Detailed information for compound 1051935

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 369.845 | Formula: C20H20ClN3O2
  • H donors: 2 H acceptors: 3 LogP: 3.68 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCNC(=O)[C@@H](NC(=O)c1cc(C)cc(c1)C)Cc1cccc(c1)Cl
  • InChi: 1S/C20H20ClN3O2/c1-13-8-14(2)10-16(9-13)19(25)24-18(20(26)23-7-6-22)12-15-4-3-5-17(21)11-15/h3-5,8-11,18H,7,12H2,1-2H3,(H,23,26)(H,24,25)/t18-/m0/s1
  • InChiKey: XGRUEGXUKKXMFE-SFHVURJKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin V Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin V 334 aa 357 aa 29.7 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0944 0.0917
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0077 0.1837 0.3403
Brugia malayi Cathepsin L-like precursor 0.0077 0.1837 0.1725
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.053 0.0455
Loa Loa (eye worm) hypothetical protein 0.0025 0.0249 0.022
Brugia malayi Cathepsin L-like precursor 0.0113 0.292 0.2823
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0113 0.292 0.29
Trypanosoma cruzi ISWI complex protein 0.0031 0.0423 0.0576
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0249 0.0131
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.1385 0.1441
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0249 0.022
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1356 0.4382
Brugia malayi hypothetical protein 0.0153 0.4128 0.4048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Schistosoma mansoni lamin 0.0027 0.032 0.0213
Schistosoma mansoni zinc finger protein 0.0039 0.0683 0.0632
Echinococcus granulosus cathepsin L cysteine protease 0.0061 0.1332 0.1379
Schistosoma mansoni cathepsin F (C01 family) 0.0077 0.1837 0.1962
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0197 0.5474 0.5461
Echinococcus granulosus cathepsin L 0.0025 0.0249 0.0131
Brugia malayi Papain family cysteine protease containing protein 0.0113 0.292 0.2823
Echinococcus multilocularis cathepsin L 0.0061 0.1332 0.1379
Giardia lamblia Cathepsin L precursor 0.0025 0.0249 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Loa Loa (eye worm) hypothetical protein 0.0186 0.5136 0.5122
Echinococcus multilocularis cysteine protease 0.0113 0.292 0.321
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0025 0.0249 0.0131
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Schistosoma mansoni hypothetical protein 0.0041 0.0748 0.0706
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0201 0.0079
Echinococcus granulosus GPCR family 2 0.0062 0.1385 0.1441
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0211 0.009
Loa Loa (eye worm) hypothetical protein 0.0082 0.197 0.1947
Entamoeba histolytica cysteine protease, putative 0.0025 0.0249 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0944 0.3162
Echinococcus granulosus cathepsin l1 0.0113 0.292 0.321
Entamoeba histolytica cysteine protease, putative 0.0025 0.0249 0.0136
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0249 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0249 0.0136
Brugia malayi Cathepsin L-like cysteine proteinase 0.0077 0.1837 0.1725
Toxoplasma gondii cathepsin CPC2 0.0025 0.0249 0.0407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Loa Loa (eye worm) hypothetical protein 0.0142 0.3794 0.3775
Schistosoma mansoni intermediate filament proteins 0.0027 0.032 0.0213
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Brugia malayi cathepsin L-like cysteine proteinase 0.0025 0.0249 0.0115
Giardia lamblia Encystation-specific protease 0.0025 0.0249 0.0136
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0075 0.176 0.3249
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0113 0.292 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0025 0.0249 0.0759
Brugia malayi cathepsin L precursor 0.0025 0.0249 0.0115
Trypanosoma cruzi ISWI complex protein 0.0031 0.0423 0.0576
Plasmodium vivax unspecified product 0.0061 0.1332 0.4505
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0944 0.1616
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0249 0.0115
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0249 0.0227
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0211 0.0076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Loa Loa (eye worm) hypothetical protein 0.0027 0.032 0.0292
Loa Loa (eye worm) hypothetical protein 0.0024 0.0211 0.0182
Toxoplasma gondii preprocathepsin c precursor, putative 0.0025 0.0249 0.0407
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0113 0.292 0.29
Brugia malayi intermediate filament protein 0.0027 0.032 0.0187
Schistosoma mansoni cathepsin C 0.0025 0.0249 0.0131
Loa Loa (eye worm) hypothetical protein 0.0027 0.0305 0.0277
Plasmodium falciparum serine repeat antigen 1 0.0025 0.0249 0.0759
Toxoplasma gondii cathepsin CPC1 0.0025 0.0249 0.0407
Toxoplasma gondii cathepsin CPL 0.0113 0.292 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.8459 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1356 0.3451
Plasmodium falciparum serine repeat antigen 4 0.0025 0.0249 0.0759
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0025 0.0249 0.0131
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1356 0.1406
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.2802 0.7235
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0135 0.0106
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.1332 0.4296
Schistosoma mansoni cathepsin F (C01 family) 0.0113 0.292 0.321
Onchocerca volvulus 0.0027 0.032 0.028
Loa Loa (eye worm) hypothetical protein 0.0036 0.0576 0.0548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Loa Loa (eye worm) cathepsin B 0.0075 0.176 0.1736
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0249 0.0136
Brugia malayi Importin beta-1 subunit 0.0029 0.0366 0.0234
Plasmodium vivax vivapain-2 0.0113 0.292 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.053 0.0455
Brugia malayi Cathepsin L-like precursor 0.0113 0.292 0.2823
Giardia lamblia Cathepsin L precursor 0.0025 0.0249 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0366 0.0828
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0119 0.3123 0.3444
Plasmodium falciparum cysteine proteinase falcipain 3 0.0113 0.292 1
Plasmodium falciparum serine repeat antigen 7 0.0025 0.0249 0.0759
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0567 0.054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0211 0.0182
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.3582 0.3493
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0025 0.0249 0.0759
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0249 0.022
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.3171 0.8188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Mycobacterium tuberculosis Probable reductase 0.0109 0.2802 0.7235
Plasmodium falciparum serine repeat antigen 8 0.0025 0.0249 0.0759
Onchocerca volvulus 0.0113 0.292 0.6916
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0025 0.0249 0.0759
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1678 0.1778
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Schistosoma mansoni lamin 0.0027 0.032 0.0213
Onchocerca volvulus 0.0113 0.292 0.6916
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.8812 0.8808
Schistosoma mansoni importin beta-1 0.0029 0.0366 0.0266
Echinococcus multilocularis cathepsin b 0.0186 0.5136 0.5763
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.1332 0.1437
Echinococcus granulosus cathepsin L 0.0061 0.1332 0.1379
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.032 0.0292
Loa Loa (eye worm) hypothetical protein 0.0036 0.0576 0.0548
Schistosoma mansoni hypothetical protein 0.0031 0.0423 0.0332
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0113 0.292 0.321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0211 0.0544
Loa Loa (eye worm) hypothetical protein 0.0153 0.4128 0.4111
Onchocerca volvulus 0.0077 0.1837 0.4152
Onchocerca volvulus 0.0027 0.032 0.028
Giardia lamblia Cysteine protease 0.0025 0.0249 0.0136
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0944 0.0931
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.3107 0.3087
Giardia lamblia Hypothetical protein 0.0025 0.0249 0.0136
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1356 0.3451
Brugia malayi Bromodomain containing protein 0.0077 0.1822 0.171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0113 0.292 0.321
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.5136 0.5763
Brugia malayi glutathione reductase 0.0048 0.0944 0.0819
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Echinococcus multilocularis zinc finger protein 0.0039 0.0683 0.0632
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.053 0.0455
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0366 0.0828
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0211 0.0472
Onchocerca volvulus 0.0025 0.0249 0.0097
Brugia malayi RNA, U transporter 1 0.0082 0.1975 0.1865
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.1385 0.1441
Echinococcus granulosus cysteine protease 0.0061 0.1332 0.1379
Plasmodium vivax vivapain-1 0.0061 0.1332 0.4505
Entamoeba histolytica cysteine protease, putative 0.0025 0.0249 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0113 0.292 0.3346
Schistosoma mansoni cathepsin s 0.0036 0.0576 0.0508
Toxoplasma gondii thioredoxin reductase 0.0048 0.0944 0.2902
Giardia lamblia Cathepsin L precursor 0.0025 0.0249 0.0136
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0211 0.0544
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.032 0.0187
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.1332 0.1437
Echinococcus granulosus intermediate filament protein 0.0027 0.032 0.0213
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0249 0.0759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0249 0.0136
Onchocerca volvulus 0.0113 0.292 0.6916
Loa Loa (eye worm) fibroinase 0.0113 0.292 0.29
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Trypanosoma cruzi cysteine proteinase, putative 0.0061 0.1332 0.2393
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0025 0.0249 0.0136
Plasmodium vivax vivapain-2 0.0113 0.292 1
Giardia lamblia Cathepsin L precursor 0.0025 0.0249 0.0136
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1356 0.3501
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0113 0.292 0.321
Trypanosoma brucei trypanothione reductase 0.0048 0.0944 0.2902
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.292 0.5569
Giardia lamblia Cathepsin B precursor 0.0075 0.176 0.1952
Leishmania major importin beta-1 subunit, putative 0.0023 0.0201 0.0235
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0211 0.0472
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.5136 0.5763
Echinococcus multilocularis cathepsin L 0.0025 0.0249 0.0131
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0366 0.0266
Schistosoma mansoni hypothetical protein 0.0171 0.4691 0.5251
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Echinococcus granulosus cathepsin l1 0.0077 0.1837 0.1962
Loa Loa (eye worm) hypothetical protein 0.0346 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0025 0.0249 0.0136
Echinococcus granulosus cathepsin b 0.0186 0.5136 0.5763
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.1332 0.2393
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0576 0.0881
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0211 0.0472
Schistosoma mansoni cathepsin S (C01 family) 0.0025 0.0249 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.1332 0.1437
Giardia lamblia Cysteine protease 0.0025 0.0249 0.0136
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.1332 0.1379
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0249 0.0227
Loa Loa (eye worm) hypothetical protein 0.0113 0.292 0.29
Loa Loa (eye worm) ctsf protein 0.0113 0.292 0.29
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0249 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0249 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0249 0.0136
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0025 0.0249 0.0759
Schistosoma mansoni hypothetical protein 0.0135 0.3582 0.3972
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0211 0.0472
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0025 0.0249 0.0136
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0249 0.0097
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0061 0.1332 0.1437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0249 0.0136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0201 0.0079
Echinococcus granulosus fetal alzheimer antigen falz 0.0045 0.0864 0.084
Loa Loa (eye worm) hypothetical protein 0.0062 0.1385 0.136
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.053 0.0455
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0748 0.0721
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0211 0.009
Plasmodium falciparum glutathione reductase 0.0048 0.0944 0.3162
Loa Loa (eye worm) hypothetical protein 0.0077 0.1837 0.1813
Echinococcus multilocularis GPCR, family 2 0.0062 0.1385 0.1441
Echinococcus multilocularis musashi 0.0027 0.032 0.0213
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0211 0.5911 0.6657
Plasmodium vivax vivapain-3 0.0061 0.1332 0.4505
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.3171 0.8188
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.1332 0.1379
Loa Loa (eye worm) hypothetical protein 0.0025 0.0249 0.022
Echinococcus granulosus cathepsin l cysteine peptidase 0.0113 0.292 0.321
Onchocerca volvulus 0.0113 0.292 0.6916
Brugia malayi cathepsin F-like cysteine proteinase 0.0025 0.0249 0.0115
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0366 0.0828
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.2802 0.7075
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.053 0.0455
Giardia lamblia Hypothetical protein 0.0025 0.0249 0.0136
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0025 0.0249 0.0759
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.1332 0.1213
Plasmodium falciparum serine repeat antigen 2 0.0025 0.0249 0.0759
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.292 0.5569
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.3171 0.8084
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0211 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0249 0.0136
Echinococcus granulosus geminin 0.0171 0.4691 0.5251
Brugia malayi Cathepsin L-like precursor 0.0036 0.0576 0.0447
Entamoeba histolytica cysteine proteinase, putative 0.0077 0.1837 0.2045
Brugia malayi Cathepsin L-like precursor 0.0113 0.292 0.2823
Giardia lamblia Cathepsin L-like protease 0.0025 0.0249 0.0136
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0249 0.0759
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.053 0.0455
Echinococcus multilocularis cathepsin b 0.0186 0.5136 0.5763
Plasmodium vivax importin-beta 2, putative 0.0029 0.0366 0.1164
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0211 0.027
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0025 0.0249 0.022
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0249 0.0131
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0025 0.0249 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0249 0.0136
Onchocerca volvulus Cathepsin F homolog 0.0113 0.292 0.6916
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.053 0.0455
Loa Loa (eye worm) hypothetical protein 0.0025 0.0249 0.022
Loa Loa (eye worm) hypothetical protein 0.0077 0.1837 0.1813
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.053 0.0455
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1356 0.1406
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Giardia lamblia Cathepsin B precursor 0.0025 0.0249 0.0136
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0249 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.1332 0.4296
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0249 0.0115
Trypanosoma brucei ISWI complex protein 0.0031 0.0423 0.1034
Giardia lamblia Cathepsin B precursor 0.0025 0.0249 0.0136
Schistosoma mansoni hypothetical protein 0.0171 0.4691 0.5251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0029 0.5
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0036 0.0576 0.0447
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0025 0.0249 0.0759
Trypanosoma cruzi cysteine proteinase, putative 0.0061 0.1332 0.2393
Trypanosoma cruzi cruzipain precursor, putative 0.0036 0.0576 0.0881
Trypanosoma cruzi cruzipain precursor, putative 0.0113 0.292 0.5569
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0025 0.0249 0.0759
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0135 0.0367
Brugia malayi Cathepsin L-like precursor 0.0113 0.292 0.2823
Loa Loa (eye worm) hypothetical protein 0.0025 0.0249 0.022
Trypanosoma brucei cysteine peptidase C (CPC) 0.0075 0.176 0.5834
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0025 0.0249 0.0759
Schistosoma mansoni hypothetical protein 0.0062 0.1385 0.1441
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.1385 0.1267
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0211 0.027
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0075 0.176 0.1873
Entamoeba histolytica cysteine protease, putative 0.0025 0.0249 0.0136
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.1332 0.1437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.1837 0.2045
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0944 0.0931
Plasmodium falciparum thioredoxin reductase 0.0048 0.0944 0.3162
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0211 0.0472
Brugia malayi Latrophilin receptor protein 2 0.0062 0.1385 0.1267
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1356 0.1406
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0029 0.0076
Loa Loa (eye worm) hypothetical protein 0.0025 0.0249 0.022
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.2802 0.7235
Loa Loa (eye worm) hypothetical protein 0.0034 0.053 0.0502
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.8459 1
Giardia lamblia Cathepsin B precursor 0.0025 0.0249 0.0136
Plasmodium falciparum serine repeat antigen 5 0.0025 0.0249 0.0759
Schistosoma mansoni hypothetical protein 0.0062 0.1385 0.1441
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0211 0.0076
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0025 0.0249 0.0115
Plasmodium falciparum serine repeat antigen 9 0.0025 0.0249 0.0759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.3873 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.3873 1
Schistosoma mansoni zinc finger protein 0.0031 0.0423 0.0332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0249 0.0136
Onchocerca volvulus 0.0113 0.292 0.6916
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0211 0.5911 0.6657
Entamoeba histolytica cysteine protease, putative 0.0025 0.0249 0.0136
Entamoeba histolytica hypothetical protein 0.0023 0.0201 0.0079
Plasmodium falciparum serine repeat antigen 3 0.0025 0.0249 0.0759
Giardia lamblia Cysteine protease 0.0025 0.0249 0.0136
Brugia malayi cathepsin L-like precursor 0.0077 0.1837 0.1725
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Loa Loa (eye worm) hypothetical protein 0.0077 0.1837 0.1813
Schistosoma mansoni hypothetical protein 0.0062 0.1385 0.1441
Onchocerca volvulus Cathepsin L homolog 0.0113 0.292 0.6916
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0119 0.3123 0.3444
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0249 0.0759
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.1385 0.136
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.3107 0.3087
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.1332 0.1437
Plasmodium falciparum serine repeat antigen 6 0.0025 0.0249 0.0759
Leishmania major hypothetical protein, conserved 0.0031 0.0423 0.1034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1356 0.3451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.1837 0.2045
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0135 0.0367
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.3873 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0295 0.8459 1
Entamoeba histolytica cysteine protease, putative 0.0025 0.0249 0.0136
Giardia lamblia Cathepsin L precursor 0.0025 0.0249 0.0136
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.1332 0.1379
Plasmodium vivax unspecified product 0.0036 0.0576 0.1891
Loa Loa (eye worm) hypothetical protein 0.0024 0.0211 0.0182
Loa Loa (eye worm) glutathione reductase 0.0048 0.0944 0.0917
Giardia lamblia Cathepsin B precursor 0.0025 0.0249 0.0136
Giardia lamblia Cathepsin B precursor 0.0075 0.176 0.1952
Onchocerca volvulus 0.0113 0.292 0.6916
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0186 0.5136 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0045 0.0864 0.084
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0576 0.0548
Schistosoma mansoni hypothetical protein 0.0307 0.8812 1
Brugia malayi Cathepsin L-like precursor 0.0077 0.1837 0.1725
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0075 0.176 0.5834
Treponema pallidum fructose-bisphosphate aldolase 0.0295 0.8459 0.5
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0045 0.0864 0.084
Loa Loa (eye worm) hypothetical protein 0.0085 0.2086 0.2063
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0025 0.0249 0.0759
Brugia malayi Cathepsin L-like precursor 0.0113 0.292 0.2823
Echinococcus multilocularis cysteine protease 0.0113 0.292 0.321
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0201 0.0131
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.292 0.5569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.2802 0.7235
Plasmodium falciparum cysteine proteinase falcipain 1 0.0061 0.1332 0.4505
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0211 0.0472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Giardia lamblia Cathepsin B precursor 0.0075 0.176 0.1952
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.1332 0.1213
Schistosoma mansoni bromodomain containing protein 0.0127 0.3341 0.3695
Trypanosoma cruzi cysteine protease, putative 0.0061 0.1332 0.2393
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0201 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0025 0.0249 0.0136
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0249 0.0136
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.2802 0.7235
Echinococcus multilocularis geminin 0.0171 0.4691 0.5251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0075 0.176 0.1952
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0249 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0249 0.0136
Mycobacterium ulcerans hypothetical protein 0.0024 0.0211 0.0472
Loa Loa (eye worm) hypothetical protein 0.0036 0.0576 0.0548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Echinococcus multilocularis lamin 0.0027 0.032 0.0213
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Entamoeba histolytica cysteine proteinase, putative 0.0113 0.292 0.3346
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Echinococcus granulosus snurportin 1 0.0307 0.8812 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0944 0.2436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.292 0.3346
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Giardia lamblia Cathepsin B precursor 0.0025 0.0249 0.0136
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0025 0.0249 0.0136
Onchocerca volvulus 0.0113 0.292 0.6916
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0061 0.1332 0.2393
Entamoeba histolytica cysteine protease, putative 0.0113 0.292 0.3346
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0025 0.0249 0.0136
Brugia malayi PHD-finger family protein 0.005 0.1008 0.0884
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.3171 0.8188
Plasmodium vivax glutathione reductase, putative 0.0048 0.0944 0.3162
Schistosoma mansoni cathepsin F (C01 family) 0.0113 0.292 0.321
Leishmania major cysteine peptidase A (CPA) 0.0113 0.292 1
Echinococcus multilocularis snurportin 1 0.0307 0.8812 1
Brugia malayi Bromodomain containing protein 0.015 0.4054 0.3972
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0249 0.0136
Schistosoma mansoni hypothetical protein 0.0062 0.1385 0.1441
Echinococcus multilocularis lamin dm0 0.0027 0.032 0.0213
Plasmodium vivax unspecified product 0.0025 0.0249 0.0759
Echinococcus granulosus zinc finger protein 0.0039 0.0683 0.0632
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0249 0.0131
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0249 0.0115
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1356 0.4382
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.5136 0.5763
Echinococcus multilocularis cathepsin L cysteine protease 0.0113 0.292 0.321
Brugia malayi cathepsin B-like cysteine proteinase 0.0186 0.5136 0.5069
Giardia lamblia Cathepsin L precursor 0.0025 0.0249 0.0136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0211 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0025 0.0249 0.0136
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.292 0.5569
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1678 0.1778
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0186 0.5136 0.5763
Brugia malayi cathepsin F-like cysteine proteinase 0.0036 0.0576 0.0447
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0211 0.0472
Echinococcus multilocularis cathepsin L cysteine protease 0.0113 0.292 0.321
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.1332 0.1437
Brugia malayi MH2 domain containing protein 0.0119 0.3107 0.3012
Leishmania major cathepsin L-like protease 0.0113 0.292 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0249 0.022
Schistosoma mansoni cathepsin B (C01 family) 0.0025 0.0249 0.0131
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0249 0.0131
Brugia malayi fibroinase precursor 0.0025 0.0249 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.8459 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.0366 0.0266
Brugia malayi Thioredoxin reductase 0.0048 0.0944 0.0819
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0211 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0113 0.292 0.3346
Loa Loa (eye worm) hypothetical protein 0.0135 0.3582 0.3563
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.292 0.3346
Onchocerca volvulus 0.0153 0.4128 1
Giardia lamblia Cysteine protease 0.0025 0.0249 0.0136
Entamoeba histolytica cysteine proteinase, putative 0.0113 0.292 0.3346
Brugia malayi Cathepsin L-like precursor 0.0113 0.292 0.2823
Loa Loa (eye worm) hypothetical protein 0.0029 0.0366 0.0338
Toxoplasma gondii cathepsin B 0.0075 0.176 0.5834
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0025 0.0249 0.0759
Onchocerca volvulus Cathepsin L homolog 0.0113 0.292 0.6916
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.2802 0.7235
Leishmania major trypanothione reductase 0.0048 0.0944 0.2902
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0249 0.0131
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1356 0.1406
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0025 0.0249 0.0759
Loa Loa (eye worm) intermediate filament protein 0.0027 0.032 0.0292
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0249 0.0136
Echinococcus granulosus lamin 0.0027 0.032 0.0213
Loa Loa (eye worm) hypothetical protein 0.0077 0.1826 0.1802
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0113 0.292 1
Loa Loa (eye worm) cysteine protease 0.0113 0.292 0.29
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0025 0.0249 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0249 0.0136
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0249 0.0131
Entamoeba histolytica cysteine proteinase 2 0.0061 0.1332 0.1437
Echinococcus granulosus lamin dm0 0.0027 0.032 0.0213
Brugia malayi Calcitonin receptor-like protein seb-1 0.0197 0.5474 0.5412
Entamoeba histolytica hypothetical protein 0.0025 0.0249 0.0136
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0249 0.0759
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.292 1
Giardia lamblia Cathepsin L-like protease 0.0025 0.0249 0.0136
Entamoeba histolytica cysteine protease, putative 0.0061 0.1332 0.1437
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0025 0.0249 0.0136
Echinococcus granulosus cathepsin b 0.0186 0.5136 0.5763
Plasmodium falciparum importin beta, putative 0.0029 0.0366 0.1164

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.1 Inhibition of cathepsin B ChEMBL. 19515558
IC50 (binding) = 5.3 Inhibition of cathepsin K ChEMBL. 19515558
IC50 (binding) = 6.5 Inhibition of cathepsin S ChEMBL. 19515558
IC50 (binding) = 6.7 Inhibition of cathepsin L2 ChEMBL. 19515558
IC50 (binding) = 7.3 Inhibition of cathepsin L ChEMBL. 19515558

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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