Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.3235 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0122 | 0.9148 | 0.9148 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.3133 | 0.3133 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0122 | 0.9148 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.073 | 0.0614 |
Schistosoma mansoni | DNA polymerase eta | 0.0021 | 0.0341 | 0.0341 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1884 | 0.1884 |
Brugia malayi | TAR-binding protein | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0179 | 0.0179 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0054 | 0.3235 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.4185 | 0.4467 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0018 | 0.0132 | 0.0132 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.073 | 0.073 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0018 | 0.0132 | 0.0132 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.073 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 0.073 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0367 | 0.0367 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.073 | 0.0707 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.073 | 0.0441 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.073 | 0.073 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.4185 | 0.4467 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0341 | 0.0341 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0341 | 0.0341 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0054 | 0.3235 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0179 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0642 | 0.0642 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.5113 | 0.5113 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0179 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.0341 | 0.0277 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.073 | 0.0614 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.073 | 0.0441 |
Onchocerca volvulus | 0.0025 | 0.073 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0054 | 0.3235 | 0.3235 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0054 | 0.3235 | 0.3235 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0132 | 0.0132 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.3235 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0054 | 0.3235 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.4185 | 0.4185 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.6818 | 0.6818 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.073 | 0.0707 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.0341 | 0.0341 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0122 | 0.9148 | 0.9148 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0179 | 0.0098 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.0341 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0179 | 0.0179 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.073 | 0.0614 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0179 | 0.0179 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.3235 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0054 | 0.3235 | 1 |
Brugia malayi | Bromodomain containing protein | 0.008 | 0.551 | 0.551 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0132 | 0.0132 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.4185 | 0.4185 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0132 | 0.0132 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0132 | 0.0132 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.6818 | 0.6818 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.3133 | 0.3133 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.073 | 0.0614 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0642 | 0.0642 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.073 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.3235 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0064 | 0.409 | 0.409 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0642 | 0.0642 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.0341 | 0.0341 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.0862 | 0.0862 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.6818 | 0.6818 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0179 | 0.0179 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1683 | 0.1683 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.073 | 0.073 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.4185 | 0.4185 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.073 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0064 | 0.409 | 0.409 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0096 | 0.6818 | 0.6818 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0132 | 0.0132 |
Brugia malayi | MAP kinase sur-1 | 0.0054 | 0.3235 | 0.3235 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0341 | 0.0181 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0341 | 0.0181 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.0341 | 0.0341 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 0.4185 | 0.4365 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0114 | 0.8435 | 0.8435 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.3133 | 0.3133 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0096 | 0.6818 | 0.6818 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0189 | 0.0189 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.6818 | 0.6818 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.073 | 0.073 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0465 | 0.0465 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.073 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0341 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2111 | 0.2111 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.0341 | 0.0341 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0179 | 0.5 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0122 | 0.9148 | 0.9148 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0465 | 0.0465 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.073 | 0.0614 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.073 | 0.073 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.073 | 0.073 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.2104 | 0.2104 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1683 | 0.1683 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0054 | 0.3235 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.6818 | 0.6818 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1683 | 0.1683 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.0341 | 0.0277 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.3235 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0122 | 0.9148 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.233 | 0.233 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0054 | 0.3235 | 0.3235 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.073 | 0.0614 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2508 | 0.2508 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.3235 | 0.3235 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.4185 | 0.4185 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.6818 | 0.6818 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1884 | 0.1884 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0179 | 0.0179 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0018 | 0.0132 | 0.0132 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.4185 | 0.4521 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.073 | 0.0441 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0122 | 0.9148 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0054 | 0.3235 | 0.3286 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.0341 | 0.0341 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0054 | 0.3235 | 0.3235 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.4185 | 0.4467 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.4185 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0054 | 0.3235 | 0.3235 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.3235 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.3133 | 0.3133 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.0341 | 0.0341 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0018 | 0.0132 | 0.0132 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0122 | 0.9148 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 1 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0122 | 0.9148 | 0.9148 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0341 | 0.0341 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0341 | 0.0341 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.073 | 0.0614 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.6818 | 0.6818 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.073 | 0.0614 |
Schistosoma mansoni | bromodomain containing protein | 0.0068 | 0.4423 | 0.4423 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0054 | 0.3235 | 0.3286 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 64 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 by agar dilution method | ChEMBL. | 19376613 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.