TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 541.46 | Formula: C25H25BrN4O3S
H donors: 0 H acceptors: 3 LogP: 3.08 Rotable bonds: 5
Rule of 5 violations (Lipinski): 2
SMILES: Brc1ccc2c(c1)ccc(c2)S(=O)(=O)N1CCN(CC1)C(=O)c1ccc(cc1)C1=NCCN1C
InChi: 1S/C25H25BrN4O3S/c1-28-11-10-27-24(28)18-2-4-19(5-3-18)25(31)29-12-14-30(15-13-29)34(32,33)23-9-7-20-16-22(26)8-6-21(20)17-23/h2-9,16-17H,10-15H2,1H3
InChiKey: YWLFJGUFYABFRF-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	coagulation factor X	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	tubulin beta chain, putative	0.004	0.0997	0.1654
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0021	0.0225	0.031
Brugia malayi	Proteasome A-type and B-type family protein	0.0021	0.0225	0.0225
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Toxoplasma gondii	heat shock protein hslv, putative	0.0021	0.0225	0.0389
Leishmania major	proteasome alpha 3 subunit, putative	0.0021	0.0225	0.031
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0021	0.0225	0.031
Leishmania major	proteasome alpha 2 subunit, putative	0.0021	0.0225	0.031
Trichomonas vaginalis	tubulin beta chain, putative	0.0022	0.0268	0.0385
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0021	0.0225	0.0389
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0021	0.0225	0.0389
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0021	0.0225	0.031
Echinococcus multilocularis	tubulin alpha chain	0.004	0.0997	0.1722
Giardia lamblia	Beta tubulin	0.0102	0.3635	0.6246
Loa Loa (eye worm)	beta-tubulin	0.0102	0.3635	0.3635
Echinococcus multilocularis	tubulin gamma 1 chain	0.004	0.0997	0.1722
Echinococcus granulosus	Tubulin alpha 1 chain	0.004	0.0997	0.1722
Trichomonas vaginalis	tubulin beta chain, putative	0.004	0.0997	0.1654
Mycobacterium ulcerans	proteasome PrcA	0.0021	0.0225	0.031
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0357	0.0357
Giardia lamblia	Proteasome subunit beta type 1	0.0021	0.0225	0.031
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0153	0.5791	0.5791
Trypanosoma cruzi	alpha tubulin, putative	0.004	0.0997	0.1654
Entamoeba histolytica	tubulin alpha-1 chain	0.004	0.0997	0.1387
Echinococcus granulosus	beta tubulin	0.0102	0.3635	0.6277
Leishmania major	proteasome alpha 1 subunit, putative	0.0021	0.0225	0.031
Echinococcus multilocularis	Tubulin beta 2C chain	0.0102	0.3635	0.6277
Trichomonas vaginalis	tubulin gamma chain, putative	0.0102	0.3635	0.6246
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0021	0.0225	0.031
Trypanosoma brucei	alpha tubulin	0.004	0.0997	0.1654
Schistosoma mansoni	alpha tubulin	0.004	0.0997	0.1722
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Leishmania major	epsilon tubulin, putative	0.004	0.0997	0.1654
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0021	0.0225	0.031
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0068	0.2199	0.3546
Trichomonas vaginalis	tubulin beta chain, putative	0.004	0.0997	0.1654
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0021	0.0225	0.0389
Leishmania major	proteasome beta 5 subunit, putative	0.0153	0.5791	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0017	0.0047	0.0081
Mycobacterium ulcerans	proteasome PrcB	0.0153	0.5791	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0102	0.3635	0.6277
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0021	0.0225	0.0389
Onchocerca volvulus		0.0022	0.0268	0.0288
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0021	0.0225	0.031
Giardia lamblia	Beta tubulin	0.0102	0.3635	0.6246
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0068	0.2199	0.2199
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0021	0.0225	0.0225
Echinococcus multilocularis	tubulin alpha 1C chain	0.004	0.0997	0.1722
Schistosoma mansoni	tubulin subunit beta	0.0102	0.3635	0.6277
Loa Loa (eye worm)	tubulin alpha chain	0.004	0.0997	0.0997
Leishmania major	alpha tubulin	0.004	0.0997	0.1654
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0021	0.0225	0.0389
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0021	0.0225	0.0389
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0021	0.0225	0.0389
Echinococcus multilocularis	tubulin subunit beta	0.0102	0.3635	0.6277
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0021	0.0225	0.0389
Schistosoma mansoni	tubulin subunit beta	0.0102	0.3635	0.6277
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Trypanosoma brucei	alpha tubulin, putative	0.0022	0.0268	0.0385
Echinococcus multilocularis	Tubulin beta 2C chain	0.0102	0.3635	0.6277
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0153	0.5791	1
Loa Loa (eye worm)	BEN-1 protein	0.0102	0.3635	0.3635
Onchocerca volvulus	Notchless protein homolog	0.0021	0.0225	0.0242
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Toxoplasma gondii	beta tubulin	0.0102	0.3635	0.6277
Leishmania major	alpha tubulin	0.004	0.0997	0.1654
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0021	0.0225	0.0389
Brugia malayi	tubulin alpha-2 chain	0.004	0.0997	0.0997
Giardia lamblia	Gamma tubulin	0.004	0.0997	0.1654
Trypanosoma brucei	proteasome beta 6 subunit	0.0021	0.0225	0.031
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Echinococcus granulosus	proteasome prosome macropain	0.0153	0.5791	1
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0021	0.0225	0.0389
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0021	0.0225	0.031
Loa Loa (eye worm)	tubulin alpha chain	0.004	0.0997	0.0997
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0021	0.0225	0.031
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0021	0.0225	0.031
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0021	0.0225	0.031
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0017	0.0047	0.0081
Brugia malayi	Tubulin beta chain	0.0017	0.0047	0.0047
Leishmania major	proteasome beta 3 subunit, putative	0.0021	0.0225	0.031
Loa Loa (eye worm)	tubulin beta chain	0.0102	0.3635	0.3635
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0021	0.0225	0.031
Trichomonas vaginalis	tubulin alpha chain, putative	0.0022	0.0268	0.0385
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0021	0.0225	0.0389
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0021	0.0225	0.031
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0021	0.0225	0.031
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0021	0.0225	0.0389
Brugia malayi	Cell division protein ftsZ	0.0017	0.0047	0.0047
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0021	0.0225	0.0389
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0021	0.0225	0.031
Giardia lamblia	20S proteasome alpha subunit 5	0.0021	0.0225	0.031
Plasmodium vivax	tubulin alpha chain, putative	0.004	0.0997	0.1654
Giardia lamblia	20S proteasome alpha subunit 6	0.0021	0.0225	0.031
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0021	0.0225	0.031
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0153	0.5791	1
Toxoplasma gondii	peptidase, T1 family protein	0.0021	0.0225	0.0389
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0021	0.0225	0.031
Loa Loa (eye worm)	PAS-3 protein	0.0021	0.0225	0.0225
Echinococcus multilocularis	tubulin alpha chain	0.004	0.0997	0.1722
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0068	0.2199	0.3746
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0153	0.5791	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.004	0.0997	0.1722
Schistosoma mansoni	tubulin subunit gamma	0.004	0.0997	0.1722
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0021	0.0225	0.031
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0021	0.0225	0.031
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0068	0.2199	0.3797
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Echinococcus granulosus	tubulin alpha 1C chain	0.004	0.0997	0.1722
Echinococcus multilocularis	tubulin alpha 1C chain	0.004	0.0997	0.1722
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0021	0.0225	0.031
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0068	0.2199	0.3797
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0021	0.0225	0.031
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0021	0.0225	0.031
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0021	0.0225	0.0389
Echinococcus granulosus	tubulin beta 4A class IVa	0.0102	0.3635	0.6277
Echinococcus multilocularis	tubulin beta 1 chain	0.0102	0.3635	0.6277
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0021	0.0225	0.0389
Trypanosoma brucei	beta tubulin	0.0102	0.3635	0.6246
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0021	0.0225	0.0389
Echinococcus granulosus	beta tubulin	0.0102	0.3635	0.6277
Leishmania major	proteasome beta 7 subunit, putative	0.0021	0.0225	0.031
Onchocerca volvulus	Tyrosine kinase homolog	0.0236	0.9296	1
Toxoplasma gondii	proteasome beta subunit	0.0021	0.0225	0.0389
Brugia malayi	proteasome subunit alpha type 4	0.0021	0.0225	0.0225
Plasmodium falciparum	tubulin beta chain	0.0102	0.3635	0.6246
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0021	0.0225	0.0389
Trypanosoma brucei	beta tubulin	0.0102	0.3635	0.6246
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0021	0.0225	0.0225
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0102	0.3635	0.6246
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0021	0.0225	0.031
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0021	0.0225	0.031
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0153	0.5791	1
Trichomonas vaginalis	tubulin beta chain, putative	0.004	0.0997	0.1654
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0021	0.0225	0.031
Brugia malayi	proteasome subunit beta type 3	0.0021	0.0225	0.0225
Trichomonas vaginalis	tubulin epsilon chain, putative	0.004	0.0997	0.1654
Treponema pallidum	cell division protein FtsZ	0.0017	0.0047	0.5
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0068	0.2199	0.3797
Giardia lamblia	20S proteasome alpha subunit 2	0.0021	0.0225	0.031
Trichomonas vaginalis	tubulin alpha chain, putative	0.0102	0.3635	0.6246
Giardia lamblia	20S proteasome alpha subunit 7	0.0021	0.0225	0.031
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0021	0.0225	0.0389
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0021	0.0225	0.0389
Brugia malayi	tubulin alpha chain - mouse	0.004	0.0997	0.0997
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0021	0.0225	0.0389
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.004	0.0997	0.1722
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0021	0.0225	0.031
Plasmodium falciparum	proteasome subunit beta type-5	0.0153	0.5791	1
Plasmodium falciparum	proteasome subunit beta type-4	0.0021	0.0225	0.031
Trichomonas vaginalis	tubulin beta chain, putative	0.004	0.0997	0.1654
Leishmania major	proteasome beta 2 subunit, putative	0.0021	0.0225	0.031
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0022	0.0268	0.0385
Entamoeba histolytica	tubulin gamma chain	0.004	0.0997	0.1387
Echinococcus multilocularis	Tubulin beta 2C chain	0.0102	0.3635	0.6277
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0021	0.0225	0.031
Echinococcus multilocularis	tubulin alpha	0.004	0.0997	0.1722
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0021	0.0225	0.0225
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0021	0.0225	0.0389
Trichomonas vaginalis	tubulin beta chain, putative	0.004	0.0997	0.1654
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0021	0.0225	0.031
Brugia malayi	proteasome subunit alpha type 6	0.0021	0.0225	0.0225
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0021	0.0225	0.031
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0068	0.2199	0.3746
Loa Loa (eye worm)	hypothetical protein	0.004	0.0997	0.0997
Echinococcus granulosus	tubulin alpha chain	0.004	0.0997	0.1722
Trypanosoma brucei	beta tubulin	0.0102	0.3635	0.6246
Schistosoma mansoni	nephrin	0.002	0.0143	0.0247
Leishmania major	proteasome beta 2 subunit, putative	0.0068	0.2199	0.3746
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0021	0.0225	0.031
Echinococcus granulosus	tubulin alpha chain	0.004	0.0997	0.1722
Brugia malayi	Tubulin alpha chain	0.0017	0.0047	0.0047
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0021	0.0225	0.0389
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0068	0.2199	0.3746
Brugia malayi	alpha-tubulin	0.004	0.0997	0.0997
Leishmania major	alpha tubulin	0.004	0.0997	0.1654
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0021	0.0225	0.0389
Echinococcus granulosus	proteasome subunit beta t family	0.0021	0.0225	0.0389
Echinococcus multilocularis	Tubulin alpha 1 chain	0.004	0.0997	0.1722
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0021	0.0225	0.0389
Brugia malayi	Proteasome A-type and B-type family protein	0.0153	0.5791	0.5791
Echinococcus granulosus	tubulin alpha 3 chain	0.004	0.0997	0.1722
Trypanosoma cruzi	epsilon tubulin, putative	0.004	0.0997	0.1654
Trichomonas vaginalis	tubulin, putative	0.0022	0.0268	0.0385
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0021	0.0225	0.031
Plasmodium vivax	tubulin alpha chain, putative	0.004	0.0997	0.1654
Schistosoma mansoni	tubulin subunit beta	0.0102	0.3635	0.6277
Trichomonas vaginalis	tubulin, putative	0.0102	0.3635	0.6246
Toxoplasma gondii	proteasome subunit beta type, putative	0.0153	0.5791	1
Entamoeba histolytica	tubulin family protein	0.0102	0.3635	0.6126
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0153	0.5791	1
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0021	0.0225	0.031
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0021	0.0225	0.031
Trypanosoma cruzi	tubulin gamma chain	0.004	0.0997	0.1654
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0153	0.5791	1
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0021	0.0225	0.031
Giardia lamblia	Alpha-tubulin	0.004	0.0997	0.1654
Echinococcus granulosus	tubulin alpha 3 chain	0.004	0.0997	0.1722
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0021	0.0225	0.0389
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0021	0.0225	0.0389
Loa Loa (eye worm)	tubulin beta-4 chain	0.0102	0.3635	0.3635
Schistosoma mansoni	tubulin subunit beta	0.0102	0.3635	0.6277
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0021	0.0225	0.031
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0153	0.5791	1
Schistosoma mansoni	alpha tubulin	0.004	0.0997	0.1722
Leishmania major	alpha tubulin	0.004	0.0997	0.1654
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0021	0.0225	1
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Giardia lamblia	Beta tubulin	0.0102	0.3635	0.6246
Echinococcus granulosus	Proteasome subunit alpha beta	0.0021	0.0225	0.0389
Trichomonas vaginalis	tubulin gamma chain, putative	0.004	0.0997	0.1654
Loa Loa (eye worm)	tubulin alpha 2	0.0022	0.0268	0.0268
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0021	0.0225	0.0389
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0021	0.0225	0.031
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0021	0.0225	0.031
Loa Loa (eye worm)	alpha-tubulin	0.004	0.0997	0.0997
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0357	0.0357
Brugia malayi	proteasome subunit alpha type 2	0.0021	0.0225	0.0225
Echinococcus granulosus	roundabout 2	0.0025	0.0357	0.0617
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0021	0.0225	0.031
Echinococcus multilocularis	beta tubulin	0.0102	0.3635	0.6277
Echinococcus granulosus	Tubulin beta 2C chain	0.0102	0.3635	0.6277
Echinococcus multilocularis	tubulin alpha chain	0.004	0.0997	0.1722
Trypanosoma brucei	tubulin gamma chain	0.004	0.0997	0.1654
Leishmania major	gamma-tubulin	0.004	0.0997	0.1654
Echinococcus multilocularis	tubulin subunit TubB	0.004	0.0997	0.1722
Leishmania major	alpha tubulin	0.004	0.0997	0.1654
Giardia lamblia	20S proteasome alpha subunit 1	0.0021	0.0225	0.031
Loa Loa (eye worm)	tubulin gamma chain	0.004	0.0997	0.0997
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0021	0.0225	0.031
Echinococcus multilocularis	roundabout 2	0.0025	0.0357	0.0617
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0021	0.0225	0.031
Echinococcus granulosus	tubulin subunit beta	0.0102	0.3635	0.6277
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0021	0.0225	0.0389
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0021	0.0225	0.0389
Echinococcus multilocularis	neuroglian	0.002	0.0143	0.0247
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0021	0.0225	0.031
Schistosoma mansoni	tubulin subunit delta	0.0017	0.0047	0.0081
Schistosoma mansoni	cell adhesion molecule	0.0021	0.019	0.0327
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0021	0.0225	0.031
Echinococcus multilocularis	beta tubulin	0.0102	0.3635	0.6277
Giardia lamblia	Proteasome subunit beta type 9 precursor	0.0021	0.0225	0.031
Leishmania major	proteasome beta-1 subunit, putative	0.0021	0.0225	0.031
Echinococcus granulosus	tubulin epsilon chain	0.004	0.0997	0.1722
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0068	0.2199	0.3746
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0268	0.0268
Brugia malayi	Tubulin gamma chain	0.004	0.0997	0.0997
Trypanosoma cruzi	beta tubulin, putative	0.0102	0.3635	0.6246
Mycobacterium leprae	probable proteasome (alpha subunit) PrcA	0.0021	0.0225	0.031
Brugia malayi	Proteasome subunit alpha type 7-1	0.0021	0.0225	0.0225
Echinococcus multilocularis	tubulin delta chain	0.0017	0.0047	0.0081
Trypanosoma brucei	alpha tubulin	0.004	0.0997	0.1654
Echinococcus granulosus	twitchin	0.002	0.0143	0.0247
Brugia malayi	Proteasome subunit alpha type 1	0.0021	0.0225	0.0225
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0021	0.0225	0.031
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0021	0.0225	0.0225
Brugia malayi	beta-tubulin, identical	0.0102	0.3635	0.3635
Trypanosoma brucei	proteasome alpha 7 subunit	0.0021	0.0225	0.031
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0253	1	1
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Loa Loa (eye worm)	tubulin beta chain	0.0017	0.0047	0.0047
Leishmania major	proteasome alpha 7 subunit, putative	0.0021	0.0225	0.031
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0021	0.0225	0.031
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0021	0.0225	0.0389
Brugia malayi	proteasome subunit beta type 1	0.0021	0.0225	0.0225
Trichomonas vaginalis	tubulin alpha chain, putative	0.0022	0.0268	0.0385
Echinococcus multilocularis	proteasome subunit beta type 6	0.0021	0.0225	0.0389
Brugia malayi	Tubulin beta chain	0.0022	0.0268	0.0268
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0021	0.0225	0.0225
Echinococcus granulosus	tubulin gamma 1 chain	0.004	0.0997	0.1722
Trypanosoma cruzi	epsilon tubulin, putative	0.004	0.0997	0.1654
Schistosoma mansoni	tubulin subunit alpha	0.004	0.0997	0.1722
Trypanosoma brucei	epsilon tubulin	0.004	0.0997	0.1654
Trichomonas vaginalis	tubulin epsilon chain, putative	0.004	0.0997	0.1654
Echinococcus granulosus	tubulin alpha 1C chain	0.004	0.0997	0.1722
Leishmania major	alpha tubulin	0.004	0.0997	0.1654
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0021	0.0225	0.031
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0021	0.0225	0.031
Brugia malayi	Tubulin alpha-2 chain	0.004	0.0997	0.0997
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0021	0.0225	0.031
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0021	0.0225	0.031
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0153	0.5791	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.004	0.0997	0.1654
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0021	0.0225	0.031
Plasmodium falciparum	tubulin gamma chain	0.004	0.0997	0.1654
Echinococcus granulosus	neuroglian	0.002	0.0143	0.0247
Echinococcus multilocularis	tubulin epsilon chain	0.004	0.0997	0.1722
Brugia malayi	Tubulin alpha-2 chain	0.004	0.0997	0.0997
Leishmania major	alpha tubulin	0.004	0.0997	0.1654
Echinococcus granulosus	peroxisome assembly protein 26	0.004	0.0997	0.1722
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0021	0.0225	0.031
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0017	0.0047	0.0047
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0021	0.0225	0.031
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0021	0.0225	0.031
Toxoplasma gondii	beta-tubulin, putative	0.0102	0.3635	0.6277
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0021	0.0225	0.031
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0068	0.2199	0.3746
Plasmodium vivax	tubulin beta chain, putative	0.0102	0.3635	0.6246
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0021	0.0225	0.031
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0021	0.0225	0.0389
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0021	0.0225	0.0389
Echinococcus multilocularis	hypothetical protein	0.004	0.0997	0.1722
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0068	0.2199	0.3797
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0657	0.0657
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0021	0.0225	0.031
Echinococcus multilocularis	tubulin alpha 3 chain	0.004	0.0997	0.1722
Onchocerca volvulus		0.0231	0.9069	0.9755
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0153	0.5791	1
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0021	0.0225	0.0389
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0021	0.0225	0.031
Echinococcus granulosus	tubulin delta chain	0.0017	0.0047	0.0081
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0021	0.0225	0.031
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0021	0.0225	0.031
Loa Loa (eye worm)	tubulin alpha-2 chain	0.004	0.0997	0.0997
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0047	0.0047
Brugia malayi	proteasome subunit alpha type 1	0.0021	0.0225	0.0225
Schistosoma mansoni	tubulin subunit beta	0.0017	0.0047	0.0081
Brugia malayi	Tubulin beta-1 chain	0.0102	0.3635	0.3635
Entamoeba histolytica	tubulin alpha chain, putative	0.004	0.0997	0.1387
Trypanosoma cruzi	20S proteasome subunit	0.0068	0.2199	0.3746
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0021	0.0225	0.031
Trypanosoma brucei	epsilon tubulin	0.004	0.0997	0.1654
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0021	0.0225	0.031
Echinococcus multilocularis	peroxisome assembly protein 26	0.004	0.0997	0.1722
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0021	0.0225	0.0389
Trypanosoma brucei	proteasome beta 7 subunit	0.0021	0.0225	0.031
Echinococcus granulosus	tubulin alpha	0.004	0.0997	0.1722
Echinococcus multilocularis	Tubulin alpha 1 chain	0.004	0.0997	0.1722
Giardia lamblia	20S proteasome alpha subunit 3	0.0021	0.0225	0.031
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Loa Loa (eye worm)	BEN-1 protein	0.0102	0.3635	0.3635
Echinococcus multilocularis	tubulin alpha chain	0.004	0.0997	0.1722
Schistosoma mansoni	tubulin subunit alpha	0.004	0.0997	0.1722
Leishmania major	alpha tubulin	0.004	0.0997	0.1654
Toxoplasma gondii	beta-1 tubulin, putative	0.0102	0.3635	0.6277
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0021	0.0225	0.0389
Giardia lamblia	20S proteasome alpha subunit 4	0.0021	0.0225	0.031
Trypanosoma brucei	beta tubulin	0.0102	0.3635	0.6246
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0021	0.0225	0.031
Schistosoma mansoni	tubulin subunit alpha	0.004	0.0997	0.1722
Echinococcus granulosus	Tubulin beta 2C chain	0.0102	0.3635	0.6277
Echinococcus granulosus	proteasome subunit alpha type 6	0.0021	0.0225	0.0389
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0068	0.2199	0.3797
Echinococcus granulosus	tubulin alpha chain	0.004	0.0997	0.1722
Trichomonas vaginalis	tubulin gamma chain, putative	0.004	0.0997	0.1654
Leishmania major	alpha tubulin	0.004	0.0997	0.1654
Echinococcus granulosus	tubulin beta 1 chain	0.0102	0.3635	0.6277
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0021	0.0225	0.031
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0021	0.0225	0.031
Leishmania major	proteasome alpha 1 subunit, putative	0.0021	0.0225	0.031
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0021	0.0225	0.031
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0153	0.5791	1
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0021	0.0225	0.031
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0102	0.3635	0.6277
Echinococcus granulosus	Tubulin beta 2C chain	0.0102	0.3635	0.6277
Brugia malayi	Proteasome A-type and B-type family protein	0.0021	0.0225	0.0225
Loa Loa (eye worm)	tubulin alpha 2	0.0022	0.0268	0.0268
Leishmania major	alpha tubulin	0.004	0.0997	0.1654
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0021	0.0225	0.0389
Loa Loa (eye worm)	tubulin beta-2A chain	0.0102	0.3635	0.3635
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0021	0.0225	0.031
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0021	0.0225	0.031
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0021	0.0225	0.031
Leishmania major	proteasome alpha 7 subunit, putative	0.0021	0.0225	0.031
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0021	0.0225	0.031
Toxoplasma gondii	alpha-tubulin I, putative	0.004	0.0997	0.1722
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0021	0.0225	0.031
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0102	0.3635	0.6246
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0022	0.0268	0.0268
Schistosoma mansoni	tubulin subunit beta	0.0102	0.3635	0.6277
Giardia lamblia	Alpha-tubulin	0.004	0.0997	0.1654
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0021	0.0225	0.0389
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Toxoplasma gondii	proteasome subunit	0.0021	0.0225	0.0389
Brugia malayi	Tubulin alpha chain	0.004	0.0997	0.0997
Leishmania major	beta tubulin	0.0102	0.3635	0.6246
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0068	0.2199	0.3746
Trypanosoma brucei	epsilon tubulin	0.004	0.0997	0.1654
Echinococcus granulosus	tubulin alpha chain	0.004	0.0997	0.1722
Trypanosoma brucei	alpha tubulin	0.004	0.0997	0.1654
Giardia lamblia	Proteasome subunit beta type 4 precursor	0.0021	0.0225	0.031
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0021	0.0225	0.0225
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0021	0.0225	0.0225
Brugia malayi	proteasome subunit alpha type 3	0.0021	0.0225	0.0225
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0021	0.0225	0.0225
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0021	0.0225	0.031
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0021	0.0225	0.0389
Schistosoma mansoni	alpha tubulin	0.004	0.0997	0.1722
Echinococcus granulosus	proteasome subunit alpha type 2	0.0021	0.0225	0.0389
Plasmodium vivax	tubulin epsilon chain, putative	0.004	0.0997	0.1654
Giardia lamblia	Proteasome subunit beta type 2	0.0068	0.2199	0.3746
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0022	0.0268	0.0385
Trichomonas vaginalis	tubulin, putative	0.0022	0.0268	0.0385
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0021	0.0225	0.031
Plasmodium falciparum	alpha tubulin 2	0.004	0.0997	0.1654
Brugia malayi	proteasome subunit beta type 2	0.0068	0.2199	0.2199
Trypanosoma brucei	beta tubulin	0.004	0.0997	0.1654
Plasmodium falciparum	alpha tubulin 1	0.004	0.0997	0.1654
Schistosoma mansoni	tubulin subunit alpha	0.0017	0.0047	0.0081
Echinococcus granulosus	proteasome subunit beta type 6	0.0021	0.0225	0.0389
Plasmodium vivax	tubulin gamma chain, putative	0.004	0.0997	0.1654
Echinococcus granulosus	Tubulin alpha 1 chain	0.004	0.0997	0.1722
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0021	0.0225	0.031
Echinococcus granulosus	proteasome subunit beta type 7	0.0021	0.0225	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0021	0.019	0.019
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0021	0.0225	0.0225
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0021	0.0225	0.031
Leishmania major	alpha tubulin	0.004	0.0997	0.1654
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0021	0.0225	0.031
Toxoplasma gondii	alpha tubulin TUBA1	0.004	0.0997	0.1722
Trichomonas vaginalis	tubulin beta chain, putative	0.0102	0.3635	0.6246
Giardia lamblia	Proteasome subunit beta type 7 precursor	0.0021	0.0225	0.031
Trypanosoma brucei	alpha tubulin	0.004	0.0997	0.1654
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0021	0.0225	0.0225
Trichomonas vaginalis	tubulin alpha chain, putative	0.0022	0.0268	0.0385
Entamoeba histolytica	tubulin family protein	0.0102	0.3635	0.6126
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0021	0.0225	0.031
Trichomonas vaginalis	tubulin alpha chain, putative	0.004	0.0997	0.1654
Brugia malayi	Proteasome A-type and B-type family protein	0.0021	0.0225	0.0225
Giardia lamblia	Proteasome subunit beta type 3	0.0021	0.0225	0.031
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0021	0.0225	0.0389
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0021	0.0225	0.031
Echinococcus granulosus	tubulin alpha chain	0.004	0.0997	0.1722
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0021	0.0225	0.0225
Leishmania major	alpha tubulin	0.004	0.0997	0.1654
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0021	0.0225	0.0389
Loa Loa (eye worm)	tubulin beta-1 chain	0.0102	0.3635	0.3635
Echinococcus multilocularis	Tubulin alpha 1 chain	0.004	0.0997	0.1722
Echinococcus multilocularis	proteasome subunit beta type 7	0.0021	0.0225	0.0389
Echinococcus granulosus	tubulin subunit TubB	0.004	0.0997	0.1722
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0153	0.5791	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.004	0.0997	0.1722
Echinococcus granulosus	alpha tubulin	0.004	0.0997	0.1722
Echinococcus granulosus	Tubulin beta 2C chain	0.0102	0.3635	0.6277
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0021	0.0225	0.0389
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0021	0.0225	0.031
Echinococcus multilocularis	tubulin alpha chain	0.004	0.0997	0.1722
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0021	0.0225	0.031
Schistosoma mansoni	tubulin subunit beta	0.0102	0.3635	0.6277
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0021	0.0225	0.031
Loa Loa (eye worm)	alpha-tubulin	0.004	0.0997	0.0997
Echinococcus multilocularis	Tubulin beta 2C chain	0.0102	0.3635	0.6277
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0021	0.0225	0.031
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0021	0.019	0.0327
Schistosoma mansoni	tubulin subunit epsilon	0.004	0.0997	0.1722
Brugia malayi	20S proteasome alpha5 subunit	0.0021	0.0225	0.0225
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0021	0.0225	0.031
Echinococcus granulosus	Tubulin beta 2C chain	0.0102	0.3635	0.6277
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0021	0.0225	0.0389
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.004	0.0997	0.1654

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 31 nM	In vitro inhibitory activity against Coagulation factor X was determined	ChEMBL.	15080981
IC50 (binding)	= 31 nM	In vitro inhibitory activity against Coagulation factor X was determined	ChEMBL.	15080981

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 105290