Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Beta tubulin | 0.0051 | 0.4407 | 0.4033 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0079 | 0.8415 | 1 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0083 | 0.9065 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0078 | 0.8269 | 0.8153 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0051 | 0.4407 | 0.4033 |
Brugia malayi | Peroxidasin | 0.0078 | 0.8269 | 0.9812 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.8269 | 0.8153 |
Trypanosoma cruzi | beta tubulin, putative | 0.0051 | 0.4407 | 0.5 |
Loa Loa (eye worm) | beta-tubulin | 0.0051 | 0.4407 | 0.4033 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0051 | 0.4407 | 0.4033 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.8269 | 0.8153 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.8269 | 0.8153 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0051 | 0.4407 | 0.4033 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0083 | 0.9065 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.009 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0078 | 0.8269 | 0.9812 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0051 | 0.4407 | 0.4033 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.8269 | 0.8153 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0051 | 0.4407 | 0.4033 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0051 | 0.4407 | 0.4862 |
Schistosoma mansoni | peroxidasin | 0.0078 | 0.8269 | 0.8153 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Plasmodium falciparum | tubulin beta chain | 0.0051 | 0.4407 | 0.5 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0051 | 0.4407 | 0.4033 |
Onchocerca volvulus | Peroxidase homolog | 0.0078 | 0.8269 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0078 | 0.8269 | 1 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0051 | 0.4407 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0051 | 0.4407 | 0.4033 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0051 | 0.4407 | 0.4033 |
Schistosoma mansoni | tubulin subunit beta | 0.0051 | 0.4407 | 0.4033 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0051 | 0.4407 | 0.4033 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0051 | 0.4407 | 0.4033 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.8269 | 0.8153 |
Echinococcus granulosus | tubulin subunit beta | 0.0051 | 0.4407 | 0.4033 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 0.8269 | 0.9812 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.8269 | 0.8153 |
Schistosoma mansoni | tubulin subunit beta | 0.0051 | 0.4407 | 0.4033 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0083 | 0.9065 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0051 | 0.4407 | 0.4853 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0083 | 0.9065 | 1 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Onchocerca volvulus | 0.0078 | 0.8269 | 1 | |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0083 | 0.9065 | 0.9003 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.009 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 0.8269 | 0.9812 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.009 | 1 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0051 | 0.4407 | 0.4033 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 0.8269 | 0.8153 |
Trypanosoma brucei | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0083 | 0.9065 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0051 | 0.4407 | 0.4033 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0051 | 0.4407 | 0.4033 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0083 | 0.9065 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0051 | 0.4407 | 0.4033 |
Onchocerca volvulus | Peroxidasin homolog | 0.0078 | 0.8269 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 0.8269 | 0.8153 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.8269 | 0.8153 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0051 | 0.4407 | 0.4033 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0083 | 0.9065 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0083 | 0.9065 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0083 | 0.9065 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0078 | 0.8269 | 1 |
Toxoplasma gondii | beta tubulin | 0.0051 | 0.4407 | 0.4033 |
Schistosoma mansoni | peroxidasin | 0.0078 | 0.8269 | 0.8153 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0051 | 0.4407 | 0.4033 |
Schistosoma mansoni | tubulin subunit beta | 0.0051 | 0.4407 | 0.4033 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0051 | 0.4407 | 0.4033 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.8269 | 0.8153 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0051 | 0.4407 | 0.4033 |
Onchocerca volvulus | Dual oxidase homolog | 0.0078 | 0.8269 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0063 | 0.6046 | 0.6669 |
Loa Loa (eye worm) | tubulin beta chain | 0.0051 | 0.4407 | 0.4033 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0079 | 0.8415 | 0.8309 |
Brugia malayi | beta-tubulin, identical | 0.0051 | 0.4407 | 0.4853 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.8269 | 0.8153 |
Echinococcus granulosus | beta tubulin | 0.0051 | 0.4407 | 0.4033 |
Toxoplasma gondii | beta-tubulin, putative | 0.0051 | 0.4407 | 0.4033 |
Trypanosoma brucei | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Brugia malayi | hypothetical protein | 0.0078 | 0.8269 | 0.9812 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0051 | 0.4407 | 0.4033 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.009 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0051 | 0.4407 | 0.4033 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.8269 | 0.8153 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0083 | 0.9065 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0051 | 0.4407 | 0.4033 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.8269 | 0.8153 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.8269 | 0.8153 |
Plasmodium vivax | tubulin beta chain, putative | 0.0051 | 0.4407 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0083 | 0.9065 | 0.9003 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 0.8269 | 0.8153 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0083 | 0.9065 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0083 | 0.9065 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0079 | 0.8415 | 0.8309 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0083 | 0.9065 | 1 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0051 | 0.4407 | 0.4033 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0083 | 0.9065 | 1 |
Onchocerca volvulus | 0.0078 | 0.8269 | 1 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0078 | 0.8269 | 1 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.009 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0051 | 0.4407 | 0.4033 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0051 | 0.4407 | 0.4033 |
Echinococcus granulosus | beta tubulin | 0.0051 | 0.4407 | 0.4033 |
Echinococcus granulosus | peroxidasin | 0.0078 | 0.8269 | 0.8153 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0083 | 0.9065 | 1 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Onchocerca volvulus | 0.0078 | 0.8269 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 0.8269 | 0.9812 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0051 | 0.4407 | 0.4862 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 0.8269 | 0.9812 |
Leishmania major | beta tubulin | 0.0051 | 0.4407 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.8269 | 0.8153 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0083 | 0.9065 | 0.9003 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.009 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0083 | 0.9065 | 1 |
Giardia lamblia | Beta tubulin | 0.0051 | 0.4407 | 0.4033 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0078 | 0.8269 | 0.8153 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 0.8269 | 0.8153 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0051 | 0.4407 | 0.4033 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.8269 | 0.8153 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0051 | 0.4407 | 0.4033 |
Echinococcus multilocularis | beta tubulin | 0.0051 | 0.4407 | 0.4033 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0051 | 0.4407 | 0.4862 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 0.8269 | 0.9812 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0051 | 0.4407 | 0.4862 |
Entamoeba histolytica | tubulin family protein | 0.0051 | 0.4407 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0051 | 0.4407 | 0.4862 |
Trichomonas vaginalis | tubulin, putative | 0.0051 | 0.4407 | 0.4862 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0079 | 0.8415 | 0.8309 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -28 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.