Detailed information for compound 1052112

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 389.49 | Formula: C24H27N3O2
  • H donors: 1 H acceptors: 2 LogP: 5.72 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(/C(=N\O)/c1ccc(nc1Oc1ccc2c(c1)cccc2)C)CC1CC1
  • InChi: 1S/C24H27N3O2/c1-3-14-27(16-18-9-10-18)23(26-28)22-13-8-17(2)25-24(22)29-21-12-11-19-6-4-5-7-20(19)15-21/h4-8,11-13,15,18,28H,3,9-10,14,16H2,1-2H3/b26-23-
  • InChiKey: KSXXVHCCUFRVFA-RWEWTDSWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0035 0.0115
Entamoeba histolytica glycogen phosphorylase, putative 0.0093 0.0749 0.3793
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0035 0.0035
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.1628 0.8214
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0188 0.0188
Brugia malayi Dopamine receptor protein 1 0.0037 0.0188 0.0615
Echinococcus granulosus dro:myosuppressin receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Loa Loa (eye worm) hypothetical protein 0.0072 0.0538 0.1757
Echinococcus multilocularis GPCR, family 2 0.0081 0.0629 0.0629
Brugia malayi Probable DNA topoisomerase II 0.0058 0.0398 0.13
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0035 0.0115
Echinococcus granulosus glycogen phosphorylase 0.0215 0.1974 0.1974
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0035 0.0035
Trypanosoma cruzi DNA topoisomerase II, putative 0.004 0.022 0.1751
Schistosoma mansoni zinc finger protein 0.0019 0.0008 0.0008
Echinococcus granulosus tachykinin peptides receptor 99D 0.0037 0.0188 0.0188
Schistosoma mansoni neuropeptide f receptor 76f 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0249 0.231 0.5209
Plasmodium vivax DNA topoisomerase II, putative 0.0058 0.0398 0.1725
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0188 0.0615
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0188 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0035 0.0115
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Schistosoma mansoni amine GPCR 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Loa Loa (eye worm) hypothetical protein 0.0076 0.0576 0.1881
Schistosoma mansoni coup transcription factor 0.0022 0.0035 0.0035
Loa Loa (eye worm) transcription factor SMAD2 0.0256 0.2383 0.7779
Brugia malayi Dopamine receptor protein 2 0.0037 0.0188 0.0615
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0035 0.0115
Schistosoma mansoni opsin-like receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0188 0.0615
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Entamoeba histolytica glycogenphosphorylase, putative 0.0093 0.0749 0.3793
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Schistosoma mansoni neuropeptide receptor 0.0037 0.0188 0.0188
Brugia malayi steroid hormone receptor 0.0022 0.0035 0.0115
Onchocerca volvulus 0.0037 0.0188 0.0791
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0035 0.0115
Brugia malayi neuropeptide F receptor 0.0037 0.0188 0.0615
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0035 0.0115
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0188 0.0188
Brugia malayi AKH receptor 0.0037 0.0188 0.0615
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0312 0.0312
Loa Loa (eye worm) RNA binding protein 0.0324 0.3064 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0324 0.3064 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0035 0.0115
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0538 0.2085
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0037 0.0188 0.0188
Toxoplasma gondii ABC1 family protein 0.0072 0.0538 0.4283
Echinococcus granulosus tar DNA binding protein 0.0324 0.3064 0.3064
Plasmodium vivax DNA gyrase subunit B, putative 0.0249 0.231 1
Schistosoma mansoni hypothetical protein 0.002 0.0018 0.0018
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0037 0.0188 0.0188
Loa Loa (eye worm) glycogen phosphorylase 0.0215 0.1974 0.6444
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0538 0.1757
Echinococcus granulosus neuropeptide FF receptor 2 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0081 0.0629 0.2054
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0037 0.0188 0.0188
Brugia malayi Tachykinin-like peptides receptor 99D 0.0037 0.0188 0.0615
Entamoeba histolytica glycogen phosphorylase, putative 0.0215 0.1974 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0035 0.0035
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0035 0.0035
Echinococcus multilocularis tumor protein p63 0.0338 0.3208 0.3208
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0188 0.0188
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0188 0.0188
Onchocerca volvulus 0.005 0.0312 0.1428
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0058 0.0398 0.0398
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0188 0.0188
Echinococcus multilocularis dro:myosuppressin receptor 0.0037 0.0188 0.0188
Echinococcus granulosus alpha 1A adrenergic receptor 0.0037 0.0188 0.0188
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0188 0.0188
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0035 0.0035
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0086 0.0674 0.9484
Loa Loa (eye worm) hypothetical protein 0.004 0.022 0.0718
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0576 0.2495
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0093 0.0749 0.1689
Brugia malayi G-protein coupled receptor 0.0037 0.0188 0.0615
Onchocerca volvulus 0.0037 0.0188 0.0791
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0629 0.2054
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0188 0.0188
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0144 0.1257 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0188 0.0188
Brugia malayi nuclear receptor NHR-88 0.0022 0.0035 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0035 0.0115
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0576 0.2495
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0538 0.1214
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0226 0.2084 0.2084
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0037 0.0188 0.0615
Echinococcus granulosus hypothetical protein 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0115
Schistosoma mansoni neuropeptide receptor 0.0037 0.0188 0.0188
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0035 0.0115
Echinococcus granulosus g protein coupled receptor 0.0037 0.0188 0.0188
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0188 0.0188
Entamoeba histolytica hypothetical protein 0.0036 0.0176 0.0889
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0089 0.0704 0.3049
Brugia malayi hypothetical protein 0.0049 0.0307 0.1001
Schistosoma mansoni hypothetical protein 0.1016 1 1
Echinococcus multilocularis glycogen phosphorylase 0.0215 0.1974 0.1974
Schistosoma mansoni myosin xvIII 0.0037 0.0188 0.0188
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0226 0.2084 0.6804
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0144 0.1257 1
Schistosoma mansoni hypothetical protein 0.0037 0.0188 0.0188
Schistosoma mansoni tar DNA-binding protein 0.0324 0.3064 0.3064
Brugia malayi Dopamine receptor 0.0037 0.0188 0.0615
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0115
Brugia malayi Melatonin receptor type 1A 0.0037 0.0188 0.0615
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0035 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0188 0.0188
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Brugia malayi Serotonin receptor 0.0037 0.0188 0.0615
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0188 0.0188
Toxoplasma gondii DNA topoisomerase 2, putative 0.0058 0.0398 0.3169
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0035 0.0115
Brugia malayi hypothetical protein 0.0076 0.0576 0.1881
Loa Loa (eye worm) TAR-binding protein 0.0324 0.3064 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0037 0.0188 0.0615
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0188 0.0188
Onchocerca volvulus Glycogen phosphorylase homolog 0.0215 0.1974 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Schistosoma mansoni neuropeptide receptor 0.0037 0.0188 0.0188
Schistosoma mansoni glutaminase 0.0276 0.2583 0.2583
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0176 0.0176
Entamoeba histolytica hypothetical protein 0.0036 0.0176 0.0889
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0058 0.0398 0.0398
Onchocerca volvulus 0.0037 0.0188 0.0791
Echinococcus multilocularis neuropeptide FF receptor 2 0.0037 0.0188 0.0188
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0538 0.0538
Echinococcus granulosus orexin receptor type 2 0.0037 0.0188 0.0188
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0257 0.2388 0.7793
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0629 0.0629
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0037 0.0037
Echinococcus granulosus allatostatin A receptor 0.0037 0.0188 0.0188
Schistosoma mansoni hypothetical protein 0.0081 0.0629 0.0629
Brugia malayi N-terminal motif family protein 0.0181 0.1628 0.5313
Schistosoma mansoni biogenic amine receptor 0.0037 0.0188 0.0188
Schistosoma mansoni biogenic amine receptor 0.0037 0.0188 0.0188
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0538 0.0538
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0188 0.0188
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0037 0.0188 0.0615
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0257 0.2388 0.7793
Schistosoma mansoni hypothetical protein 0.0081 0.0629 0.0629
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0576 0.2495
Brugia malayi G protein-coupled receptor 0.0037 0.0188 0.0615
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0037 0.0188 0.0188
Mycobacterium ulcerans hypothetical protein 0.0072 0.0538 0.2085
Onchocerca volvulus 0.0037 0.0188 0.0791
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0398 0.0398
Onchocerca volvulus 0.0037 0.0188 0.0791
Echinococcus multilocularis sex peptide receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Schistosoma mansoni hypothetical protein 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.005 0.0312 0.1019
Schistosoma mansoni hypothetical protein 0.1016 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0629 0.0629
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0035 0.0035
Echinococcus granulosus tumor protein p63 0.0338 0.3208 0.3208
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0188 0.0188
Schistosoma mansoni hypothetical protein 0.0175 0.1574 0.1574
Mycobacterium tuberculosis Conserved protein 0.0072 0.0538 0.1214
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0176 0.0176
Schistosoma mansoni tar DNA-binding protein 0.0324 0.3064 0.3064
Mycobacterium tuberculosis Conserved protein 0.0072 0.0538 0.1214
Brugia malayi PHD-finger family protein 0.0024 0.006 0.0196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0226 0.2084 0.2084
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0058 0.0398 0.1873
Loa Loa (eye worm) hypothetical protein 0.0181 0.1628 0.5313
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.6596 0.6596
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0058 0.0398 0.13
Schistosoma mansoni tar DNA-binding protein 0.0324 0.3064 0.3064
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0037 0.0188 0.0615
Schistosoma mansoni peptidase Clp (S14 family) 0.0089 0.0704 0.0704
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0538 0.1214
Echinococcus granulosus g protein coupled receptor 0.0037 0.0188 0.0188
Brugia malayi hypothetical protein 0.0037 0.0188 0.0615
Echinococcus multilocularis neuropeptide receptor A26 0.0037 0.0188 0.0188
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0035 0.0035
Trypanosoma brucei DNA topoisomerase ii 0.0144 0.1257 1
Leishmania major mitochondrial DNA topoisomerase II 0.0144 0.1257 1
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0188 0.0188
Giardia lamblia Glycogen phosphorylase 0.0215 0.1974 1
Leishmania major hypothetical protein, conserved 0.0076 0.0576 0.4584
Brugia malayi hypothetical protein 0.0037 0.0188 0.0615
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0035 0.0035
Schistosoma mansoni bromodomain containing protein 0.0062 0.0436 0.0436
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0188 0.0188
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0538 0.1757
Echinococcus multilocularis geminin 0.1016 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0037 0.0188 0.0188
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0122 0.0527
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0538 0.0538
Schistosoma mansoni hypothetical protein 0.0034 0.0157 0.0157
Entamoeba histolytica hypothetical protein 0.0036 0.0176 0.0889
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0089 0.0704 0.0704
Schistosoma mansoni neuropeptide receptor 0.0037 0.0188 0.0188
Echinococcus multilocularis Glycosyl transferase, family 35 0.0215 0.1974 0.1974
Mycobacterium ulcerans DNA gyrase subunit B 0.0249 0.231 0.8942
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0188 0.0188
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0188 0.0188
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0704 0.3049
Schistosoma mansoni glycogen phosphorylase 0.0093 0.0749 0.0749
Echinococcus multilocularis g-protein coupled receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0089 0.0704 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Trypanosoma brucei DNA topoisomerase II beta, putative 0.004 0.022 0.1751
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0037 0.0188 0.0188
Brugia malayi putative neuropeptide receptor 0.0037 0.0188 0.0615
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0037 0.0188 0.0615
Schistosoma mansoni biogenic amine receptor 0.0037 0.0188 0.0188
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0576 0.4584
Onchocerca volvulus 0.0037 0.0188 0.0791
Brugia malayi hypothetical protein 0.0037 0.0188 0.0615
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0037 0.0188 0.0615
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0188 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0035 0.0115
Chlamydia trachomatis DNA gyrase subunit B 0.0163 0.1451 0.4651
Schistosoma mansoni alpha-1 adrenergic receptor 0.0037 0.0188 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0035 0.0115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0035 0.0035
Schistosoma mansoni glycogen phosphorylase 0.0215 0.1974 0.1974
Onchocerca volvulus Neuropeptide F receptor homolog 0.0037 0.0188 0.0791
Onchocerca volvulus 0.0037 0.0188 0.0791
Onchocerca volvulus 0.0037 0.0188 0.0791
Echinococcus granulosus g protein coupled receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0115
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0089 0.0704 0.0704
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0037 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0188 0.0188
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0401 0.0401
Entamoeba histolytica glycogen phosphorylase, putative 0.0093 0.0749 0.3793
Loa Loa (eye worm) hypothetical protein 0.0072 0.0538 0.1757
Brugia malayi G-protein coupled receptor 0.0037 0.0188 0.0615
Echinococcus granulosus microtubule associated protein 2 0.0676 0.6596 0.6596
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0188 0.0188
Onchocerca volvulus 0.0037 0.0188 0.0791
Loa Loa (eye worm) hypothetical protein 0.0072 0.0538 0.1757
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0538 0.0538
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0226 0.2084 0.2084
Loa Loa (eye worm) hypothetical protein 0.0042 0.0234 0.0764
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0538 0.2085
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.0704 0.2727
Schistosoma mansoni tar DNA-binding protein 0.0324 0.3064 0.3064
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Brugia malayi hypothetical protein 0.0036 0.0176 0.0573
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0188 0.0188
Onchocerca volvulus 0.0037 0.0188 0.0791
Echinococcus granulosus neuropeptide receptor A26 0.0037 0.0188 0.0188
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0704 0.5603
Brugia malayi hypothetical protein 0.0037 0.0188 0.0615
Loa Loa (eye worm) hypothetical protein 0.004 0.0215 0.0703
Mycobacterium ulcerans glutaminase 0.0276 0.2583 1
Schistosoma mansoni adenoreceptor 0.0037 0.0188 0.0188
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0188 0.0188
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.004 0.022 0.1751
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0629 0.0629
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0226 0.2084 0.2084
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0188 0.0188
Onchocerca volvulus 0.0072 0.0538 0.2595
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0035 0.0115
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0093 0.0749 0.2899
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0035 0.0115
Loa Loa (eye worm) hypothetical protein 0.0175 0.1574 0.5137
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0037 0.0037
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0398 0.0398
Leishmania major DNA topoisomerase ii 0.004 0.022 0.1751
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0037 0.0188 0.0188
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0188 0.0188
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0188 0.0188
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.0704 0.2727
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Brugia malayi larval opioid receptor 0.0037 0.0188 0.0615
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Echinococcus granulosus 7tm_1 domain containing protein 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Echinococcus granulosus G protein coupled receptor 139 0.0037 0.0188 0.0188
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0538 0.2085
Onchocerca volvulus 0.0072 0.0538 0.2595
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0538 0.4283
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0037 0.0188 0.0188
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0081 0.0629 0.0629
Brugia malayi hypothetical protein 0.0037 0.0188 0.0615
Onchocerca volvulus 0.0037 0.0188 0.0791
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0226 0.2084 0.6804
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0037 0.0188 0.0615
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0576 0.4584
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0115
Schistosoma mansoni opsin-like receptor 0.0037 0.0188 0.0188
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0629 0.0629
Brugia malayi ORL1-like opioid receptor 0.0037 0.0188 0.0615
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0398 0.4744
Loa Loa (eye worm) glutaminase 0.0276 0.2583 0.8431
Brugia malayi carbohydrate phosphorylase 0.0215 0.1974 0.6444
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0035 0.0115
Loa Loa (eye worm) hypothetical protein 0.0038 0.0192 0.0627
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0035 0.0035
Brugia malayi follicle stimulating hormone receptor 0.0037 0.0188 0.0615
Loa Loa (eye worm) hypothetical protein 0.0072 0.0538 0.1757
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0037 0.0188 0.0188
Brugia malayi beta-lactamase family protein 0.0072 0.0538 0.1757
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0188 0.0188
Brugia malayi hypothetical protein 0.0037 0.0188 0.0615
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0257 0.2388 0.7793
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0401 0.0401
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0398 0.0898
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0037 0.0188 0.0188
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0035 0.0035
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0188 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0035 0.0115
Plasmodium falciparum DNA topoisomerase 2 0.0058 0.0398 0.1725
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0538 0.1214
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0249 0.231 1
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.6596 0.6596
Brugia malayi Bromodomain containing protein 0.0073 0.0551 0.18
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0122 0.0527
Echinococcus multilocularis glycogen phosphorylase 0.0215 0.1974 0.1974
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0035 0.0115
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0035 0.0035
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0037 0.0188 0.0615
Echinococcus granulosus zinc finger protein 0.0019 0.0008 0.0008
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0188 0.0188
Echinococcus granulosus g-protein coupled receptor 0.0037 0.0188 0.0188
Trichomonas vaginalis glycogen phosphorylase, putative 0.0215 0.1974 0.7643
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0037 0.0188 0.0188
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Chlamydia trachomatis DNA gyrase subunit B 0.0249 0.231 1
Brugia malayi latrophilin 2 splice variant baaae 0.0175 0.1574 0.5137
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0704 0.3049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0226 0.2084 0.2084
Echinococcus multilocularis G protein coupled receptor 139 0.0037 0.0188 0.0188
Onchocerca volvulus 0.0037 0.0188 0.0791
Brugia malayi hypothetical protein 0.0037 0.0188 0.0615
Onchocerca volvulus 0.0037 0.0188 0.0791
Brugia malayi nuclear hormone receptor 0.0022 0.0035 0.0115
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Loa Loa (eye worm) hypothetical protein 0.0072 0.0538 0.1757
Loa Loa (eye worm) beta-lactamase 0.0072 0.0538 0.1757
Schistosoma mansoni amine GPCR 0.0526 0.5092 0.5092
Schistosoma mansoni amine GPCR 0.0037 0.0188 0.0188
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0035 0.0035
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0704 0.5603
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0538 0.2085
Echinococcus granulosus neuropeptide receptor 0.0037 0.0188 0.0188
Entamoeba histolytica DNA topoisomerase II, putative 0.0058 0.0398 0.2018
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0089 0.0704 0.3049
Echinococcus multilocularis neuropeptide s receptor 0.0037 0.0188 0.0188
Mycobacterium ulcerans beta-lactamase 0.0072 0.0538 0.2085
Schistosoma mansoni opsin-like receptor 0.0037 0.0188 0.0188
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0035 0.0035
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0188 0.0188
Brugia malayi hypothetical protein 0.0037 0.0188 0.0615
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0188 0.0188
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0037 0.0188 0.0188
Schistosoma mansoni glycogen phosphorylase 0.0215 0.1974 0.1974
Brugia malayi ecdysteroid receptor 0.0022 0.0035 0.0115
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0176 0.0176
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0037 0.0188 0.0188
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Trichomonas vaginalis glycogen phosphorylase, putative 0.0215 0.1974 0.7643
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0538 0.2085
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0157 0.0157
Giardia lamblia DNA topoisomerase II 0.005 0.032 0.1622
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0035 0.0035
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0058 0.0398 0.1873
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0188 0.0188
Onchocerca volvulus 0.0037 0.0188 0.0791
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0188 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0035 0.0115
Brugia malayi RNA binding protein 0.0324 0.3064 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Schistosoma mansoni growth hormone secretagogue receptor 0.0037 0.0188 0.0188
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0037 0.0188 0.0188
Trypanosoma cruzi DNA topoisomerase II, putative 0.004 0.022 0.1751
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Loa Loa (eye worm) hypothetical protein 0.0072 0.0538 0.1757
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0188 0.0188
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0188 0.0188
Brugia malayi beta-lactamase 0.0072 0.0538 0.1757
Schistosoma mansoni tar DNA-binding protein 0.0324 0.3064 0.3064
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0629 0.2054
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0018 0.0059
Echinococcus multilocularis serotonin receptor 0.0037 0.0188 0.0188
Entamoeba histolytica hypothetical protein 0.0036 0.0176 0.0889
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Onchocerca volvulus 0.0037 0.0188 0.0791
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0188 0.0188
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0249 0.231 1
Schistosoma mansoni DNA topoisomerase II 0.0058 0.0398 0.0398
Echinococcus granulosus neuropeptide s receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0188 0.0615
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0035 0.0115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0115
Mycobacterium tuberculosis Conserved protein 0.0072 0.0538 0.1214
Echinococcus granulosus fmrfamide receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0037 0.0188 0.0615
Echinococcus granulosus Glycosyl transferase family 35 0.0215 0.1974 0.1974
Echinococcus multilocularis allatostatin A receptor 0.0037 0.0188 0.0188
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0035 0.0035
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0035 0.0035
Trichomonas vaginalis DNA topoisomerase II, putative 0.0058 0.0398 0.1542
Brugia malayi TAR-binding protein 0.0324 0.3064 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0188 0.0188
Brugia malayi sulfakinin receptor protein 0.0037 0.0188 0.0615
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0188 0.0188
Echinococcus granulosus serotonin receptor 0.0037 0.0188 0.0188
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0035 0.0035
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0538 0.1214
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0122 0.0527
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0035 0.0035
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.004 0.022 0.0718
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0037 0.0188 0.0615
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0157 0.0157
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0538 0.1214
Brugia malayi hypothetical protein 0.0037 0.0188 0.0615
Echinococcus granulosus GPCR family 2 0.0081 0.0629 0.0629
Brugia malayi RNA recognition motif domain containing protein 0.0324 0.3064 1
Schistosoma mansoni amine GPCR 0.0037 0.0188 0.0188
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0035 0.0035
Onchocerca volvulus 0.0037 0.0188 0.0791
Brugia malayi glutaminase DH11.1 0.0276 0.2583 0.8431
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0398 0.0898
Brugia malayi putative neuropeptide receptor NPR1 0.0037 0.0188 0.0615
Echinococcus granulosus somatostatin receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0058 0.0398 0.13
Trichomonas vaginalis esterase, putative 0.0072 0.0538 0.2085
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0188 0.0188
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0037 0.0188 0.0188
Echinococcus multilocularis serotonin receptor 0.0037 0.0188 0.0188
Brugia malayi Bromodomain containing protein 0.0037 0.0191 0.0625
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0037 0.0188 0.0188
Echinococcus granulosus 7TM GPCR rhodopsin 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0629 0.2054
Loa Loa (eye worm) hypothetical protein 0.0089 0.0704 0.2299
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Leishmania major hypothetical protein, conserved 0.0072 0.0538 0.4283
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0188 0.0188
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0188 0.0188
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0144 0.1257 1
Loa Loa (eye worm) TYRA-2 protein 0.0037 0.0188 0.0615
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0188 0.0188
Schistosoma mansoni hypothetical protein 0.0081 0.0629 0.0629
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0576 0.4584
Brugia malayi Calcitonin receptor-like protein seb-1 0.0257 0.2388 0.7793
Loa Loa (eye worm) MH2 domain-containing protein 0.0256 0.2383 0.7779
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0576 0.4584
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0538 0.4283
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Trichomonas vaginalis glutaminase, putative 0.0276 0.2583 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0188 0.0188
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0037 0.0188 0.0791
Loa Loa (eye worm) hypothetical protein 0.0069 0.0509 0.1663
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0538 0.7152
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0058 0.0398 0.1873
Mycobacterium ulcerans lipase LipD 0.0072 0.0538 0.2085
Brugia malayi GnHR receptor homolog 0.0037 0.0188 0.0615
Onchocerca volvulus 0.0072 0.0538 0.2595
Entamoeba histolytica glycogen phosphorylase, putative 0.0215 0.1974 1
Brugia malayi RE15519p 0.0037 0.0188 0.0615
Brugia malayi hypothetical protein 0.0037 0.0188 0.0615
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0035 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0188 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0035 0.0115
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0791 0.7743 0.7743
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0226 0.2084 0.2084
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0188 0.0188
Echinococcus multilocularis somatostatin receptor 0.0037 0.0188 0.0188
Loa Loa (eye worm) glutaminase 2 0.0276 0.2583 0.8431
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0188 0.0188
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0035 0.0115
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0115
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0538 0.2085
Brugia malayi beta-lactamase family protein 0.0072 0.0538 0.1757
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0538 0.2331
Echinococcus granulosus neuropeptide receptor 0.0037 0.0188 0.0188
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0188 0.0188
Brugia malayi G protein-coupled receptor F59B2.13 0.0037 0.0188 0.0615
Mycobacterium leprae Probable lipase LipE 0.0072 0.0538 0.7152
Brugia malayi MH2 domain containing protein 0.0256 0.2383 0.7779
Schistosoma mansoni histamine h1 receptor 0.0037 0.0188 0.0188
Echinococcus multilocularis orexin receptor type 2 0.0037 0.0188 0.0188
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0538 0.2085
Plasmodium falciparum DNA gyrase subunit B 0.0249 0.231 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0168 0.0168
Loa Loa (eye worm) melatonin receptor type 1A 0.0037 0.0188 0.0615
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0035 0.0115
Brugia malayi Probable ClpP-like protease 0.0089 0.0704 0.2299
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0037 0.0188 0.0188
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0188 0.0188
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0037 0.0188 0.0188
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0035 0.0115
Schistosoma mansoni hypothetical protein 0.0036 0.0176 0.0176
Echinococcus multilocularis tar DNA binding protein 0.0324 0.3064 0.3064
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0035 0.0035
Echinococcus granulosus peptide allatostatin:somatostatin 0.0037 0.0188 0.0188
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0035 0.0035
Chlamydia trachomatis glycogen phosphorylase 0.0215 0.1974 0.791
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0615
Loa Loa (eye worm) TOPoisomerase family member 0.0058 0.0398 0.13
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0188 0.0188
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0037 0.0188 0.0188
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0538 0.4283
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0115
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0035 0.0035
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0538 0.1214
Schistosoma mansoni amine GPCR 0.0037 0.0188 0.0188
Echinococcus multilocularis zinc finger protein 0.0019 0.0008 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0188 0.0188
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0188 0.0615
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0538 0.1214
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0035 0.0115
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0115
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0188 0.0188
Echinococcus granulosus sex peptide receptor 0.0037 0.0188 0.0188
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0226 0.2084 0.2084
Toxoplasma gondii hypothetical protein 0.0031 0.0122 0.0969
Brugia malayi Serotonin receptor 0.0037 0.0188 0.0615
Onchocerca volvulus 0.0037 0.0188 0.0791
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0461 0.4434 1
Brugia malayi neuropeptide F receptor 0.0037 0.0188 0.0615
Echinococcus granulosus glycogen phosphorylase 0.0215 0.1974 0.1974

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 12 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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