TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 375.915 | Formula: C19H22ClN3OS
H donors: 0 H acceptors: 1 LogP: 3.33 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)N1CCN(C1=O)CCN1CCCc2c(C1)ccs2
InChi: 1S/C19H22ClN3OS/c20-16-3-1-4-17(13-16)23-11-10-22(19(23)24)9-8-21-7-2-5-18-15(14-21)6-12-25-18/h1,3-4,6,12-13H,2,5,7-11,14H2
InChiKey: KAEBDVFJWYJWBA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dopamine receptor D2	Starlite/ChEMBL	References
Homo sapiens	dopamine receptor D3	Starlite/ChEMBL	References
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	hypothetical protein	dopamine receptor D3	400 aa	392 aa	19.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein kinase, putative	0.1554	1	1
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0072	0.0374	0.0552
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0072	0.0374	0.0373
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0072	0.0374	0.0526
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0072	0.0374	0.0198
Brugia malayi	Uncoordinated protein 104	0.0072	0.0374	0.0356
Schistosoma mansoni	serine/threonine protein kinase	0.0508	0.3209	0.4723
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0226	0.0306
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0072	0.0374	0.0198
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0082	0.0445	1
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0072	0.0374	0.0552
Entamoeba histolytica	protein kinase, putative	0.0082	0.0445	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0072	0.0374	0.0552
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0072	0.0374	0.0552
Schistosoma mansoni	hypothetical protein	0.0072	0.0374	0.0526
Schistosoma mansoni	hypothetical protein	0.0072	0.0374	0.0526
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0975	0.6237	0.9209
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0017	0.0019	0.0028
Echinococcus multilocularis	rac serine:threonine kinase	0.1057	0.6772	1
Brugia malayi	Oxysterol-binding protein	0.0072	0.0374	0.0356
Echinococcus granulosus	oxysterol binding protein 9	0.0072	0.0374	0.0552
Toxoplasma gondii	protein kinase domain-containing protein	0.0082	0.0445	0.0448
Brugia malayi	Plekhf2 protein	0.0072	0.0374	0.0356
Onchocerca volvulus		0.0072	0.0374	0.5
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0072	0.0374	0.0356
Echinococcus multilocularis	pdz domain containing protein	0.0072	0.0374	0.0552
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0082	0.0445	0.0438
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Schistosoma mansoni	atypical protein kinase C	0.0508	0.3209	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0072	0.0374	0.0198
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0017	0.0019	0.0028
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0072	0.0374	0.0552
Brugia malayi	TBC domain containing protein	0.0072	0.0374	0.0356
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0986	0.6308	1
Brugia malayi	Dynamin	0.0072	0.0374	0.0356
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Onchocerca volvulus		0.0072	0.0374	0.5
Echinococcus multilocularis	dynamin 1	0.0072	0.0374	0.0552
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0072	0.0374	0.0356
Schistosoma mansoni	serine/threonine protein kinase	0.0508	0.3209	0.4723
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0072	0.0374	0.0552
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Schistosoma mansoni	zinc finger protein	0.0072	0.0374	0.0526
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0072	0.0374	0.0552
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0508	0.3209	0.3195
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Schistosoma mansoni	oxysterol-binding protein 1	0.0072	0.0374	0.0526
Loa Loa (eye worm)	oxysterol binding protein	0.0072	0.0374	0.0356
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Entamoeba histolytica	PH domain containing protein kinase, putative	0.1057	0.6772	0.6647
Brugia malayi	PH domain containing protein	0.0072	0.0374	0.0356
Echinococcus multilocularis	oxysterol binding protein 1	0.0072	0.0374	0.0552
Echinococcus granulosus	serine/threonine protein kinase	0.1057	0.6772	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0508	0.3209	0.4738
Leishmania major	folate/biopterin transporter, putative	0.0082	0.0445	1
Brugia malayi	PH domain containing protein	0.0072	0.0374	0.0356
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0508	0.3209	0.4738
Echinococcus multilocularis	protein kinase c iota type	0.0508	0.3209	0.4738
Echinococcus granulosus	Pleckstrin y	0.0072	0.0374	0.0552
Schistosoma mansoni	serine/threonine protein kinase	0.0508	0.3209	0.4723
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0508	0.3209	0.3195
Echinococcus multilocularis	Glutaredoxin protein 5	0.0975	0.6237	0.9209
Trichomonas vaginalis	AGC family protein kinase	0.0508	0.3209	0.3084
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Toxoplasma gondii	hypothetical protein	0.0072	0.0374	0.0373
Echinococcus granulosus	oxysterol binding protein 3	0.0072	0.0374	0.0552
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Brugia malayi	Cadps2 protein	0.0072	0.0374	0.0356
Schistosoma mansoni	growth factor receptor-bound protein	0.0072	0.0374	0.0526
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0199	0.018
Schistosoma mansoni	hypothetical protein	0.0072	0.0374	0.0526
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0072	0.0374	0.0552
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0082	0.0445	0.0677
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0199	0.018
Echinococcus granulosus	NDR protein kinase	0.0508	0.3209	0.4738
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.1483	0.9536	0.9535
Echinococcus multilocularis	protein kinase c epsilon type	0.0508	0.3209	0.4738
Echinococcus granulosus	nervana 2	0.0975	0.6237	0.9209
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0072	0.0374	0.0356
Trichomonas vaginalis	alpha chimerin, putative	0.0072	0.0374	0.0198
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0508	0.3209	0.4738
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0082	0.0445	0.0111
Brugia malayi	PH domain containing protein	0.0072	0.0374	0.0356
Brugia malayi	PH domain containing protein	0.0072	0.0374	0.0356
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0072	0.0374	0.0356
Trichomonas vaginalis	protein transport protein sec7, putative	0.0072	0.0374	0.0198
Loa Loa (eye worm)	cytohesin 3	0.0072	0.0374	0.0356
Schistosoma mansoni	hypothetical protein	0.0072	0.0374	0.0526
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0072	0.0374	0.0552
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0199	0.0294
Schistosoma mansoni	myotubularin-related protein	0.0072	0.0374	0.0526
Trypanosoma brucei	protein kinase, putative	0.0082	0.0445	0.0438
Entamoeba histolytica	protein kinase, putative	0.1554	1	1
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0017	0.0019	0.0028
Loa Loa (eye worm)	uncoordinated protein 104	0.0072	0.0374	0.0356
Echinococcus granulosus	calcium dependent secretion activator 1	0.0072	0.0374	0.0552
Echinococcus granulosus	dynamin 1	0.0072	0.0374	0.0552
Toxoplasma gondii	hypothetical protein	0.0072	0.0374	0.0373
Schistosoma mansoni	syntrophin	0.0072	0.0374	0.0526
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0082	0.0445	0.0111
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0082	0.0445	0.0074
Echinococcus granulosus	protein kinase c epsilon type	0.0508	0.3209	0.4738
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Onchocerca volvulus	Protein melted homolog	0.0072	0.0374	0.5
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0082	0.0445	0.0438
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Echinococcus granulosus	nervana 2	0.0975	0.6237	0.9209
Brugia malayi	PH domain containing protein	0.0072	0.0374	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Echinococcus multilocularis	serine threonine protein kinase	0.0508	0.3209	0.4738
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0072	0.0374	0.0552
Schistosoma mansoni	oxysterol-binding protein 1	0.0072	0.0374	0.0526
Brugia malayi	PH domain containing protein	0.0072	0.0374	0.0356
Echinococcus granulosus	pleckstrin y domain containing family A	0.0072	0.0374	0.0552
Entamoeba histolytica	protein kinase, putative	0.0508	0.3209	0.2945
Loa Loa (eye worm)	rho-GTPase-activating	0.0072	0.0374	0.0356
Schistosoma mansoni	goodpasture antigen-binding protein	0.0072	0.0374	0.0526
Trypanosoma cruzi	Protein kinase B	0.1057	0.6772	1
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0975	0.6237	0.9209
Trichomonas vaginalis	AGC family protein kinase	0.1554	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Schistosoma mansoni	dynamin	0.0072	0.0374	0.0526
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0072	0.0374	0.0198
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0986	0.6308	0.9315
Echinococcus multilocularis	cytohesin 1	0.0072	0.0374	0.0552
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0082	0.0445	0.0074
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0508	0.3209	0.3195
Brugia malayi	Variant SH3 domain containing protein	0.0072	0.0374	0.0356
Trichomonas vaginalis	AGC family protein kinase	0.1554	1	1
Echinococcus multilocularis	actin binding protein anillin	0.0072	0.0374	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Brugia malayi	protein kinase C II.	0.0508	0.3209	0.3195
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Echinococcus granulosus	Glutaredoxin protein 5	0.0975	0.6237	0.9209
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0508	0.3209	0.4738
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0161	0.0142
Schistosoma mansoni	serine/threonine-protein kinase	0.1057	0.6772	1
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Echinococcus multilocularis	Pleckstrin y	0.0072	0.0374	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0508	0.3209	0.3195
Echinococcus multilocularis	expressed conserved protein	0.0017	0.0019	0.0028
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0508	0.3209	0.4738
Echinococcus multilocularis	Oxysterol binding protein 11	0.0072	0.0374	0.0552
Brugia malayi	PH domain containing protein	0.0072	0.0374	0.0356
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Echinococcus granulosus	oxysterol binding protein 1	0.0072	0.0374	0.0552
Brugia malayi	PH domain containing protein	0.0072	0.0374	0.0356
Schistosoma mansoni	vav2	0.0072	0.0374	0.0526
Echinococcus granulosus	Protein kinase C brain isozyme	0.0508	0.3209	0.4738
Echinococcus granulosus	DCC interacting protein 13 beta	0.0072	0.0374	0.0552
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0072	0.0374	0.0526
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0508	0.3209	0.3195
Schistosoma mansoni	zinc finger protein	0.0072	0.0374	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0508	0.3209	0.4738
Echinococcus granulosus	serine threonine protein kinase nrc	0.0986	0.6308	0.9315
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0072	0.0374	0.0552
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0082	0.0445	0.0111
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0082	0.0445	0.027
Loa Loa (eye worm)	Plekhf2 protein	0.0072	0.0374	0.0356
Trichomonas vaginalis	AGC family protein kinase	0.0508	0.3209	0.3084
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0072	0.0374	0.0552
Echinococcus granulosus	pdz domain containing protein	0.0072	0.0374	0.0552
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0072	0.0374	0.0564
Brugia malayi	PH domain containing protein	0.0072	0.0374	0.0356
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0072	0.0374	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Echinococcus granulosus	serine:threonine protein kinase N2	0.0508	0.3209	0.4738
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Echinococcus granulosus	Rho GTPase activating protein 24	0.0072	0.0374	0.0552
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0072	0.0374	0.0356
Brugia malayi	p70 ribosomal S6 kinase beta	0.1483	0.9536	0.9535
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Entamoeba histolytica	protein kinase, putative	0.0082	0.0445	0.0074
Onchocerca volvulus		0.0072	0.0374	0.5
Trichomonas vaginalis	AGC family protein kinase	0.1554	1	1
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0082	0.0445	0.0448
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0082	0.0445	0.0111
Brugia malayi	Syntrophin-1	0.0072	0.0374	0.0356
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0508	0.3209	0.3195
Trypanosoma cruzi	NIMA-related kinase, putative	0.0082	0.0445	0.0111
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0072	0.0374	0.0564
Schistosoma mansoni	centaurin alpha	0.0072	0.0374	0.0526
Trichomonas vaginalis	AGC family protein kinase	0.1554	1	1
Entamoeba histolytica	protein kinase, putative	0.1483	0.9536	0.9518
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0072	0.0374	0.0198
Entamoeba histolytica	protein kinase, putative	0.0082	0.0445	0.0074
Schistosoma mansoni	serine/threonine protein kinase	0.0508	0.3209	0.4723
Trichomonas vaginalis	centaurin gamma, putative	0.0072	0.0374	0.0198
Onchocerca volvulus		0.0072	0.0374	0.5
Onchocerca volvulus		0.0072	0.0374	0.5
Echinococcus multilocularis	oxysterol binding protein 3	0.0072	0.0374	0.0552
Leishmania major	hypothetical protein, conserved	0.0072	0.0374	0.833
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0986	0.6308	1
Toxoplasma gondii	AGC kinase	0.1483	0.9536	1
Onchocerca volvulus		0.0072	0.0374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Schistosoma mansoni	serine/threonine-protein kinase	0.1057	0.6772	1
Echinococcus granulosus	myotubularin protein 13	0.0072	0.0374	0.0552
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Entamoeba histolytica	protein kinase, putative	0.0082	0.0445	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.1554	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0072	0.0374	0.0552
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0082	0.0445	1
Echinococcus multilocularis	Pleckstrin y	0.0072	0.0374	0.0552
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0082	0.0445	0.0111
Echinococcus multilocularis	oxysterol binding protein 9	0.0072	0.0374	0.0552
Trichomonas vaginalis	centaurin/arf, putative	0.0072	0.0374	0.0198
Schistosoma mansoni	hypothetical protein	0.0072	0.0374	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Schistosoma mansoni	serine/threonine protein kinase	0.0508	0.3209	0.4723
Brugia malayi	Dynamin	0.0072	0.0374	0.0356
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0072	0.0374	0.0356
Echinococcus granulosus	beta 1 syntrophin	0.0072	0.0374	0.0552
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Plasmodium falciparum	oxysterol-binding protein, putative	0.0072	0.0374	0.0564
Trypanosoma cruzi	NIMA-related kinase, putative	0.0082	0.0445	0.0111
Entamoeba histolytica	hypothetical protein	0.0082	0.0445	0.0074
Brugia malayi	Protein kinase domain containing protein	0.0508	0.3209	0.3195
Echinococcus multilocularis	beta 1 syntrophin	0.0072	0.0374	0.0552
Echinococcus multilocularis	Pleckstrin y	0.0072	0.0374	0.0552
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.1057	0.6772	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0199	0.0294
Trichomonas vaginalis	AGC family protein kinase	0.1554	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Trypanosoma brucei	PH domain containing protein, putative	0.0072	0.0374	0.0367
Schistosoma mansoni	rho gtpase activating protein	0.0072	0.0374	0.0526
Echinococcus multilocularis	myotubularin protein 13	0.0072	0.0374	0.0552
Loa Loa (eye worm)	syntrophin-1	0.0072	0.0374	0.0356
Entamoeba histolytica	p21-activated kinase	0.0082	0.0445	0.0074
Onchocerca volvulus	Putative zinc finger protein	0.0072	0.0374	0.5
Loa Loa (eye worm)	PH domain-containing protein	0.0072	0.0374	0.0356
Loa Loa (eye worm)	AGC/AKT protein kinase	0.1554	1	1
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0508	0.3209	0.4738
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0072	0.0374	0.0552
Trichomonas vaginalis	centaurin/arf, putative	0.0072	0.0374	0.0198
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0072	0.0374	0.0564
Trichomonas vaginalis	centaurin beta, putative	0.0072	0.0374	0.0198
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0072	0.0374	0.0552
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0497	0.3137	0.3012
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0072	0.0374	0.0526
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0017	0.0019	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Brugia malayi	probable spectrin beta chain	0.0072	0.0374	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0072	0.0374	0.0552
Echinococcus granulosus	Oxysterol binding protein 11	0.0072	0.0374	0.0552
Onchocerca volvulus	outspread protein homolog	0.0072	0.0374	0.5
Toxoplasma gondii	AtPH1 family protein	0.0072	0.0374	0.0373
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0082	0.0445	0.0074
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0986	0.6308	0.9315
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0072	0.0374	0.0552
Leishmania major	hypothetical protein, conserved	0.0072	0.0374	0.833
Brugia malayi	Pleckstrin Homology Domain	0.0072	0.0374	0.0356
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0082	0.0445	0.0074
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0082	0.0445	0.0438
Entamoeba histolytica	hypothetical protein	0.0082	0.0445	0.0074
Brugia malayi	MAX-1A	0.0072	0.0374	0.0356
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0072	0.0374	0.0552
Onchocerca volvulus		0.0072	0.0374	0.5
Echinococcus granulosus	protein kinase C gamma type	0.0508	0.3209	0.4738
Trichomonas vaginalis	hypothetical protein	0.0072	0.0374	0.0198
Echinococcus granulosus	Pleckstrin y	0.0072	0.0374	0.0552
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0082	0.0445	0.012
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0508	0.3209	0.4738
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.0445	0.027
Entamoeba histolytica	PH domain containing protein kinase, putative	0.1057	0.6772	0.6647
Entamoeba histolytica	protein kinase, putative	0.0082	0.0445	0.0074
Schistosoma mansoni	dynamin	0.0072	0.0374	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Plasmodium falciparum	PH domain-containing protein, putative	0.0072	0.0374	0.0564
Trichomonas vaginalis	AGC family protein kinase	0.058	0.3673	0.3557
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0082	0.0445	0.0111
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0508	0.3209	0.4738
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0986	0.6308	0.9274
Leishmania major	serine/threonine-protein kinase a, putative	0.0082	0.0445	1
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0508	0.3209	0.3195
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0072	0.0374	0.0356
Entamoeba histolytica	protein kinase 2, putative	0.0986	0.6308	0.6165
Schistosoma mansoni	goodpasture antigen-binding protein	0.0072	0.0374	0.0526
Toxoplasma gondii	Oxysterol-binding protein	0.0072	0.0374	0.0373
Trichomonas vaginalis	centaurin alpha, putative	0.0072	0.0374	0.0198
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0072	0.0374	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0072	0.0374	0.0552
Trypanosoma brucei	rac serine-threonine kinase, putative	0.1554	1	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0508	0.3209	0.4738
Leishmania major	protein kinase, putative	0.0082	0.0445	1
Brugia malayi	Cytohesin 3	0.0072	0.0374	0.0356
Echinococcus multilocularis	nervana 2	0.0975	0.6237	0.9209
Brugia malayi	hypothetical protein	0.0072	0.0374	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Brugia malayi	Oxysterol binding protein	0.0072	0.0374	0.0356
Brugia malayi	Hr1 repeat family protein	0.0508	0.3209	0.3195
Echinococcus granulosus	cGMP dependent protein kinase	0.0017	0.0019	0.0028
Trichomonas vaginalis	kinesin light chain, putative	0.0072	0.0374	0.0198
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0082	0.0445	0.0438
Trichomonas vaginalis	AGC family protein kinase	0.1554	1	1
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0072	0.0374	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0374	0.0356
Echinococcus multilocularis	nervana 2	0.0975	0.6237	0.9209
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0374	0.0198
Trichomonas vaginalis	AGC family protein kinase	0.0508	0.3209	0.3084
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0072	0.0374	0.0526
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0072	0.0374	0.5
Echinococcus granulosus	protein kinase c iota type	0.0508	0.3209	0.4738
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0082	0.0445	0.0111
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0082	0.0445	0.027
Brugia malayi	Protein kinase domain containing protein	0.0508	0.3209	0.3195
Leishmania major	protein kinase, putative	0.0082	0.0445	1
Schistosoma mansoni	serine/threonine kinase	0.0508	0.3209	0.4723
Schistosoma mansoni	serine/threonine protein kinase	0.0508	0.3209	0.4723
Trichomonas vaginalis	protein transport protein sec7, putative	0.0072	0.0374	0.0198
Brugia malayi	Variant SH3 domain containing protein	0.0072	0.0374	0.0356
Schistosoma mansoni	serine/threonine protein kinase	0.0508	0.3209	0.4723
Giardia lamblia	Kinase, AGC PKA	0.0986	0.6308	0.5
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0072	0.0374	0.0552
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0082	0.0445	0.0111
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0072	0.0374	0.5
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0072	0.0374	0.0198
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0226	0.0306
Echinococcus granulosus	cytohesin 1	0.0072	0.0374	0.0552
Echinococcus granulosus	Pleckstrin y	0.0072	0.0374	0.0552
Echinococcus granulosus	GRB2 associated binding protein 3	0.0072	0.0374	0.0552

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.1	Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay	ChEMBL.	19560918
IC50 (binding)	= 6.1	Displacement of [3H]dofetilide from human ERG	ChEMBL.	19635669
Ki (functional)	= 8.5	Antagonist activity at human D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL.	19560918
Ki (binding)	= 8.5	Binding affinity to human DRD2 receptor by GTPgammaS binding assay	ChEMBL.	19635669
Ki (functional)	= 9.2	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL.	19560918
Ki (binding)	= 9.2	Binding affinity to human DRD3 receptor by GTPgammaS binding assay	ChEMBL.	19635669

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL559873

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 1053387