histolytica hypothetical protein 0.0159 0.0076 1
Brugia malayi Pre-SET motif family protein 0.0035 0.0012 0.0011
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0015 0.026
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0033 0.0068
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0006
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0014
Schistosoma mansoni agrin 0.0041 0.0015 0.0015
Echinococcus multilocularis jumonji domain containing 1A 0.0034 0.0011 0.0011
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.002 0.0386
Schistosoma mansoni ap endonuclease 0.0022 0.0005 0.0005
Trichomonas vaginalis peroxiredoxin, putative 0.0025 0.0007 0.0082
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0031 0.001 0.002
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0146 0.0069 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0057 0.0023 0.0022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0002 0.0001
Echinococcus multilocularis caspase 0.0135 0.0063 0.0063
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0054 0.0022 0.0021
Onchocerca volvulus 0.0056 0.0022 0.0204
Leishmania major DNA polymerase eta, putative 0.0068 0.0029 0.006
Echinococcus granulosus thymidylate synthase 0.1637 0.0835 0.0834
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0057 0.0023 0.0023
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0057 0.0023 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.0057 0.0023 0.0022
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0031 0.001 0.0697
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0003 0.0107
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0075 0.0032 0.0032
Echinococcus multilocularis conserved hypothetical protein 0.0031 0.001 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0012 0.0012
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0003 0.0003
Brugia malayi Probable ClpP-like protease 0.009 0.004 0.0039
Echinococcus multilocularis dihydrofolate reductase 1.9479 1 1
Mycobacterium ulcerans oxidoreductase 0.0031 0.001 0.001
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0015 0.003
Echinococcus multilocularis retinol dehydrogenase 13 0.0031 0.001 0.0009
Brugia malayi hypothetical protein 0.006 0.0024 0.0024
Mycobacterium leprae PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) 0.0443 0.0221 0.0218
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0005 0.0004
Schistosoma mansoni follistatin 0.0041 0.0015 0.0015
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0005 0.0005
Mycobacterium ulcerans short chain dehydrogenase 0.0075 0.0032 0.0032
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0057 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0015 0.026
Plasmodium falciparum metacaspase-like protein 0.0051 0.002 0.0041
Leishmania major hypothetical protein, conserved 0.0031 0.001 0.002
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0031 0.001 0.002
Mycobacterium ulcerans short chain dehydrogenase 0.0075 0.0032 0.0032
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0037 0.0013 0.1116
Echinococcus multilocularis dnaJ subfamily B 0.0472 0.0236 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0057 0.0023 0.0022
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0015 0.003
Toxoplasma gondii oxidoreductase, putative 0.0031 0.001 0.002
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0014 0.0013
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0033 0.0068
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0029 0.006
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0872 0.0442 0.0916
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0009 0.0018
Echinococcus granulosus apoptotic protease activating factor 1 0.0048 0.0018 0.0018
Onchocerca volvulus 0.0031 0.001 0.0053
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.001 0.0154
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0008 0.0026
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0051 0.002 0.0041
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0003 0.0007
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0005 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0057 0.0023 0.0022
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.002 0.0386
Echinococcus granulosus microtubule associated protein 2 0.0796 0.0403 0.0402
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0008
Schistosoma mansoni DNA helicase recq1 0.0022 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.003 0.0061
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0009 0.0018
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0023 0.0023
Brugia malayi jmjC domain containing protein 0.0034 0.0011 0.001
Schistosoma mansoni peptidase Clp (S14 family) 0.009 0.004 0.004
Schistosoma mansoni ferritin 0.0018 0.0003 0.0003
Loa Loa (eye worm) oxidoreductase 0.0075 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0273 0.0134 0.0133
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0005 0.0005
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0043 0.0016 0.0015
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0005 0.0005
Brugia malayi hypothetical protein 0.0023 0.0005 0.0005
Schistosoma mansoni rotamase 0.0038 0.0013 0.0013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0057 0.0023 0.0022
Loa Loa (eye worm) jmjC domain-containing protein 0.0128 0.0059 0.0058
Leishmania major importin beta-1 subunit, putative 0.0027 0.0008 0.0016
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.004 0.0037
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0031 0.001 0.0007
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0135 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0057 0.0023 0.0022
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0088 0.0039 0.0038
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0054 0.0022 0.0045
Echinococcus granulosus transcription factor btf3 0.004 0.0015 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0003 0.0007
Echinococcus multilocularis lamin 0.0031 0.001 0.0009
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0011 0.001
Echinococcus multilocularis caspase 2 0.0099 0.0044 0.0044
Leishmania major quinonoid dihydropteridine reductase 0.0031 0.001 0.002
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0003 0.0007
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0005 0.0005
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.004 0.0083
Trypanosoma brucei unspecified product 0.0062 0.0026 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0016 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0018 0.0037
Trypanosoma brucei unspecified product 0.0027 0.0008 0.0016
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0031 0.001 0.002
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0075 0.0032 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0012 0.0012
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0075 0.0032 0.0032
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.0059 0.0059
Toxoplasma gondii peptidylprolyl isomerase 0.0037 0.0013 0.0027
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0031 0.001 0.0697
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0017 0.0035
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0027 0.0008 0.0006
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0005 0.001
Echinococcus granulosus geminin 0.0554 0.0278 0.0278
Echinococcus multilocularis Protein lozenge 0.0064 0.0027 0.0026
Brugia malayi hypothetical protein 0.014 0.0066 0.0065
Loa Loa (eye worm) oxidoreductase 0.0031 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0004
Brugia malayi Pre-SET motif family protein 0.0241 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0009
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0031 0.001 0.1823
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0057 0.0023 0.0022
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0031 0.001 0.002
Leishmania major DNA polymerase eta, putative 0.0041 0.0015 0.0031
Loa Loa (eye worm) hypothetical protein 0.006 0.0024 0.0023
Leishmania major short chain dehydrogenase-like protein 0.0031 0.001 0.002
Entamoeba histolytica hypothetical protein 0.0022 0.0005 0.003
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0027 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0112 0.0051 0.005
Brugia malayi thymidylate synthase 0.1637 0.0835 0.0834
Schistosoma mansoni tar DNA-binding protein 0.0146 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0006
Onchocerca volvulus Putative organic anion transporter 0.006 0.0024 0.0229
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0031 0.001 0.0007
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0037 0.0013 0.0027
Echinococcus granulosus lamin dm0 0.0031 0.001 0.0009
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0012 0.0011
Brugia malayi Thioredoxin reductase 0.0055 0.0022 0.0021
Schistosoma mansoni short chain dehydrogenase 0.0031 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0112 0.0051 0.005
Brugia malayi Bloom's syndrome protein homolog 0.0052 0.0021 0.002
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0015 0.0014
Mycobacterium tuberculosis Possible oxidoreductase 0.0031 0.001 0.0007
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0443 0.0221 0.0221
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0009
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0075 0.0032 0.0032
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.002
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0075 0.0032 0.0029
Schistosoma mansoni phosphatidylserine receptor 0.0034 0.0011 0.0011
Schistosoma mansoni carbonyl reductase 0.0031 0.001 0.001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0075 0.0032 0.0032
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0171 0.0082 0.0081
Leishmania major quinonoid dihydropteridine reductase 0.0031 0.001 0.002
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0054 0.0022 0.0045
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0006
Schistosoma mansoni ferritin light chain 0.0018 0.0003 0.0003
Mycobacterium ulcerans carveol-like dehydrogenase 0.0031 0.001 0.001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0057 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.003 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.0554 0.0278 0.0278
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0106 0.0048 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0057 0.0023 0.0022
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.001 0.001
Echinococcus granulosus JmjC domain containing protein 4 0.0034 0.0011 0.0011
Echinococcus granulosus multidrug resistance associated protein 7 0.0029 0.0009 0.0008
Mycobacterium ulcerans short-chain dehydrogenase 0.0031 0.001 0.001
Echinococcus granulosus bloom syndrome protein 0.0052 0.0021 0.002
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0005 0.0005
Brugia malayi hypothetical protein 0.0029 0.0009 0.0008
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0031 0.001 0.0007
Onchocerca volvulus 0.0027 0.0008 0.0026
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 0.0387 0.0193 0.0399
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Trypanosoma brucei DNA polymerase IV, putative 0.007 0.003 0.0061
Plasmodium vivax hypothetical protein, conserved 0.0031 0.001 0.002
Schistosoma mansoni organic anion transporter 0.006 0.0024 0.0024
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0003 0.0003
Echinococcus granulosus expressed protein 0.0038 0.0013 0.0013
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0051 0.002 0.002
Onchocerca volvulus 0.0031 0.001 0.0053
Onchocerca volvulus 0.0057 0.0023 0.0212
Brugia malayi Dihydrofolate reductase 1.9479 1 1
Leishmania major ABC-thiol transporter 0.0029 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0112 0.0051 0.005
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0011 0.0023
Echinococcus multilocularis FTZ F1 alpha 0.0057 0.0023 0.0023
Schistosoma mansoni steroid dehydrogenase 0.0031 0.001 0.001
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0167 0.008 0.008
Echinococcus multilocularis agrin 0.0041 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0006
Mycobacterium tuberculosis Possible oxidoreductase 0.0075 0.0032 0.0029
Trypanosoma cruzi MFS transporter, putative 0.006 0.0024 0.0051
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0443 0.0221 0.0221
Schistosoma mansoni ferritin 0.0018 0.0003 0.0003
Schistosoma mansoni short chain dehydrogenase 0.0031 0.001 0.001
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0031 0.001 0.0009
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0057 0.0023 0.0023
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0075 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0013 0.0232
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0005 0.0005
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0005 0.0494
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0011 0.0023
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0022 0.0021
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0075 0.0032 0.0067
Brugia malayi hypothetical protein 0.0023 0.0005 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0026 0.0053
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.0048 0.0048
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0112 0.0051 0.005
Brugia malayi hypothetical protein 0.0022 0.0005 0.0004
Mycobacterium tuberculosis Probable thiol peroxidase Tpx 0.0025 0.0007 0.0004
Brugia malayi polk-prov protein 0.0043 0.0016 0.0015
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0076 0.0033 0.0068
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0118 0.0055 0.0054
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0031 0.001 0.001
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.0033 0.0032
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0015 0.0014
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0002 0.0001
Brugia malayi jmjC domain containing protein 0.0034 0.0011 0.001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0011 0.001
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0054 0.0022 0.0021
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0031 0.001 0.0007
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.9401 0.4823 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0022 0.0021
Echinococcus multilocularis expressed protein 0.0018 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0034 0.0011 0.0011
Echinococcus multilocularis aryl hydrocarbon receptor 0.0061 0.0025 0.0024
Mycobacterium ulcerans epimerase 0.0023 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0057 0.0023 0.0022
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase 0.0387 0.0193 0.0399
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.0033 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0025 0.0025
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0005
Echinococcus multilocularis carbonyl reductase 1 0.0031 0.001 0.0009
Schistosoma mansoni hypothetical protein 0.0159 0.0076 0.0076
Schistosoma mansoni jumonji domain containing protein 0.0126 0.0058 0.0058
Trichomonas vaginalis peroxiredoxin, putative 0.0025 0.0007 0.0082
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0006 0.0003
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0031 0.001 0.0009
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0049 0.0048
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0031 0.001 0.002
Trypanosoma brucei metacaspase MCA3 0.0051 0.002 0.0041
Onchocerca volvulus 0.0112 0.0051 0.0552
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0003 0.0683
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0003 0.0003
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.0134 0.0133
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0054 0.0022 0.0021
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.002 0.0386
Loa Loa (eye worm) hypothetical protein 0.0366 0.0182 0.0181
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0012 0.0012
Echinococcus granulosus Solute carrier organic anion transporter family 0.006 0.0024 0.0024
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.0034 0.0034
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0003 0.0003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.001 0.0009
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.006 0.0024 0.0023
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0005 0.0005
Brugia malayi hypothetical protein 0.0031 0.001 0.0009
Mycobacterium ulcerans glutaminase 0.0314 0.0155 0.0155
Schistosoma mansoni caspase-7 (C14 family) 0.0135 0.0063 0.0063
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0031 0.001 0.0007
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.9401 0.4823 1
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0031 0.001 0.0007
Onchocerca volvulus 0.006 0.0024 0.0229
Plasmodium falciparum importin beta, putative 0.0033 0.0011 0.0023
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0138 0.0065 0.0062
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0037 0.0013 0.0027
Echinococcus granulosus tumor protein p63 0.039 0.0194 0.0194
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0057 0.0023 0.0023
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0005
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.001 0.0007
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0138 0.0065 0.0062
Echinococcus granulosus dnaJ subfamily B 0.0472 0.0236 0.0236
Chlamydia trachomatis dihydrofolate reductase 1.9479 1 1
Echinococcus granulosus expressed protein 0.0431 0.0215 0.0215
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0011 0.0011
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0027 0.0008 0.0007
Brugia malayi MH2 domain containing protein 0.0116 0.0053 0.0052
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0005 0.001
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0055 0.0055
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.9401 0.4823 1
Echinococcus multilocularis expressed protein 0.0038 0.0013 0.0013
Loa Loa (eye worm) intermediate filament protein 0.0031 0.001 0.0009
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.0033 0.0032
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0124 0.0058 0.0055
Schistosoma mansoni retinal dehydrogenase 0.0031 0.001 0.001
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0003 0.0007
Trypanosoma brucei p-glycoprotein 0.0029 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0006
Schistosoma mansoni coup transcription factor 0.0057 0.0023 0.0023
Brugia malayi jmjC domain containing protein 0.0126 0.0058 0.0058
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.0059 0.0059
Brugia malayi tailless protein 0.0027 0.0008 0.0007
Schistosoma mansoni thyroid hormone receptor 0.0057 0.0023 0.0023
Plasmodium vivax hypothetical protein, conserved 0.0051 0.002 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0005 0.0047
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0049 0.0047
Brugia malayi hypothetical protein 0.006 0.0024 0.0024
Schistosoma mansoni ferritin light chain 0.0018 0.0003 0.0003
Leishmania major quinonoid dihydropteridine reductase 0.0031 0.001 0.002
Schistosoma mansoni ferritin 0.0018 0.0003 0.0003
Plasmodium vivax dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0443 0.0221 0.0459
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0159 0.0076 0.0075
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0015 0.003
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0031 0.001 0.0697
Echinococcus granulosus carbonyl reductase 1 0.0031 0.001 0.0009
Echinococcus multilocularis Solute carrier organic anion transporter family 0.006 0.0024 0.0024
Brugia malayi ImpB/MucB/SamB family protein 0.0068 0.0029 0.0028
Onchocerca volvulus Putative folylpolyglutamate synthase 0.0443 0.0221 0.2603
Echinococcus multilocularis multidrug resistance associated protein 4 0.0023 0.0005 0.0005
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0146 0.0069 0.0066
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0042 0.0016 0.0016
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0027 0.0008 0.0008
Schistosoma mansoni RAR-like nuclear receptor 0.0057 0.0023 0.0023
Brugia malayi Steroid receptor seven-up type 2 0.0057 0.0023 0.0022
Echinococcus granulosus folate receptor beta 0.0961 0.0488 0.0487
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0124 0.0058 0.0055
Onchocerca volvulus 0.0031 0.001 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0057 0.0023 0.0022
Schistosoma mansoni microtubule-associated protein tau 0.0796 0.0403 0.0403
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0031 0.001 0.0154
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0014
Toxoplasma gondii thioredoxin reductase 0.0055 0.0022 0.0045
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0075 0.0032 0.0067
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0014 0.1257
Brugia malayi TAR-binding protein 0.0146 0.0069 0.0068
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0014 0.0011
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0075 0.0032 0.0031
Brugia malayi jmjC domain containing protein 0.0034 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0095 0.0043 0.0042
Schistosoma mansoni steroid dehydrogenase 0.0031 0.001 0.001
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0031 0.001 0.0154
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0075 0.0032 0.0067
Echinococcus multilocularis bloom syndrome protein 0.0052 0.0021 0.002
Brugia malayi hypothetical protein 0.0061 0.0025 0.0024
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0054 0.0022 0.0045
Brugia malayi RNA, U transporter 1 0.0095 0.0042 0.0041
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 1.9479 1 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0051 0.005
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0046 0.0017 0.0036
Brugia malayi nuclear hormone receptor family member nhr-6 0.0027 0.0008 0.0007
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0075 0.0032 0.0029
Brugia malayi acetyltransferase, GNAT family protein 0.0167 0.008 0.0079
Echinococcus multilocularis apoptotic protease activating factor 1 0.0048 0.0018 0.0018
Echinococcus granulosus Major facilitator superfamily general substrate transporter 0.0173 0.0082 0.0082
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0075 0.0032 0.0032
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0031 0.001 0.0007
Schistosoma mansoni steroid dehydrogenase 0.0031 0.001 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.001 0.002
Leishmania major DNA polymerase kappa, putative 0.0047 0.0018 0.0037
Schistosoma mansoni hypothetical protein 0.0048 0.0018 0.0018
Brugia malayi RNA binding protein 0.0146 0.0069 0.0068
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0057 0.0023 0.0022
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.9401 0.4823 1
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.003 0.0061
Schistosoma mansoni short chain dehydrogenase 0.0031 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0004
Echinococcus granulosus caspase 3 0.0084 0.0037 0.0036
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0008
Schistosoma mansoni single-minded 0.0018 0.0003 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0009 0.0018
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.001 0.0009
Schistosoma mansoni nuclear receptor 0.0027 0.0008 0.0008
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0019 0.0364
Brugia malayi hypothetical protein 0.0048 0.0018 0.0017
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0088 0.0039 0.0036
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0018 0.0003 0.0006
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.0033 0.0032
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0501 0.0251 0.025
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0005
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0029 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0112 0.0051 0.005
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0005 0.0042
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0003 0.0007
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0005 0.0002
Toxoplasma gondii isocitrate dehydrogenase 0.0054 0.0022 0.0045
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0031 0.001 0.002
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0031 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.0048 0.0018 0.0017
Onchocerca volvulus Bile acid receptor homolog 0.0057 0.0023 0.0212
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0005 0.0005
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0022 0.0045
Mycobacterium tuberculosis Probable dehydrogenase 0.0124 0.0058 0.0055
Onchocerca volvulus 0.0112 0.0051 0.0552
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0008 0.0008
Trypanosoma cruzi DNA polymerase eta, putative 0.0068 0.0029 0.006
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0051 0.002 0.0041
Schistosoma mansoni importin beta-1 0.0033 0.0011 0.0011
Echinococcus multilocularis expressed protein 0.0041 0.0015 0.0014
Echinococcus multilocularis follistatin 0.0041 0.0015 0.0014
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0075 0.0032 0.0032
Brugia malayi photoreceptor-specific nuclear receptor 0.0057 0.0023 0.0022
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Schistosoma mansoni intermediate filament proteins 0.0031 0.001 0.001
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0029 0.0009 0.0018
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0031 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0004
Schistosoma mansoni retinoic acid receptor RXR 0.0171 0.0082 0.0082
Onchocerca volvulus 0.0031 0.001 0.0053
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0031 0.001 0.001
Echinococcus granulosus carbonyl reductase 1 0.0031 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0005
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0075 0.0032 0.0067
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0031 0.001 0.0053
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0031 0.001 0.0009
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0019 0.004
Schistosoma mansoni ap endonuclease 0.0022 0.0005 0.0005
Loa Loa (eye worm) oxidoreductase 0.0031 0.001 0.0009
Chlamydia trachomatis oxoacy-ACP reductase 0.0075 0.0032 0.0029
Loa Loa (eye worm) hypothetical protein 0.0073 0.0031 0.003
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.004 0.004
Trypanosoma brucei Metacaspase-4 0.0051 0.002 0.0041
Loa Loa (eye worm) hypothetical protein 0.0057 0.0023 0.0022
Echinococcus multilocularis GPCR, family 2 0.0034 0.0011 0.0011
Leishmania major biopterin transporter, putative;with=GeneDB:LinJ35_V3.5120 0.0512 0.0257 0.0532
Echinococcus granulosus folylpolyglutamate synthase mitochondrial 0.0443 0.0221 0.0221
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0005 0.001
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0088 0.0039 0.0036
Echinococcus multilocularis lamin dm0 0.0031 0.001 0.0009
Brugia malayi hypothetical protein 0.0031 0.001 0.0009
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0031 0.001 0.002
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.004 0.004
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 0.0387 0.0193 0.0399
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0035 0.0012 0.0012
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0099 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.0051 0.002 0.0019
Echinococcus granulosus snurportin 1 0.0355 0.0176 0.0176
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0075 0.0032 0.7843
Plasmodium vivax JmjC domain containing protein 0.0034 0.0011 0.0023
Onchocerca volvulus Folate transporter 1 homolog 0.0112 0.0051 0.0552
Brugia malayi sodium-independent organic anion transporter family protein 0.006 0.0024 0.0024
Treponema pallidum NADH oxidase 0.0019 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.001 0.002
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0019 0.004
Onchocerca volvulus 0.0031 0.001 0.0053
Schistosoma mansoni short chain dehydrogenase 0.0031 0.001 0.001
Schistosoma mansoni multidrug resistance protein 0.0029 0.0009 0.0009
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0146 0.0069 0.0069
Brugia malayi multidrug resistance related protein 1 0.0029 0.0009 0.0008
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative 0.0387 0.0193 0.0399
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.007 0.003 0.0604
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0015 0.003
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0009 0.0018
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0057 0.0023 0.0022
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0005
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0075 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0079 0.0034 0.0033

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5 nM In vitro binding affinity against substance P receptor using [3H]-SP as radioligand in guinea pig lung membrane ChEMBL. 7518002
IC50 (binding) = 5 nM In vitro binding affinity against substance P receptor using [3H]-SP as radioligand in guinea pig lung membrane ChEMBL. 7518002
Inhibition (functional) = 0 % In vivo inhibitory activity against airway edema induced by Substance P at a dose 10 mg/kg administered orally ChEMBL. 7518002

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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