TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 335.828 | Formula: C17H22ClN3O2
H donors: 1 H acceptors: 1 LogP: 3.06 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COC[C@H](n1cc(Cl)nc(c1=O)Nc1c(C)cc(cc1C)C)C
InChi: 1S/C17H22ClN3O2/c1-10-6-11(2)15(12(3)7-10)20-16-17(22)21(8-14(18)19-16)13(4)9-23-5/h6-8,13H,9H2,1-5H3,(H,19,20)/t13-/m1/s1
InChiKey: DYWGXFSFJDUCMV-CYBMUJFWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Corticotropin releasing factor receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	Get druggable targets OG5_130760	All targets in OG5_130760
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130760	All targets in OG5_130760
Schistosoma japonicum	IPR001879,Hormone receptor, extracellular,domain-containing	Get druggable targets OG5_130760	All targets in OG5_130760
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	hypothetical protein	Corticotropin releasing factor receptor 1	415 aa	359 aa	21.4 %
Onchocerca volvulus		Corticotropin releasing factor receptor 1	415 aa	401 aa	30.2 %
Onchocerca volvulus	Pseudouridine-5 prime-monophosphatase homolog	Corticotropin releasing factor receptor 1	415 aa	401 aa	27.2 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	Corticotropin releasing factor receptor 1	415 aa	394 aa	27.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Conserved protein	0.008	0.0419	0.0296
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0166	0.012
Trichomonas vaginalis	D-aminoacylase, putative	0.008	0.0419	0.2262
Trichomonas vaginalis	D-aminoacylase, putative	0.008	0.0419	0.2262
Toxoplasma gondii	HEAT repeat-containing protein	0.0032	0.0047	0.0238
Echinococcus granulosus	neutral amino acid transporter	0.1318	1	1
Plasmodium vivax	thioredoxin reductase, putative	0.0042	0.0127	0.2723
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0047	0.0164	0.0685
Mycobacterium tuberculosis	Probable esterase LipL	0.008	0.0419	0.0296
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0342	0.2449	0.2436
Mycobacterium ulcerans	hypothetical protein	0.0177	0.1168	0.8804
Echinococcus granulosus	tumor protein p63	0.0378	0.2727	0.2693
Schistosoma mansoni	hypothetical protein	0.019	0.1267	0.1226
Mycobacterium ulcerans	aldehyde dehydrogenase	0.019	0.127	1
Echinococcus granulosus	muscleblind protein	0.0155	0.0998	0.0956
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0038	0.0089	0.0481
Loa Loa (eye worm)	hypothetical protein	0.008	0.0419	0.0402
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0043	0.0131	0.0084
Echinococcus granulosus	excitatory amino acid transporter 2	0.1318	1	1
Brugia malayi	Thioredoxin reductase	0.0042	0.0127	0.011
Plasmodium vivax	importin-beta 2, putative	0.0032	0.0047	0.0742
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0097	0.0546	0.6048
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.008	0.0419	0.0296
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0089	0.0481
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.1318	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.008	0.0419	0.1746
Echinococcus multilocularis	excitatory amino acid transporter 3	0.1318	1	1
Loa Loa (eye worm)	hypothetical protein	0.0245	0.1697	0.1683
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0204	0.1379	0.1338
Brugia malayi	glutathione reductase	0.0042	0.0127	0.011
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0047	0.0164	0.0618
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.0584	0.432	0.4294
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0265	0.0248
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0057	0.0011
Mycobacterium tuberculosis	Probable C4-dicarboxylate-transport transmembrane protein DctA	0.1318	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.019	0.127	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.0419	0.0402
Trichomonas vaginalis	penicillin-binding protein, putative	0.008	0.0419	0.2262
Plasmodium falciparum	thioredoxin reductase	0.0042	0.0127	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0502	0.3686	0.3675
Entamoeba histolytica	hypothetical protein	0.0083	0.0439	1
Brugia malayi	Pre-SET motif family protein	0.0033	0.0057	0.004
Brugia malayi	Pre-SET motif family protein	0.0233	0.1602	0.1588
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0166	0.012
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0057	0.0011
Toxoplasma gondii	aldehyde dehydrogenase	0.019	0.127	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0054	0.0214	0.0197
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0089	0.0481
Echinococcus multilocularis	geminin	0.019	0.1267	0.1226
Plasmodium vivax	hypothetical protein, conserved	0.008	0.0419	1
Echinococcus granulosus	neutral alpha glucosidase AB	0.0038	0.0089	0.0042
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0089	0.0481
Echinococcus granulosus	Excitatory amino acid transporter	0.1318	1	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0159	0.1029	0.4291
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0166	0.012
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0057	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0057	0.004
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.008	0.0419	0.0402
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0265	0.0248
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0336	0.2399	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.0419	0.0402
Plasmodium falciparum	importin beta, putative	0.0032	0.0047	0.2723
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0038	0.0089	0.0481
Schistosoma mansoni	hypothetical protein	0.0342	0.2449	0.2413
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0169	0.1107	0.1092
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0089	0.0481
Trypanosoma brucei	importin beta-1 subunit, putative	0.0032	0.0047	0.0125
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.019	0.127	0.1229
Chlamydia trachomatis	glutamate symporter	0.1318	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.0518	0.3806	0.3777
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0089	0.0481
Loa Loa (eye worm)	hypothetical protein	0.008	0.0419	0.0402
Brugia malayi	Importin beta-1 subunit	0.0032	0.0047	0.003
Trichomonas vaginalis	esterase, putative	0.008	0.0419	0.2262
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.008	0.0419	0.0296
Echinococcus granulosus	survival motor neuron protein 1	0.0263	0.1834	0.1796
Trichomonas vaginalis	set domain proteins, putative	0.0265	0.1851	1
Echinococcus multilocularis	neutral amino acid transporter A	0.1318	1	1
Echinococcus multilocularis	muscleblind protein 1	0.0155	0.0998	0.0956
Loa Loa (eye worm)	hypothetical protein	0.008	0.0419	0.0402
Brugia malayi	beta-lactamase family protein	0.008	0.0419	0.0402
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0107	0.063	1
Treponema pallidum	glutamate/aspartate transporter	0.0584	0.432	0.5
Brugia malayi	MH2 domain containing protein	0.0124	0.0757	0.0741
Schistosoma mansoni	alpha-glucosidase	0.0146	0.0925	0.0882
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.019	0.127	0.1158
Loa Loa (eye worm)	excitatory amino acid transporter	0.1318	1	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0159	0.1029	0.425
Brugia malayi	RNA, U transporter 1	0.0091	0.0505	0.0488
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0038	0.0089	0.0072
Echinococcus granulosus	excitatory amino acid transporter 3	0.1318	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0117	0.01
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0166	0.012
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0089	0.0371
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0097	0.0546	0.0425
Brugia malayi	hypothetical protein	0.0083	0.0439	0.0423
Mycobacterium tuberculosis	Probable lipase LipD	0.008	0.0419	0.0296
Trypanosoma brucei	hypothetical protein, conserved	0.008	0.0419	0.1687
Loa Loa (eye worm)	MH2 domain-containing protein	0.0124	0.0757	0.0741
Mycobacterium tuberculosis	Probable oxidoreductase	0.0107	0.063	0.051
Schistosoma mansoni	hypothetical protein	0.0083	0.0439	0.0394
Echinococcus multilocularis	Excitatory amino acid transporter	0.1318	1	1
Trypanosoma brucei	glucosidase, putative	0.0038	0.0089	0.0302
Leishmania major	hypothetical protein, conserved	0.0028	0.0017	0.0072
Onchocerca volvulus		0.008	0.0419	0.0363
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0166	0.012
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0089	0.0481
Mycobacterium tuberculosis	Conserved protein	0.008	0.0419	0.0296
Plasmodium vivax	glutathione reductase, putative	0.0042	0.0127	0.2723
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0159	0.1029	0.4291
Brugia malayi	beta-lactamase family protein	0.008	0.0419	0.0402
Echinococcus granulosus	neuropeptide s receptor	0.0518	0.3806	0.3777
Loa Loa (eye worm)	transcription factor SMAD2	0.0124	0.0757	0.0741
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0089	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0047	0.003
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0233	0.1602	0.1588
Echinococcus granulosus	thioredoxin glutathione reductase	0.0043	0.0131	0.0084
Onchocerca volvulus		0.0265	0.1851	0.1804
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0117	0.01
Onchocerca volvulus		0.0098	0.0555	0.0501
Trypanosoma cruzi	trypanothione reductase, putative	0.0042	0.0127	0.0528
Onchocerca volvulus		0.008	0.0419	0.0363
Schistosoma mansoni	transcription factor LCR-F1	0.0083	0.0439	0.0394
Leishmania major	hypothetical protein, conserved	0.008	0.0419	0.1746
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0057	0.0011
Mycobacterium tuberculosis	Probable dehydrogenase	0.0097	0.0546	0.0425
Echinococcus multilocularis	snurportin 1	0.0342	0.2449	0.2413
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0512	0.376	0.368
Echinococcus multilocularis	tumor protein p63	0.0378	0.2727	0.2693
Toxoplasma gondii	hypothetical protein	0.0054	0.0218	0.1604
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0017	0.0072
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0166	0.012
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0089	0.2026
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0998	0.0983
Onchocerca volvulus		0.0055	0.0227	0.0171
Schistosoma mansoni	hypothetical protein	0.0041	0.0117	0.0071
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0245	0.1697	0.1683
Echinococcus multilocularis	excitatory amino acid transporter 2	0.1318	1	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0169	0.1107	0.1092
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0584	0.432	0.4294
Echinococcus granulosus	sodium:dicarboxylate symporter	0.1318	1	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0048	0.0001
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0089	0.2026
Echinococcus granulosus	neuropeptide receptor A26	0.0518	0.3806	0.3777
Echinococcus granulosus	beta LACTamase domain containing family member	0.008	0.0419	0.0374
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0038	0.0089	0.0573
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.008	0.0419	0.0296
Echinococcus granulosus	neutral amino acid transporter A	0.1318	1	1
Schistosoma mansoni	survival motor neuron protein	0.0054	0.0214	0.0168
Trypanosoma brucei	trypanothione reductase	0.0042	0.0127	0.0459
Schistosoma mansoni	hypothetical protein	0.0054	0.0214	0.0168
Trypanosoma cruzi	hypothetical protein, conserved	0.008	0.0419	0.1746
Onchocerca volvulus		0.0054	0.0214	0.0157
Echinococcus multilocularis	beta LACTamase domain containing family member	0.008	0.0419	0.0374
Mycobacterium tuberculosis	Probable reductase	0.0097	0.0546	0.0425
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0047	0.0164	0.0685
Entamoeba histolytica	hypothetical protein	0.0083	0.0439	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0998	0.0983
Schistosoma mansoni	alpha-glucosidase	0.0146	0.0925	0.0882
Echinococcus granulosus	excitatory amino acid transporter 2	0.1318	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.019	0.127	0.1229
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0057	0.0011
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0177	0.1168	0.1055
Loa Loa (eye worm)	hypothetical protein	0.008	0.0419	0.0402
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0166	0.0149
Echinococcus granulosus	snurportin 1	0.0342	0.2449	0.2413
Brugia malayi	follicle stimulating hormone receptor	0.0502	0.3686	0.3675
Echinococcus granulosus	geminin	0.019	0.1267	0.1226
Mycobacterium ulcerans	aldehyde dehydrogenase	0.019	0.127	1
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.1318	1	1
Echinococcus granulosus	neutral amino acid transporter A	0.1318	1	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0057	0.0011
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.008	0.0419	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0263	0.1834	0.182
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0097	0.0546	0.0425
Echinococcus multilocularis	Excitatory amino acid transporter	0.1318	1	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0227	0.0211
Entamoeba histolytica	hypothetical protein	0.0083	0.0439	1
Leishmania major	trypanothione reductase	0.0042	0.0127	0.0528
Echinococcus granulosus	Excitatory amino acid transporter	0.1318	1	1
Onchocerca volvulus		0.008	0.0419	0.0363
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.019	0.127	0.5295
Mycobacterium tuberculosis	Probable hydrolase	0.008	0.0419	0.0296
Echinococcus multilocularis	muscleblind protein	0.0155	0.0998	0.0956
Plasmodium vivax	SET domain protein, putative	0.0033	0.0057	0.1002
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0097	0.0546	0.0425
Schistosoma mansoni	cellular tumor antigen P53	0.0055	0.0227	0.0181
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0336	0.2399	1
Echinococcus multilocularis	excitatory amino acid transporter 2	0.1318	1	1
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0038	0.0089	0.0042
Toxoplasma gondii	ABC1 family protein	0.008	0.0419	0.3206
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0107	0.063	0.051
Mycobacterium tuberculosis	Probable lipase LipE	0.008	0.0419	0.0296
Plasmodium falciparum	glutathione reductase	0.0042	0.0127	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0057	0.0011
Schistosoma mansoni	alpha glucosidase	0.0038	0.0089	0.0042
Wolbachia endosymbiont of Brugia malayi	Na+/H+-dicarboxylate symporter	0.1318	1	0.5
Schistosoma mansoni	aldehyde dehydrogenase	0.019	0.127	0.1229
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.019	0.127	0.1229
Echinococcus multilocularis	survival motor neuron protein 1	0.0263	0.1834	0.1796
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0083	0.0439	0.0394
Loa Loa (eye worm)	thioredoxin reductase	0.0042	0.0127	0.011
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0169	0.1107	0.1065
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0166	0.012
Schistosoma mansoni	hypothetical protein	0.019	0.1267	0.1226
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.008	0.0419	0.0374
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0336	0.2399	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0089	0.0371
Echinococcus multilocularis	neuropeptide receptor A26	0.0518	0.3806	0.3777
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.0584	0.432	0.4294
Entamoeba histolytica	hypothetical protein	0.0083	0.0439	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.0169	0.1107	0.1065
Loa Loa (eye worm)	glutathione reductase	0.0042	0.0127	0.011
Leishmania major	mitochondrial DNA polymerase beta	0.0336	0.2399	1
Treponema pallidum	glutamate transporter	0.0584	0.432	0.5
Brugia malayi	Muscleblind-like protein	0.0155	0.0998	0.0983
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0166	0.0149
Mycobacterium tuberculosis	Conserved protein	0.008	0.0419	0.0296
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0057	0.0321
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0169	0.1107	0.1065
Trichomonas vaginalis	D-aminoacylase, putative	0.008	0.0419	0.2262
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.008	0.0419	0.0402
Loa Loa (eye worm)	beta-lactamase	0.008	0.0419	0.0402
Trichomonas vaginalis	penicillin-binding protein, putative	0.008	0.0419	0.2262
Brugia malayi	beta-lactamase	0.008	0.0419	0.0402
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0107	0.063	0.051
Echinococcus multilocularis	neutral amino acid transporter A	0.1318	1	1
Toxoplasma gondii	thioredoxin reductase	0.0042	0.0127	0.0873
Brugia malayi	hypothetical protein	0.0263	0.1834	0.182
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0204	0.1379	0.1338
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0083	0.0439	0.0394
Onchocerca volvulus	Excitatory amino acid transporter homolog	0.1318	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0017	0.0072
Echinococcus multilocularis	neutral amino acid transporter A	0.1318	1	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0047	0.0164	0.0685
Leishmania major	alpha glucosidase II subunit, putative	0.0038	0.0089	0.0371
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0097	0.0546	0.0425
Schistosoma mansoni	solute carrier family 1 (glial high affinity glutamate transporter	0.1318	1	1
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0584	0.432	0.4294
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0058	0.0244	0.1018
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0038	0.0089	0.0072
Trypanosoma brucei	importin beta-1 subunit, putative	0.0032	0.0047	0.0125

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 12 nM	Displacement of [125I]Tyr-ovine-CRF from CRF1 receptor in rat frontal cortex homogenate by gamma counting	ChEMBL.	19552437

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL560098

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1051971