Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenylate cyclase 6 | References | |
Homo sapiens | adenylate cyclase 7 | References | |
Homo sapiens | adenylate cyclase 8 (brain) | References | |
Homo sapiens | adenylate cyclase 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | adenylate cyclase 2 (brain) | References | |
Homo sapiens | adenylate cyclase 3 | References | |
Homo sapiens | adenylate cyclase 9 | References | |
Homo sapiens | glucagon receptor | Starlite/ChEMBL | References |
Homo sapiens | adenylate cyclase 5 | References | |
Homo sapiens | adenylate cyclase 4 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | adenylate cyclase, type IX | adenylate cyclase 1 (brain) | 338 aa | 281 aa | 40.2 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon receptor | 477 aa | 457 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0123 | 0.0168 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0168 | 0.0168 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0123 | 0.0168 | 0.0362 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0123 | 0.0168 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0123 | 0.0168 | 0.0362 |
Onchocerca volvulus | 0.0618 | 0.383 | 0.3974 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0123 | 0.0168 | 0.5 |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.1368 | 0.9383 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0728 | 0.4645 | 0.7529 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0123 | 0.0168 | 0.0273 |
Echinococcus granulosus | acetylcholinesterase | 0.0728 | 0.4645 | 0.7529 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0123 | 0.0168 | 0.0362 |
Echinococcus granulosus | neuroligin | 0.0123 | 0.0168 | 0.0273 |
Onchocerca volvulus | Adenylate cyclase type 2 homolog | 0.0618 | 0.383 | 0.3974 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0123 | 0.0168 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0168 | 0.0168 |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0618 | 0.383 | 0.6208 |
Loa Loa (eye worm) | hypothetical protein | 0.0618 | 0.383 | 0.383 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0123 | 0.0168 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0168 | 0.0168 |
Brugia malayi | Adenylyl cyclase protein | 0.0618 | 0.383 | 0.8246 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0123 | 0.0168 | 0.0362 |
Onchocerca volvulus | 0.0586 | 0.3593 | 0.3717 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0123 | 0.0168 | 0.0273 |
Loa Loa (eye worm) | carboxylesterase | 0.0728 | 0.4645 | 0.4645 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0168 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0168 | 0.0168 |
Brugia malayi | Carboxylesterase family protein | 0.0123 | 0.0168 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0168 | 0.0168 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0123 | 0.0168 | 0.0273 |
Brugia malayi | Carboxylesterase family protein | 0.0123 | 0.0168 | 0.0362 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0123 | 0.0168 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1336 | 0.9146 | 0.9146 |
Echinococcus multilocularis | acetylcholinesterase | 0.0728 | 0.4645 | 0.7529 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0123 | 0.0168 | 0.0273 |
Echinococcus granulosus | adenylate cyclase type IX | 0.0934 | 0.617 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0123 | 0.0168 | 0.0362 |
Echinococcus granulosus | carboxylesterase 5A | 0.0728 | 0.4645 | 0.7529 |
Echinococcus multilocularis | acetylcholinesterase | 0.0728 | 0.4645 | 0.7529 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0728 | 0.4645 | 0.7529 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0123 | 0.0168 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0168 | 0.0168 |
Brugia malayi | hypothetical protein | 0.0123 | 0.0168 | 0.0362 |
Echinococcus granulosus | adenylate cyclase 9 | 0.0618 | 0.383 | 0.6208 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0728 | 0.4645 | 1 |
Echinococcus multilocularis | neuroligin | 0.0123 | 0.0168 | 0.0273 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0123 | 0.0168 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0123 | 0.0168 | 0.0362 |
Schistosoma mansoni | acetylcholinesterase | 0.0123 | 0.0168 | 0.0362 |
Brugia malayi | Carboxylesterase family protein | 0.0123 | 0.0168 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0728 | 0.4645 | 0.4645 |
Echinococcus multilocularis | adenylate cyclase type IX | 0.0934 | 0.617 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0123 | 0.0168 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0728 | 0.4645 | 0.4645 |
Brugia malayi | Carboxylesterase family protein | 0.0728 | 0.4645 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0123 | 0.0168 | 0.0168 |
Brugia malayi | Carboxylesterase family protein | 0.0728 | 0.4645 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0123 | 0.0168 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0728 | 0.4645 | 0.4645 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 70 nM | In vitro binding affinity against human glucagon receptor (h-GlucR) was determined | ChEMBL. | 15080976 |
Ki (binding) | = 70 nM | In vitro binding affinity against human glucagon receptor (h-GlucR) was determined | ChEMBL. | 15080976 |
Ki (binding) | > 2000 nM | In vitro inhibitory activity against glucagon induced human adenylate cyclase | ChEMBL. | 15080976 |
Ki (binding) | > 2000 nM | In vitro inhibitory activity against glucagon induced human adenylate cyclase | ChEMBL. | 15080976 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.