Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0044 | 0.1991 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.37 | 0.6284 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.01 | 0.57 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0389 | 0.1529 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0317 | 0.1245 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0119 | 0.6907 | 0.8837 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.1991 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1991 | 0.7521 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0018 | 0.0317 | 0.1245 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0389 | 0.1529 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.57 | 0.556 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0389 | 0.0134 |
Leishmania major | trypanothione reductase | 0.0052 | 0.2543 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0044 | 0.1991 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0052 | 0.2543 | 0.2952 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0389 | 0.0448 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0119 | 0.6907 | 0.8837 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0389 | 0.0097 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1991 | 0.7521 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.37 | 0.403 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0044 | 0.1991 | 0.311 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.37 | 0.403 |
Plasmodium falciparum | thioredoxin reductase | 0.0052 | 0.2543 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.01 | 0.57 | 0.6623 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0119 | 0.6907 | 0.8837 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.37 | 0.3494 |
Brugia malayi | RNA binding protein | 0.007 | 0.37 | 0.4297 |
Trypanosoma brucei | trypanothione reductase | 0.0052 | 0.2543 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0389 | 0.1529 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0052 | 0.2543 | 0.4135 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0389 | 0.1529 |
Plasmodium falciparum | glutathione reductase | 0.0052 | 0.2543 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0389 | 0.0134 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0044 | 0.1991 | 0.311 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0052 | 0.2543 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.8605 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0389 | 0.1529 |
Loa Loa (eye worm) | glutathione reductase | 0.0052 | 0.2543 | 0.2622 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.37 | 0.3494 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.37 | 0.6284 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0389 | 0.0134 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0052 | 0.2543 | 0.2622 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0018 | 0.0317 | 0.1245 |
Brugia malayi | hypothetical protein | 0.0145 | 0.8605 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0044 | 0.1991 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0389 | 0.1529 |
Brugia malayi | Inositol-1 | 0.0044 | 0.1991 | 0.2311 |
Plasmodium vivax | glutathione reductase, putative | 0.0052 | 0.2543 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.37 | 0.403 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0389 | 0.0324 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0389 | 0.0431 |
Toxoplasma gondii | thioredoxin reductase | 0.0052 | 0.2543 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0389 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.01 | 0.57 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0145 | 0.8605 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0132 | 0.7774 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0389 | 0.0097 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0317 | 0.0364 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0389 | 0.0431 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0119 | 0.6907 | 0.8837 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.01 | 0.57 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0132 | 0.7774 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0119 | 0.6907 | 0.8837 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0044 | 0.1991 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0389 | 0.0431 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.37 | 0.3494 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.37 | 0.3494 |
Brugia malayi | glutathione reductase | 0.0052 | 0.2543 | 0.2952 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0.0317 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.01 | 0.57 | 0.6465 |
Treponema pallidum | NADH oxidase | 0.0018 | 0.0317 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.8605 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0039 | 0.1692 | 0.1844 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0389 | 0.0134 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0389 | 0.0324 |
Mycobacterium tuberculosis | Probable reductase | 0.0119 | 0.6907 | 0.8837 |
Loa Loa (eye worm) | inositol-1 | 0.0044 | 0.1991 | 0.195 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.1991 | 0.1729 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.01 | 0.57 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0119 | 0.6907 | 0.8574 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.1991 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0389 | 0.1529 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0389 | 0.0448 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0389 | 0.0324 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0389 | 0.1529 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0389 | 0.0324 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0389 | 0.0075 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0389 | 0.1529 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0389 | 0.0324 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0389 | 0.1529 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.57 | 0.556 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.37 | 0.4297 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.1991 | 0.1729 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0389 | 0.0134 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0052 | 0.2543 | 0.4135 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0132 | 0.7774 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0141 | 0.8363 | 0.9719 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0141 | 0.8363 | 0.9706 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0317 | 0.1245 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0141 | 0.8363 | 0.9706 |
Onchocerca volvulus | Huntingtin homolog | 0.0145 | 0.8605 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0389 | 0.1529 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.57 | 0.556 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.37 | 0.3494 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0044 | 0.1991 | 0.7521 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0389 | 0.0075 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0389 | 0.1529 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0052 | 0.2543 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1991 | 0.7521 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0052 | 0.2543 | 0.2985 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0132 | 0.7774 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0389 | 0.0134 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1991 | 0.7829 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0389 | 0.1529 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.0389 | 0.0324 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0389 | 0.0324 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0389 | 0.0431 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0389 | 0.1529 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0389 | 0.0324 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0389 | 0.1529 |
Brugia malayi | TAR-binding protein | 0.007 | 0.37 | 0.4297 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0389 | 0.0075 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0 % | Displacement of [3H]SCH23390 from pig dopamine D1 receptor at 100 nM | ChEMBL. | 19481941 |
Activity (binding) | = 0 % | Displacement of [3H]spiperone from human cloned dopamine D2 long receptor expressed in CHO cells at 100 nM | ChEMBL. | 19481941 |
Activity (binding) | = 0 % | Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO cells at 100 nM | ChEMBL. | 19481941 |
Activity (binding) | = 0 % | Displacement of [3H]spiperone from human cloned dopamine D4.4 receptor expressed in CHO cells at 100 nM | ChEMBL. | 19481941 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.