Detailed information for compound 1052138

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.4 | Formula: C20H22N2O3
  • H donors: 0 H acceptors: 1 LogP: 3.96 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cccc(c1)c1occ(n1)CN(c1ccc(cc1)OC)C
  • InChi: 1S/C20H22N2O3/c1-4-24-19-7-5-6-15(12-19)20-21-16(14-25-20)13-22(2)17-8-10-18(23-3)11-9-17/h5-12,14H,4,13H2,1-3H3
  • InChiKey: CHVLXHSYLDTMKU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TAR-binding protein 0.0571 0.516 0.516
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0408 0.0568
Schistosoma mansoni hypothetical protein 0.0171 0.1441 0.2792
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0194 0.0757
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0023 0.0032
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0073 0.0286
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0194 0.0172
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0053 0.003
Mycobacterium ulcerans hypothetical protein 0.0037 0.0194 0.1361
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.1136 0.4424
Brugia malayi hypothetical protein 0.0072 0.0517 0.0517
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0073 0.005
Schistosoma mansoni DNA polymerase eta 0.0019 0.0023 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0194 0.0172
Schistosoma mansoni tar DNA-binding protein 0.0571 0.516 1
Plasmodium falciparum macrophage migration inhibitory factor 0.1092 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.2567 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0431 0.0431
Onchocerca volvulus 0.0063 0.0431 0.1798
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0053 0.0205
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0194 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.1092 1 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.1509 1
Mycobacterium ulcerans beta-lactamase 0.0037 0.0194 0.1361
Loa Loa (eye worm) hypothetical protein 0.0037 0.0194 0.0194
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0023 0.0045
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0088 0.0088
Plasmodium vivax macrophage migration inhibitory factor, putative 0.1092 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0194 0.0194
Leishmania major DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Onchocerca volvulus 0.0063 0.0431 0.1798
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0194 0.0946
Loa Loa (eye worm) hypothetical protein 0.0063 0.0431 0.0431
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0088 0.0122
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0053 0.0053
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0408 0.0408
Leishmania major hypothetical protein, conserved 0.0037 0.0194 0.0194
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0023 0.0112
Echinococcus granulosus tar DNA binding protein 0.0571 0.516 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0194 0.0194
Schistosoma mansoni ran 0.0022 0.0053 0.0102
Schistosoma mansoni tar DNA-binding protein 0.0571 0.516 1
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0088 0.0342
Entamoeba histolytica hypothetical protein 0.0072 0.0517 0.0496
Mycobacterium tuberculosis Conserved protein 0.0037 0.0194 0.0946
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0023 0.009
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1136 0.1136
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.1092 1 1
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0063 0.0431 0.0431
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0408 0.3057
Entamoeba histolytica hypothetical protein 0.0024 0.0073 0.005
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0507 0.4564 0.4564
Echinococcus multilocularis geminin 0.0518 0.4662 0.6496
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0053 0.0073
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0053 0.0053
Schistosoma mansoni tar DNA-binding protein 0.0571 0.516 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0408 0.3057
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0194 0.0757
Brugia malayi Calcitonin receptor-like protein seb-1 0.025 0.2178 0.2178
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0088 0.0065
Schistosoma mansoni ran 0.0022 0.0053 0.0102
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.009
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0053 0.0205
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.009
Plasmodium falciparum importin beta, putative 0.003 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0171 0.1441 0.1441
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.009
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0194 0.0946
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0586 0.0817
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0088 0.0065
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0053 0.0053
Loa Loa (eye worm) RNA binding protein 0.0571 0.516 0.516
Giardia lamblia Macrophage migration inhibitory factor 0.1092 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.009
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0079 0.0586 0.1136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.1567 0.2184
Trichomonas vaginalis esterase, putative 0.0037 0.0194 0.0172
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0088 0.0088
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0194 0.0946
Echinococcus multilocularis snurportin 1 0.0317 0.2798 0.39
Onchocerca volvulus 0.0063 0.0431 0.1798
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0315 0.1227
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0586 0.0586
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0232 0.0902
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0517 0.1003
Schistosoma mansoni hypothetical protein 0.0079 0.0586 0.1136
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0408 0.1985
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.009
Leishmania major importin beta-1 subunit, putative 0.0024 0.0073 0.0073
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0586 0.0586
Mycobacterium ulcerans hypothetical protein 0.0154 0.1281 1
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0088 0.017
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0194 0.0946
Schistosoma mansoni tar DNA-binding protein 0.0571 0.516 1
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0194 0.5
Mycobacterium ulcerans lipase LipD 0.0037 0.0194 0.1361
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0053 0.0053
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.009
Schistosoma mansoni hypothetical protein 0.0317 0.2798 0.5423
Loa Loa (eye worm) hypothetical protein 0.0063 0.0431 0.0431
Brugia malayi beta-lactamase 0.0037 0.0194 0.0194
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0088 0.017
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.2567 0.2567
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.009
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1281 0.6239
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0194 0.1361
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0126 0.0489
Loa Loa (eye worm) hypothetical protein 0.0079 0.0586 0.0586
Toxoplasma gondii ABC1 family protein 0.0037 0.0194 0.0194
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0088 0.0088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.1567 0.3038
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0023 0.0112
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0194 0.0271
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0232 0.0902
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0023 0.0023
Brugia malayi RNA binding protein 0.0571 0.516 0.516
Entamoeba histolytica hypothetical protein 0.0072 0.0517 0.0496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.1567 0.3038
Leishmania major DNA polymerase eta, putative 0.0019 0.0023 0.0023
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0232 0.0902
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0023
Brugia malayi Importin beta-1 subunit 0.003 0.0126 0.0126
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0053 0.0053
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0023 0.0023
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.1092 1 1
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0088 0.0088
Entamoeba histolytica Ran family GTPase 0.0022 0.0053 0.003
Brugia malayi secreted modular calcium-binding protein 1 0.0063 0.0431 0.0431
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.009
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0088 0.0065
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0126 0.0126
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0194 0.0946
Loa Loa (eye worm) hypothetical protein 0.025 0.2178 0.2178
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.1567 0.3038
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0194 0.1361
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0408 0.0408
Onchocerca volvulus 0.0063 0.0431 0.1798
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0194 0.0172
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0408 0.079
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.2053 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0194 0.0376
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0517 0.0721
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.009
Trypanosoma brucei unspecified product 0.0019 0.0023 0.009
Trichomonas vaginalis ran, putative 0.0022 0.0053 0.003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0194 0.0376
Echinococcus granulosus dna polymerase kappa 0.0019 0.0023 0.0045
Echinococcus granulosus dna polymerase eta 0.0019 0.0023 0.0045
Loa Loa (eye worm) macrophage migration inhibitory factor 0.1092 1 1
Brugia malayi RNA, U transporter 1 0.0085 0.0635 0.0635
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0408 0.079
Schistosoma mansoni hypothetical protein 0.0518 0.4662 0.9034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.1567 0.3038
Leishmania major macrophage migration inhibitory factor-like protein 0.1092 1 1
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0063 0.0431 0.0431
Loa Loa (eye worm) pigment dispersing factor receptor c 0.025 0.2178 0.2178
Loa Loa (eye worm) hypothetical protein 0.0037 0.0194 0.0194
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.009
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0507 0.4564 0.4564
Loa Loa (eye worm) hypothetical protein 0.0037 0.0194 0.0194
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0586 0.0817
Plasmodium vivax importin-beta 2, putative 0.003 0.0126 0.0126
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0053 0.0102
Schistosoma mansoni hypothetical protein 0.0518 0.4662 0.9034
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0571 0.516 0.516
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0232 0.0902
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0126 0.0489
Echinococcus granulosus snurportin 1 0.0317 0.2798 0.5423
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0194 0.0376
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0073 0.005
Entamoeba histolytica hypothetical protein 0.0072 0.0517 0.0496
Schistosoma mansoni importin beta-1 0.003 0.0126 0.0243
Loa Loa (eye worm) hypothetical protein 0.0037 0.0194 0.0194
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0179 0.1509 0.1509
Entamoeba histolytica hypothetical protein 0.0072 0.0517 0.0496
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.009
Brugia malayi RNA recognition motif domain containing protein 0.0571 0.516 0.516
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0408 0.3057
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0023 0.009
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0053 0.0205
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0586 0.1136
Echinococcus multilocularis importin subunit beta 1 0.003 0.0126 0.0175
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0185 0.1567 0.1567
Echinococcus multilocularis dna polymerase eta 0.0019 0.0023 0.0032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.1567 0.3038
Brugia malayi beta-lactamase family protein 0.0037 0.0194 0.0194
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.1441 0.1441
Echinococcus multilocularis GPCR, family 2 0.0079 0.0586 0.0817
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0023 0.0045
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0194 0.0194
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0063 0.0431 0.0431
Echinococcus granulosus importin subunit beta 1 0.003 0.0126 0.0243
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.2567 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.7176 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0073 0.005
Mycobacterium tuberculosis Conserved protein 0.0037 0.0194 0.0946
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0586 0.0586
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.2798 0.2798
Loa Loa (eye worm) hypothetical protein 0.003 0.0126 0.0126
Brugia malayi TAR-binding protein 0.0571 0.516 0.516
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0194 0.0946
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.2567 1
Schistosoma mansoni hypothetical protein 0.0079 0.0586 0.1136
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0088 0.017
Trichomonas vaginalis chaperonin, putative 0.0026 0.0088 0.0065
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0088 0.0088
Leishmania major macrophage migration inhibitory factor-like protein 0.1092 1 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.0194 0.5
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0088 0.0342
Brugia malayi beta-lactamase family protein 0.0037 0.0194 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.009
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.1092 1 1
Echinococcus granulosus GPCR family 2 0.0079 0.0586 0.1136
Schistosoma mansoni hypothetical protein 0.0079 0.0586 0.1136
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0194 0.0757
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0571 0.516 1
Loa Loa (eye worm) beta-lactamase 0.0037 0.0194 0.0194
Leishmania major GTP-binding protein, putative 0.0022 0.0053 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.009
Toxoplasma gondii hypothetical protein 0.0047 0.0288 0.0288
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.1567 0.2184
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0194 0.0194
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0088 0.0088
Brugia malayi N-terminal motif family protein 0.0179 0.1509 0.1509
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0063 0.0431 0.0431
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1136 0.4424
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0063 0.0431 0.0431
Echinococcus multilocularis tar DNA binding protein 0.0571 0.516 0.7191
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0088 0.017
Loa Loa (eye worm) hypothetical protein 0.0063 0.0431 0.0431
Mycobacterium tuberculosis Conserved protein 0.0037 0.0194 0.0946
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0408 0.079
Echinococcus granulosus geminin 0.0518 0.4662 0.9034
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0194 0.0194
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0517 0.1003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0586 0.1136
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0185 0.1567 0.1567
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0194 0.0946
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.025 0.2178 0.2178
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0045
Schistosoma mansoni hypothetical protein 0.0072 0.0517 0.1003
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0194 0.0172

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = -9 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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