Detailed information for compound 1054440

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 330.769 | Formula: C16H15ClN4O2
  • H donors: 0 H acceptors: 2 LogP: 2.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(Cn1nc(oc1=O)c1ccncc1)Cc1ccccc1Cl
  • InChi: 1S/C16H15ClN4O2/c1-20(10-13-4-2-3-5-14(13)17)11-21-16(22)23-15(19-21)12-6-8-18-9-7-12/h2-9H,10-11H2,1H3
  • InChiKey: NHEHQSUAZAUJAK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi trypanothione synthetase 0.0068 0.0056 0.052
Plasmodium vivax subtilisin-like serine protease, putative 0.0288 0.0394 0.7105
Brugia malayi GCC2 and GCC3 family protein 0.0059 0.0043 0.0043
Chlamydia trachomatis protoporphyrinogen oxidase 0.01 0.0106 0.5
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0217 0.0285 0.0285
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0304 0.0417 0.366
Brugia malayi Integrin beta pat-3 precursor 0.1591 0.2387 0.2387
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0006 0.0006
Plasmodium falciparum plasmepsin I 0.0035 0.0006 0.0066
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0288 0.0394 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0105 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0033 0.0033
Brugia malayi hypothetical protein 0.0039 0.0013 0.0013
Onchocerca volvulus 0.0074 0.0065 0.0844
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0076 0.0069 0.1116
Loa Loa (eye worm) hypothetical protein 0.0101 0.0107 0.0107
Echinococcus granulosus protein kinase c epsilon type 0.0093 0.0094 0.0094
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0074 0.0065 0.0065
Echinococcus granulosus tissue type plasminogen activator 0.0033 0.0002 0.0002
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0304 0.0417 0.399
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0006 0.0006
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0061 0.0045 0.0472
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0109 0.012 0.1131
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.01 0.0106 0.2131
Echinococcus granulosus protein arginine methyltransferase 0.0194 0.025 0.025
Mycobacterium ulcerans chitinase/cellulase 0.0062 0.0048 0.0539
Mycobacterium ulcerans Sir2-like regulatory protein 0.0105 0.0113 0.2334
Plasmodium falciparum plasmepsin X 0.0035 0.0006 0.0066
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.0033 0.0033
Plasmodium falciparum subtilisin-like protease 2 0.0288 0.0394 0.7105
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0288 0.0394 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0061 0.0045 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.1305 0.195 0.3201
Loa Loa (eye worm) acyl carrier protein 0.0036 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.01 0.0106 0.0106
Brugia malayi hypothetical protein 0.0035 0.0006 0.0006
Echinococcus multilocularis protein will die slowly 0.0276 0.0375 0.0469
Brugia malayi hypothetical protein 0.0039 0.0013 0.0013
Leishmania major UDP-galactopyranose mutase 0.01 0.0106 0.0996
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0109 0.012 0.0197
Loa Loa (eye worm) cuticular endochitinase 0.0073 0.0064 0.0064
Schistosoma mansoni site-1 peptidase (S08 family) 0.0288 0.0394 0.0394
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0229 0.0303 0.0303
Echinococcus granulosus protein arginine N methyltransferase 7 0.0109 0.012 0.012
Mycobacterium tuberculosis Possible chitinase 0.0062 0.0048 0.1183
Echinococcus granulosus Tolloid protein 1 0.0057 0.004 0.004
Onchocerca volvulus 0.0035 0.0006 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0033 0.0054
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0109 0.012 0.1131
Echinococcus granulosus lysine specific histone demethylase 1A 0.01 0.0106 0.0106
Onchocerca volvulus Putative endochitinase 0.0073 0.0064 0.0831
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0052 0.0033 0.0033
Echinococcus granulosus methyltransferase protein 5 0.0109 0.012 0.012
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0057 0.004 0.004
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0288 0.0394 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0194 0.025 0.041
Loa Loa (eye worm) hypothetical protein 0.01 0.0106 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0033 0.0054
Loa Loa (eye worm) hypothetical protein 0.0243 0.0325 0.0325
Onchocerca volvulus 0.0042 0.0017 0.0223
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0113 0.0113
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0081 0.0076 0.132
Brugia malayi Sodium:solute symporter family protein 0.0038 0.001 0.001
Toxoplasma gondii histone deacetylase SIR2-like 0.0105 0.0113 0.2231
Plasmodium vivax plasmepsin V, putative 0.0393 0.0553 1
Schistosoma mansoni discoidin domain receptor 0.0052 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.013 0.0151 0.0151
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0113 0.0186
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0113 0.0186
Onchocerca volvulus Putative endochitinase 0.0073 0.0064 0.0831
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.0069 0.1116
Echinococcus multilocularis MAM 0.0101 0.0107 0.0133
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.0033 0.0041
Loa Loa (eye worm) transcriptional regulator 0.0712 0.1043 0.1043
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0109 0.012 0.1131
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.0013
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0105 0.0113 0.1067
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0033 0.0054
Loa Loa (eye worm) chitinase I 0.0073 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0288 0.0394 0.0646
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0712 0.1043 0.1303
Trichomonas vaginalis conserved hypothetical protein 0.1305 0.195 0.3201
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0493 0.0708 0.0884
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.1305 0.195 0.3201
Schistosoma mansoni high-affinity choline transporter 0.0038 0.001 0.001
Schistosoma mansoni growth factor receptor-bound protein 0.0144 0.0173 0.0173
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Toxoplasma gondii bicoid-interacting protein BIN3 0.0109 0.012 0.2365
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0712 0.1043 0.1711
Brugia malayi protein kinase C II. 0.0093 0.0094 0.0094
Echinococcus granulosus sodium:glucose cotransporter 0.0147 0.0178 0.0178
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0105 0.0113 0.2015
Brugia malayi Kringle domain containing protein 0.0033 0.0002 0.0002
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.0033 0.0033
Plasmodium falciparum plasmepsin II 0.0035 0.0006 0.0066
Leishmania major subtilisin-like serine peptidase 0.0288 0.0394 0.3764
Entamoeba histolytica hypothetical protein, conserved 0.0105 0.0113 0.1072
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0288 0.0394 0.0394
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0712 0.1043 1
Plasmodium vivax LCCL domain-containing protein 0.0052 0.0033 0.0551
Loa Loa (eye worm) hypothetical protein 0.0101 0.0107 0.0107
Schistosoma mansoni hypothetical protein 0.1305 0.195 0.195
Echinococcus multilocularis c4b binding protein beta chain 0.0039 0.0013 0.0016
Mycobacterium leprae Possible secreted protease 0.0288 0.0394 1
Schistosoma mansoni btb and poz domain-containing protein 0.0052 0.0033 0.0033
Brugia malayi endochitinase 0.0073 0.0064 0.0064
Echinococcus granulosus Furin 1 0.1594 0.2391 0.2391
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0109 0.012 0.0645
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0105 0.0113 0.1067
Echinococcus granulosus membrane bound transcription factor site 1 0.0288 0.0394 0.0394
Echinococcus granulosus high affinity choline transporter 1 0.0038 0.001 0.001
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0052 0.0033 0.0054
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0712 0.1043 1
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0052 0.0033 0.0054
Schistosoma mansoni tyrosine kinase 0.0464 0.0663 0.0663
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0027
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0288 0.0394 0.3764
Brugia malayi Carm1-pending protein 0.0109 0.012 0.012
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0076 0.0069 0.1734
Mycobacterium ulcerans NAD-dependent deacetylase 0.0105 0.0113 0.2334
Echinococcus granulosus protein will die slowly 0.0276 0.0375 0.0375
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Schistosoma mansoni amine oxidase 0.01 0.0106 0.0106
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0109 0.012 0.2365
Brugia malayi Sushi domain 0.0039 0.0013 0.0013
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0113 0.0113
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0035 0.0006 0.0007
Trichomonas vaginalis hypothetical protein 0.1305 0.195 0.3201
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.01 0.0106 0.2131
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1594 0.2391 0.3925
Plasmodium falciparum plasmepsin IV 0.0035 0.0006 0.0066
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0109 0.012 0.1131
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0194 0.025 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0033 0.0054
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0006 0.0006
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0288 0.0394 1
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.001 0.001
Toxoplasma gondii hypothetical protein 0.004 0.0014 0.0226
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0194 0.025 0.025
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0006 0.0066
Loa Loa (eye worm) subtilase 0.0288 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0288 0.0394 0.0646
Trypanosoma brucei SIR2-like protein 4, putative 0.0105 0.0113 0.0577
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.0033 0.061
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.0033 0.061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Plasmodium vivax protoporphyrinogen oxidase, putative 0.01 0.0106 0.188
Mycobacterium tuberculosis Conserved hypothetical protein 0.01 0.0106 0.2667
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0035 0.0006 0.001
Echinococcus multilocularis neuroendocrine convertase 2 0.4147 0.6299 0.7871
Onchocerca volvulus 0.0039 0.0013 0.0167
Onchocerca volvulus Putative endochitinase 0.0073 0.0064 0.0831
Loa Loa (eye worm) hypothetical protein 0.004 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0057 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0038 0.001 0.001
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.01 0.0106 0.2082
Loa Loa (eye worm) hypothetical protein 0.0105 0.0113 0.0113
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0076 0.0069 0.172
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0144 0.0173 0.0173
Schistosoma mansoni hypothetical protein 0.0052 0.0033 0.0033
Echinococcus granulosus serine:threonine protein kinase N2 0.0076 0.0068 0.0068
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0304 0.0417 0.3993
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0194 0.025 0.4492
Schistosoma mansoni dock 0.0052 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0033 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0033 0.0054
Schistosoma mansoni septate junction protein 0.0072 0.0062 0.0062
Echinococcus multilocularis protoporphyrinogen oxidase 0.01 0.0106 0.0132
Entamoeba histolytica SWIRM domain protein 0.0042 0.0016 0.0141
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0042 0.0017 0.0017
Schistosoma mansoni chromatin regulatory protein sir2 0.0712 0.1043 0.1043
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4012 0.6093 0.6093
Echinococcus multilocularis 0.01 0.0106 0.0132
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0061 0.0045 0.0472
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0105 0.0113 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.1305 0.195 0.3201
Leishmania major sir2-family protein-like protein 0.0105 0.0113 0.1067
Echinococcus multilocularis integrin beta 2 0.1175 0.1751 0.2188
Schistosoma mansoni growth factor receptor-bound protein 0.0144 0.0173 0.0173
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0105 0.0113 0.0142
Toxoplasma gondii aspartyl protease 0.0035 0.0006 0.0073
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0105 0.0113 0.0274
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0194 0.025 0.025
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.6566 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1305 0.195 0.3201
Echinococcus multilocularis chromatin regulatory protein sir2 0.0712 0.1043 0.1303
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0057 0.0039 0.0964
Brugia malayi hypothetical protein 0.0304 0.0417 0.0417
Plasmodium falciparum apical sushi protein 0.0039 0.0013 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0033 0.0054
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0042 0.0017 0.0017
Schistosoma mansoni discoidin domain receptor 0.0052 0.0033 0.0033
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0039 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.0013
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0147 0.0177 0.0177
Brugia malayi hypothetical protein 0.01 0.0106 0.0106
Onchocerca volvulus 0.0101 0.0107 0.1384
Plasmodium vivax aspartyl protease, putative 0.0035 0.0006 0.0066
Onchocerca volvulus Putative endochitinase 0.0073 0.0064 0.0831
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0319 0.0441 0.422
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0057 0.004 0.004
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.004 0.0013 0.0223
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0288 0.0394 1
Leishmania major silent information regulator 2, putative 0.0712 0.1043 1
Brugia malayi GH02984p 0.0038 0.001 0.001
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0045 0.0021 0.0504
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Toxoplasma gondii aspartyl protease ASP1 0.0035 0.0006 0.0073
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0081 0.0076 0.1911
Giardia lamblia Hypothetical protein 0.0712 0.1043 0.2827
Brugia malayi transcriptional regulator, Sir2 family protein 0.0712 0.1043 0.1043
Echinococcus granulosus c-Jun N-terminal kinases 0.0229 0.0303 0.0303
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0113 0.0186
Brugia malayi Calcium binding EGF domain containing protein 0.005 0.003 0.003
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0006 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Echinococcus granulosus neuroendocrine convertase 2 0.4147 0.6299 0.6299
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.01 0.0106 0.188
Schistosoma mansoni c4b-binding protein beta chain 0.0039 0.0013 0.0013
Brugia malayi Protein kinase domain containing protein 0.0101 0.0107 0.0107
Onchocerca volvulus 0.0039 0.0013 0.0167
Brugia malayi Sex muscle abnormal protein 5 0.0144 0.0173 0.0173
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0319 0.0441 0.422
Onchocerca volvulus 0.0039 0.0013 0.0167
Mycobacterium ulcerans thioesterase TesA 0.0066 0.0053 0.0683
Brugia malayi hypothetical protein 0.0039 0.0013 0.0013
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0113 0.0186
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0288 0.0394 0.0394
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0035 0.0006 0.0006
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0035 0.0006 0.0073
Loa Loa (eye worm) sirtuin 4 0.0105 0.0113 0.0113
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0042 0.0016 0.0016
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0709 0.1038 0.1038
Brugia malayi hypothetical protein 0.0243 0.0325 0.0325
Echinococcus multilocularis protein arginine methyltransferase 0.0194 0.025 0.0312
Loa Loa (eye worm) hypothetical protein 0.0035 0.0006 0.0006
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0006 0.0006
Brugia malayi hypothetical protein 0.0101 0.0107 0.0107
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0275 0.0373 0.0373
Schistosoma mansoni protein kinase 0.0248 0.0332 0.0332
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0066 0.0053 0.0683
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0033 0.0054
Echinococcus multilocularis Furin 1 0.1594 0.2391 0.2988
Brugia malayi SWIRM domain containing protein 0.0042 0.0016 0.0016
Mycobacterium ulcerans polyketide synthase 0.0081 0.0076 0.132
Loa Loa (eye worm) fatty acid synthase 0.0078 0.0071 0.0071
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0304 0.0417 0.399
Loa Loa (eye worm) WD40 repeat protein 0.0276 0.0375 0.0375
Onchocerca volvulus 0.0052 0.0033 0.0424
Schistosoma mansoni SWI/SNF complex-related 0.0042 0.0016 0.0016
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0194 0.025 0.025
Echinococcus granulosus C type lectin domian containing protein 0.0039 0.0013 0.0013
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0074 0.0065 0.1627
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0076 0.0069 0.0069
Brugia malayi Protein arginine N-methyltransferase 0.0109 0.012 0.012
Plasmodium falciparum subtilisin-like protease 1 0.0288 0.0394 0.7105
Brugia malayi Angiotensin-converting enzyme family protein 0.0709 0.1038 0.1038
Plasmodium falciparum LCCL domain-containing protein 0.0052 0.0033 0.0551
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0033 0.0054
Echinococcus multilocularis serine:threonine protein kinase N2 0.0085 0.0082 0.0103
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1594 0.2391 0.3925
Toxoplasma gondii subtilisin SUB9 0.0288 0.0394 0.7867
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0052 0.0033 0.0129
Schistosoma mansoni protein kinase 0.0248 0.0332 0.0332
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0115 0.0128 0.3239
Leishmania major arginine N-methyltransferase, type I 0.0109 0.012 0.1131
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0194 0.025 0.0312
Plasmodium vivax plasmepsin IV, putative 0.0035 0.0006 0.0066
Mycobacterium ulcerans oxidoreductase 0.01 0.0106 0.2131
Entamoeba histolytica hypothetical protein 0.0304 0.0417 0.3993
Onchocerca volvulus 0.0039 0.0013 0.0167
Schistosoma mansoni hypothetical protein 0.0276 0.0375 0.0375
Onchocerca volvulus 0.004 0.0014 0.0176
Loa Loa (eye worm) hypothetical protein 0.0035 0.0006 0.0006
Leishmania major trypanothione synthetase, putative 0.0068 0.0056 0.052
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0033 0.0054
Onchocerca volvulus 0.0136 0.0161 0.2083
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0033 0.0054
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0051 0.003 0.003
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.0033 0.061
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0105 0.0113 0.1072
Trichomonas vaginalis conserved hypothetical protein 0.1305 0.195 0.3201
Onchocerca volvulus 0.0039 0.0013 0.0167
Echinococcus multilocularis expressed protein 0.0361 0.0504 0.063
Plasmodium vivax hypothetical protein, conserved 0.01 0.0106 0.188
Entamoeba histolytica SWIRM domain protein 0.0042 0.0016 0.0141
Loa Loa (eye worm) transcriptional regulator 0.0105 0.0113 0.0113
Toxoplasma gondii subtilisin SUB1 0.0288 0.0394 0.7867
Plasmodium vivax hypothetical protein, conserved 0.01 0.0106 0.188
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0052 0.0033 0.0041
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.0006 0.0006
Brugia malayi EGF-like domain containing protein 0.004 0.0014 0.0014
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0105 0.0113 0.0142
Toxoplasma gondii subtilisin SUB2 0.0288 0.0394 0.7867
Schistosoma mansoni hypothetical protein 0.0033 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0101 0.0107 0.0107
Echinococcus multilocularis tissue type plasminogen activator 0.0033 0.0002 0.0003
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0229 0.0303 0.0379
Toxoplasma gondii subtilisin SUB7 0.0288 0.0394 0.7867
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0109 0.012 0.012
Toxoplasma gondii subtilisin SUB5 0.0288 0.0394 0.7867
Echinococcus granulosus fibrillin 1 0.0041 0.0016 0.0016
Toxoplasma gondii aspartyl protease ASP3 0.0035 0.0006 0.0073
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0194 0.025 0.041
Mycobacterium ulcerans polyketide synthase Pks13 0.0115 0.0128 0.2745
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0109 0.012 0.015
Toxoplasma gondii subtilisin SUB11 0.0288 0.0394 0.7867
Loa Loa (eye worm) hypothetical protein 0.005 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0288 0.0394 0.0646
Onchocerca volvulus 0.0039 0.0013 0.0167
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Leishmania major chitinase 0.0073 0.0064 0.0594
Brugia malayi Stress-activated protein kinase jnk-1 0.0229 0.0303 0.0303
Echinococcus granulosus integrin beta 2 0.1175 0.1751 0.1751
Brugia malayi Pepsin A precursor 0.0035 0.0006 0.0006
Echinococcus granulosus sodium:myo inositol cotransporter 0.0147 0.0178 0.0178
Plasmodium falciparum subtilisin-like protease 3 0.0288 0.0394 0.7105
Echinococcus granulosus solute carrier family 5 0.0147 0.0178 0.0178
Brugia malayi hypothetical protein 0.0035 0.0006 0.0006
Brugia malayi hypothetical protein 0.0039 0.0013 0.0013
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0035 0.0006 0.0073
Entamoeba histolytica chitinase, putative 0.0073 0.0064 0.06
Trypanosoma brucei subtilisin peptidase 0.0288 0.0394 0.3422
Schistosoma mansoni hypothetical protein 0.0101 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.004 0.0014 0.0014
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0081 0.0076 0.132
Echinococcus multilocularis fibrillin 1 0.0068 0.0056 0.007
Brugia malayi EGF-like domain containing protein 0.004 0.0014 0.0014
Echinococcus multilocularis membrane bound transcription factor site 1 0.0288 0.0394 0.0492
Echinococcus granulosus fibrillin 2 0.004 0.0014 0.0014
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.0069 0.1116
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0288 0.0394 1
Toxoplasma gondii rhoptry neck protein RON9 0.0039 0.0013 0.0212
Onchocerca volvulus 0.0052 0.0033 0.0424
Onchocerca volvulus 0.0038 0.001 0.0131
Schistosoma mansoni chromatin regulatory protein sir2 0.0712 0.1043 0.1043
Echinococcus granulosus chromatin regulatory protein sir2 0.0712 0.1043 0.1043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Echinococcus multilocularis fibrillin 2 0.004 0.0014 0.0017
Onchocerca volvulus 0.0039 0.0013 0.0167
Entamoeba histolytica hypothetical protein 0.0042 0.0016 0.0141
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0288 0.0394 0.0394
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4012 0.6093 1
Brugia malayi endochitinase 0.0073 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0142 0.017 0.017
Plasmodium falciparum plasmepsin VII 0.0035 0.0006 0.0066
Toxoplasma gondii type I fatty acid synthase, putative 0.0081 0.0076 0.1486
Brugia malayi Protein kinase domain containing protein 0.0052 0.0033 0.0033
Brugia malayi celfurPC protein 0.526 0.8002 0.8002
Echinococcus multilocularis epidermal growth factor receptor 0.0464 0.0663 0.0829
Toxoplasma gondii PA14 domain-containing protein 0.0052 0.0033 0.061
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0109 0.012 0.1136
Loa Loa (eye worm) hypothetical protein 0.004 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0033 0.0054
Onchocerca volvulus 0.0039 0.0013 0.0167
Echinococcus granulosus MAM 0.0101 0.0107 0.0107
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0113 0.2015
Loa Loa (eye worm) hypothetical protein 0.0033 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Brugia malayi Furin-like cysteine rich region family protein 0.0464 0.0663 0.0663
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0109 0.012 0.0197
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0006 0.0006
Toxoplasma gondii subtilisin SUB4 0.0288 0.0394 0.7867
Loa Loa (eye worm) hypothetical protein 0.0035 0.0006 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Toxoplasma gondii rhoptry neck protein RON1 0.0039 0.0013 0.0212
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0248 0.0332 0.0332
Brugia malayi Kelch motif family protein 0.0275 0.0373 0.0373
Loa Loa (eye worm) transcriptional regulator 0.0105 0.0113 0.0113
Onchocerca volvulus Fatty acid synthase homolog 0.0142 0.017 0.2201
Onchocerca volvulus 0.0137 0.0162 0.2104
Echinococcus granulosus epidermal growth factor receptor 0.0464 0.0663 0.0663
Trichomonas vaginalis conserved hypothetical protein 0.1305 0.195 0.3201
Loa Loa (eye worm) hypothetical protein 0.0288 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0101 0.0107 0.0107
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0228 0.0301 0.0301
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0081 0.0076 0.132
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0109 0.012 0.1131
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0288 0.0394 0.0394
Plasmodium vivax NAD-dependent deacetylase, putative 0.0105 0.0113 0.2015
Onchocerca volvulus 0.0288 0.0394 0.5106
Plasmodium falciparum plasmepsin V 0.0393 0.0553 1
Brugia malayi Will die slowly protein 0.0276 0.0375 0.0375
Plasmodium falciparum LCCL domain-containing protein 0.0052 0.0033 0.0551
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0105 0.0113 0.1072
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4012 0.6093 0.7614
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.01 0.0106 0.0106
Trypanosoma cruzi UDP-galactopyranose mutase 0.01 0.0106 0.0996
Loa Loa (eye worm) hypothetical protein 0.0493 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0493 0.0708 0.0708
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0113 0.0113
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1594 0.2391 0.2391
Loa Loa (eye worm) TK/EGFR protein kinase 0.0464 0.0663 0.0663
Plasmodium vivax aspartyl protease, putative 0.0035 0.0006 0.0066
Echinococcus granulosus growth factor receptor bound protein 2 0.0144 0.0173 0.0173
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0288 0.0394 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.01 0.0106 0.2131
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0051 0.003 0.003
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0217 0.0285 0.0285
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0076 0.0069 0.172
Brugia malayi Subtilase family protein 0.0288 0.0394 0.0394
Echinococcus granulosus protein arginine N methyltransferase 8 0.0194 0.025 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0033 0.0054
Mycobacterium tuberculosis Probable thioesterase TesA 0.0066 0.0053 0.1317
Toxoplasma gondii aspartyl protease ASP5 0.0358 0.05 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0712 0.1043 0.1043
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0081 0.0076 0.1911
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0109 0.012 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.1305 0.195 0.3201
Schistosoma mansoni sodium/solute symporter 0.0038 0.001 0.001
Plasmodium vivax LCCL domain-containing protein 0.0052 0.0033 0.0551
Toxoplasma gondii type I fatty acid synthase, putative 0.0056 0.0038 0.0723
Loa Loa (eye worm) hypothetical protein 0.0038 0.001 0.001
Brugia malayi Protein kinase domain containing protein 0.0033 0.0002 0.0002
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0105 0.0113 0.2015
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0006 0.0006
Giardia lamblia Sirtuin type 2 0.0105 0.0113 0.0274
Loa Loa (eye worm) hypothetical protein 0.0535 0.0771 0.0771
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1594 0.2391 0.3925
Plasmodium vivax apical sushi protein, putative 0.0039 0.0013 0.0191
Loa Loa (eye worm) TK/ROR protein kinase 0.0033 0.0002 0.0002
Trypanosoma cruzi subtilisin peptidase 0.0288 0.0394 0.3764
Plasmodium falciparum plasmepsin VIII, putative 0.0035 0.0006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0042 0.0017 0.0017
Onchocerca volvulus Putative endochitinase 0.0073 0.0064 0.0831
Loa Loa (eye worm) hypothetical protein 0.2553 0.386 0.386
Leishmania major arginine N-methyltransferase-like protein 0.0194 0.025 0.238
Echinococcus multilocularis adam 0.004 0.0014 0.0017
Giardia lamblia hypothetical protein 0.0042 0.0016 0.0008
Onchocerca volvulus 0.0039 0.0013 0.0167
Schistosoma mansoni amine oxidase 0.01 0.0106 0.0106
Plasmodium vivax aspartyl protease, putative 0.0035 0.0006 0.0066
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.01 0.0106 0.188
Plasmodium falciparum plasmepsin IX 0.0035 0.0006 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0033 0.0054
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.004 0.0014 0.0022
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0113 0.0186
Toxoplasma gondii subtilisin SUB10 0.0288 0.0394 0.7867
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0113 0.0186
Mycobacterium ulcerans polyketide synthase 0.0076 0.0069 0.1116
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0712 0.1043 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0027
Trypanosoma cruzi UDP-galactopyranose mutase 0.01 0.0106 0.0996
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0035 0.0006 0.0006
Loa Loa (eye worm) proprotein convertase 2 0.1594 0.2391 0.2391
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0712 0.1043 0.1043
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.0033 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1594 0.2391 0.3925
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0105 0.0113 0.1067
Toxoplasma gondii subtilisin SUB12 0.0288 0.0394 0.7867
Mycobacterium ulcerans chitinase/cellulase 0.0062 0.0048 0.0539
Trichomonas vaginalis conserved hypothetical protein 0.1305 0.195 0.3201
Echinococcus multilocularis Tolloid protein 1 0.0057 0.004 0.005
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0042 0.0016 0.002
Loa Loa (eye worm) hypothetical protein 0.0059 0.0043 0.0043
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0006 0.0006
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0006 0.0006
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0712 0.1043 0.1711
Echinococcus multilocularis protein kinase c epsilon type 0.0093 0.0094 0.0118
Mycobacterium ulcerans protoporphyrinogen oxidase 0.01 0.0106 0.2131
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0288 0.0394 1
Toxoplasma gondii subtilisin SUB6 0.0288 0.0394 0.7867
Echinococcus granulosus discoidin domain receptor 0.0052 0.0033 0.0033
Echinococcus granulosus furin 0.6566 1 1
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0147 0.0178 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0033 0.0054
Echinococcus multilocularis 0.526 0.8002 1
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.001 0.0013
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0076 0.0069 0.1734
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0006 0.0006
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0081 0.0076 0.1911
Onchocerca volvulus 0.0035 0.0006 0.0077
Loa Loa (eye worm) hypothetical protein 0.004 0.0014 0.0014
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0006 0.0006
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0712 0.1043 1
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0065 0.0065
Trypanosoma cruzi glutathionylspermidine synthase, putative 0.0353 0.0493 0.4716
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0319 0.0441 0.3903
Plasmodium vivax subtilisin-like protease 1 0.0288 0.0394 0.7105
Plasmodium vivax subtilisin-like protease 2, putative 0.0288 0.0394 0.7105
Onchocerca volvulus Putative cubilin 0.005 0.003 0.0385
Schistosoma mansoni inositol transporter 0.0147 0.0178 0.0178
Plasmodium falciparum plasmepsin VI 0.0035 0.0006 0.0066
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0051 0.0031 0.057
Loa Loa (eye worm) hypothetical protein 0.0062 0.0048 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.1305 0.195 0.3201
Giardia lamblia Furin precursor putative serine protease 0.1305 0.195 0.532
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.0013
Mycobacterium ulcerans dehydrogenase 0.01 0.0106 0.2131
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0076 0.007 0.007
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.001 0.0156
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.0069 0.1116
Toxoplasma gondii histone lysine-specific demethylase 0.01 0.0106 0.2082
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.01 0.0106 0.188
Toxoplasma gondii histone deacetylase SIR2 0.0105 0.0113 0.2231
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0105 0.0113 0.0113
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0076 0.0069 0.1116
Trichomonas vaginalis hypothetical protein 0.004 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.0013
Echinococcus multilocularis C type lectin domian containing protein 0.0039 0.0013 0.0016
Brugia malayi pregnancy-associated plasma protein-A 0.0039 0.0013 0.0013
Echinococcus granulosus c4b binding protein beta chain 0.0039 0.0013 0.0013
Plasmodium falciparum plasmepsin III 0.0035 0.0006 0.0066
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0194 0.025 0.4974
Echinococcus multilocularis solute carrier family 5 0.0147 0.0178 0.0223
Brugia malayi EGF-like domain containing protein 0.004 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.0013
Giardia lamblia Transcriptional regulator, Sir2 family 0.0105 0.0113 0.0274
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Brugia malayi hypothetical protein 0.0039 0.0013 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0006 0.0066
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0113 0.0186
Loa Loa (eye worm) TK/ALK protein kinase 0.0101 0.0107 0.0107
Mycobacterium tuberculosis Possible oxidoreductase 0.01 0.0106 0.2667
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0081 0.0076 0.132
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1594 0.2391 0.3925
Trichomonas vaginalis conserved hypothetical protein 0.0288 0.0394 0.0646
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0109 0.012 0.015
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.0033 0.0041
Loa Loa (eye worm) hypothetical protein 0.0052 0.0033 0.0033
Brugia malayi EGF-like domain containing protein 0.004 0.0014 0.0014
Schistosoma mansoni furin-1 (S08 family) 0.2842 0.4301 0.4301
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0109 0.012 0.2365
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1305 0.195 0.3201
Mycobacterium ulcerans thioesterase 0.0066 0.0053 0.0683
Loa Loa (eye worm) microfilarial chitinase 0.0062 0.0048 0.0048
Echinococcus granulosus adam 0.004 0.0014 0.0014
Brugia malayi transcriptional regulator, Sir2 family protein 0.0105 0.0113 0.0113
Echinococcus granulosus sodium:glucose cotransporter 2 0.0147 0.0178 0.0178
Onchocerca volvulus 0.0276 0.0375 0.486
Plasmodium falciparum protoporphyrinogen oxidase 0.01 0.0106 0.188
Brugia malayi amine oxidase, flavin-containing family protein 0.0142 0.017 0.017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4012 0.6093 1
Loa Loa (eye worm) Carm1-pending protein 0.0109 0.012 0.012
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0105 0.0113 0.0113
Brugia malayi SWIRM domain containing protein 0.0535 0.0771 0.0771
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0006 0.0006
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0062 0.0047 0.1161
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.0033 0.0041
Schistosoma mansoni integrin beta subunit 0.0932 0.1379 0.1379
Mycobacterium leprae Probable polyketide synthase Pks1 0.0081 0.0076 0.132
Loa Loa (eye worm) hypothetical protein 0.6566 1 1
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1305 0.195 0.3201
Loa Loa (eye worm) hypothetical protein 0.0149 0.0181 0.0181
Brugia malayi transcriptional regulator, Sir2 family protein 0.0105 0.0113 0.0113
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0115 0.0128 0.3239
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0113 0.0186
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0016
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0248 0.0332 0.0415
Schistosoma mansoni site-1 peptidase (S08 family) 0.0288 0.0394 0.0394
Echinococcus multilocularis high affinity choline transporter 1 0.0038 0.001 0.0013
Mycobacterium ulcerans monoamine oxidase 0.01 0.0106 0.2131
Trichomonas vaginalis conserved hypothetical protein 0.1305 0.195 0.3201
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0288 0.0394 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0076 0.0068 0.064
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0288 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0304 0.0417 0.0417
Echinococcus granulosus expressed protein 0.0361 0.0504 0.0504
Giardia lamblia High cysteine membrane protein Group 2 0.2419 0.3654 1
Brugia malayi proprotein convertase 2 0.4147 0.6299 0.6299
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0052 0.0033 0.0801
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Echinococcus granulosus lysine specific histone demethylase 1A 0.0493 0.0708 0.0708
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0006 0.0006
Onchocerca volvulus 0.0535 0.0771 1
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1305 0.195 0.3201
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0712 0.1043 1
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0194 0.025 0.4492
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0109 0.012 0.012
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0288 0.0394 0.0492
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0113 0.0113
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0093 0.0094 0.0094
Trichomonas vaginalis hypothetical protein 0.0052 0.0033 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0288 0.0394 0.0646
Schistosoma mansoni hypothetical protein 0.0109 0.012 0.012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Trichomonas vaginalis WD repeat domain, putative 0.0276 0.0375 0.0615
Echinococcus multilocularis protein jagged 2 0.004 0.0014 0.0017
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0113 0.0186
Onchocerca volvulus 0.0039 0.0013 0.0167
Brugia malayi neuroendocrine convertase 1 precursor 0.4147 0.6299 0.6299
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0147 0.0178 0.0223
Loa Loa (eye worm) hypothetical protein 0.0041 0.0016 0.0016
Loa Loa (eye worm) integrin beta-2 0.1591 0.2387 0.2387
Onchocerca volvulus 0.0033 0.0002 0.003
Onchocerca volvulus 0.0101 0.0107 0.1384
Schistosoma mansoni inositol transporter 0.0147 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.0013
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0052 0.0033 0.0054
Toxoplasma gondii subtilisin SUB8 0.0288 0.0394 0.7867
Toxoplasma gondii SWIRM domain-containing protein 0.0042 0.0016 0.0283
Schistosoma mansoni serine/threonine protein kinase 0.0229 0.0303 0.0303
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0105 0.0113 0.2855
Mycobacterium leprae Polyketide synthase Pks13 0.0115 0.0128 0.2745
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0006 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1594 0.2391 0.3925
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0052 0.0033 0.0041
Schistosoma mansoni protein arginine n-methyltransferase 0.0109 0.012 0.012
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0105 0.0113 0.0577
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Brugia malayi NAD-dependent deacetylase SIRT1 0.0105 0.0113 0.0113
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0288 0.0394 0.0646
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0076 0.0069 0.1116
Echinococcus multilocularis growth factor receptor bound protein 2 0.0144 0.0173 0.0216
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0076 0.0069 0.172
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0493 0.0708 0.0708
Echinococcus multilocularis discoidin domain receptor 0.0052 0.0033 0.0041
Trypanosoma cruzi trypanothione synthetase 0.0068 0.0056 0.052
Schistosoma mansoni protein kinase 0.0248 0.0332 0.0332
Brugia malayi Endochitinase 0.0073 0.0064 0.0064
Loa Loa (eye worm) endoprotease bli-4 0.6566 1 1
Brugia malayi hypothetical protein 0.0039 0.0013 0.0013
Brugia malayi hypothetical protein 0.0039 0.0013 0.0013
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0006 0.0006
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1252 0.1868 0.1868
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0094 0.0094

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 8 ug ml-1 Antitubercular activity against Mycobacterium tuberculosis H37Rv by microdilution resazurin assay ChEMBL. 19467603

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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